PROJECT #19002 RESEARCH FOR CANNABINOID
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Cannabinoid Receptors The endocannabinoid signaling system consists of receptors (Cannabinoid Receptors; CB1 and CB2), endogeneous molecules (Endocannabinoids; 2-AG, Anandamide), and enzymes.

Endocannabinoids are produced in postsynaptic neurons and bind to Cannabinoid Receptors to maintain homeostasis in neuron signaling and a plethora of physiological processes.

These receptors are targeted for pain, obesity, and other central nervous system disorders.

Endocannabinoids show more than 10-fold selectivity towards CB1 compared to CB2.

Therefore, a mechanistic understanding of endocannabinoid selectivity will help us design selective therapeutics.

In this project, we are running binding simulation of anandmide to CB1 and CB2 to decipher ligand selectivity..

PROJECT INFO

Manager(s): Soumajit Dutta

Institution: University of Illinois Urbana-Champaign

Project URL: shuklagroup.org/

PROJECT WORK UNIT SUMMARY

Atoms: 98,432

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Tuesday, 07 February 2023 06:14:50

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	8,501,154	174,407	48.74	0 ^hrs 30 ^mins
2	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,950,207	170,214	46.71	0 ^hrs 31 ^mins
3	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	6,536,590	159,102	41.08	0 ^hrs 35 ^mins
4	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,390,741	158,992	40.20	0 ^hrs 36 ^mins
5	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,183,278	155,215	39.84	0 ^hrs 36 ^mins
6	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,771,115	143,553	33.24	0 ^hrs 43 ^mins
7	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,549,956	141,537	32.15	0 ^hrs 45 ^mins
8	RTX A5000 GA102GL [RTX A5000]	Nvidia	GA102GL	4,389,720	139,505	31.47	0 ^hrs 46 ^mins
9	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,240,419	136,856	30.98	0 ^hrs 46 ^mins
10	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,040,134	135,756	29.76	0 ^hrs 48 ^mins
11	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,465,063	124,508	27.83	0 ^hrs 52 ^mins
12	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,302,286	127,380	25.92	0 ^hrs 56 ^mins
13	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,182,983	124,097	25.65	0 ^hrs 56 ^mins
14	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,121,423	124,463	25.08	0 ^hrs 57 ^mins
15	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,892,129	122,717	23.57	1 ^hrs 1 ^mins
16	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,844,240	122,837	23.15	1 ^hrs 2 ^mins
17	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	2,788,067	120,775	23.08	1 ^hrs 2 ^mins
18	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,320,205	112,979	20.54	1 ^hrs 10 ^mins
19	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,203,412	111,687	19.73	1 ^hrs 13 ^mins
20	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,049,800	107,134	19.13	1 ^hrs 15 ^mins
21	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,967,569	106,055	18.55	1 ^hrs 18 ^mins
22	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	1,903,300	106,339	17.90	1 ^hrs 20 ^mins
23	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	1,755,413	100,346	17.49	1 ^hrs 22 ^mins
24	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,754,518	103,312	16.98	1 ^hrs 25 ^mins
25	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,700,340	102,171	16.64	1 ^hrs 27 ^mins
26	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	1,622,161	100,884	16.08	1 ^hrs 30 ^mins
27	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,454,218	96,837	15.02	2 ^hrs 36 ^mins
28	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,332,410	93,569	14.24	2 ^hrs 41 ^mins
29	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,250,541	91,527	13.66	2 ^hrs 45 ^mins
30	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,199,174	91,032	13.17	2 ^hrs 49 ^mins
31	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,178,887	89,611	13.16	2 ^hrs 49 ^mins
32	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,170,601	90,380	12.95	2 ^hrs 51 ^mins
33	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,103,032	88,586	12.45	2 ^hrs 56 ^mins
34	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,020,897	84,490	12.08	2 ^hrs 59 ^mins
35	P104-100 GP104 [P104-100]	Nvidia	GP104	844,550	81,657	10.34	2 ^hrs 19 ^mins
36	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	701,367	71,529	9.81	2 ^hrs 27 ^mins
37	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	657,449	74,986	8.77	3 ^hrs 44 ^mins
38	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	616,614	73,903	8.34	3 ^hrs 53 ^mins
39	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	541,988	69,995	7.74	3 ^hrs 6 ^mins
40	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	513,510	68,760	7.47	3 ^hrs 13 ^mins
41	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	464,689	65,274	7.12	3 ^hrs 22 ^mins
42	P106-090 GP106 [P106-090]	Nvidia	GP106	283,949	56,401	5.03	5 ^hrs 46 ^mins
43	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	270,956	56,451	4.80	5 ^hrs 0 ^mins
44	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	267,316	49,878	5.36	4 ^hrs 29 ^mins
45	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	254,711	56,515	4.51	5 ^hrs 20 ^mins
46	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	219,658	52,212	4.21	6 ^hrs 42 ^mins
47	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	193,183	49,704	3.89	6 ^hrs 10 ^mins
48	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	120,238	42,485	2.83	8 ^hrs 29 ^mins
49	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	98,764	39,754	2.48	10 ^hrs 40 ^mins
50	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	91,947	38,768	2.37	10 ^hrs 7 ^mins
51	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	79,330	38,802	2.04	12 ^hrs 44 ^mins
52	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	44,620	30,479	1.46	16 ^hrs 24 ^mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA