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Research: CANNABINOID Folding Project #19005

Project #19005 overview

Project Summary AI Beta

Our project looks at how the body's natural chemicals (called endocannabinoids) fit into special receptors (CB1 and CB2). These receptors control things like pain, hunger, and brain activity. We're using computer simulations to see how well one of these chemicals, anandamide, fits into each receptor. This could help us develop new medicines that target specific receptors for treating diseases.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Soumajit Dutta
Institution
University of Illinois Urbana-Champaign

Work unit

Atoms
103,284
Core
0xa8
Status
Public
Source material

Official Project Description

Cannabinoid Receptors The endocannabinoid signaling system consists of receptors (Cannabinoid Receptors; CB1 and CB2), endogeneous molecules (Endocannabinoids; 2-AG, Anandamide), and enzymes.

Endocannabinoids are produced in postsynaptic neurons and bind to Cannabinoid Receptors to maintain homeostasis in neuron signaling and a plethora of physiological processes.

These receptors are targeted for pain, obesity, and other central nervous system disorders.

Endocannabinoids show more than 10-fold selectivity towards CB1 compared to CB2.

Therefore, a mechanistic understanding of endocannabinoid selectivity will help us design selective therapeutics.

In this project, we are running binding simulation of anandmide to CB1 and CB2 to decipher ligand selectivity.

Performance data

Hardware Performance for Project 19005

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:49:41

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 5950X 16-CORE 32 21,948 702,336 AMD
2 12TH GEN CORE I7-12700K 20 22,869 457,380 Intel
3 12TH GEN CORE I9-12900K 24 17,899 429,576 Intel
4 RYZEN 7 3800X 8-CORE 16 24,646 394,336 AMD
5 RYZEN 9 3900X 12-CORE 24 13,415 321,960 AMD
6 RYZEN 7 5700X 8-CORE 16 19,588 313,408 AMD
7 CORE I7-8700 CPU @ 3.20GHZ 12 19,049 228,588 Intel
8 RYZEN 7 5800X 8-CORE 16 13,703 219,248 AMD
9 RYZEN 5 5600X 6-CORE 12 14,687 176,244 AMD
10 11TH GEN CORE I9-11900K @ 3.50GHZ 16 10,348 165,568 Intel
11 RYZEN 5 3600 6-CORE 12 13,547 162,564 AMD
12 RYZEN THREADRIPPER 2950X 16-CORE 32 4,717 150,944 AMD
13 CORE I7-5930K CPU @ 3.50GHZ 12 8,742 104,904 Intel
14 CORE I7-7700K CPU @ 4.20GHZ 8 11,547 92,376 Intel
15 CORE I5-9600K CPU @ 3.70GHZ 6 13,693 82,158 Intel
16 CORE I7-10700T CPU @ 2.00GHZ 16 4,723 75,568 Intel
17 CORE I9-8950HK CPU @ 2.90GHZ 12 6,293 75,516 Intel
18 XEON CPU E5-2697 V2 @ 2.70GHZ 24 2,961 71,064 Intel
19 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 8,131 65,048 Intel
20 CORE I5-4590 CPU @ 3.30GHZ 4 11,812 47,248 Intel
21 CORE I7-4770HQ CPU @ 2.20GHZ 8 5,769 46,152 Intel
22 CORE I3-6006U CPU @ 2.00GHZ 4 1,517 6,068 Intel