Folding project #12705, CANCER research

Research section Research projects and references

Project #12705 overview

Project Summary AI Beta

Class F GPCR proteins help our bodies send signals but sometimes mess up. When they malfunction, it can lead to serious illnesses like cancer. Studying these proteins helps scientists create new drugs to treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Michael Chen
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 104,869
Core: 0x27
Status: Public

Source material

Official Project Description

Class F G Protein Coupled Receptors Improper signaling through Class F GPCRs is linked to Gastric Cancer, Coloboma of Macula, colon cancer and triple negative breast cancer.

Simulation of these proteins helps us to understand their function and therefore be able to design drugs specific to these diseases.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F GPCRs

Family of G protein-coupled receptors.

Scientific: BiotechnologyReceptor / G Protein-Coupled Receptor

Class F GPCRs are a type of cell surface receptor that plays a role in various biological processes. They are activated by specific ligands and trigger intracellular signaling cascades. Dysregulation of Class F GPCR signaling has been implicated in several diseases, including cancer and eye disorders.

Gastric Cancer

Cancer that originates in the stomach.

Disease: MedicineOncology / Gastrointestinal Cancer

Gastric cancer is a malignant tumor that develops in the lining of the stomach. It can be caused by various factors, including infection with Helicobacter pylori bacteria, smoking, and diet high in salt and processed foods. Symptoms may include abdominal pain, nausea, vomiting, and weight loss.

Coloboma

A gap or hole in a part of the eye.

Disease: MedicineOphthalmology / Congenital Eye Anomaly

Coloboma is a birth defect that causes a gap or opening in one or more parts of the eye, such as the retina, optic nerve, or iris. It can lead to vision problems and may require surgery to repair.

Colon Cancer

Cancer that starts in the large intestine (colon).

Disease: MedicineOncology / Gastrointestinal Cancer

Colon cancer is a malignant tumor that develops in the lining of the colon. It can be caused by various factors, including diet high in red meat and processed foods, obesity, and family history of the disease. Symptoms may include abdominal pain, changes in bowel habits, and blood in the stool.

Triple Negative Breast Cancer

A type of breast cancer that does not express estrogen receptors, progesterone receptors, or HER2.

Disease: MedicineOncology / Breast Cancer Subtype

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks the expression of certain hormone receptors and HER2 proteins. This makes it more difficult to treat with traditional therapies targeting these receptors.

Simulation

The process of creating a model or representation of something.

Method: BiotechnologyResearch / Computational Modeling

Simulation involves creating a virtual environment or system that mimics real-world processes. This allows researchers to study complex phenomena and test hypotheses in a controlled setting.

Drug

A substance used for the treatment, prevention, or diagnosis of a disease.

Substance: BiotechnologyPharmacology / Medicinal Product

Drugs are chemical compounds that interact with biological systems to produce specific effects. They are designed to treat or prevent diseases, alleviate symptoms, or diagnose medical conditions.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	28,499,226	58,100	490.52	0 ^hrs 3 ^mins
2	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	19,372,769	248,614	77.92	0 ^hrs 18 ^mins
3	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	17,002,752	76,256	222.97	0 ^hrs 6 ^mins
4	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	15,677,045	98,143	159.74	0 ^hrs 9 ^mins
5	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	14,372,308	131,729	109.11	0 ^hrs 13 ^mins
6	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	12,235,276	147,151	83.15	0 ^hrs 17 ^mins
7	RTX 6000 Ada Generation AD102GL [RTX 6000 Ada Generation]	Nvidia	AD102GL	11,570,041	58,100	199.14	0 ^hrs 7 ^mins
8	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	10,577,674	373,147	28.35	0 ^hrs 51 ^mins
9	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	10,407,904	292,796	35.55	0 ^hrs 41 ^mins
10	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	10,388,280	73,889	140.59	0 ^hrs 10 ^mins
11	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	10,182,681	346,326	29.40	0 ^hrs 49 ^mins
12	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	9,687,520	204,703	47.32	0 ^hrs 30 ^mins
13	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	8,748,343	197,765	44.24	0 ^hrs 33 ^mins
14	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	8,301,057	304,253	27.28	0 ^hrs 53 ^mins
15	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	7,100,224	304,220	23.34	1 ^hrs 2 ^mins
16	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	7,018,267	156,734	44.78	0 ^hrs 32 ^mins
17	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	6,773,462	206,980	32.73	0 ^hrs 44 ^mins
18	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	6,335,510	226,920	27.92	0 ^hrs 52 ^mins
19	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	6,027,459	72,792	82.80	0 ^hrs 17 ^mins

20	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	5,887,759	58,100	101.34	0 ^hrs 14 ^mins
21	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	5,852,624	305,332	19.17	1 ^hrs 15 ^mins
22	RTX A4500 GA102GL [RTX A4500]	Nvidia	GA102GL	5,652,811	58,100	97.29	0 ^hrs 15 ^mins
23	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,036,787	274,592	18.34	1 ^hrs 19 ^mins
24	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	4,825,026	106,244	45.41	0 ^hrs 32 ^mins
25	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	4,638,709	58,100	79.84	0 ^hrs 18 ^mins
26	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,574,627	266,792	17.15	1 ^hrs 24 ^mins
27	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	4,432,456	58,100	76.29	0 ^hrs 19 ^mins
28	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	4,127,603	58,100	71.04	0 ^hrs 20 ^mins
29	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	3,886,332	58,100	66.89	0 ^hrs 22 ^mins
30	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	3,833,276	268,105	14.30	1 ^hrs 41 ^mins
31	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,622,664	65,524	55.29	0 ^hrs 26 ^mins
32	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,604,930	58,100	62.05	0 ^hrs 23 ^mins
33	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,445,482	75,397	45.70	0 ^hrs 32 ^mins
34	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,399,041	254,618	13.35	1 ^hrs 48 ^mins
35	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	3,224,855	58,100	55.51	0 ^hrs 26 ^mins
36	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	3,181,630	58,100	54.76	0 ^hrs 26 ^mins
37	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,137,508	235,587	13.32	1 ^hrs 48 ^mins
38	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,973,360	239,295	12.43	1 ^hrs 56 ^mins
39	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	2,950,753	72,876	40.49	0 ^hrs 36 ^mins

40	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 Super]	Nvidia	TU106	2,926,656	58,100	50.37	0 ^hrs 29 ^mins
41	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,720,498	200,874	13.54	1 ^hrs 46 ^mins
42	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,622,864	235,020	11.16	2 ^hrs 9 ^mins
43	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	2,587,476	58,100	44.53	0 ^hrs 32 ^mins
44	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,180,010	154,227	14.14	1 ^hrs 42 ^mins
45	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	2,062,461	217,661	9.48	2 ^hrs 32 ^mins
46	GeForce RTX 2070 Mobile TU106BM [GeForce RTX 2070 Mobile]	Nvidia	TU106BM	2,051,721	220,625	9.30	2 ^hrs 35 ^mins
47	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,809,812	58,100	31.15	0 ^hrs 46 ^mins
48	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,803,880	58,100	31.05	0 ^hrs 46 ^mins
49	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,763,754	162,154	10.88	2 ^hrs 12 ^mins
50	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,604,555	169,990	9.44	2 ^hrs 33 ^mins
51	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	1,598,768	58,100	27.52	0 ^hrs 52 ^mins
52	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,518,485	197,208	7.70	3 ^hrs 7 ^mins
53	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,440,716	193,542	7.44	3 ^hrs 13 ^mins
54	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,409,991	58,100	24.27	0 ^hrs 59 ^mins
55	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,316,909	121,066	10.88	2 ^hrs 12 ^mins
56	P104-100 GP104 [P104-100]	Nvidia	GP104	1,216,415	58,100	20.94	1 ^hrs 9 ^mins
57	RTX A1000 GA107GL [RTX A1000]	Nvidia	GA107GL	1,175,607	58,100	20.23	1 ^hrs 11 ^mins
58	Radeon RX 6600(XT/M) Navi 23 XT-XL [Radeon RX 6600(XT/M)]	AMD	Navi 23 XT-XL	1,151,675	116,125	9.92	2 ^hrs 25 ^mins
59	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,128,095	179,801	6.27	3 ^hrs 50 ^mins

60	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	999,523	58,100	17.20	1 ^hrs 24 ^mins
61	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	943,230	166,690	5.66	4 ^hrs 14 ^mins
62	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	910,812	58,100	15.68	1 ^hrs 32 ^mins
63	P106-100 GP106 [P106-100]	Nvidia	GP106	798,214	158,768	5.03	4 ^hrs 46 ^mins
64	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	795,829	158,562	5.02	4 ^hrs 47 ^mins
65	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	718,389	58,100	12.36	1 ^hrs 56 ^mins
66	Quadro P3200 Mobile GP104GLM [Quadro P3200 Mobile]	Nvidia	GP104GLM	647,844	142,787	4.54	5 ^hrs 17 ^mins
67	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	630,588	58,100	10.85	2 ^hrs 13 ^mins
68	GeForce GTX 1650 TU106 [GeForce GTX 1650]	Nvidia	TU106	575,693	58,100	9.91	2 ^hrs 25 ^mins
69	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	550,695	150,027	3.67	6 ^hrs 32 ^mins
70	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	514,541	58,100	8.86	2 ^hrs 43 ^mins
71	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	505,694	66,158	7.64	3 ^hrs 8 ^mins
72	Quadro P2000 GP106GL [Quadro P2000] [MED-XN71] 3935	Nvidia	GP106GL	478,143	58,100	8.23	2 ^hrs 55 ^mins
73	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	423,523	58,100	7.29	3 ^hrs 18 ^mins
74	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	403,005	58,100	6.94	3 ^hrs 28 ^mins
75	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	394,297	58,100	6.79	3 ^hrs 32 ^mins
76	Radeon RX 580 2048SP Polaris 20 XL [Radeon RX 580 2048SP]	AMD	Polaris 20 XL	389,680	124,498	3.13	7 ^hrs 40 ^mins
77	RX 5600 OEM/5600XT/5700(XT) Navi 10 [RX 5600 OEM/5600XT/5700(XT)]	AMD	Navi 10	374,784	58,100	6.45	3 ^hrs 43 ^mins
78	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	340,167	58,100	5.85	4 ^hrs 6 ^mins
79	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	292,877	58,100	5.04	4 ^hrs 46 ^mins

80	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	257,581	88,721	2.90	8 ^hrs 16 ^mins
81	GeForce GTX 760 GK104 [GeForce GTX 760] 2258	Nvidia	GK104	182,607	58,100	3.14	7 ^hrs 38 ^mins
82	Radeon 740M/760M/780M Phoenix [Radeon 740M/760M/780M]	AMD	Phoenix	170,771	58,100	2.94	8 ^hrs 10 ^mins
83	GeForce GTX 770 GK104 [GeForce GTX 770] 3213	Nvidia	GK104	152,709	58,100	2.63	9 ^hrs 8 ^mins
84	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	150,216	90,903	1.65	14 ^hrs 31 ^mins
85	RX 5500(M)/Pro 5500M Navi 14 [RX 5500(M)/Pro 5500M]	AMD	Navi 14	137,871	58,306	2.36	10 ^hrs 9 ^mins
86	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	99,610	59,997	1.66	14 ^hrs 27 ^mins

Research: CANCER Folding Project #12705

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12705

GPU PPD Averages

Research: CANCER Folding Project #12705

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages