Folding project #12700, CANCER research

Research section Research projects and references

Project #12700 overview

Project Summary AI Beta

This project relates to Class F G Protein Coupled Receptors, which are involved in diseases like gastric and colon cancer. Simulating these receptors helps us understand how they work so we can develop targeted drugs for these cancers.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Michael Chen
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 100,374
Core: 0x23
Status: Public

Source material

Official Project Description

Class F G Protein Coupled Receptors Improper signaling through Class F GPCRs is linked to Gastric Cancer, Coloboma of Macula and colon cancer.

Simulation of these proteins helps us to understand their function and therefore be able to design drugs specific to these diseases.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F GPCRs

G protein-coupled receptors belonging to class F.

Scientific: BiotechnologyReceptor / Cell Signaling

Class F G Protein-Coupled Receptors (GPCRs) are a family of cell surface receptors involved in transmitting signals within cells. They play crucial roles in various physiological processes, including sensory perception, hormone regulation, and immune responses. Dysregulation of Class F GPCR signaling has been implicated in several diseases, such as gastric cancer, coloboma of the macula (a retinal birth defect), and colon cancer.

Gastric Cancer

Cancer that originates in the stomach.

Medical Condition: MedicineDisease / Gastrointestinal Disorders

Gastric cancer is a malignant tumor that develops in the cells lining the stomach. It is a common type of cancer worldwide, with risk factors including Helicobacter pylori infection, diet high in salt and processed foods, and smoking. Symptoms may include abdominal pain, nausea, vomiting, weight loss, and anemia.

Coloboma of Macula

A birth defect in which a part of the macula (central area of the retina) is missing.

Medical Condition: MedicineDisease / Ophthalmological Disorders

Coloboma of the macula is a rare eye disorder present at birth. It involves a gap or hole in the macula, the central part of the retina responsible for sharp vision. Symptoms include blurred vision, difficulty seeing fine details, and distorted vision. Treatment options may include eyeglasses, contact lenses, or surgery.

Colon Cancer

Cancer that originates in the colon or rectum.

Medical Condition: MedicineDisease / Gastrointestinal Disorders

Colon cancer is a malignant tumor that develops in the cells lining the colon or rectum. It is one of the most common cancers worldwide, with risk factors including diet low in fruits and vegetables, obesity, smoking, and family history. Symptoms may include changes in bowel habits, rectal bleeding, abdominal pain, and unexplained weight loss.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	21,816,714	236,665	92.18	0 ^hrs 16 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	15,916,601	205,878	77.31	0 ^hrs 19 ^mins
3	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	15,821,140	121,183	130.56	0 ^hrs 11 ^mins
4	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	12,005,283	378,081	31.75	0 ^hrs 45 ^mins
5	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	11,830,347	17,500	676.02	0 ^hrs 2 ^mins
6	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	10,243,331	149,921	68.32	0 ^hrs 21 ^mins
7	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	9,769,623	142,448	68.58	0 ^hrs 21 ^mins
8	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,273,359	147,972	62.67	0 ^hrs 23 ^mins
9	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,184,772	207,219	44.32	0 ^hrs 32 ^mins
10	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	7,664,463	177,972	43.07	0 ^hrs 33 ^mins
11	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,946,842	157,637	44.07	0 ^hrs 33 ^mins
12	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,411,905	128,407	49.93	0 ^hrs 29 ^mins
13	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,322,701	83,428	75.79	0 ^hrs 19 ^mins
14	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	6,070,434	88,349	68.71	0 ^hrs 21 ^mins
15	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,733,217	104,499	54.86	0 ^hrs 26 ^mins
16	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,649,378	59,841	94.41	0 ^hrs 15 ^mins
17	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	5,565,989	71,649	77.68	0 ^hrs 19 ^mins
18	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	5,521,307	290,257	19.02	1 ^hrs 16 ^mins
19	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,132,479	99,324	51.67	0 ^hrs 28 ^mins

20	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,821,320	115,418	41.77	0 ^hrs 34 ^mins
21	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	4,274,214	55,578	76.90	0 ^hrs 19 ^mins
22	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,121,205	109,562	37.62	0 ^hrs 38 ^mins
23	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,867,739	146,867	26.33	0 ^hrs 55 ^mins
24	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,644,929	117,201	31.10	0 ^hrs 46 ^mins
25	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,447,567	55,578	62.03	0 ^hrs 23 ^mins
26	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,233,672	66,769	48.43	0 ^hrs 30 ^mins
27	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	3,195,803	109,416	29.21	0 ^hrs 49 ^mins
28	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	3,131,046	67,557	46.35	0 ^hrs 31 ^mins
29	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	3,126,670	30,192	103.56	0 ^hrs 14 ^mins
30	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	3,076,836	52,757	58.32	0 ^hrs 25 ^mins
31	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,843,993	120,846	23.53	1 ^hrs 1 ^mins
32	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,754,873	188,454	14.62	1 ^hrs 39 ^mins
33	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	2,733,780	59,947	45.60	0 ^hrs 32 ^mins
34	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,675,333	111,292	24.04	0 ^hrs 60 ^mins
35	GeForce RTX 2060 12GB TU106 [GeForce RTX 2060 12GB]	Nvidia	TU106	2,606,429	105,142	24.79	0 ^hrs 58 ^mins
36	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,547,668	17,500	145.58	0 ^hrs 10 ^mins
37	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,533,798	104,080	24.34	0 ^hrs 59 ^mins
38	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,478,151	128,831	19.24	1 ^hrs 15 ^mins
39	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,448,627	222,503	11.00	2 ^hrs 11 ^mins

40	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,366,611	83,791	28.24	0 ^hrs 51 ^mins
41	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,365,146	86,156	27.45	0 ^hrs 52 ^mins
42	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,340,747	100,569	23.28	1 ^hrs 2 ^mins
43	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	2,305,319	213,848	10.78	2 ^hrs 14 ^mins
44	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,149,013	93,378	23.01	1 ^hrs 3 ^mins
45	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,938,081	104,110	18.62	1 ^hrs 17 ^mins
46	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,830,730	93,624	19.55	1 ^hrs 14 ^mins
47	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,819,324	17,500	103.96	0 ^hrs 14 ^mins
48	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,815,215	119,086	15.24	1 ^hrs 34 ^mins
49	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,807,345	77,653	23.27	1 ^hrs 2 ^mins
50	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,510,152	86,804	17.40	1 ^hrs 23 ^mins
51	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,367,801	161,384	8.48	2 ^hrs 50 ^mins
52	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,366,509	40,409	33.82	0 ^hrs 43 ^mins
53	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,360,467	42,885	31.72	0 ^hrs 45 ^mins
54	P104-100 GP104 [P104-100]	Nvidia	GP104	1,337,266	55,578	24.06	0 ^hrs 60 ^mins
55	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,254,141	74,154	16.91	1 ^hrs 25 ^mins
56	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,242,989	43,067	28.86	0 ^hrs 50 ^mins
57	RTX A1000 GA107GL [RTX A1000]	Nvidia	GA107GL	1,201,564	55,578	21.62	1 ^hrs 7 ^mins
58	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,197,909	81,293	14.74	1 ^hrs 38 ^mins
59	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,096,024	55,578	19.72	1 ^hrs 13 ^mins

60	Radeon RX 6600(XT/M) Navi 23 XT-XL [Radeon RX 6600(XT/M)]	AMD	Navi 23 XT-XL	1,054,239	168,998	6.24	3 ^hrs 51 ^mins
61	Radeon RX 7700S/7600(S) Navi 33 [Radeon RX 7700S/7600(S)]	AMD	Navi 33	1,007,747	74,249	13.57	1 ^hrs 46 ^mins
62	Radeon Vega FE Vega 10 XTX [Radeon Vega FE]	AMD	Vega 10 XTX	1,006,753	73,181	13.76	1 ^hrs 45 ^mins
63	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	952,939	81,123	11.75	2 ^hrs 3 ^mins
64	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	932,351	55,578	16.78	1 ^hrs 26 ^mins
65	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	931,574	55,578	16.76	1 ^hrs 26 ^mins
66	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	905,305	17,500	51.73	0 ^hrs 28 ^mins
67	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	860,196	156,539	5.50	4 ^hrs 22 ^mins
68	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	817,841	55,578	14.72	1 ^hrs 38 ^mins
69	P106-100 GP106 [P106-100]	Nvidia	GP106	805,443	124,052	6.49	3 ^hrs 42 ^mins
70	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	791,558	46,386	17.06	1 ^hrs 24 ^mins
71	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	686,521	17,500	39.23	0 ^hrs 37 ^mins
72	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	666,989	134,819	4.95	4 ^hrs 51 ^mins
73	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	665,188	65,986	10.08	2 ^hrs 23 ^mins
74	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	624,246	47,549	13.13	1 ^hrs 50 ^mins
75	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	561,745	17,500	32.10	0 ^hrs 45 ^mins
76	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	435,194	58,599	7.43	3 ^hrs 14 ^mins
77	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	434,224	17,500	24.81	0 ^hrs 58 ^mins
78	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	406,154	55,578	7.31	3 ^hrs 17 ^mins
79	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	326,596	52,481	6.22	3 ^hrs 51 ^mins

80	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	313,607	52,594	5.96	4 ^hrs 1 ^mins
81	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	285,933	23,954	11.94	2 ^hrs 1 ^mins
82	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	267,523	43,184	6.19	3 ^hrs 52 ^mins
83	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	267,388	55,578	4.81	4 ^hrs 59 ^mins
84	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	162,193	17,500	9.27	2 ^hrs 35 ^mins
85	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	150,062	69,880	2.15	11 ^hrs 11 ^mins
86	Ryzen 7000 Series iGPU Raphael [Ryzen 7000 Series iGPU]	AMD	Raphael	141,555	22,789	6.21	3 ^hrs 52 ^mins
87	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	123,804	56,876	2.18	11 ^hrs 2 ^mins
88	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	122,711	17,500	7.01	3 ^hrs 25 ^mins
89	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	102,658	55,578	1.85	12 ^hrs 60 ^mins
90	HD 7850/R7 265/R9 270 1024SP Pitcairn PRO [HD 7850/R7 265/R9 270 1024SP]	AMD	Pitcairn PRO	63,345	32,595	1.94	12 ^hrs 21 ^mins
91	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	58,948	35,619	1.65	14 ^hrs 30 ^mins
92	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	51,044	28,796	1.77	13 ^hrs 32 ^mins
93	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	49,566	29,101	1.70	14 ^hrs 5 ^mins
94	RX Vega 10 Mobile Picasso APU [RX Vega 10 Mobile]	AMD	Picasso APU	48,514	26,573	1.83	13 ^hrs 9 ^mins

Research: CANCER Folding Project #12700

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12700

GPU PPD Averages

Research: CANCER Folding Project #12700

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages