PROJECT #17917 RESEARCH FOR MEMBRANE TRANSPORT
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Measuring the Effects of Post-translational Modification on Membrane Transporter Function and Oligomerization: Membrane transporters possess terminal tails which can variably regulate their substrate recognition, gating dynamics, and oligomerization (see https://royalsocietypublishing.org/doi/full/10.1098/rsob.190083 for a review).

To reflect physiological conditions and satisfy the instantaneous demands of cells, these termini are known to be post-translationally modified (PTM).

PTMs, like phosphorylation, have been shown to regulate transporter function through allostery or direct local interactions, thus blocking transmembrane substrate import and/or export. Simulations in this project will be focused on studying how C-terminal phosphorylation affects oligomerization dynamics of a sugar transporter.

While a basic protein folding problem, understanding how PTMs affect transporter oligomerization, and oligomer dynamics, is critical for understanding biological regulations for basal transport activity.

This study's ability to observe how terminal PTMs may influence sugar transport dynamics has implications for studying cells in altered metabolic states..

PROJECT INFO

Manager(s): Austin Weigle

Institution: University of Illinois at Urbana-Champaign

Project URL: https://shuklagroup.org/

PROJECT WORK UNIT SUMMARY

Atoms: 179,595

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:30

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 10,185,124 362,077 28.13 1 hrs 51 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,830,859 341,295 25.87 1 hrs 56 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 8,000,305 332,520 24.06 1 hrs 60 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,007,339 318,093 22.03 1 hrs 5 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 6,921,415 314,010 22.04 1 hrs 5 mins
6 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,428,274 292,552 18.55 1 hrs 18 mins
7 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,323,082 292,223 18.22 1 hrs 19 mins
8 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,890,470 284,609 17.18 1 hrs 24 mins
9 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,784,808 282,005 16.97 1 hrs 25 mins
10 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,774,999 275,896 17.31 1 hrs 23 mins
11 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,445,915 273,630 16.25 1 hrs 29 mins
12 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 4,146,674 271,573 15.27 2 hrs 34 mins
13 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 3,494,753 255,113 13.70 2 hrs 45 mins
14 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,487,664 252,778 13.80 2 hrs 44 mins
15 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,436,501 251,907 13.64 2 hrs 46 mins
16 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,216,579 246,069 13.07 2 hrs 50 mins
17 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,172,967 246,434 12.88 2 hrs 52 mins
18 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,512,500 228,491 11.00 2 hrs 11 mins
19 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,466,645 191,398 12.89 2 hrs 52 mins
20 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,420,010 225,831 10.72 2 hrs 14 mins
21 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,327,516 222,278 10.47 2 hrs 18 mins
22 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,240,434 216,347 10.36 2 hrs 19 mins
23 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,084,512 213,780 9.75 2 hrs 28 mins
24 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,066,084 207,708 9.95 2 hrs 25 mins
25 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 2,042,332 209,658 9.74 2 hrs 28 mins
26 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,920,695 206,109 9.32 3 hrs 35 mins
27 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,846,740 201,461 9.17 3 hrs 37 mins
28 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,604,631 195,336 8.21 3 hrs 55 mins
29 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,534,512 191,531 8.01 3 hrs 60 mins
30 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,468,312 188,352 7.80 3 hrs 5 mins
31 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,452,183 178,916 8.12 3 hrs 57 mins
32 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,418,774 189,884 7.47 3 hrs 13 mins
33 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,400,262 186,982 7.49 3 hrs 12 mins
34 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,388,276 187,579 7.40 3 hrs 15 mins
35 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,240,385 179,124 6.92 3 hrs 28 mins
36 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,210,266 176,737 6.85 4 hrs 30 mins
37 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,191,389 174,302 6.84 4 hrs 31 mins
38 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,034,525 169,735 6.09 4 hrs 56 mins
39 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 977,045 165,216 5.91 4 hrs 4 mins
40 P104-100
GP104 [P104-100]
Nvidia GP104 960,442 166,312 5.77 4 hrs 9 mins
41 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 829,124 156,955 5.28 5 hrs 33 mins
42 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 815,262 159,924 5.10 5 hrs 42 mins
43 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 748,011 152,033 4.92 5 hrs 53 mins
44 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 731,448 148,053 4.94 5 hrs 51 mins
45 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 593,799 141,085 4.21 6 hrs 42 mins
46 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 589,377 140,561 4.19 6 hrs 43 mins
47 P106-100
GP106 [P106-100]
Nvidia GP106 552,856 147,241 3.75 6 hrs 24 mins
48 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 539,428 144,096 3.74 6 hrs 25 mins
49 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 515,497 143,808 3.58 7 hrs 42 mins
50 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 472,134 121,408 3.89 6 hrs 10 mins
51 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 453,551 130,642 3.47 7 hrs 55 mins
52 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 403,103 126,148 3.20 8 hrs 31 mins
53 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 360,411 115,742 3.11 8 hrs 42 mins
54 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 358,763 119,761 3.00 8 hrs 1 mins
55 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 344,710 118,432 2.91 8 hrs 15 mins
56 P106-090
GP106 [P106-090]
Nvidia GP106 310,401 111,308 2.79 9 hrs 36 mins
57 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 295,030 114,655 2.57 9 hrs 20 mins
58 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 259,995 88,880 2.93 8 hrs 12 mins
59 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 239,602 104,258 2.30 10 hrs 27 mins
60 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 214,579 100,485 2.14 11 hrs 14 mins
61 FirePro Series
Tonga PRO GL [FirePro Series]
Tonga PRO GL 167,625 103,803 1.61 15 hrs 52 mins
62 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 161,478 93,440 1.73 14 hrs 53 mins
63 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 153,766 89,850 1.71 14 hrs 1 mins
64 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 131,897 85,320 1.55 16 hrs 31 mins
65 Radeon Rx 270/370
Curacao Pro [Radeon Rx 270/370]
AMD Curacao Pro 125,113 81,024 1.54 16 hrs 33 mins
66 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 95,264 76,553 1.24 19 hrs 17 mins
67 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 85,123 72,820 1.17 21 hrs 32 mins
68 Radeon Vega Series / Radeon Vega Mobile Series
Raven Ridge [Radeon Vega Series / Radeon Vega Mobile Series]
AMD Raven Ridge 71,331 69,803 1.02 23 hrs 29 mins
69 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 70,161 70,861 0.99 24 hrs 14 mins
70 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 64,718 67,064 0.97 25 hrs 52 mins
71 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 61,894 61,274 1.01 24 hrs 46 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:30

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make