Folding project #16753, POLYMERASE research

Research section Research projects and references

Project #16753 overview

Project Summary AI Beta

This project uses computer simulations to study how bacteria work. One part looks at how a specific loop in bacterial RNA polymerase folds, which is important for making antibiotics work. Another part studies how proteins called chaperones help other proteins fold correctly.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prof. Xuhui Huang
Institution: Hong Kong University of Science and Technology

Work unit

Atoms: 330,482
Core: OPENMM_22
Status: Beta

Source material

Official Project Description

This series of GPU projects to simulation the Bacterial RNA Polymerase.

16700,16701: Simulation of E.

coli RNA Polymerase Trigger Loop folding, the target for antibiotics (CBR compounds). 16750-16755: Simulation of folding of client proteins with a chaperone Hsp70.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

GPU

Graphics Processing Unit

Technical: BiotechnologyBiotechnology / Computational Biology

A GPU is a specialized electronic circuit designed to rapidly manipulate and alter memory to accelerate the creation of images in a frame buffer intended for output to a display. GPUs are used extensively in computer graphics, scientific computing, and machine learning.

Bacterial RNA Polymerase

The enzyme responsible for transcribing DNA into RNA in bacteria.

Scientific: BiotechnologyBiotechnology / Microbiology

Bacterial RNA Polymerase is a crucial enzyme found in bacteria. Its primary function is to read the genetic information stored in DNA and create a complementary messenger RNA (mRNA) molecule. This mRNA then serves as a template for protein synthesis, allowing the cell to produce the proteins it needs to function.

Antibiotics

Drugs that inhibit the growth of or kill bacteria.

Scientific: PharmaceuticalsBiotechnology / Pharmacology

Antibiotics are a class of medications that combat bacterial infections. They work by interfering with essential processes in bacteria, such as cell wall synthesis or protein production, ultimately leading to their death or inhibiting their growth.

CBR compounds

Chemically-Based Reagents

Scientific: PharmaceuticalsBiotechnology / Drug Discovery

CBR compounds are a class of molecules used in drug discovery research. They often mimic natural substrates or inhibitors of biological targets, allowing researchers to study their function and identify potential therapeutic agents.

Hsp70

Heat Shock Protein 70

Scientific: BiotechnologyBiotechnology / Molecular Biology

Hsp70 is a highly conserved family of chaperone proteins that play a crucial role in protein folding, assembly, and degradation. They are particularly important during cellular stress, such as heat shock, where they help prevent the aggregation of misfolded proteins.

Chaperone

A protein that assists other proteins in folding correctly.

Scientific: BiotechnologyBiotechnology / Molecular Biology

Chaperones are a class of proteins that act as guides and assistants for other proteins during the process of folding. They help ensure that proteins adopt their correct three-dimensional shapes, which is essential for their proper function.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,768,791	430,775	22.68	1 ^hrs 3 ^mins
2	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,364,692	354,299	15.14	1 ^hrs 35 ^mins
3	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,210,384	222,482	5.44	4 ^hrs 25 ^mins

Research: POLYMERASE Folding Project #16753

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 16753

GPU PPD Averages

Research: POLYMERASE Folding Project #16753

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages