PROJECT #17903 RESEARCH FOR MEMBRANE TRANSPORT
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
Measuring the Effects of Post-translational Modification on Membrane Transporter Function and Oligomerization: Membrane transporters possess terminal tails which can variably regulate their substrate recognition, gating dynamics, and oligomerization (see https://royalsocietypublishing.org/doi/full/10.1098/rsob.190083 for a review).
To reflect physiological conditions and satisfy the instantaneous demands of cells, these termini are known to be post-translationally modified (PTM).
PTMs, like phosphorylation, have been shown to regulate transporter function through allostery or direct local interactions, thus blocking transmembrane substrate import and/or export. Simulations in this project will be focused on studying how C-terminal phosphorylation affects oligomerization dynamics of a sugar transporter.
While a basic protein folding problem, understanding how PTMs affect transporter oligomerization, and oligomer dynamics, is critical for understanding biological regulations for basal transport activity.
This study's ability to observe how terminal PTMs may influence sugar transport dynamics has implications for studying cells in altered metabolic states..
PROJECT INFO
Manager(s): Austin Weigle
Institution: University of Illinois at Urbana-Champaign
Project URL: https://shuklagroup.org/
PROJECT WORK UNIT SUMMARY
Atoms: 179,499
Core: OPENMM_22
Status: Beta
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Tuesday, 07 February 2023 06:14:51
Rank Project |
Model Name Folding@Home Identifier |
Make Brand |
GPU Model |
PPD Average |
Points WU Average |
WUs Day Average |
WU Time Average |
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1 | GeForce RTX 3090 GA102 [GeForce RTX 3090] |
Nvidia | GA102 | 10,329,369 | 363,756 | 28.40 | 0 hrs 51 mins |
2 | GeForce RTX 2060 TU104 [GeForce RTX 2060] |
Nvidia | TU104 | 1,616,997 | 196,568 | 8.23 | 3 hrs 55 mins |
PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Tuesday, 07 February 2023 06:14:51
Rank Project |
CPU Model |
Logical Processors (LP) |
PPD-PLP AVG PPD per 1 LP |
ALL LP-PPD (Estimated) |
Make |
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