PROJECT #18810 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Disordered proteins are essential regulators of cellular function.

In particular, they regulate the transcription of genes.

In this project we want to understand how disordered proteins involved in gene regulation interact with each other and how their interactions are modulated.

Disordered proteins are often modified by the attachment of chemical groups, for example via phosphorylation.

This addition of a negatively charged phosphoryl group can change how they interact with binding partners, for example favoring binding to a positively charged partner and disfavoring binding to a negatively charged or hydrophobic binding site.

In this project we look specifically at small fragments of disordered proteins to understand how phosphorylation mediates their interactions.

In subsequent projects we will look at larger fragments or even full-length disordered proteins.

Our research may help to better understand the diverse functions of disordered proteins in regulating genes -- a starting point for understanding the dysregulation of disordered proteins, which is implicated in the development of age-related diseases such as cancer..

PROJECT INFO

Manager(s): Dr. Sonya Hanson

Institution: Flatiron Institute

Project URL: https://www.simonsfoundation.org/people/sonya-hanson/

PROJECT WORK UNIT SUMMARY

Atoms: 61,050

Core: 0xa8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 7950X 16-CORE 32 41,030 1,312,960 AMD
2 RYZEN 9 5950X 16-CORE 32 24,623 787,936 AMD
3 RYZEN 7 7700X 8-CORE 16 42,187 674,992 AMD
4 RYZEN 9 5900X 12-CORE 24 27,163 651,912 AMD
5 RYZEN 9 3900XT 12-CORE 24 22,913 549,912 AMD
6 RYZEN 7 5800X3D 8-CORE 16 31,769 508,304 AMD
7 RYZEN 7 5700G 16 31,101 497,616 AMD
8 RYZEN 9 3900X 12-CORE 24 20,336 488,064 AMD
9 RYZEN 7 5700X 8-CORE 16 27,050 432,800 AMD
10 RYZEN THREADRIPPER 1950X 16-CORE 32 13,403 428,896 AMD
11 RYZEN 7 5800X 8-CORE 16 26,591 425,456 AMD
12 CORE I9-10900X CPU @ 3.70GHZ 20 20,185 403,700 Intel
13 RYZEN 7 3800X 8-CORE 16 24,453 391,248 AMD
14 RYZEN 7 3700X 8-CORE 16 18,062 288,992 AMD
15 CORE I9-9900K CPU @ 3.60GHZ 16 17,572 281,152 Intel
16 RYZEN 5 5600G 12 23,353 280,236 AMD
17 RYZEN 5 PRO 5650G 12 22,925 275,100 AMD
18 RYZEN 5 5600X 6-CORE 12 21,560 258,720 AMD
19 RYZEN 7 5800H 16 15,676 250,816 AMD
20 RYZEN 7 PRO 4750G 16 15,563 249,008 AMD
21 RYZEN 9 5900 12-CORE 24 10,179 244,296 AMD
22 CORE I7-10700K CPU @ 3.80GHZ 16 15,050 240,800 Intel
23 12TH GEN CORE I9-12900H 20 10,745 214,900 Intel
24 CORE I5-8600K CPU @ 3.60GHZ 6 35,102 210,612 Intel
25 CORE I7-9700K CPU @ 3.60GHZ 8 26,296 210,368 Intel
26 RYZEN 3 3300X 4-CORE 8 22,835 182,680 AMD
27 RYZEN 5 3600 6-CORE 12 14,935 179,220 AMD
28 CORE I7-9700 CPU @ 3.00GHZ 8 21,713 173,704 Intel
29 11TH GEN CORE I7-11850H @ 2.50GHZ 16 10,275 164,400 Intel
30 CORE I7-6950X CPU @ 3.00GHZ 20 7,668 153,360 Intel
31 CORE I5-10400 CPU @ 2.90GHZ 12 11,812 141,744 Intel
32 CORE I7-7700K CPU @ 4.20GHZ 8 17,110 136,880 Intel
33 CORE I7-8705G CPU @ 3.10GHZ 8 15,251 122,008 Intel
34 XEON CPU E5-2650L V4 @ 1.70GHZ 28 4,100 114,800 Intel
35 11TH GEN CORE I5-11400 @ 2.60GHZ 12 9,015 108,180 Intel
36 CORE I7-9750H CPU @ 2.60GHZ 12 8,167 98,004 Intel
37 RYZEN 5 2600X SIX-CORE 12 7,988 95,856 AMD
38 RYZEN 7 2700X EIGHT-CORE 16 5,955 95,280 AMD
39 CORE I9-8950HK CPU @ 2.90GHZ 12 7,578 90,936 Intel
40 CORE I7-5820K CPU @ 3.30GHZ 12 6,434 77,208 Intel
41 CORE I7-6700K CPU @ 4.00GHZ 8 9,583 76,664 Intel
42 RYZEN 5 2400G 8 8,606 68,848 AMD
43 CORE I5-4690 CPU @ 3.50GHZ 4 16,364 65,456 Intel
44 APPLE M1 8 7,595 60,760 Apple
45 CORE I5-8265U CPU @ 1.60GHZ 8 6,846 54,768 Intel
46 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,595 52,760 Intel
47 XEON CPU E5-2680 0 @ 2.70GHZ 16 3,155 50,480 Intel
48 CORE I7-4770K CPU @ 3.50GHZ 8 6,186 49,488 Intel
49 CORE I5-4590 CPU @ 3.30GHZ 4 12,019 48,076 Intel
50 CORE I7-7700HQ CPU @ 2.80GHZ 8 5,849 46,792 Intel
51 CORE I7-4800MQ CPU @ 2.70GHZ 8 4,983 39,864 Intel
52 CORE I7-4850HQ CPU @ 2.30GHZ 8 3,054 24,432 Intel
53 RYZEN 7 3700U 8 2,323 18,584 AMD
54 CORE I3-6006U CPU @ 2.00GHZ 4 3,342 13,368 Intel
55 CORE I7-4700MQ CPU @ 2.40GHZ 8 1,002 8,016 Intel