PROJECT #18037 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

We are simulating publicly available protein and small molecule structures of the currently very hot cancer target KRas, see https://www.fiercepharma.com/pharma/amgen-s-lumakras-becomes-first-fda-approved-kras-inhibitor-for-lung-cancer-patients for recent developments.

Folding@home has previously looked at this protein (in project 10490), and the following part of the description is copied from there: This project is "studying a small protein called KRAS, which forms a key link in growth signaling and cancer.

This gene is something like a molecular switch with a timer.

When it is bound to a molecule called GDP, it is off, and does not signal that the cell should grow.

However, other proteins can cause it to swap its GDP for a GTP, turning KRAS on.

In the on state, it signals that the cell should grow and divide.

Normally, after some time, KRAS, with the aid of some partners, will chemically convert its GTP to GDP and return to its inactive state. In many cancers, this protein becomes mutated, and cannot return to its off state.

The result? The cells continue to divide without limit.

What’s worse, cancers with this protein mutated tend to have much poorer prognoses.

As a result, scientists have been trying to target this protein for decades." We are investigating the dynamic behavior of KRas with these publicly disclosed inhibitors so that we can apply this knowledge to our own drug design.

At the same time, we are further testing the adaptive sampling methodology.

All data is being made publicly available at https://console.cloud.google.com/storage/browser/stxfah-bucket, and insights from methodology developments will be shared.

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket.

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 90,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:29

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 6,882,372 507,859 13.55 2 hrs 46 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 5,322,029 464,541 11.46 2 hrs 6 mins
3 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 4,998,685 449,248 11.13 2 hrs 9 mins
4 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 4,958,170 458,918 10.80 2 hrs 13 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 4,279,961 435,009 9.84 2 hrs 26 mins
6 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 3,857,196 423,422 9.11 3 hrs 38 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 3,649,030 415,288 8.79 3 hrs 44 mins
8 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,362,553 402,931 8.35 3 hrs 53 mins
9 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,291,141 400,508 8.22 3 hrs 55 mins
10 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 3,081,859 393,781 7.83 3 hrs 4 mins
11 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 2,936,849 389,390 7.54 3 hrs 11 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 2,928,474 383,141 7.64 3 hrs 8 mins
13 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,435,162 363,002 6.71 4 hrs 35 mins
14 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,405,727 362,649 6.63 4 hrs 37 mins
15 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,320,624 357,344 6.49 4 hrs 42 mins
16 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,258,829 350,240 6.45 4 hrs 43 mins
17 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,120,656 349,444 6.07 4 hrs 57 mins
18 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,050,238 346,244 5.92 4 hrs 3 mins
19 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 1,746,995 321,120 5.44 4 hrs 25 mins
20 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,707,671 328,139 5.20 5 hrs 37 mins
21 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 1,659,101 314,922 5.27 5 hrs 33 mins
22 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 1,565,355 312,741 5.01 5 hrs 48 mins
23 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 1,540,924 307,699 5.01 5 hrs 48 mins
24 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 1,523,027 315,534 4.83 5 hrs 58 mins
25 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,467,931 313,294 4.69 5 hrs 7 mins
26 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 1,436,156 305,106 4.71 5 hrs 6 mins
27 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,434,266 304,520 4.71 5 hrs 6 mins
28 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 1,384,732 299,656 4.62 5 hrs 12 mins
29 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,292,146 298,282 4.33 6 hrs 32 mins
30 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,247,854 291,196 4.29 6 hrs 36 mins
31 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,237,020 289,533 4.27 6 hrs 37 mins
32 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,162,438 287,055 4.05 6 hrs 56 mins
33 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 983,369 267,056 3.68 7 hrs 31 mins
34 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 944,824 262,429 3.60 7 hrs 40 mins
35 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 926,174 269,329 3.44 7 hrs 59 mins
36 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 912,726 261,775 3.49 7 hrs 53 mins
37 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 892,501 262,468 3.40 7 hrs 3 mins
38 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 872,684 260,925 3.34 7 hrs 11 mins
39 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 827,381 262,576 3.15 8 hrs 37 mins
40 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 798,573 249,220 3.20 7 hrs 29 mins
41 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 766,209 238,092 3.22 7 hrs 27 mins
42 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 684,710 236,884 2.89 8 hrs 18 mins
43 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 551,682 220,819 2.50 10 hrs 36 mins
44 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 458,998 211,476 2.17 11 hrs 3 mins
45 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 455,527 206,466 2.21 11 hrs 53 mins
46 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 442,132 144,767 3.05 8 hrs 51 mins
47 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 431,393 196,450 2.20 11 hrs 56 mins
48 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 402,349 198,791 2.02 12 hrs 51 mins
49 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 389,269 198,194 1.96 12 hrs 13 mins
50 P106-090
GP106 [P106-090]
Nvidia GP106 353,046 190,278 1.86 13 hrs 56 mins
51 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 332,484 191,696 1.73 14 hrs 50 mins
52 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 325,908 185,809 1.75 14 hrs 41 mins
53 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 306,965 181,480 1.69 14 hrs 11 mins
54 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 271,774 174,741 1.56 15 hrs 26 mins
55 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 231,876 158,809 1.46 16 hrs 26 mins
56 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 194,267 153,628 1.26 19 hrs 59 mins
57 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 102,293 126,320 0.81 30 hrs 38 mins
58 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 91,510 121,683 0.75 32 hrs 55 mins
59 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 81,841 117,186 0.70 34 hrs 22 mins
60 Radeon Vega Series / Radeon Vega Mobile Series
Raven Ridge [Radeon Vega Series / Radeon Vega Mobile Series]
AMD Raven Ridge 70,101 115,000 0.61 39 hrs 22 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:29

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make