PROJECT #17918 RESEARCH FOR MEMBRANE TRANSPORT
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Measuring the Effects of Post-translational Modification on Membrane Transporter Function and Oligomerization: Membrane transporters possess terminal tails which can variably regulate their substrate recognition, gating dynamics, and oligomerization (see https://royalsocietypublishing.org/doi/full/10.1098/rsob.190083 for a review).

To reflect physiological conditions and satisfy the instantaneous demands of cells, these termini are known to be post-translationally modified (PTM).

PTMs, like phosphorylation, have been shown to regulate transporter function through allostery or direct local interactions, thus blocking transmembrane substrate import and/or export. Simulations in this project will be focused on studying how C-terminal phosphorylation affects oligomerization dynamics of a sugar transporter.

While a basic protein folding problem, understanding how PTMs affect transporter oligomerization, and oligomer dynamics, is critical for understanding biological regulations for basal transport activity.

This study's ability to observe how terminal PTMs may influence sugar transport dynamics has implications for studying cells in altered metabolic states..

PROJECT INFO

Manager(s): Austin Weigle

Institution: University of Illinois at Urbana-Champaign

Project URL: https://shuklagroup.org/

PROJECT WORK UNIT SUMMARY

Atoms: 179,499

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:30

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 10,052,792 360,319 27.90 1 hrs 52 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,679,646 340,029 25.53 1 hrs 56 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,838,786 330,076 23.75 1 hrs 1 mins
4 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 7,649,691 320,515 23.87 1 hrs 0 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 7,395,737 324,785 22.77 1 hrs 3 mins
6 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,228,870 321,287 22.50 1 hrs 4 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,420,031 293,159 18.49 1 hrs 18 mins
8 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,060,706 287,037 17.63 1 hrs 22 mins
9 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 5,006,913 284,458 17.60 1 hrs 22 mins
10 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,869,538 282,444 17.24 1 hrs 24 mins
11 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,630,127 277,545 16.68 1 hrs 26 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,399,874 273,213 16.10 1 hrs 29 mins
13 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 4,354,335 272,617 15.97 2 hrs 30 mins
14 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 4,254,920 270,808 15.71 2 hrs 32 mins
15 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,702,348 258,925 14.30 2 hrs 41 mins
16 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,499,614 253,282 13.82 2 hrs 44 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,423,604 251,707 13.60 2 hrs 46 mins
18 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 3,066,326 243,420 12.60 2 hrs 54 mins
19 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 2,917,621 228,813 12.75 2 hrs 53 mins
20 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,886,238 241,302 11.96 2 hrs 0 mins
21 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,680,331 233,896 11.46 2 hrs 6 mins
22 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,624,082 231,582 11.33 2 hrs 7 mins
23 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,343,929 221,882 10.56 2 hrs 16 mins
24 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,309,829 219,867 10.51 2 hrs 17 mins
25 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,058,522 213,684 9.63 2 hrs 29 mins
26 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 2,012,471 213,009 9.45 3 hrs 32 mins
27 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,960,726 208,702 9.39 3 hrs 33 mins
28 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,937,254 208,010 9.31 3 hrs 35 mins
29 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,914,469 204,464 9.36 3 hrs 34 mins
30 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,655,402 197,007 8.40 3 hrs 51 mins
31 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,587,516 188,355 8.43 3 hrs 51 mins
32 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,556,500 192,779 8.07 3 hrs 58 mins
33 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,540,922 193,982 7.94 3 hrs 1 mins
34 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,515,826 191,971 7.90 3 hrs 2 mins
35 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,476,250 191,168 7.72 3 hrs 6 mins
36 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,440,905 189,045 7.62 3 hrs 9 mins
37 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,421,365 188,196 7.55 3 hrs 11 mins
38 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,252,061 179,143 6.99 3 hrs 26 mins
39 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,215,769 180,169 6.75 4 hrs 33 mins
40 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,073,176 171,768 6.25 4 hrs 50 mins
41 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 998,880 168,231 5.94 4 hrs 3 mins
42 P104-100
GP104 [P104-100]
Nvidia GP104 955,568 166,045 5.75 4 hrs 10 mins
43 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 918,325 97,645 9.40 3 hrs 33 mins
44 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 835,471 162,905 5.13 5 hrs 41 mins
45 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 811,429 152,344 5.33 5 hrs 30 mins
46 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 784,058 156,252 5.02 5 hrs 47 mins
47 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 779,022 147,667 5.28 5 hrs 33 mins
48 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 702,904 147,859 4.75 5 hrs 3 mins
49 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 682,745 147,483 4.63 5 hrs 11 mins
50 P106-100
GP106 [P106-100]
Nvidia GP106 636,952 149,396 4.26 6 hrs 38 mins
51 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 605,992 141,787 4.27 6 hrs 37 mins
52 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 527,527 136,522 3.86 6 hrs 13 mins
53 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 450,317 128,325 3.51 7 hrs 50 mins
54 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 437,000 131,925 3.31 7 hrs 15 mins
55 Radeon Pro WX 7100 Graphics
[Radeon Pro WX 7100 Graphics] 4150
AMD 409,240 126,709 3.23 7 hrs 26 mins
56 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 369,066 123,650 2.98 8 hrs 2 mins
57 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 352,915 118,296 2.98 8 hrs 3 mins
58 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 339,451 116,786 2.91 8 hrs 15 mins
59 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 331,413 111,327 2.98 8 hrs 4 mins
60 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 318,074 115,567 2.75 9 hrs 43 mins
61 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 301,599 114,301 2.64 9 hrs 6 mins
62 P106-090
GP106 [P106-090]
Nvidia GP106 295,971 111,890 2.65 9 hrs 4 mins
63 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 239,170 104,006 2.30 10 hrs 26 mins
64 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 227,253 104,727 2.17 11 hrs 4 mins
65 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 218,947 101,159 2.16 11 hrs 5 mins
66 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 154,666 90,222 1.71 14 hrs 0 mins
67 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 137,247 86,598 1.58 15 hrs 9 mins
68 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 132,308 85,748 1.54 16 hrs 33 mins
69 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 119,067 83,067 1.43 17 hrs 45 mins
70 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 101,916 78,669 1.30 19 hrs 32 mins
71 Radeon RX 460
Baffin XT [Radeon RX 460]
AMD Baffin XT 100,035 68,245 1.47 16 hrs 22 mins
72 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 91,349 76,026 1.20 20 hrs 58 mins
73 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 78,811 77,223 1.02 24 hrs 31 mins
74 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 75,858 71,076 1.07 22 hrs 29 mins
75 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 68,304 61,402 1.11 22 hrs 34 mins
76 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 42,807 63,064 0.68 35 hrs 21 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:30

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make