Folding project #19001, CANNABINOID research

Research section Research projects and references

Project #19001 overview

Project Summary AI Beta

The body uses special chemicals called endocannabinoids to help with things like pain and mood. These chemicals work by binding to receptors (CB1 and CB2). This project is simulating how a specific endocannabinoid, anandamide, interacts with these receptors to understand how it prefers one type of receptor over the other. This knowledge could help create better medications for conditions like pain or obesity.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Soumajit Dutta
Institution: University of Illinois Urbana-Champaign
Website: Open project site

Work unit

Atoms: 103,284
Core: 0x22
Status: Public

No related projects listed.

Source material

Official Project Description

Cannabinoid Receptors The endocannabinoid signaling system consists of receptors (Cannabinoid Receptors; CB1 and CB2), endogeneous molecules (Endocannabinoids; 2-AG, Anandamide), and enzymes.

Endocannabinoids are produced in postsynaptic neurons and bind to Cannabinoid Receptors to maintain homeostasis in neuron signaling and a plethora of physiological processes.

These receptors are targeted for pain, obesity, and other central nervous system disorders.

Endocannabinoids show more than 10-fold selectivity towards CB1 compared to CB2.

Therefore, a mechanistic understanding of endocannabinoid selectivity will help us design selective therapeutics.

In this project, we are running binding simulation of anandmide to CB1 and CB2 to decipher ligand selectivity.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Cannabinoid Receptors

Receptors that bind to cannabinoids.

Scientific: BiotechnologyPharmacology / Neuropharmacology

Cannabinoid receptors are proteins found on cells in the body that bind to cannabinoids. There are two main types of cannabinoid receptors: CB1 and CB2. CB1 receptors are primarily found in the brain and central nervous system, while CB2 receptors are found throughout the body, including the immune system. Cannabinoids can activate or inhibit these receptors, leading to a variety of effects.

CB1

Cannabinoid receptor 1

Acronym: BiotechnologyPharmacology / Neuropharmacology

CB1 receptors are found primarily in the brain and central nervous system. They are responsible for many of the psychoactive effects of cannabinoids.

CB2

Cannabinoid receptor 2

Acronym: BiotechnologyPharmacology / Immunology

CB2 receptors are found throughout the body, including the immune system. They play a role in inflammation and pain.

Endocannabinoids

Naturally occurring molecules that bind to cannabinoid receptors.

Scientific: BiotechnologyPharmacology / Neuropharmacology

Endocannabinoids are signaling molecules produced by the body. They act on cannabinoid receptors, which are involved in a variety of functions, including pain sensation, mood regulation, and appetite.

Anandamide

A type of endocannabinoid.

Scientific: BiotechnologyPharmacology / Neuropharmacology

Anandamide is a fatty acid molecule that acts as an endocannabinoid. It binds to CB1 receptors in the brain and produces a variety of effects, including pain relief, relaxation, and euphoria.

2-AG

2-Arachidonoylglycerol

Acronym: BiotechnologyPharmacology / Neuropharmacology

2-AG is a type of endocannabinoid that binds to CB1 and CB2 receptors.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	15,075,984	211,920	71.14	0 ^hrs 20 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	11,961,947	196,981	60.73	0 ^hrs 24 ^mins
3	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	9,100,942	181,044	50.27	0 ^hrs 29 ^mins
4	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	7,586,290	170,564	44.48	0 ^hrs 32 ^mins
5	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,737,358	160,815	41.90	0 ^hrs 34 ^mins
6	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,383,378	160,992	39.65	0 ^hrs 36 ^mins
7	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	6,283,035	158,092	39.74	0 ^hrs 36 ^mins
8	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,218,104	159,209	39.06	0 ^hrs 37 ^mins
9	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,209,571	161,457	38.46	0 ^hrs 37 ^mins
10	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,044,805	155,289	38.93	0 ^hrs 37 ^mins
11	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,599,720	143,617	32.03	0 ^hrs 45 ^mins
12	RTX A5000 GA102GL [RTX A5000]	Nvidia	GA102GL	4,464,860	142,954	31.23	0 ^hrs 46 ^mins
13	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,434,291	143,207	30.96	0 ^hrs 47 ^mins
14	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,249,653	139,458	30.47	0 ^hrs 47 ^mins
15	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	3,894,312	135,090	28.83	0 ^hrs 50 ^mins
16	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,615,122	133,114	27.16	0 ^hrs 53 ^mins
17	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,285,314	129,539	25.36	0 ^hrs 57 ^mins
18	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,047,804	125,340	24.32	0 ^hrs 59 ^mins
19	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,796,631	122,268	22.87	1 ^hrs 3 ^mins

20	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,794,956	122,843	22.75	1 ^hrs 3 ^mins
21	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,738,369	118,513	23.11	1 ^hrs 2 ^mins
22	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,649,428	119,199	22.23	1 ^hrs 5 ^mins
23	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,638,019	120,435	21.90	1 ^hrs 6 ^mins
24	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,380,098	116,961	20.35	1 ^hrs 11 ^mins
25	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	2,323,671	115,009	20.20	1 ^hrs 11 ^mins
26	Tesla P100 16GB GP100GL [Tesla P100 16GB] 9340	Nvidia	GP100GL	2,278,956	115,442	19.74	1 ^hrs 13 ^mins
27	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,196,953	113,021	19.44	1 ^hrs 14 ^mins
28	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,057,011	110,797	18.57	1 ^hrs 18 ^mins
29	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,028,736	109,549	18.52	1 ^hrs 18 ^mins
30	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	1,723,922	104,182	16.55	1 ^hrs 27 ^mins
31	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	1,639,760	99,396	16.50	1 ^hrs 27 ^mins
32	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,440,884	96,897	14.87	1 ^hrs 37 ^mins
33	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,338,959	96,109	13.93	1 ^hrs 43 ^mins
34	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,282,587	95,093	13.49	1 ^hrs 47 ^mins
35	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,271,846	94,757	13.42	1 ^hrs 47 ^mins
36	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,202,083	92,941	12.93	1 ^hrs 51 ^mins
37	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,141,453	91,110	12.53	1 ^hrs 55 ^mins
38	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,105,729	90,141	12.27	1 ^hrs 57 ^mins
39	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,030,331	87,008	11.84	2 ^hrs 2 ^mins

40	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	998,475	76,518	13.05	1 ^hrs 50 ^mins
41	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	992,650	86,327	11.50	2 ^hrs 5 ^mins
42	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	942,236	82,966	11.36	2 ^hrs 7 ^mins
43	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	937,833	85,037	11.03	2 ^hrs 11 ^mins
44	P104-100 GP104 [P104-100]	Nvidia	GP104	859,137	80,773	10.64	2 ^hrs 15 ^mins
45	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	775,391	80,315	9.65	2 ^hrs 29 ^mins
46	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	686,065	77,344	8.87	2 ^hrs 42 ^mins
47	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	618,376	66,458	9.30	2 ^hrs 35 ^mins
48	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	613,178	74,020	8.28	2 ^hrs 54 ^mins
49	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	533,222	70,556	7.56	3 ^hrs 11 ^mins
50	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	521,578	70,253	7.42	3 ^hrs 14 ^mins
51	Quadro M5000 GM204GL [Quadro M5000]	Nvidia	GM204GL	412,254	65,541	6.29	3 ^hrs 49 ^mins
52	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	380,029	63,717	5.96	4 ^hrs 1 ^mins
53	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	299,953	58,515	5.13	4 ^hrs 41 ^mins
54	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	283,857	55,699	5.10	4 ^hrs 43 ^mins
55	GeForce GTX 980M GM204 [GeForce GTX 980M] 3189	Nvidia	GM204	272,900	56,034	4.87	4 ^hrs 56 ^mins
56	P106-090 GP106 [P106-090]	Nvidia	GP106	269,797	56,385	4.78	5 ^hrs 1 ^mins
57	T600 TU117GL [T600]	Nvidia	TU117GL	233,927	53,338	4.39	5 ^hrs 28 ^mins
58	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	215,292	52,414	4.11	5 ^hrs 51 ^mins
59	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	203,144	50,856	3.99	6 ^hrs 0 ^mins

60	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	114,739	42,504	2.70	8 ^hrs 53 ^mins
61	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	102,594	41,295	2.48	9 ^hrs 40 ^mins
62	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	93,659	39,817	2.35	10 ^hrs 12 ^mins
63	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	93,031	39,480	2.36	10 ^hrs 11 ^mins
64	GeForce GTX 950M GM107 [GeForce GTX 950M] 1439	Nvidia	GM107	90,565	39,070	2.32	10 ^hrs 21 ^mins
65	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	50,609	32,398	1.56	15 ^hrs 22 ^mins
66	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	42,153	30,378	1.39	17 ^hrs 18 ^mins
67	Quadro P400 GP107GL [Quadro P400] 641	Nvidia	GP107GL	20,386	21,300	0.96	25 ^hrs 5 ^mins

Research: CANNABINOID Folding Project #19001

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 19001

GPU PPD Averages

Research: CANNABINOID Folding Project #19001

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages