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Research: CANNABINOID Folding Project #19003

Project #19003 overview

Project Summary AI Beta

Our project explores how a natural molecule called anandamide interacts with two receptors in our body called CB1 and CB2. Understanding this interaction can help us create new drugs to treat things like pain, obesity, and other brain disorders.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Soumajit Dutta
Institution
University of Illinois Urbana-Champaign

Work unit

Atoms
98,432
Core
0xa8
Status
Public
Source material

Official Project Description

Cannabinoid Receptors The endocannabinoid signaling system consists of receptors (Cannabinoid Receptors; CB1 and CB2), endogeneous molecules (Endocannabinoids; 2-AG, Anandamide), and enzymes.

Endocannabinoids are produced in postsynaptic neurons and bind to Cannabinoid Receptors to maintain homeostasis in neuron signaling and a plethora of physiological processes.

These receptors are targeted for pain, obesity, and other central nervous system disorders.

Endocannabinoids show more than 10-fold selectivity towards CB1 compared to CB2.

Therefore, a mechanistic understanding of endocannabinoid selectivity will help us design selective therapeutics.

In this project, we are running binding simulation of anandmide to CB1 and CB2 to decipher ligand selectivity.

Performance data

Hardware Performance for Project 19003

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:49:43

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 5950X 16-CORE 32 17,749 567,968 AMD
2 RYZEN 7 7700X 8-CORE 16 29,395 470,320 AMD
3 11TH GEN CORE I7-11700K @ 3.60GHZ 16 23,598 377,568 Intel
4 RYZEN 9 3900X 12-CORE 24 14,172 340,128 AMD
5 12TH GEN CORE I5-12600K 16 20,363 325,808 Intel
6 RYZEN 7 5700X 8-CORE 16 19,812 316,992 AMD
7 CORE I7-10700K CPU @ 3.80GHZ 16 18,014 288,224 Intel
8 RYZEN 7 3700X 8-CORE 16 15,828 253,248 AMD
9 12TH GEN CORE I7-12700 20 12,124 242,480 Intel
10 RYZEN 5 3500 6-CORE 6 30,880 185,280 AMD
11 RYZEN 5 5600X 6-CORE 12 14,333 171,996 AMD
12 RYZEN 5 3600 6-CORE 12 14,267 171,204 AMD
13 11TH GEN CORE I9-11900K @ 3.50GHZ 16 9,335 149,360 Intel
14 CORE I7-7700K CPU @ 4.20GHZ 8 11,753 94,024 Intel
15 APPLE M1 8 10,929 87,432 Apple
16 CORE I7-5820K CPU @ 3.30GHZ 12 7,222 86,664 Intel
17 12TH GEN CORE I7-12700H 20 4,000 80,000 Intel
18 RYZEN 5 5600H 12 6,504 78,048 AMD
19 CORE I9-8950HK CPU @ 2.90GHZ 12 6,439 77,268 Intel
20 APPLE M1 PRO 10 7,531 75,310 Apple
21 XEON CPU L5640 @ 2.27GHZ 24 2,853 68,472 Intel
22 CORE I7-8705G CPU @ 3.10GHZ 8 8,317 66,536 Intel
23 CORE I7-6700K CPU @ 4.00GHZ 8 6,487 51,896 Intel
24 CORE I5-4590 CPU @ 3.30GHZ 4 12,511 50,044 Intel
25 CORE I7-4770HQ CPU @ 2.20GHZ 8 5,892 47,136 Intel
26 CORE I5-7400 CPU @ 3.00GHZ 4 11,763 47,052 Intel
27 CORE I5-3210M CPU @ 2.50GHZ 4 2,441 9,764 Intel
28 CORE I3-6006U CPU @ 2.00GHZ 4 1,778 7,112 Intel