PROJECT #16927 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Halorubrum lacusprofundi is a microorganism found in the extremely cold and hypersaline Deep Lake, Antarctica. This microorganism has a polyextremophilic β-galactosidase that works to break down carbohydrates. Recent work from the DasSarma group identified six key amino acid residues in β-galactosidase which, when mutated with amino acids conserved in homologs from mesophilic haloarchaea, induced significant changes to the catalytic efficiency of the enzyme and its temperature dependence (1). 

We are running molecular simulations of β-galactosidase and its mutated variants to explore how these subtle sequence changes affect the behavior of this enzyme at various temperatures. We will analyze the trajectory data to formulate explanations for the mechanisms that cause differences in catalytic efficiencies. 

In the future, a better understanding of how evolved mutations help optimize enzyme efficiency may lead to improved methods for computational enzyme design.

 

References

  1. Laye, V. J., Karan, R., Kim, J.-M., Pecher, W. T., DasSarma, P., & DasSarma, S. (2017). Key amino acid residues conferring enhanced enzyme activity at cold temperatures in an Antarctic polyextremophilic β-galactosidase. Proceedings of the National Academy of Sciences of the United States of America, 114(47), 12530–12535. http://doi.org/10.1073/pnas.1711542114

 

PROJECT INFO

Manager(s): Prof. Vincent Voelz

Institution: Temple University

PROJECT WORK UNIT SUMMARY

Atoms: 127,200

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 18 January 2021 21:29:13

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 18 January 2021 21:29:13

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 CELERON(R) CPU G550 @ 2.60GHZ 2 9,025,404 18,050,808 Intel
2 RYZEN THREADRIPPER 3960X 24-CORE 48 14,323 687,504 AMD
3 RYZEN 9 3950X 16-CORE 32 17,273 552,736 AMD
4 RYZEN 9 5950X 16-CORE 32 14,059 449,888 AMD
5 RYZEN 9 5900X 12-CORE 24 15,704 376,896 AMD
6 CORE I9-9980XE CPU @ 3.00GHZ 36 10,303 370,908 Intel
7 RYZEN 9 3900X 12-CORE 24 13,119 314,856 AMD
8 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,210 298,080 AMD
9 RYZEN 9 3900XT 12-CORE 24 12,316 295,584 AMD
10 RYZEN THREADRIPPER 2950X 16-CORE 32 8,455 270,560 AMD
11 XEON PLATINUM 8124M CPU @ 3.00GHZ 36 7,349 264,564 Intel
12 CORE I9-9900K CPU @ 3.60GHZ 16 13,641 218,256 Intel
13 RYZEN 7 5800X 8-CORE 16 13,626 218,016 AMD
14 CORE I9-10900K CPU @ 3.70GHZ 20 10,355 207,100 Intel
15 XEON CPU E5-2667 V4 @ 3.20GHZ 32 6,382 204,224 Intel
16 XEON W-2245 CPU @ 3.90GHZ 16 10,255 164,080 Intel
17 RYZEN THREADRIPPER 1920X 12-CORE 24 6,818 163,632 AMD
18 CORE I9-7920X CPU @ 2.90GHZ 24 6,762 162,288 Intel
19 RYZEN 7 3700X 8-CORE 16 9,679 154,864 AMD
20 CORE I7-8700 CPU @ 3.20GHZ 12 12,538 150,456 Intel
21 RYZEN 5 3600X 6-CORE 12 12,295 147,540 AMD
22 RYZEN 7 3800X 8-CORE 16 9,088 145,408 AMD
23 RYZEN 7 4800H 16 7,962 127,392 AMD
24 RYZEN 5 3600 6-CORE 12 9,994 119,928 AMD
25 RYZEN 5 1600X SIX-CORE 12 9,565 114,780 AMD
26 XEON CPU E5-2660 0 @ 2.20GHZ 32 3,572 114,304 Intel
27 CORE I7-9700K CPU @ 3.60GHZ 8 14,221 113,768 Intel
28 RYZEN 5 3600XT 6-CORE 12 9,344 112,128 AMD
29 CORE I7-5960X CPU @ 3.00GHZ 16 6,931 110,896 Intel
30 XEON CPU E5-2690 V2 @ 3.00GHZ 20 5,168 103,360 Intel
31 GENUINE CPU 0000 @ 1.60GHZ 32 2,907 93,024 Intel
32 CORE I7-9700 CPU @ 3.00GHZ 8 11,230 89,840 Intel
33 RYZEN 7 2700X EIGHT-CORE 16 5,596 89,536 AMD
34 CORE I7-6820HQ CPU @ 2.70GHZ 8 11,151 89,208 Intel
35 CORE I9-9980HK CPU @ 2.40GHZ 16 5,146 82,336 Intel
36 RYZEN 5 3500 6-CORE 6 12,725 76,350 AMD
37 CORE I7-8700K CPU @ 3.70GHZ 12 6,150 73,800 Intel
38 XEON CPU E5-2630 0 @ 2.30GHZ 24 3,049 73,176 Intel
39 CORE I7-10710U CPU @ 1.10GHZ 12 5,965 71,580 Intel
40 CORE I9-9900 CPU @ 3.10GHZ 16 4,234 67,744 Intel
41 RYZEN 7 1700X EIGHT-CORE 16 4,054 64,864 AMD
42 CORE2 DUO CPU T7700 @ 2.40GHZ 12 5,322 63,864 Intel
43 CORE I3-10100 CPU @ 3.60GHZ 8 7,952 63,616 Intel
44 RYZEN 7 1700 EIGHT-CORE 16 3,859 61,744 AMD
45 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,485 59,640 Intel
46 RYZEN 5 2600X SIX-CORE 12 4,938 59,256 AMD
47 RYZEN 5 5600X 6-CORE 12 4,794 57,528 AMD
48 CORE I5-9400F CPU @ 2.90GHZ 6 9,106 54,636 Intel
49 RYZEN 5 4600HS 12 4,513 54,156 AMD
50 CORE I7-6700K CPU @ 4.00GHZ 8 6,252 50,016 Intel
51 CORE I7-8550U CPU @ 1.80GHZ 8 6,047 48,376 Intel
52 CORE I7-8705G CPU @ 3.10GHZ 8 5,872 46,976 Intel
53 CORE I3-6100 CPU @ 3.70GHZ 4 11,353 45,412 Intel
54 XEON CPU E3-1270 V5 @ 3.60GHZ 8 5,662 45,296 Intel
55 RYZEN 5 2600 SIX-CORE 12 3,741 44,892 AMD
56 XEON W-2123 CPU @ 3.60GHZ 8 5,346 42,768 Intel
57 CORE I7-4790K CPU @ 4.00GHZ 8 5,300 42,400 Intel
58 CORE I7-6700 CPU @ 3.40GHZ 8 4,616 36,928 Intel
59 CORE I7-6700T CPU @ 2.80GHZ 8 4,594 36,752 Intel
60 CORE I5-8400 CPU @ 2.80GHZ 6 6,062 36,372 Intel
61 CORE I3-8100 CPU @ 3.60GHZ 4 8,794 35,176 Intel
62 CORE I5-7600 CPU @ 3.50GHZ 4 8,436 33,744 Intel
63 CORE I7-2600K CPU @ 3.40GHZ 8 4,102 32,816 Intel
64 XEON CPU E5-2609 V2 @ 2.50GHZ 8 3,811 30,488 Intel
65 RYZEN 3 3200G 4 7,179 28,716 AMD
66 CORE I5-6500 CPU @ 3.20GHZ 4 6,841 27,364 Intel
67 CORE I7-8565U CPU @ 1.80GHZ 8 3,215 25,720 Intel
68 CORE I7-3770 CPU @ 3.40GHZ 8 3,121 24,968 Intel
69 XEON CPU E3-1230 V2 @ 3.30GHZ 8 3,034 24,272 Intel
70 CORE I5-6600K CPU @ 3.50GHZ 4 5,976 23,904 Intel
71 FX-8350 EIGHT-CORE 8 2,814 22,512 AMD
72 RYZEN 7 4700U 8 2,614 20,912 AMD
73 CORE I5-2500K CPU @ 3.30GHZ 4 4,703 18,812 Intel
74 CORE I7-6700HQ CPU @ 2.60GHZ 8 2,317 18,536 Intel
75 CORE I5-4590 CPU @ 3.30GHZ 4 4,451 17,804 Intel
76 CORE I5-2400S CPU @ 2.50GHZ 4 3,643 14,572 Intel
77 CORE I5-4300U CPU @ 1.90GHZ 4 3,585 14,340 Intel
78 CORE I5-6200U CPU @ 2.30GHZ 4 3,576 14,304 Intel
79 CORE I5-10210U CPU @ 1.60GHZ 7 1,962 13,734 Intel
80 CORE I3-7100 CPU @ 3.90GHZ 4 3,394 13,576 Intel
81 CORE I5-4570 CPU @ 3.20GHZ 4 3,099 12,396 Intel
82 CORE I7-8665U CPU @ 1.90GHZ 8 1,326 10,608 Intel
83 PHENOM II X4 965 4 2,641 10,564 AMD
84 CORE I5-2540M CPU @ 2.60GHZ 4 2,282 9,128 Intel
85 FX-8320 EIGHT-CORE 8 956 7,648 AMD
86 CORE I5-4460 CPU @ 3.20GHZ 4 1,767 7,068 Intel
87 CORE I3-6006U CPU @ 2.00GHZ 4 1,766 7,064 Intel
88 CORE I3-3240 CPU @ 3.40GHZ 4 1,257 5,028 Intel
89 CORE I5-3320M CPU @ 2.60GHZ 4 1,079 4,316 Intel
90 CORE2 QUAD CPU Q6600 @ 2.40GHZ 4 1,036 4,144 Intel
91 FX-8300 EIGHT-CORE 8 302 2,416 AMD
92 A8-6410 APU 4 172 688 AMD
 

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