PROJECT #17918 RESEARCH FOR MEMBRANE TRANSPORT
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
Measuring the Effects of Post-translational Modification on Membrane Transporter Function and Oligomerization: Membrane transporters possess terminal tails which can variably regulate their substrate recognition, gating dynamics, and oligomerization (see https://royalsocietypublishing.org/doi/full/10.1098/rsob.190083 for a review).
To reflect physiological conditions and satisfy the instantaneous demands of cells, these termini are known to be post-translationally modified (PTM).
PTMs, like phosphorylation, have been shown to regulate transporter function through allostery or direct local interactions, thus blocking transmembrane substrate import and/or export. Simulations in this project will be focused on studying how C-terminal phosphorylation affects oligomerization dynamics of a sugar transporter.
While a basic protein folding problem, understanding how PTMs affect transporter oligomerization, and oligomer dynamics, is critical for understanding biological regulations for basal transport activity.
This study's ability to observe how terminal PTMs may influence sugar transport dynamics has implications for studying cells in altered metabolic states..
PROJECT INFO
Manager(s): Austin Weigle
Institution: University of Illinois at Urbana-Champaign
Project URL: https://shuklagroup.org/
PROJECT WORK UNIT SUMMARY
Atoms: 179,499
Core: OPENMM_22
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Sunday, 22 May 2022 15:22:31
Rank Project |
Model Name Folding@Home Identifier |
Make Brand |
GPU Model |
PPD Average |
Points WU Average |
WUs Day Average |
WU Time Average |
---|---|---|---|---|---|---|---|
1 | GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate] |
Nvidia | GA102 | 8,358,362 | 340,004 | 24.58 | 1 hrs 59 mins |
2 | GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti] |
Nvidia | GA102 | 8,348,859 | 338,894 | 24.64 | 1 hrs 58 mins |
3 | GeForce RTX 3090 GA102 [GeForce RTX 3090] |
Nvidia | GA102 | 7,020,774 | 290,472 | 24.17 | 1 hrs 60 mins |
4 | GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 |
Nvidia | TU102 | 5,386,416 | 292,883 | 18.39 | 1 hrs 18 mins |
5 | GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti] |
Nvidia | GA104 | 5,317,906 | 292,553 | 18.18 | 1 hrs 19 mins |
6 | RTX A5000 GA102GL [RTX A5000] |
Nvidia | GA102GL | 5,098,938 | 288,002 | 17.70 | 1 hrs 21 mins |
7 | GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448 |
Nvidia | TU102 | 4,974,060 | 286,366 | 17.37 | 1 hrs 23 mins |
8 | GeForce RTX 3070 GA104 [GeForce RTX 3070] |
Nvidia | GA104 | 4,672,429 | 280,717 | 16.64 | 1 hrs 27 mins |
9 | GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate] |
Nvidia | GA104 | 3,627,234 | 256,887 | 14.12 | 2 hrs 42 mins |
10 | GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER] |
Nvidia | TU106 | 2,304,313 | 221,216 | 10.42 | 2 hrs 18 mins |
11 | GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380 |
Nvidia | GP102 | 2,276,288 | 218,049 | 10.44 | 2 hrs 18 mins |
12 | GeForce RTX 2070 TU106 [GeForce RTX 2070] |
Nvidia | TU106 | 2,091,276 | 215,587 | 9.70 | 2 hrs 28 mins |
13 | GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB] |
Nvidia | GA104M | 1,853,722 | 201,272 | 9.21 | 3 hrs 36 mins |
14 | GeForce RTX 2060 TU104 [GeForce RTX 2060] |
Nvidia | TU104 | 1,691,077 | 202,394 | 8.36 | 3 hrs 52 mins |
15 | GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463 |
Nvidia | GP104 | 1,262,344 | 180,986 | 6.97 | 3 hrs 26 mins |
16 | Tesla M40 GM200GL [Tesla M40] 6844 |
Nvidia | GM200GL | 1,134,634 | 173,840 | 6.53 | 4 hrs 41 mins |
17 | GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER] |
Nvidia | TU116 | 1,117,318 | 172,757 | 6.47 | 4 hrs 43 mins |
18 | Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64] |
AMD | Vega 10 XL/XT | 1,027,821 | 170,877 | 6.01 | 4 hrs 59 mins |
19 | GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372 |
Nvidia | GP106 | 734,800 | 151,604 | 4.85 | 5 hrs 57 mins |
20 | GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate] |
Nvidia | GA106 | 701,890 | 155,329 | 4.52 | 5 hrs 19 mins |
21 | Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590] |
AMD | Ellesmere XT | 390,042 | 122,883 | 3.17 | 8 hrs 34 mins |
22 | P106-090 GP106 [P106-090] |
Nvidia | GP106 | 297,391 | 112,345 | 2.65 | 9 hrs 4 mins |
23 | GeForce GTX 1650 TU117 [GeForce GTX 1650] |
Nvidia | TU117 | 266,378 | 120,919 | 2.20 | 11 hrs 54 mins |
24 | GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634 |
Nvidia | GK104 | 118,842 | 83,068 | 1.43 | 17 hrs 47 mins |
25 | Radeon R9 200 Series Hawaii [Radeon R9 200 Series] |
AMD | Hawaii | 101,916 | 78,669 | 1.30 | 19 hrs 32 mins |
26 | Radeon RX 460 Baffin XT [Radeon RX 460] |
AMD | Baffin XT | 100,035 | 68,245 | 1.47 | 16 hrs 22 mins |
27 | Quadro K2200 GM107GL [Quadro K2200] |
Nvidia | GM107GL | 75,455 | 84,083 | 0.90 | 27 hrs 45 mins |
PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Sunday, 22 May 2022 15:22:31
Rank Project |
CPU Model |
Logical Processors (LP) |
PPD-PLP AVG PPD per 1 LP |
ALL LP-PPD (Estimated) |
Make |
---|
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