PROJECT #19003 RESEARCH FOR CANNABINOID
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
Cannabinoid Receptors The endocannabinoid signaling system consists of receptors (Cannabinoid Receptors; CB1 and CB2), endogeneous molecules (Endocannabinoids; 2-AG, Anandamide), and enzymes.
Endocannabinoids are produced in postsynaptic neurons and bind to Cannabinoid Receptors to maintain homeostasis in neuron signaling and a plethora of physiological processes.
These receptors are targeted for pain, obesity, and other central nervous system disorders.
Endocannabinoids show more than 10-fold selectivity towards CB1 compared to CB2.
Therefore, a mechanistic understanding of endocannabinoid selectivity will help us design selective therapeutics.
In this project, we are running binding simulation of anandmide to CB1 and CB2 to decipher ligand selectivity..
PROJECT INFO
Manager(s): Soumajit Dutta
Institution: University of Illinois Urbana-Champaign
Project URL: shuklagroup.org/
PROJECT WORK UNIT SUMMARY
Atoms: 98,432
Core: 0xa8
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Monday, 20 March 2023 06:14:51
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PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Monday, 20 March 2023 06:14:51