PROJECT #14188 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Halorubrum lacusprofundi is a microorganism found in the extremely cold and hypersaline Deep Lake, Antarctica. This microorganism has a polyextremophilic β-galactosidase that works to break down carbohydrates. Recent work from the DasSarma group identified six key amino acid residues in β-galactosidase which, when mutated with amino acids conserved in homologs from mesophilic haloarchaea, induced significant changes to the catalytic efficiency of the enzyme and its temperature dependence (1). 

We are running molecular simulations of β-galactosidase and its mutated variants to explore how these subtle sequence changes affect the behavior of this enzyme at various temperatures. We will analyze the trajectory data to formulate explanations for the mechanisms that cause differences in catalytic efficiencies. 

In the future, a better understanding of how evolved mutations help optimize enzyme efficiency may lead to improved methods for computational enzyme design.

 

References

  1. Laye, V. J., Karan, R., Kim, J.-M., Pecher, W. T., DasSarma, P., & DasSarma, S. (2017). Key amino acid residues conferring enhanced enzyme activity at cold temperatures in an Antarctic polyextremophilic β-galactosidase. Proceedings of the National Academy of Sciences of the United States of America, 114(47), 12530–12535. http://doi.org/10.1073/pnas.1711542114

 

PROJECT INFO

Manager(s): Prof. Vincent Voelz

Institution: Temple University

PROJECT WORK UNIT SUMMARY

Atoms: 127,200

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 25 February 2021 23:18:49

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 25 February 2021 23:18:49

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 CELERON(R) CPU N3350 @ 1.10GHZ 2 6,045,634 12,091,268 Intel
2 RYZEN 9 3950X 16-CORE 32 22,348 715,136 AMD
3 RYZEN 9 5900X 12-CORE 24 16,541 396,984 AMD
4 RYZEN 9 5950X 16-CORE 32 11,881 380,192 AMD
5 XEON PLATINUM 8124M CPU @ 3.00GHZ 36 8,762 315,432 Intel
6 RYZEN THREADRIPPER 2950X 16-CORE 32 9,749 311,968 AMD
7 RYZEN 9 3900XT 12-CORE 24 12,931 310,344 AMD
8 RYZEN THREADRIPPER 2970WX 24-CORE 48 6,281 301,488 AMD
9 RYZEN 9 3900X 12-CORE 24 12,486 299,664 AMD
10 RYZEN 7 5800X 8-CORE 16 14,839 237,424 AMD
11 CORE I9-9900K CPU @ 3.60GHZ 16 14,561 232,976 Intel
12 RYZEN 7 3700X 8-CORE 16 12,230 195,680 AMD
13 CORE I7-1065G7 CPU @ 1.30GHZ 8 21,664 173,312 Intel
14 RYZEN 5 PRO 4650G 12 11,614 139,368 AMD
15 RYZEN 7 3800X 8-CORE 16 7,974 127,584 AMD
16 CORE I7-9700K CPU @ 3.60GHZ 8 15,713 125,704 Intel
17 RYZEN 5 3600 6-CORE 12 10,309 123,708 AMD
18 XEON CPU E5-2660 0 @ 2.20GHZ 32 3,637 116,384 Intel
19 CORE I7-9700 CPU @ 3.00GHZ 8 12,640 101,120 Intel
20 RYZEN 7 2700X EIGHT-CORE 16 5,965 95,440 AMD
21 XEON CPU E5-2690 V2 @ 3.00GHZ 20 4,703 94,060 Intel
22 RYZEN 5 2600X SIX-CORE 12 6,681 80,172 AMD
23 RYZEN 5 3500 6-CORE 6 13,167 79,002 AMD
24 CORE I3-6100 CPU @ 3.70GHZ 4 18,533 74,132 Intel
25 RYZEN 7 1700 EIGHT-CORE 16 4,016 64,256 AMD
26 XEON CPU E5-2620 V2 @ 2.10GHZ 24 2,571 61,704 Intel
27 CORE I5-9600K CPU @ 3.70GHZ 6 9,762 58,572 Intel
28 CORE I5-9400F CPU @ 2.90GHZ 6 9,173 55,038 Intel
29 CORE I7-8705G CPU @ 3.10GHZ 8 6,441 51,528 Intel
30 CORE I7-8550U CPU @ 1.80GHZ 8 6,433 51,464 Intel
31 CORE I7-6700K CPU @ 4.00GHZ 8 5,861 46,888 Intel
32 CORE I7-4790K CPU @ 4.00GHZ 8 5,606 44,848 Intel
33 RYZEN 5 2600 SIX-CORE 12 3,538 42,456 AMD
34 RYZEN 3 3200G 4 9,875 39,500 AMD
35 XEON CPU E5-2650 0 @ 2.00GHZ 16 2,386 38,176 Intel
36 CORE I5-7600 CPU @ 3.50GHZ 4 8,243 32,972 Intel
37 CORE I7-8565U CPU @ 1.80GHZ 8 3,821 30,568 Intel
38 CORE I7-2600K CPU @ 3.40GHZ 8 3,704 29,632 Intel
39 CORE I7-3770 CPU @ 3.40GHZ 8 3,239 25,912 Intel
40 XEON CPU E3-1230 V2 @ 3.30GHZ 8 3,080 24,640 Intel
41 CORE I3-7100 CPU @ 3.90GHZ 4 3,805 15,220 Intel
42 PHENOM II X4 965 4 2,825 11,300 AMD
43 PHENOM II X6 1090T 6 1,749 10,494 AMD
 

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