PROJECT #17916 RESEARCH FOR MEMBRANE TRANSPORT
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Measuring the Effects of Post-translational Modification on Membrane Transporter Function and Oligomerization: Membrane transporters possess terminal tails which can variably regulate their substrate recognition, gating dynamics, and oligomerization (see https://royalsocietypublishing.org/doi/full/10.1098/rsob.190083 for a review).

To reflect physiological conditions and satisfy the instantaneous demands of cells, these termini are known to be post-translationally modified (PTM).

PTMs, like phosphorylation, have been shown to regulate transporter function through allostery or direct local interactions, thus blocking transmembrane substrate import and/or export. Simulations in this project will be focused on studying how C-terminal phosphorylation affects oligomerization dynamics of a sugar transporter.

While a basic protein folding problem, understanding how PTMs affect transporter oligomerization, and oligomer dynamics, is critical for understanding biological regulations for basal transport activity.

This study's ability to observe how terminal PTMs may influence sugar transport dynamics has implications for studying cells in altered metabolic states..

PROJECT INFO

Manager(s): Austin Weigle

Institution: University of Illinois at Urbana-Champaign

Project URL: https://shuklagroup.org/

PROJECT WORK UNIT SUMMARY

Atoms: 179,534

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:30

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 10,035,063 360,094 27.87 1 hrs 52 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,882,895 344,573 25.78 1 hrs 56 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,831,287 330,179 23.72 1 hrs 1 mins
4 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 7,623,076 328,230 23.22 1 hrs 2 mins
5 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,273,364 321,788 22.60 1 hrs 4 mins
6 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,300,933 291,614 18.18 1 hrs 19 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,269,385 289,470 18.20 1 hrs 19 mins
8 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,878,833 278,976 17.49 1 hrs 22 mins
9 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,773,868 282,525 16.90 1 hrs 25 mins
10 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,655,353 278,317 16.73 1 hrs 26 mins
11 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,420,861 274,062 16.13 1 hrs 29 mins
12 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 4,410,655 275,425 16.01 1 hrs 30 mins
13 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,594,622 256,115 14.04 2 hrs 43 mins
14 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,466,835 251,636 13.78 2 hrs 45 mins
15 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 3,459,061 254,616 13.59 2 hrs 46 mins
16 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,394,998 246,665 13.76 2 hrs 45 mins
17 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,989,727 241,679 12.37 2 hrs 56 mins
18 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,632,732 231,484 11.37 2 hrs 7 mins
19 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,597,730 230,400 11.27 2 hrs 8 mins
20 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 2,519,484 225,255 11.19 2 hrs 9 mins
21 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,315,036 221,873 10.43 2 hrs 18 mins
22 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,238,805 217,247 10.31 2 hrs 20 mins
23 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,092,269 212,472 9.85 2 hrs 26 mins
24 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 2,044,275 213,455 9.58 3 hrs 30 mins
25 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,030,674 199,397 10.18 2 hrs 21 mins
26 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,994,469 209,399 9.52 3 hrs 31 mins
27 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,902,828 207,383 9.18 3 hrs 37 mins
28 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,563,103 193,763 8.07 3 hrs 59 mins
29 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,551,640 192,792 8.05 3 hrs 59 mins
30 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,515,097 190,390 7.96 3 hrs 1 mins
31 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,437,744 188,804 7.62 3 hrs 9 mins
32 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,405,353 186,130 7.55 3 hrs 11 mins
33 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,303,399 182,246 7.15 3 hrs 21 mins
34 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,284,120 175,749 7.31 3 hrs 17 mins
35 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,245,211 178,327 6.98 3 hrs 26 mins
36 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,198,352 177,910 6.74 4 hrs 34 mins
37 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,164,455 177,059 6.58 4 hrs 39 mins
38 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,111,195 170,577 6.51 4 hrs 41 mins
39 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,091,403 172,510 6.33 4 hrs 48 mins
40 P104-100
GP104 [P104-100]
Nvidia GP104 958,053 166,064 5.77 4 hrs 10 mins
41 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 949,672 156,438 6.07 4 hrs 57 mins
42 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 920,510 162,290 5.67 4 hrs 14 mins
43 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 837,364 164,463 5.09 5 hrs 43 mins
44 Radeon Instinct MI25
Vega 10 [Radeon Instinct MI25]
AMD Vega 10 759,757 153,044 4.96 5 hrs 50 mins
45 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 726,375 151,752 4.79 5 hrs 1 mins
46 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 720,066 153,234 4.70 5 hrs 6 mins
47 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 688,308 146,219 4.71 5 hrs 6 mins
48 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 624,452 142,577 4.38 5 hrs 29 mins
49 P106-100
GP106 [P106-100]
Nvidia GP106 613,057 147,101 4.17 6 hrs 46 mins
50 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 552,974 137,535 4.02 6 hrs 58 mins
51 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 516,083 143,504 3.60 7 hrs 40 mins
52 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 474,845 115,542 4.11 6 hrs 50 mins
53 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 427,884 124,580 3.43 7 hrs 59 mins
54 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 416,361 121,192 3.44 7 hrs 59 mins
55 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 360,407 119,372 3.02 8 hrs 57 mins
56 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 345,700 117,469 2.94 8 hrs 9 mins
57 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 338,931 117,402 2.89 8 hrs 19 mins
58 P106-090
GP106 [P106-090]
Nvidia GP106 295,183 111,873 2.64 9 hrs 6 mins
59 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 269,276 114,600 2.35 10 hrs 13 mins
60 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 240,012 104,496 2.30 10 hrs 27 mins
61 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 218,920 101,292 2.16 11 hrs 6 mins
62 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 162,474 94,200 1.72 14 hrs 55 mins
63 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 154,421 90,181 1.71 14 hrs 1 mins
64 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 118,008 87,563 1.35 18 hrs 48 mins
65 Radeon HD 7800 Series
Pitcairn PRO [Radeon HD 7800 Series]
AMD Pitcairn PRO 114,346 79,220 1.44 17 hrs 38 mins
66 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 104,356 79,070 1.32 18 hrs 11 mins
67 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 94,038 75,990 1.24 19 hrs 24 mins
68 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 91,184 74,016 1.23 19 hrs 29 mins
69 Radeon R7/R6 360 Series
Bonaire [Radeon R7/R6 360 Series]
AMD Bonaire 78,041 66,658 1.17 20 hrs 30 mins
70 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 77,104 71,719 1.08 22 hrs 19 mins
71 Radeon Vega Series / Radeon Vega Mobile Series
Raven Ridge [Radeon Vega Series / Radeon Vega Mobile Series]
AMD Raven Ridge 70,393 69,329 1.02 24 hrs 38 mins
72 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 53,326 63,343 0.84 29 hrs 30 mins
73 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 53,262 61,845 0.86 28 hrs 52 mins
74 Radeon APU A4-6000 R2
Mullins [Radeon APU A4-6000 R2]
AMD Mullins 4,770 40,000 0.12 201 hrs 15 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:30

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make