Folding project #16575, LIQUID-PHASE-SEPARATION research

Research section Research projects and references

Project #16575 overview

Project Summary AI Beta

This project uses computer simulations to study how tiny droplets (condensates) in cells change when different molecules are added. Researchers are looking at how peptides like ADMA, ARG, and LYS affect these droplets, both alone and with RNA.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prof. Xuhui Huang
Institution: Hong Kong University of Science and Technology

Work unit

Atoms: 441,672
Core: 0x22
Status: Public

Source material

Official Project Description

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Liquid-liquid Phase separation

Separation of molecules based on their solubility in two immiscible liquids.

Scientific: BiotechnologyBiochemistry / Molecular Biology

Liquid-liquid phase separation is a process where different substances within a solution separate into distinct layers due to differences in their solubility. This occurs when the mixture contains two liquids that don't mix well together, creating separate phases. In biological systems, this phenomenon plays a crucial role in various processes like protein aggregation, membrane formation, and RNA transport.

Condensate

A dense, concentrated phase of molecules formed through liquid-liquid phase separation.

Scientific: BiotechnologyBiochemistry / Molecular Biology

A condensate is a highly concentrated region within a cell where specific molecules like proteins and RNA come together. This assembly process is driven by various interactions, including hydrophobic forces and electrostatic attractions. Condensates often serve as compartments for important cellular processes, allowing for efficient organization and regulation of molecular activity.

Peptide

A short chain of amino acids linked together by peptide bonds.

Scientific: BiotechnologyBiochemistry / Molecular Biology

Peptides are chains of amino acids that are shorter than proteins. They play diverse roles in biological systems, acting as signaling molecules, hormones, antibiotics, and components of larger proteins. Peptides can be synthesized chemically or produced by enzymatic cleavage of proteins.

ADMA

Asparagine-dimethylarginine

Technical: PharmacologyBiochemistry / Molecular Biology

ADMA (aspartic acid methylated arginine) is a naturally occurring molecule that acts as an endogenous inhibitor of nitric oxide synthase. It plays a role in regulating blood pressure and vascular function.

ARG

Arginine

Technical: PharmacologyBiochemistry / Molecular Biology

Arginine is a semi-essential amino acid that plays various roles in the body, including protein synthesis, wound healing, and immune function.

LYS

Lysine

Technical: PharmacologyBiochemistry / Molecular Biology

Lysine is an essential amino acid that plays a crucial role in protein synthesis, collagen formation, and calcium absorption.

RNA

Ribonucleic acid

Scientific: BiotechnologyBiochemistry / Molecular Biology

RNA (ribonucleic acid) is a nucleic acid that plays a vital role in protein synthesis. It carries genetic information from DNA to ribosomes, where proteins are assembled.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	23,853,866	1,383,669	17.24	1 ^hrs 24 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	14,965,642	1,196,030	12.51	1 ^hrs 55 ^mins
3	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	13,364,183	1,106,804	12.07	1 ^hrs 59 ^mins
4	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	8,811,178	976,276	9.03	2 ^hrs 40 ^mins
5	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,129,266	973,385	8.35	2 ^hrs 52 ^mins
6	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	7,801,799	963,605	8.10	2 ^hrs 58 ^mins
7	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	7,529,369	946,604	7.95	3 ^hrs 1 ^mins
8	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	7,451,064	951,872	7.83	3 ^hrs 4 ^mins
9	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,598,783	899,712	7.33	3 ^hrs 16 ^mins
10	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,996,517	884,516	6.78	3 ^hrs 32 ^mins
11	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,095,247	835,946	6.10	3 ^hrs 56 ^mins
12	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,003,604	838,906	5.96	4 ^hrs 1 ^mins
13	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	4,528,974	804,930	5.63	4 ^hrs 16 ^mins
14	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,324,878	803,163	5.38	4 ^hrs 27 ^mins
15	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	3,986,906	771,156	5.17	4 ^hrs 39 ^mins
16	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,555,678	747,858	4.75	5 ^hrs 3 ^mins
17	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,480,508	740,915	4.70	5 ^hrs 7 ^mins
18	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	3,452,698	749,914	4.60	5 ^hrs 13 ^mins
19	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,172,367	729,310	4.35	5 ^hrs 31 ^mins

20	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,035,058	702,725	4.32	5 ^hrs 33 ^mins
21	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,746,262	681,019	4.03	5 ^hrs 57 ^mins
22	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,609,704	661,389	3.95	6 ^hrs 5 ^mins
23	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,607,849	672,532	3.88	6 ^hrs 11 ^mins
24	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,588,132	690,344	3.75	6 ^hrs 24 ^mins
25	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,494,878	665,486	3.75	6 ^hrs 24 ^mins
26	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,357,588	688,598	3.42	7 ^hrs 1 ^mins
27	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,348,257	656,681	3.58	6 ^hrs 43 ^mins
28	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,254,656	613,004	3.68	6 ^hrs 32 ^mins
29	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,178,453	636,782	3.42	7 ^hrs 1 ^mins
30	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,125,891	642,993	3.31	7 ^hrs 16 ^mins
31	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,020,827	593,145	3.41	7 ^hrs 3 ^mins
32	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,010,520	581,760	3.46	6 ^hrs 57 ^mins
33	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	1,758,239	589,947	2.98	8 ^hrs 3 ^mins
34	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,705,495	582,043	2.93	8 ^hrs 11 ^mins
35	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,275,765	529,940	2.41	9 ^hrs 58 ^mins
36	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,270,275	551,031	2.31	10 ^hrs 25 ^mins
37	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,215,263	519,923	2.34	10 ^hrs 16 ^mins
38	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,159,777	504,612	2.30	10 ^hrs 27 ^mins
39	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,125,869	486,558	2.31	10 ^hrs 22 ^mins

40	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,102,069	501,900	2.20	10 ^hrs 56 ^mins
41	P104-100 GP104 [P104-100]	Nvidia	GP104	985,793	484,932	2.03	11 ^hrs 48 ^mins
42	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	971,586	474,948	2.05	11 ^hrs 44 ^mins
43	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	890,862	372,357	2.39	10 ^hrs 2 ^mins
44	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	852,148	438,517	1.94	12 ^hrs 21 ^mins
45	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	818,804	478,270	1.71	14 ^hrs 1 ^mins
46	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	645,538	436,884	1.48	16 ^hrs 15 ^mins
47	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	622,340	427,382	1.46	16 ^hrs 29 ^mins
48	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	517,467	392,488	1.32	18 ^hrs 12 ^mins
49	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	466,056	346,810	1.34	17 ^hrs 52 ^mins
50	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	417,725	363,515	1.15	20 ^hrs 53 ^mins
51	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	320,394	333,714	0.96	24 ^hrs 60 ^mins
52	P106-090 GP106 [P106-090]	Nvidia	GP106	292,231	324,037	0.90	26 ^hrs 37 ^mins
53	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	237,736	364,911	0.65	36 ^hrs 50 ^mins
54	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	135,216	256,039	0.53	45 ^hrs 27 ^mins

Research: LIQUID-PHASE-SEPARATION Folding Project #16575

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 16575

GPU PPD Averages

Research: LIQUID-PHASE-SEPARATION Folding Project #16575

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages