Folding project #12703, CANCER research

Research section Research projects and references

Project #12703 overview

Project Summary AI Beta

Class F GPCR proteins are important for our bodies to work properly. Problems with these proteins can cause serious diseases like cancer. The project relates to making computer models of these proteins so scientists can understand how they work and design new drugs to treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Michael Chen
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 111,283
Core: 0x27
Status: Public

Source material

Official Project Description

Class F G Protein Coupled Receptors Improper signaling through Class F GPCRs is linked to Gastric Cancer, Coloboma of Macula, colon cancer and triple negative breast cancer.

Simulation of these proteins helps us to understand their function and therefore be able to design drugs specific to these diseases.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F G Protein Coupled Receptors

A family of cell surface receptors that bind to G proteins and mediate various cellular responses.

Scientific: BiotechnologyPharmacology / Signal Transduction

Class F GPCRs are a type of receptor found on the surface of cells. They play a crucial role in transmitting signals within the body by activating G proteins. These signals influence a wide range of cellular processes, including growth, differentiation, and metabolism. Disruptions in Class F GPCR signaling have been linked to several diseases, such as cancer and vision disorders.

Gastric Cancer

Cancer that originates in the stomach lining.

Pathology: HealthcareMedicine / Oncology

Gastric cancer is a malignant growth of cells in the stomach. It can develop due to various factors, including infection with Helicobacter pylori bacteria, genetics, and dietary habits. Symptoms may include abdominal pain, nausea, vomiting, and weight loss. Treatment options vary depending on the stage and severity of the cancer and may include surgery, chemotherapy, and radiation therapy.

Coloboma

A developmental defect that involves a gap or hole in a part of the body.

Pathology: HealthcareMedicine / Ophthalmology

Coloboma is a rare birth defect characterized by a missing or incompletely formed structure. It can affect various parts of the body, most commonly the eye (coloboma of the macula). In the eye, coloboma often involves the retina and choroid, leading to vision problems. Treatment options may include surgery or corrective lenses.

Colon Cancer

Cancer that originates in the colon (large intestine).

Pathology: HealthcareMedicine / Oncology

Colon cancer is a type of cancer that starts in the cells lining the colon. Risk factors include a diet high in processed meats and red meat, obesity, and family history of colon cancer. Symptoms may include changes in bowel habits, blood in the stool, abdominal pain, and weight loss. Colonoscopy and other imaging tests are used for diagnosis and treatment options include surgery, chemotherapy, and radiation therapy.

Triple Negative Breast Cancer

A type of breast cancer that lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).

Pathology: HealthcareMedicine / Oncology

Triple-negative breast cancer is a particularly aggressive form of breast cancer that does not respond to hormone therapy or HER2-targeted therapies. It is characterized by the absence of three key receptors: estrogen receptor, progesterone receptor, and HER2. Treatment often involves chemotherapy, radiation therapy, and surgery.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	32,379,929	69,961	462.83	0 ^hrs 3 ^mins
2	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	22,298,791	296,403	75.23	0 ^hrs 19 ^mins
3	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	18,683,689	80,444	232.26	0 ^hrs 6 ^mins
4	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	18,603,485	239,112	77.80	0 ^hrs 19 ^mins
5	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	18,358,346	164,177	111.82	0 ^hrs 13 ^mins
6	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	15,160,519	84,353	179.73	0 ^hrs 8 ^mins
7	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	13,334,064	292,606	45.57	0 ^hrs 32 ^mins
8	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	12,753,017	447,366	28.51	0 ^hrs 51 ^mins
9	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	11,782,177	324,702	36.29	0 ^hrs 40 ^mins
10	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	11,467,243	196,469	58.37	0 ^hrs 25 ^mins
11	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	11,097,701	193,603	57.32	0 ^hrs 25 ^mins
12	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	10,658,372	79,338	134.34	0 ^hrs 11 ^mins
13	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	10,099,171	179,946	56.12	0 ^hrs 26 ^mins
14	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	8,176,793	278,337	29.38	0 ^hrs 49 ^mins
15	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	8,097,923	122,794	65.95	0 ^hrs 22 ^mins
16	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	7,907,073	192,273	41.12	0 ^hrs 35 ^mins
17	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	7,565,132	69,961	108.13	0 ^hrs 13 ^mins
18	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	6,721,967	355,869	18.89	1 ^hrs 16 ^mins
19	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	6,372,329	144,006	44.25	0 ^hrs 33 ^mins

20	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	6,114,763	69,961	87.40	0 ^hrs 16 ^mins
21	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	6,070,859	246,778	24.60	0 ^hrs 59 ^mins
22	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,514,045	64,184	85.91	0 ^hrs 17 ^mins
23	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	5,493,562	76,213	72.08	0 ^hrs 20 ^mins
24	RTX 4000 SFF Ada Generation AD104GL [RTX 4000 SFF Ada Generation]	Nvidia	AD104GL	5,405,258	54,885	98.48	0 ^hrs 15 ^mins
25	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	5,220,058	69,961	74.61	0 ^hrs 19 ^mins
26	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,155,590	116,560	44.23	0 ^hrs 33 ^mins
27	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	4,854,254	95,498	50.83	0 ^hrs 28 ^mins
28	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,565,436	202,994	22.49	1 ^hrs 4 ^mins
29	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	4,130,765	134,638	30.68	0 ^hrs 47 ^mins
30	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	4,103,767	88,978	46.12	0 ^hrs 31 ^mins
31	GeForce RTX 4090 Laptop GPU AD103M / GN21-X11 [GeForce RTX 4090 Laptop GPU]	Nvidia	AD103M / GN21-X11	3,918,687	137,885	28.42	0 ^hrs 51 ^mins
32	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,846,278	173,421	22.18	1 ^hrs 5 ^mins
33	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	3,788,890	69,961	54.16	0 ^hrs 27 ^mins
34	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,625,304	135,801	26.70	0 ^hrs 54 ^mins
35	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,621,174	203,158	17.82	1 ^hrs 21 ^mins
36	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	3,565,967	223,144	15.98	1 ^hrs 30 ^mins
37	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	3,498,499	58,422	59.88	0 ^hrs 24 ^mins
38	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	3,313,345	255,539	12.97	1 ^hrs 51 ^mins
39	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	3,277,981	46,234	70.90	0 ^hrs 20 ^mins

40	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	2,985,639	199,844	14.94	1 ^hrs 36 ^mins
41	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,782,057	70,795	39.30	0 ^hrs 37 ^mins
42	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	2,755,664	224,521	12.27	1 ^hrs 57 ^mins
43	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,669,598	69,961	38.16	0 ^hrs 38 ^mins
44	GeForce RTX 2070 Mobile TU106BM [GeForce RTX 2070 Mobile]	Nvidia	TU106BM	2,564,601	264,846	9.68	2 ^hrs 29 ^mins
45	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,495,268	186,672	13.37	1 ^hrs 48 ^mins
46	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,450,812	260,872	9.39	2 ^hrs 33 ^mins
47	GeForce GTX 1650 TU106 [GeForce GTX 1650]	Nvidia	TU106	2,399,329	69,961	34.30	0 ^hrs 42 ^mins
48	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,316,608	179,505	12.91	1 ^hrs 52 ^mins
49	Quadro P6000 GP102GL [Quadro P6000]	Nvidia	GP102GL	2,231,006	69,961	31.89	0 ^hrs 45 ^mins
50	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,126,884	108,015	19.69	1 ^hrs 13 ^mins
51	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	2,046,815	152,802	13.40	1 ^hrs 48 ^mins
52	Radeon VII Vega 20 [Radeon VII]	AMD	Vega 20	1,858,331	21,200	87.66	0 ^hrs 16 ^mins
53	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,731,296	129,897	13.33	1 ^hrs 48 ^mins
54	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,678,638	69,961	23.99	1 ^hrs 0 ^mins
55	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,630,358	69,961	23.30	1 ^hrs 2 ^mins
56	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,583,990	41,018	38.62	0 ^hrs 37 ^mins
57	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,555,783	159,411	9.76	2 ^hrs 28 ^mins
58	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,509,354	100,141	15.07	1 ^hrs 36 ^mins
59	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,442,745	188,597	7.65	3 ^hrs 8 ^mins

60	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,389,152	69,961	19.86	1 ^hrs 13 ^mins
61	P104-100 GP104 [P104-100]	Nvidia	GP104	1,379,410	69,961	19.72	1 ^hrs 13 ^mins
62	RTX A1000 GA107GL [RTX A1000]	Nvidia	GA107GL	1,360,052	69,961	19.44	1 ^hrs 14 ^mins
63	GeForce RTX 3050 Ti Mobile GA107M [GeForce RTX 3050 Ti Mobile]	Nvidia	GA107M	1,355,203	96,123	14.10	1 ^hrs 42 ^mins
64	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,324,424	87,567	15.12	1 ^hrs 35 ^mins
65	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,311,430	132,428	9.90	2 ^hrs 25 ^mins
66	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,271,547	94,800	13.41	1 ^hrs 47 ^mins
67	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	1,231,748	21,200	58.10	0 ^hrs 25 ^mins
68	GeForce RTX 3050 6GB GA107 [GeForce RTX 3050 6GB]	Nvidia	GA107	1,151,227	21,200	54.30	0 ^hrs 27 ^mins
69	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,132,677	39,736	28.51	0 ^hrs 51 ^mins
70	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,065,760	28,462	37.45	0 ^hrs 38 ^mins
71	Quadro P3200 Mobile GP104GLM [Quadro P3200 Mobile]	Nvidia	GP104GLM	1,043,120	199,153	5.24	4 ^hrs 35 ^mins
72	Radeon RX 6600(XT/M) Navi 23 XT-XL [Radeon RX 6600(XT/M)]	AMD	Navi 23 XT-XL	902,961	175,914	5.13	4 ^hrs 41 ^mins
73	P106-100 GP106 [P106-100]	Nvidia	GP106	878,226	145,485	6.04	3 ^hrs 59 ^mins
74	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	799,029	167,576	4.77	5 ^hrs 2 ^mins
75	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	785,222	47,246	16.62	1 ^hrs 27 ^mins
76	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	764,081	70,203	10.88	2 ^hrs 12 ^mins
77	RX 5600 OEM/5600XT/5700(XT) Navi 10 [RX 5600 OEM/5600XT/5700(XT)]	AMD	Navi 10	673,384	180,184	3.74	6 ^hrs 25 ^mins
78	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	662,546	156,350	4.24	5 ^hrs 40 ^mins
79	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	631,232	52,977	11.92	2 ^hrs 1 ^mins

80	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	622,315	63,829	9.75	2 ^hrs 28 ^mins
81	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	609,970	58,277	10.47	2 ^hrs 18 ^mins
82	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	524,020	46,482	11.27	2 ^hrs 8 ^mins
83	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	506,049	38,075	13.29	1 ^hrs 48 ^mins
84	RX 5500(M)/Pro 5500M Navi 14 [RX 5500(M)/Pro 5500M]	AMD	Navi 14	456,542	69,961	6.53	3 ^hrs 41 ^mins
85	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	454,652	69,961	6.50	3 ^hrs 42 ^mins
86	Radeon RX 580 2048SP Polaris 20 XL [Radeon RX 580 2048SP]	AMD	Polaris 20 XL	415,433	145,240	2.86	8 ^hrs 23 ^mins
87	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	376,425	69,277	5.43	4 ^hrs 25 ^mins
88	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	276,582	68,878	4.02	5 ^hrs 59 ^mins
89	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	265,801	66,651	3.99	6 ^hrs 1 ^mins
90	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	241,399	53,746	4.49	5 ^hrs 21 ^mins
91	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	192,629	48,569	3.97	6 ^hrs 3 ^mins
92	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	167,666	100,202	1.67	14 ^hrs 21 ^mins
93	GeForce GTX 760 GK104 [GeForce GTX 760] 2258	Nvidia	GK104	132,126	69,961	1.89	12 ^hrs 42 ^mins
94	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	117,265	72,833	1.61	14 ^hrs 54 ^mins
95	Quadro P2000 GP106GL [Quadro P2000] [MED-XN71] 3935	Nvidia	GP106GL	116,481	69,961	1.66	14 ^hrs 25 ^mins
96	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	113,379	69,961	1.62	14 ^hrs 49 ^mins
97	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	81,188	21,200	3.83	6 ^hrs 16 ^mins
98	Quadro M1200 GM107GLM [Quadro M1200] 1399	Nvidia	GM107GLM	23,694	69,961	0.34	70 ^hrs 52 ^mins

Research: CANCER Folding Project #12703

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12703

GPU PPD Averages

Research: CANCER Folding Project #12703

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages