Official Project Description
Impact of mutations on signaling proteins Mutations in proteins are often found to have dramatic functional consequences through changes in conformational dynamics, ligand binding, and association with signaling partners.
These changes sometimes lead to pathological outcomes.
Additionally, proteins involved in cell signaling are the target of over half of approved drugs.
This project aims to understand how a small number of mutations in signaling proteins can cause a dramatic change in how they modulate cell signaling pathways.