PROJECT #18806 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Disordered proteins are essential regulators of cellular function.

In particular, they regulate the transcription of genes.

In this project we want to understand how disordered proteins involved in gene regulation interact with each other and how their interactions are modulated.

Disordered proteins are often modified by the attachment of chemical groups, for example via phosphorylation.

This addition of a negatively charged phosphoryl group can change how they interact with binding partners, for example favoring binding to a positively charged partner and disfavoring binding to a negatively charged or hydrophobic binding site.

In this project we look specifically at small fragments of disordered proteins to understand how phosphorylation mediates their interactions.

In subsequent projects we will look at larger fragments or even full-length disordered proteins.

Our research may help to better understand the diverse functions of disordered proteins in regulating genes -- a starting point for understanding the dysregulation of disordered proteins, which is implicated in the development of age-related diseases such as cancer..

PROJECT INFO

Manager(s): Dr. Sonya Hanson

Institution: Flatiron Institute

Project URL: https://www.simonsfoundation.org/people/sonya-hanson/

PROJECT WORK UNIT SUMMARY

Atoms: 721,242

Core: 0xa9

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5900X 12-CORE 24 18,954 454,896 AMD
2 RYZEN 7 5700X 8-CORE 16 27,727 443,632 AMD
3 RYZEN 7 6800H 16 24,658 394,528 AMD
4 RYZEN 7 5800X3D 8-CORE 16 24,595 393,520 AMD
5 RYZEN 7 5800X 8-CORE 16 19,845 317,520 AMD
6 RYZEN 5 5600X 6-CORE 12 21,556 258,672 AMD
7 CORE I9-9900K CPU @ 3.60GHZ 16 15,155 242,480 Intel
8 RYZEN 7 3700X 8-CORE 16 14,338 229,408 AMD
9 12TH GEN CORE I9-12900H 20 11,240 224,800 Intel
10 CORE I7-9750H CPU @ 2.60GHZ 12 10,746 128,952 Intel
11 CORE I7-10700T CPU @ 2.00GHZ 16 5,860 93,760 Intel
12 CORE I3-9100F CPU @ 3.60GHZ 4 21,688 86,752 Intel
13 CORE I7-10510U CPU @ 1.80GHZ 8 7,267 58,136 Intel