PROJECT #17918 RESEARCH FOR MEMBRANE TRANSPORT
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Measuring the Effects of Post-translational Modification on Membrane Transporter Function and Oligomerization: Membrane transporters possess terminal tails which can variably regulate their substrate recognition, gating dynamics, and oligomerization (see https://royalsocietypublishing.org/doi/full/10.1098/rsob.190083 for a review).

To reflect physiological conditions and satisfy the instantaneous demands of cells, these termini are known to be post-translationally modified (PTM).

PTMs, like phosphorylation, have been shown to regulate transporter function through allostery or direct local interactions, thus blocking transmembrane substrate import and/or export. Simulations in this project will be focused on studying how C-terminal phosphorylation affects oligomerization dynamics of a sugar transporter.

While a basic protein folding problem, understanding how PTMs affect transporter oligomerization, and oligomer dynamics, is critical for understanding biological regulations for basal transport activity.

This study's ability to observe how terminal PTMs may influence sugar transport dynamics has implications for studying cells in altered metabolic states..

PROJECT INFO

Manager(s): Austin Weigle

Institution: University of Illinois at Urbana-Champaign

Project URL: https://shuklagroup.org/

PROJECT WORK UNIT SUMMARY

Atoms: 179,499

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 22 May 2022 15:22:31

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 8,358,362 340,004 24.58 1 hrs 59 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 8,348,859 338,894 24.64 1 hrs 58 mins
3 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,020,774 290,472 24.17 1 hrs 60 mins
4 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,386,416 292,883 18.39 1 hrs 18 mins
5 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 5,317,906 292,553 18.18 1 hrs 19 mins
6 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,098,938 288,002 17.70 1 hrs 21 mins
7 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,974,060 286,366 17.37 1 hrs 23 mins
8 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,672,429 280,717 16.64 1 hrs 27 mins
9 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,627,234 256,887 14.12 2 hrs 42 mins
10 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,304,313 221,216 10.42 2 hrs 18 mins
11 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,276,288 218,049 10.44 2 hrs 18 mins
12 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,091,276 215,587 9.70 2 hrs 28 mins
13 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,853,722 201,272 9.21 3 hrs 36 mins
14 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,691,077 202,394 8.36 3 hrs 52 mins
15 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,262,344 180,986 6.97 3 hrs 26 mins
16 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,134,634 173,840 6.53 4 hrs 41 mins
17 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,117,318 172,757 6.47 4 hrs 43 mins
18 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,027,821 170,877 6.01 4 hrs 59 mins
19 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 734,800 151,604 4.85 5 hrs 57 mins
20 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 701,890 155,329 4.52 5 hrs 19 mins
21 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 390,042 122,883 3.17 8 hrs 34 mins
22 P106-090
GP106 [P106-090]
Nvidia GP106 297,391 112,345 2.65 9 hrs 4 mins
23 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 266,378 120,919 2.20 11 hrs 54 mins
24 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 118,842 83,068 1.43 17 hrs 47 mins
25 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 101,916 78,669 1.30 19 hrs 32 mins
26 Radeon RX 460
Baffin XT [Radeon RX 460]
AMD Baffin XT 100,035 68,245 1.47 16 hrs 22 mins
27 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 75,455 84,083 0.90 27 hrs 45 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 22 May 2022 15:22:31

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make