PROJECT #19001 RESEARCH FOR CANNABINOID
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Cannabinoid Receptors The endocannabinoid signaling system consists of receptors (Cannabinoid Receptors; CB1 and CB2), endogeneous molecules (Endocannabinoids; 2-AG, Anandamide), and enzymes.

Endocannabinoids are produced in postsynaptic neurons and bind to Cannabinoid Receptors to maintain homeostasis in neuron signaling and a plethora of physiological processes.

These receptors are targeted for pain, obesity, and other central nervous system disorders.

Endocannabinoids show more than 10-fold selectivity towards CB1 compared to CB2.

Therefore, a mechanistic understanding of endocannabinoid selectivity will help us design selective therapeutics.

In this project, we are running binding simulation of anandmide to CB1 and CB2 to decipher ligand selectivity..

PROJECT INFO

Manager(s): Soumajit Dutta

Institution: University of Illinois Urbana-Champaign

Project URL: shuklagroup.org/

PROJECT WORK UNIT SUMMARY

Atoms: 103,284

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 22 May 2022 15:22:29

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	9,886,727	190,103	52.01	0 ^hrs 28 ^mins
2	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	7,314,246	168,615	43.38	1 ^hrs 33 ^mins
3	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,628,639	159,215	41.63	1 ^hrs 35 ^mins
4	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	6,416,863	160,013	40.10	1 ^hrs 36 ^mins
5	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,714,826	156,255	36.57	1 ^hrs 39 ^mins
6	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,537,159	142,757	31.78	1 ^hrs 45 ^mins
7	RTX A5000 GA102GL [RTX A5000]	Nvidia	GA102GL	4,464,860	142,954	31.23	1 ^hrs 46 ^mins
8	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,406,738	142,472	30.93	1 ^hrs 47 ^mins
9	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,394,345	143,812	30.56	1 ^hrs 47 ^mins
10	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,247,188	139,076	30.54	1 ^hrs 47 ^mins
11	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,947,661	137,276	28.76	1 ^hrs 50 ^mins
12	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,285,314	129,539	25.36	1 ^hrs 57 ^mins
13	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,831,744	122,892	23.04	1 ^hrs 2 ^mins
14	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,755,817	117,554	23.44	1 ^hrs 1 ^mins
15	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,603,884	120,390	21.63	1 ^hrs 7 ^mins
16	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	2,323,671	115,009	20.20	1 ^hrs 11 ^mins
17	Tesla P100 16GB GP100GL [Tesla P100 16GB] 9340	Nvidia	GP100GL	2,278,956	115,442	19.74	1 ^hrs 13 ^mins
18	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,220,205	113,479	19.56	1 ^hrs 14 ^mins
19	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,052,799	110,592	18.56	1 ^hrs 18 ^mins
20	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	1,723,922	104,182	16.55	1 ^hrs 27 ^mins
21	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	1,658,570	101,649	16.32	1 ^hrs 28 ^mins
22	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,529,413	100,826	15.17	2 ^hrs 35 ^mins
23	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,440,884	96,897	14.87	2 ^hrs 37 ^mins
24	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,338,959	96,109	13.93	2 ^hrs 43 ^mins
25	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,213,672	93,407	12.99	2 ^hrs 51 ^mins
26	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,185,518	90,220	13.14	2 ^hrs 50 ^mins
27	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,158,483	91,364	12.68	2 ^hrs 54 ^mins
28	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,035,693	86,417	11.98	2 ^hrs 0 ^mins
29	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,014,032	86,040	11.79	2 ^hrs 2 ^mins
30	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,003,316	86,049	11.66	2 ^hrs 4 ^mins
31	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	937,833	85,037	11.03	2 ^hrs 11 ^mins
32	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	705,326	78,196	9.02	3 ^hrs 40 ^mins
33	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	612,811	73,979	8.28	3 ^hrs 54 ^mins
34	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	533,222	70,556	7.56	3 ^hrs 11 ^mins
35	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	521,578	70,253	7.42	3 ^hrs 14 ^mins
36	Quadro M5000 GM204GL [Quadro M5000]	Nvidia	GM204GL	412,254	65,541	6.29	4 ^hrs 49 ^mins
37	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	380,029	63,717	5.96	4 ^hrs 1 ^mins
38	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	283,857	55,699	5.10	5 ^hrs 43 ^mins
39	GeForce GTX 980M GM204 [GeForce GTX 980M] 3189	Nvidia	GM204	272,900	56,034	4.87	5 ^hrs 56 ^mins
40	P106-090 GP106 [P106-090]	Nvidia	GP106	270,311	56,416	4.79	5 ^hrs 1 ^mins
41	T600 TU117GL [T600]	Intel	TU117GL	233,927	53,338	4.39	5 ^hrs 28 ^mins
42	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	215,292	52,414	4.11	6 ^hrs 51 ^mins
43	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	203,172	50,664	4.01	6 ^hrs 59 ^mins
44	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	114,250	42,331	2.70	9 ^hrs 54 ^mins
45	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	102,594	41,295	2.48	10 ^hrs 40 ^mins
46	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	93,031	39,480	2.36	10 ^hrs 11 ^mins
47	GeForce GTX 950M GM107 [GeForce GTX 950M] 1439	Nvidia	GM107	90,565	39,070	2.32	10 ^hrs 21 ^mins
48	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	50,609	32,398	1.56	15 ^hrs 22 ^mins
49	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	42,153	30,378	1.39	17 ^hrs 18 ^mins
50	Quadro P400 GP107GL [Quadro P400] 641	Nvidia	GP107GL	20,386	21,300	0.96	25 ^hrs 5 ^mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 22 May 2022 15:22:29

Rank Project	CPU Model	Logical Processors (LP)	PPD-PLP AVG PPD per 1 LP	ALL LP-PPD (Estimated)	Make

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