Folding project #16752, POLYMERASE research

Research section Research projects and references

Project #16752 overview

Project Summary AI Beta

This project uses powerful computer simulations to study how bacteria work. One part looks at how a protein called RNA polymerase folds, which is important for making bacterial DNA into RNA and a target for some antibiotics. Another part studies how proteins called chaperones help other proteins fold correctly.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prof. Xuhui Huang
Institution: Hong Kong University of Science and Technology

Work unit

Atoms: 330,482
Core: OPENMM_22
Status: Beta

Source material

Official Project Description

This series of GPU projects to simulation the Bacterial RNA Polymerase.

16700,16701: Simulation of E.

coli RNA Polymerase Trigger Loop folding, the target for antibiotics (CBR compounds). 16750-16755: Simulation of folding of client proteins with a chaperone Hsp70.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

GPU

Graphics Processing Unit

Technical: TechnologyBiotechnology / Computational Biology

A specialized electronic circuit designed to rapidly manipulate and alter memory to accelerate the creation of images in a frame buffer intended for output to a display. GPUs are commonly used in computer graphics, gaming, and scientific computing.

Bacterial RNA Polymerase

The enzyme complex responsible for transcribing DNA into RNA in bacteria.

Scientific: BiotechnologyBiology / Molecular Biology

Bacterial RNA polymerase is a crucial enzyme that reads the genetic information stored in DNA and creates messenger RNA (mRNA). This mRNA then serves as a template for protein synthesis. Understanding how bacterial RNA polymerase works is essential for developing new antibiotics that can target this process.

Antibiotics

Drugs that kill or inhibit the growth of bacteria.

Pharmaceutical: HealthcareMedicine / Infectious Diseases

Antibiotics are medications used to treat bacterial infections. They work by interfering with various processes essential for bacterial survival and replication. The discovery and development of antibiotics have revolutionized healthcare, saving countless lives.

CBR Compounds

Chemically Biologically Responsive compounds

Technical: PharmaceuticalsBiotechnology / Drug Discovery

CBR compounds are a class of molecules designed to interact with specific biological targets. They often exhibit responsiveness to changes in their environment, such as pH or temperature.

Hsp70

Heat shock protein 70

Scientific: BiotechnologyBiology / Molecular Biology

Hsp70 is a family of chaperone proteins that play a crucial role in cellular stress response. They assist in folding and stabilizing other proteins, preventing their aggregation.

Chaperone

A protein that assists in the folding and assembly of other proteins.

Scientific: BiotechnologyBiology / Molecular Biology

Chaperone proteins act as cellular guides, helping other proteins fold into their correct shapes. They prevent misfolding and aggregation, ensuring proper protein function.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,673,690	429,056	22.55	1 ^hrs 4 ^mins
2	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,330,033	353,647	15.07	1 ^hrs 36 ^mins
3	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,208,744	222,164	5.44	4 ^hrs 25 ^mins

Research: POLYMERASE Folding Project #16752

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 16752

GPU PPD Averages

Research: POLYMERASE Folding Project #16752

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages