PROJECT #18800 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Disordered proteins are essential regulators of cellular function.

In particular, they regulate the transcription of genes.

In this project we want to understand how disordered proteins involved in gene regulation interact with each other and how their interactions are modulated.

Disordered proteins are often modified by the attachment of chemical groups, for example via phosphorylation.

This addition of a negatively charged phosphoryl group can change how they interact with binding partners, for example favoring binding to a positively charged partner and disfavoring binding to a negatively charged or hydrophobic binding site.

In this project we look specifically at small fragments of disordered proteins to understand how phosphorylation mediates their interactions.

In subsequent projects we will look at larger fragments or even full-length disordered proteins.

Our research may help to better understand the diverse functions of disordered proteins in regulating genes -- a starting point for understanding the dysregulation of disordered proteins, which is implicated in the development of age-related diseases such as cancer..

PROJECT INFO

Manager(s): Dr. Sonya Hanson

Institution: Flatiron Institute

Project URL: https://www.simonsfoundation.org/people/sonya-hanson/

PROJECT WORK UNIT SUMMARY

Atoms: 28,306

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 27 June 2022 11:45:16

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 27 June 2022 11:45:16

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 12TH GEN CORE I9-12900K 24 22,861 548,664 Intel
2 RYZEN 7 3700X 8-CORE 16 24,575 393,200 AMD
3 CORE I5-7400 CPU @ 3.00GHZ 4 19,012 76,048 Intel
4 CORE I7-10510U CPU @ 1.80GHZ 8 8,612 68,896 Intel
5 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,031 56,248 Intel
6 CORE I5-5200U CPU @ 2.20GHZ 4 5,389 21,556 Intel