Folding project #12704, CANCER research

Research section Research projects and references

Project #12704 overview

Project Summary AI Beta

This project relates to understanding how a type of protein called Class F GPCRs works. These proteins are involved in diseases like stomach and colon cancer, as well as eye problems. Scientists can use computer simulations to learn more about these proteins and develop new drugs to treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Michael Chen
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 109,289
Core: 0x23
Status: Public

Source material

Official Project Description

Class F G Protein Coupled Receptors Improper signaling through Class F GPCRs is linked to Gastric Cancer, Coloboma of Macula, colon cancer and triple negative breast cancer.

Simulation of these proteins helps us to understand their function and therefore be able to design drugs specific to these diseases.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F G Protein Coupled Receptors

A family of cell surface receptors involved in signal transduction.

Scientific: BiotechnologyCellular Signaling / Receptor Biology

Class F G Protein Coupled Receptors (GPCRs) are a type of protein found on the surface of cells. They act as receptors, receiving signals from outside the cell and triggering a response inside. These receptors play a crucial role in many cellular processes, including communication between cells, growth and development, and immune responses. Dysfunction in Class F GPCR signaling has been linked to various diseases such as cancer, developmental disorders, and neurodegenerative diseases.

Gastric Cancer

Cancer that originates in the stomach lining.

Pathological: HealthcareOncology / Gastrointestinal Cancers

Gastric cancer is a malignant tumor that develops in the cells of the stomach. It's characterized by uncontrolled growth and spread of these abnormal cells. Risk factors include Helicobacter pylori infection, diet high in salt and processed meats, smoking, and family history. Symptoms may include persistent indigestion, unexplained weight loss, nausea, vomiting, and abdominal pain.

Coloboma

A developmental defect where a part of the eye is missing.

Pathological: HealthcareOphthalmology / Congenital Eye Disorders

Coloboma is a birth defect that occurs when a part of the developing eye fails to close completely. This can result in a gap or hole in the iris, retina, choroid, or optic nerve. Coloboma can cause vision problems ranging from mild to severe, and may require surgery or other treatments.

Colon Cancer

Cancer that originates in the colon or rectum.

Pathological: HealthcareOncology / Gastrointestinal Cancers

Colon cancer is a malignant tumor that forms in the tissues of the colon or rectum. Risk factors include age, diet high in red meat and processed foods, lack of physical activity, smoking, and family history. Symptoms may include changes in bowel habits, abdominal pain, rectal bleeding, and weight loss.

Triple Negative Breast Cancer

TNBC - A type of breast cancer that lacks estrogen receptors, progesterone receptors, and HER2.

Pathological: HealthcareOncology / Breast Cancers

Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer. It's characterized by the absence of three key proteins: estrogen receptors, progesterone receptors, and HER2. This makes TNBC harder to treat with hormone therapies or targeted therapies that target these specific proteins.

Drugs

Chemical substances used to treat or prevent disease.

Medical: Biotechnology, PharmaceuticalsPharmacology / Drug Development

Drugs are chemical compounds designed to have a specific effect on the body. They can be used to treat various conditions, from infections and inflammation to chronic diseases and mental health disorders. The development of new drugs is a complex process that involves extensive research, testing, and regulatory approval.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	31,170,983	68,448	455.40	0 ^hrs 3 ^mins
2	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	22,117,763	319,276	69.27	0 ^hrs 21 ^mins
3	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	18,590,974	219,583	84.66	0 ^hrs 17 ^mins
4	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	18,504,005	159,883	115.73	0 ^hrs 12 ^mins
5	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	18,430,199	83,176	221.58	0 ^hrs 6 ^mins
6	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	15,044,180	95,722	157.17	0 ^hrs 9 ^mins
7	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	14,407,578	462,365	31.16	0 ^hrs 46 ^mins
8	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	12,730,610	442,911	28.74	0 ^hrs 50 ^mins
9	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	11,354,003	353,060	32.16	0 ^hrs 45 ^mins
10	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	11,226,385	174,123	64.47	0 ^hrs 22 ^mins
11	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	11,040,100	79,773	138.39	0 ^hrs 10 ^mins
12	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,669,778	166,466	58.09	0 ^hrs 25 ^mins
13	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	9,085,814	399,524	22.74	1 ^hrs 3 ^mins
14	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	8,260,830	280,835	29.42	0 ^hrs 49 ^mins
15	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	7,790,647	160,358	48.58	0 ^hrs 30 ^mins
16	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	7,786,120	146,914	53.00	0 ^hrs 27 ^mins
17	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	7,548,557	110,196	68.50	0 ^hrs 21 ^mins
18	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	6,752,412	131,961	51.17	0 ^hrs 28 ^mins
19	GeForce RTX 4090 Laptop GPU AD103M / GN21-X11 [GeForce RTX 4090 Laptop GPU]	Nvidia	AD103M / GN21-X11	6,649,723	119,813	55.50	0 ^hrs 26 ^mins

20	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	6,444,188	256,905	25.08	0 ^hrs 57 ^mins
21	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	6,187,754	68,448	90.40	0 ^hrs 16 ^mins
22	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	6,090,830	336,158	18.12	1 ^hrs 19 ^mins
23	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,859,168	68,448	85.60	0 ^hrs 17 ^mins
24	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,734,517	68,808	83.34	0 ^hrs 17 ^mins
25	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	5,692,704	72,220	78.82	0 ^hrs 18 ^mins
26	RTX 4000 SFF Ada Generation AD104GL [RTX 4000 SFF Ada Generation]	Nvidia	AD104GL	5,628,554	68,448	82.23	0 ^hrs 18 ^mins
27	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	5,181,968	97,790	52.99	0 ^hrs 27 ^mins
28	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,075,260	139,113	36.48	0 ^hrs 39 ^mins
29	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,274,275	199,733	21.40	1 ^hrs 7 ^mins
30	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	4,167,819	66,420	62.75	0 ^hrs 23 ^mins
31	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	4,161,239	68,448	60.79	0 ^hrs 24 ^mins
32	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,923,256	147,466	26.60	0 ^hrs 54 ^mins
33	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,672,259	110,187	33.33	0 ^hrs 43 ^mins
34	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	3,583,903	127,867	28.03	0 ^hrs 51 ^mins
35	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	3,543,091	38,716	91.51	0 ^hrs 16 ^mins
36	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	3,360,871	227,414	14.78	1 ^hrs 37 ^mins
37	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	3,359,280	227,340	14.78	1 ^hrs 37 ^mins
38	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	3,027,463	247,531	12.23	1 ^hrs 58 ^mins
39	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,918,180	68,448	42.63	0 ^hrs 34 ^mins

40	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	2,819,639	68,448	41.19	0 ^hrs 35 ^mins
41	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,782,808	73,981	37.62	0 ^hrs 38 ^mins
42	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,758,545	202,245	13.64	1 ^hrs 46 ^mins
43	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,748,649	68,448	40.16	0 ^hrs 36 ^mins
44	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,666,714	204,733	13.03	1 ^hrs 51 ^mins
45	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,461,545	53,601	45.92	0 ^hrs 31 ^mins
46	GeForce RTX 2070 Mobile TU106BM [GeForce RTX 2070 Mobile]	Nvidia	TU106BM	2,446,391	258,321	9.47	2 ^hrs 32 ^mins
47	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,436,040	47,545	51.24	0 ^hrs 28 ^mins
48	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	2,387,056	210,640	11.33	2 ^hrs 7 ^mins
49	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,368,513	156,726	15.11	1 ^hrs 35 ^mins
50	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,186,185	93,802	23.31	1 ^hrs 2 ^mins
51	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	2,083,596	167,516	12.44	1 ^hrs 56 ^mins
52	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,910,291	136,587	13.99	1 ^hrs 43 ^mins
53	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	1,742,693	166,697	10.45	2 ^hrs 18 ^mins
54	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,742,562	157,004	11.10	2 ^hrs 10 ^mins
55	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,670,809	68,448	24.41	0 ^hrs 59 ^mins
56	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,637,449	68,448	23.92	1 ^hrs 0 ^mins
57	P104-100 GP104 [P104-100]	Nvidia	GP104	1,478,419	68,448	21.60	1 ^hrs 7 ^mins
58	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,437,353	89,472	16.06	1 ^hrs 30 ^mins
59	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,417,882	183,716	7.72	3 ^hrs 7 ^mins

60	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,413,725	158,471	8.92	2 ^hrs 41 ^mins
61	GeForce RTX 3050 Ti Mobile GA107M [GeForce RTX 3050 Ti Mobile]	Nvidia	GA107M	1,372,793	94,842	14.47	1 ^hrs 39 ^mins
62	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,365,947	68,448	19.96	1 ^hrs 12 ^mins
63	RTX A1000 GA107GL [RTX A1000]	Nvidia	GA107GL	1,343,454	68,448	19.63	1 ^hrs 13 ^mins
64	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,278,701	93,992	13.60	1 ^hrs 46 ^mins
65	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,270,693	31,743	40.03	0 ^hrs 36 ^mins
66	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,267,787	123,594	10.26	2 ^hrs 20 ^mins
67	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,237,950	114,407	10.82	2 ^hrs 13 ^mins
68	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	1,235,546	20,800	59.40	0 ^hrs 24 ^mins
69	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	1,233,751	68,448	18.02	1 ^hrs 20 ^mins
70	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	1,164,418	24,200	48.12	0 ^hrs 30 ^mins
71	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,145,389	33,721	33.97	0 ^hrs 42 ^mins
72	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,135,616	116,706	9.73	2 ^hrs 28 ^mins
73	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,083,385	68,448	15.83	1 ^hrs 31 ^mins
74	Radeon RX 6600(XT/M) Navi 23 XT-XL [Radeon RX 6600(XT/M)]	AMD	Navi 23 XT-XL	1,017,333	148,416	6.85	3 ^hrs 30 ^mins
75	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	983,668	68,443	14.37	1 ^hrs 40 ^mins
76	Radeon Vega FE Vega 10 XTX [Radeon Vega FE]	AMD	Vega 10 XTX	934,019	83,234	11.22	2 ^hrs 8 ^mins
77	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	900,074	64,837	13.88	1 ^hrs 44 ^mins
78	P106-100 GP106 [P106-100]	Nvidia	GP106	876,189	144,657	6.06	3 ^hrs 58 ^mins
79	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	813,910	46,759	17.41	1 ^hrs 23 ^mins

80	Quadro P3200 Mobile GP104GLM [Quadro P3200 Mobile]	Nvidia	GP104GLM	813,855	182,251	4.47	5 ^hrs 22 ^mins
81	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	794,365	20,800	38.19	0 ^hrs 38 ^mins
82	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	772,418	149,077	5.18	4 ^hrs 38 ^mins
83	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	602,721	143,552	4.20	5 ^hrs 43 ^mins
84	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	570,049	49,398	11.54	2 ^hrs 5 ^mins
85	GeForce GTX 1650 TU106 [GeForce GTX 1650]	Nvidia	TU106	496,082	68,448	7.25	3 ^hrs 19 ^mins
86	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	472,846	68,448	6.91	3 ^hrs 28 ^mins
87	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	448,738	62,700	7.16	3 ^hrs 21 ^mins
88	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	436,817	21,609	20.21	1 ^hrs 11 ^mins
89	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	334,835	68,448	4.89	4 ^hrs 54 ^mins
90	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	323,032	60,711	5.32	4 ^hrs 31 ^mins
91	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	322,938	83,489	3.87	6 ^hrs 12 ^mins
92	RX 5500(M)/Pro 5500M Navi 14 [RX 5500(M)/Pro 5500M]	AMD	Navi 14	284,151	68,448	4.15	5 ^hrs 47 ^mins
93	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	264,772	68,448	3.87	6 ^hrs 12 ^mins
94	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	245,859	78,210	3.14	7 ^hrs 38 ^mins
95	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	236,216	49,741	4.75	5 ^hrs 3 ^mins
96	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	221,712	52,029	4.26	5 ^hrs 38 ^mins
97	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	206,332	68,448	3.01	7 ^hrs 58 ^mins
98	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	162,769	101,023	1.61	14 ^hrs 54 ^mins
99	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	152,640	49,929	3.06	7 ^hrs 51 ^mins

100	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	110,939	68,448	1.62	14 ^hrs 48 ^mins
101	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	53,072	68,448	0.78	30 ^hrs 57 ^mins
102	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	46,671	20,800	2.24	10 ^hrs 42 ^mins
103	Quadro M1200 GM107GLM [Quadro M1200] 1399	Nvidia	GM107GLM	26,968	68,448	0.39	60 ^hrs 55 ^mins
104	Ryzen 7000 Series iGPU Raphael [Ryzen 7000 Series iGPU]	AMD	Raphael	17,554	20,800	0.84	28 ^hrs 26 ^mins

Research: CANCER Folding Project #12704

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12704

GPU PPD Averages

Research: CANCER Folding Project #12704

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages