Folding project #16706, POLYMERASE research

Research section Research projects and references

Project #16706 overview

Project Summary AI Beta

This project uses computer simulations to study how proteins fold. One part looks at how a protein called RNA polymerase folds, which is important for bacteria and a target for antibiotics. The other part studies how a helper protein called Hsp70 helps other proteins fold correctly.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prof. Xuhui Huang
Institution: Hong Kong University of Science and Technology

Work unit

Atoms: 446,955
Core: 0x22
Status: Public

Source material

Official Project Description

This series of GPU projects to simulation the Bacterial RNA Polymerase.

16700-16706: Simulation of E.

coli RNA Polymerase Trigger Loop folding, the target for antibiotics (CBR compounds). 16750-16755: Simulation of folding of client proteins with a chaperone Hsp70.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

GPU

Graphics Processing Unit

Technical: TechnologyBiotechnology / Computational Biology

A specialized electronic circuit designed to rapidly manipulate and alter memory to accelerate the creation of images in a frame buffer intended for output to a display device.

Bacterial RNA Polymerase

An enzyme complex responsible for transcribing DNA into RNA in bacteria.

Scientific: BiotechnologyMicrobiology / Molecular Biology

Bacterial RNA polymerase is a vital enzyme that plays a crucial role in gene expression. It binds to specific DNA sequences called promoters and synthesizes RNA molecules complementary to the DNA template. This process is essential for producing proteins and regulating cellular functions.

Antibiotics

Drugs that inhibit the growth of or kill bacteria.

Pharmaceutical: HealthcareMedicine / Infectious Diseases

Antibiotics are a class of antimicrobial drugs used to treat bacterial infections. They work by targeting specific mechanisms essential for bacterial survival, such as cell wall synthesis, protein production, or DNA replication. The judicious use of antibiotics is crucial to prevent antibiotic resistance.

CBR compounds

Chemically-Based Receptor compounds

Scientific: BiotechnologyPharmacology / Drug Discovery

CBR compounds are a class of molecules designed to interact with specific receptors in the body. They are often used as drug candidates in research and development.

Hsp70

Heat Shock Protein 70

Scientific: ResearchBiochemistry / Molecular Chaperones

Hsp70 is a family of proteins that play a crucial role in assisting the folding and assembly of other proteins. They are particularly important under stress conditions, such as heat shock, where they help prevent protein misfolding.

Chaperone

A protein that assists in the folding and assembly of other proteins.

Scientific: ResearchBiochemistry / Protein Folding

Chaperones are essential cellular proteins that help guide the folding of newly synthesized proteins into their correct three-dimensional shapes. They prevent misfolding and aggregation, ensuring proper protein function.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	19,957,803	900,794	22.16	1 ^hrs 5 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	15,009,398	818,548	18.34	1 ^hrs 19 ^mins
3	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	10,471,724	728,219	14.38	1 ^hrs 40 ^mins
4	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	7,159,690	636,133	11.26	2 ^hrs 8 ^mins
5	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,645,027	626,598	10.60	2 ^hrs 16 ^mins
6	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	6,539,757	625,820	10.45	2 ^hrs 18 ^mins
7	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,304,741	603,844	10.44	2 ^hrs 18 ^mins
8	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	6,275,416	611,919	10.26	2 ^hrs 20 ^mins
9	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	5,907,052	600,008	9.84	2 ^hrs 26 ^mins
10	RTX A5000 GA102GL [RTX A5000]	Nvidia	GA102GL	5,380,528	588,516	9.14	2 ^hrs 38 ^mins
11	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,090,061	567,679	8.97	2 ^hrs 41 ^mins
12	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	5,058,749	573,043	8.83	2 ^hrs 43 ^mins
13	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	4,925,989	557,053	8.84	2 ^hrs 43 ^mins
14	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	4,628,687	556,716	8.31	2 ^hrs 53 ^mins
15	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,199,204	536,751	7.82	3 ^hrs 4 ^mins
16	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,132,050	528,981	7.81	3 ^hrs 4 ^mins
17	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,020,193	531,238	7.57	3 ^hrs 10 ^mins
18	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	3,874,345	526,418	7.36	3 ^hrs 16 ^mins
19	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,745,930	522,848	7.16	3 ^hrs 21 ^mins

20	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	3,515,065	503,946	6.98	3 ^hrs 26 ^mins
21	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	3,249,835	499,747	6.50	3 ^hrs 41 ^mins
22	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,144,340	495,713	6.34	3 ^hrs 47 ^mins
23	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	2,962,927	483,206	6.13	3 ^hrs 55 ^mins
24	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,914,319	479,380	6.08	3 ^hrs 57 ^mins
25	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,436,221	448,670	5.43	4 ^hrs 25 ^mins
26	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,410,361	446,796	5.39	4 ^hrs 27 ^mins
27	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,409,953	447,200	5.39	4 ^hrs 27 ^mins
28	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,341,878	446,311	5.25	4 ^hrs 34 ^mins
29	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,224,534	452,464	4.92	4 ^hrs 53 ^mins
30	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,182,754	434,856	5.02	4 ^hrs 47 ^mins
31	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,075,866	442,073	4.70	5 ^hrs 7 ^mins
32	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,045,640	438,399	4.67	5 ^hrs 9 ^mins
33	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	2,031,167	445,336	4.56	5 ^hrs 16 ^mins
34	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	1,996,399	422,121	4.73	5 ^hrs 4 ^mins
35	Geforce RTX 3070 Ti Laptop GPU GA104 [Geforce RTX 3070 Ti Laptop GPU]	Nvidia	GA104	1,956,703	417,983	4.68	5 ^hrs 8 ^mins
36	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	1,907,997	416,849	4.58	5 ^hrs 15 ^mins
37	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,840,764	409,900	4.49	5 ^hrs 21 ^mins
38	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,827,785	404,735	4.52	5 ^hrs 19 ^mins
39	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	1,774,504	403,511	4.40	5 ^hrs 27 ^mins

40	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	1,701,909	400,966	4.24	5 ^hrs 39 ^mins
41	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,594,746	376,683	4.23	5 ^hrs 40 ^mins
42	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	1,592,011	336,026	4.74	5 ^hrs 4 ^mins
43	Quadro RTX 5000 Mobile / Max-Q TU104GLM [Quadro RTX 5000 Mobile / Max-Q]	Nvidia	TU104GLM	1,569,189	369,787	4.24	5 ^hrs 39 ^mins
44	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,540,664	381,383	4.04	5 ^hrs 56 ^mins
45	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,205,505	361,938	3.33	7 ^hrs 12 ^mins
46	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	1,088,462	330,092	3.30	7 ^hrs 17 ^mins
47	P104-100 GP104 [P104-100]	Nvidia	GP104	1,086,218	344,935	3.15	7 ^hrs 37 ^mins
48	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,061,824	357,094	2.97	8 ^hrs 4 ^mins
49	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,053,370	356,772	2.95	8 ^hrs 8 ^mins
50	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	976,689	335,270	2.91	8 ^hrs 14 ^mins
51	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	969,871	327,924	2.96	8 ^hrs 7 ^mins
52	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	954,230	330,597	2.89	8 ^hrs 19 ^mins
53	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	923,557	327,348	2.82	8 ^hrs 30 ^mins
54	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	914,758	316,954	2.89	8 ^hrs 19 ^mins
55	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	860,558	340,941	2.52	9 ^hrs 31 ^mins
56	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	855,747	310,465	2.76	8 ^hrs 42 ^mins
57	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	841,922	319,788	2.63	9 ^hrs 7 ^mins
58	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	822,773	291,583	2.82	8 ^hrs 30 ^mins
59	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	794,747	318,630	2.49	9 ^hrs 37 ^mins

60	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	792,824	305,658	2.59	9 ^hrs 15 ^mins
61	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	792,556	309,996	2.56	9 ^hrs 23 ^mins
62	Ryzen 7000 Series iGPU Raphael [Ryzen 7000 Series iGPU]	AMD	Raphael	739,872	298,540	2.48	9 ^hrs 41 ^mins
63	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	735,694	306,027	2.40	9 ^hrs 59 ^mins
64	P106-100 GP106 [P106-100]	Nvidia	GP106	713,626	299,012	2.39	10 ^hrs 3 ^mins
65	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	602,002	287,333	2.10	11 ^hrs 27 ^mins
66	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	582,200	273,805	2.13	11 ^hrs 17 ^mins
67	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	518,563	293,432	1.77	13 ^hrs 35 ^mins
68	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	503,100	275,772	1.82	13 ^hrs 9 ^mins
69	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	494,176	283,973	1.74	13 ^hrs 47 ^mins
70	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	453,093	258,211	1.75	13 ^hrs 41 ^mins
71	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	424,356	263,049	1.61	14 ^hrs 53 ^mins
72	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	401,221	258,315	1.55	15 ^hrs 27 ^mins
73	P106-090 GP106 [P106-090]	Nvidia	GP106	375,399	242,069	1.55	15 ^hrs 29 ^mins
74	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	370,730	237,864	1.56	15 ^hrs 24 ^mins
75	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	369,735	238,607	1.55	15 ^hrs 29 ^mins
76	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	321,315	232,558	1.38	17 ^hrs 22 ^mins
77	Radeon R9 285/380 Tonga PRO [Radeon R9 285/380]	AMD	Tonga PRO	279,522	219,889	1.27	18 ^hrs 53 ^mins
78	Tesla K40c GK110 [Tesla K40c] 5046	Nvidia	GK110	275,512	254,345	1.08	22 ^hrs 9 ^mins
79	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	261,331	214,532	1.22	19 ^hrs 42 ^mins

80	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	255,083	206,860	1.23	19 ^hrs 28 ^mins
81	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	234,908	233,165	1.01	23 ^hrs 49 ^mins
82	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	230,000	205,662	1.12	21 ^hrs 28 ^mins
83	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	213,057	199,850	1.07	22 ^hrs 31 ^mins
84	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	201,990	192,429	1.05	22 ^hrs 52 ^mins
85	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	196,916	206,108	0.96	25 ^hrs 7 ^mins
86	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	150,241	179,812	0.84	28 ^hrs 43 ^mins
87	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	149,491	177,421	0.84	28 ^hrs 29 ^mins
88	GeForce MX450 TU117M [GeForce MX450]	Nvidia	TU117M	143,196	164,791	0.87	27 ^hrs 37 ^mins
89	Tesla K40m GK110 [Tesla K40m] 5046	Nvidia	GK110	126,420	195,673	0.65	37 ^hrs 9 ^mins
90	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	102,233	157,046	0.65	36 ^hrs 52 ^mins
91	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	82,636	145,950	0.57	42 ^hrs 23 ^mins
92	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	77,865	166,305	0.47	51 ^hrs 16 ^mins
93	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	62,609	124,027	0.50	47 ^hrs 33 ^mins
94	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	59,441	113,908	0.52	45 ^hrs 60 ^mins
95	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	50,113	122,949	0.41	58 ^hrs 53 ^mins
96	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	32,706	127,569	0.26	93 ^hrs 37 ^mins
97	GeForce GTX 745 GM107 [GeForce GTX 745] 793	Nvidia	GM107	31,226	125,900	0.25	96 ^hrs 46 ^mins

Research: POLYMERASE Folding Project #16706

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 16706

GPU PPD Averages

Research: POLYMERASE Folding Project #16706

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages