PROJECT #18040 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

We are simulating publicly available protein and small molecule structures of the currently very hot cancer target KRas, see https://www.fiercepharma.com/pharma/amgen-s-lumakras-becomes-first-fda-approved-kras-inhibitor-for-lung-cancer-patients for recent developments.

Folding@home has previously looked at this protein (in project 10490), and the following part of the description is copied from there: This project is "studying a small protein called KRAS, which forms a key link in growth signaling and cancer.

This gene is something like a molecular switch with a timer.

When it is bound to a molecule called GDP, it is off, and does not signal that the cell should grow.

However, other proteins can cause it to swap its GDP for a GTP, turning KRAS on.

In the on state, it signals that the cell should grow and divide.

Normally, after some time, KRAS, with the aid of some partners, will chemically convert its GTP to GDP and return to its inactive state. In many cancers, this protein becomes mutated, and cannot return to its off state.

The result? The cells continue to divide without limit.

What’s worse, cancers with this protein mutated tend to have much poorer prognoses.

As a result, scientists have been trying to target this protein for decades." We are investigating the dynamic behavior of KRas with these publicly disclosed inhibitors so that we can apply this knowledge to our own drug design.

At the same time, we are further testing the adaptive sampling methodology.

All data is being made publicly available at https://console.cloud.google.com/storage/browser/stxfah-bucket, and insights from methodology developments will be shared.

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket.

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 150,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:29

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 8,630,929 1,024,712 8.42 3 hrs 51 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,812,692 954,636 7.14 3 hrs 22 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,194,522 933,559 6.64 4 hrs 37 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,733,559 912,105 6.29 4 hrs 49 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,080,839 852,331 5.96 4 hrs 2 mins
6 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,462,218 850,949 5.24 5 hrs 35 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,410,349 842,245 5.24 5 hrs 35 mins
8 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,957,015 806,645 4.91 5 hrs 54 mins
9 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 3,778,011 808,322 4.67 5 hrs 8 mins
10 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,456,042 756,500 4.57 5 hrs 15 mins
11 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 3,326,739 769,143 4.33 6 hrs 33 mins
12 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,308,881 757,930 4.37 5 hrs 30 mins
13 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,829,456 720,902 3.92 6 hrs 7 mins
14 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 2,753,229 713,800 3.86 6 hrs 13 mins
15 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,720,909 714,612 3.81 6 hrs 18 mins
16 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,634,220 701,239 3.76 6 hrs 23 mins
17 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,460,309 689,125 3.57 7 hrs 43 mins
18 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,423,061 691,385 3.50 7 hrs 51 mins
19 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 2,198,061 661,317 3.32 7 hrs 13 mins
20 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,044,160 668,800 3.06 8 hrs 51 mins
21 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 1,935,927 635,110 3.05 8 hrs 52 mins
22 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,925,972 642,597 3.00 8 hrs 0 mins
23 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 1,917,790 629,321 3.05 8 hrs 53 mins
24 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,820,791 639,090 2.85 8 hrs 25 mins
25 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 1,795,277 619,184 2.90 8 hrs 17 mins
26 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 1,659,246 600,569 2.76 9 hrs 41 mins
27 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 1,655,686 581,217 2.85 8 hrs 26 mins
28 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,535,249 586,717 2.62 9 hrs 10 mins
29 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,496,318 595,436 2.51 10 hrs 33 mins
30 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,299,362 543,094 2.39 10 hrs 2 mins
31 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,261,671 554,618 2.27 11 hrs 33 mins
32 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,152,670 532,309 2.17 11 hrs 5 mins
33 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,111,888 526,739 2.11 11 hrs 22 mins
34 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,109,003 546,659 2.03 12 hrs 50 mins
35 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,062,776 502,879 2.11 11 hrs 21 mins
36 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,025,786 531,904 1.93 12 hrs 27 mins
37 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,019,710 528,487 1.93 12 hrs 26 mins
38 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 969,424 502,960 1.93 12 hrs 27 mins
39 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 958,988 500,137 1.92 13 hrs 31 mins
40 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 843,199 482,072 1.75 14 hrs 43 mins
41 GeForce RTX 2060 12GB
TU106 [GeForce RTX 2060 12GB]
Nvidia TU106 841,338 297,000 2.83 8 hrs 28 mins
42 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 838,606 366,319 2.29 10 hrs 29 mins
43 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 830,403 478,032 1.74 14 hrs 49 mins
44 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 687,239 448,498 1.53 16 hrs 40 mins
45 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 654,251 325,175 2.01 12 hrs 56 mins
46 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 512,479 406,664 1.26 19 hrs 3 mins
47 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 466,622 394,598 1.18 20 hrs 18 mins
48 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 444,263 380,612 1.17 21 hrs 34 mins
49 Radeon R9 200/HD 7900/8970
Tahiti XT [Radeon R9 200/HD 7900/8970]
AMD Tahiti XT 346,145 359,865 0.96 25 hrs 57 mins
50 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 325,871 365,727 0.89 27 hrs 56 mins
51 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 206,956 299,251 0.69 35 hrs 42 mins
52 T600
TU117GL [T600]
Intel TU117GL 116,606 301,407 0.39 62 hrs 2 mins
53 Radeon WX 3100
[Radeon WX 3100]
AMD 109,589 297,000 0.37 65 hrs 3 mins
54 Radeon Vega Series / Radeon Vega Mobile Series
Raven Ridge [Radeon Vega Series / Radeon Vega Mobile Series]
AMD Raven Ridge 104,340 297,000 0.35 68 hrs 19 mins
55 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 101,998 297,000 0.34 70 hrs 53 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:29

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make