Folding project #14971, STE2-GPCR-DYNAMICS research

Research section Research projects and references

Project #14971 overview

Project Summary AI Beta

This project looks at Ste2, a protein found in fungi that's important for their survival. Understanding how Ste2 works could help us develop new antifungal medications to treat infections in people.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 91,693
Core: 0x22
Status: Public

Source material

Official Project Description

Class D GPCR Ste2 Ste2 is a transmembrane protein of the Class D of G-Protein Coupled Receptors.

These receptors exist as dimers and are important target for understanding the physiological functioning of fungi.

While pivotal for survival, these receptors provide a useful platform for the development of antifungal medications, which can be useful as therapy in human-targeting fungal infections.

The lack of dynamical insights into the function of these proteins is what prompted the emergence of this study.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

GPCR

G Protein-Coupled Receptor

Scientific: PharmaceuticalReceptor Biology / Drug Discovery

GPCRs are a large family of cell surface receptors that play a crucial role in signal transduction pathways. They bind to various ligands and activate intracellular signaling cascades, influencing diverse cellular processes.

Class D GPCR

A subfamily of G protein-coupled receptors with specific structural and functional characteristics.

Scientific: PharmaceuticalReceptor Biology / Drug Discovery

Class D GPCRs are a distinct group within the larger GPCR family. They are characterized by their unique amino acid sequences and binding preferences for certain ligands. Understanding their structure and function is important for developing targeted therapies.

Ste2

A transmembrane protein belonging to the Class D GPCR family found in the yeast *Saccharomyces cerevisiae*.

Scientific: BiotechnologyFungal Biology / Molecular Genetics

Ste2 is a vital receptor in yeast that plays a role in mating and cell signaling. It binds to specific pheromones and triggers downstream pathways leading to cellular responses.

Antifungal Medications

Drugs used to treat fungal infections.

Medical: PharmaceuticalInfectious Diseases / Pharmacology

Antifungal medications target specific pathways or structures within fungi to inhibit their growth and spread. They are essential for managing a range of fungal infections in humans.

Fungi

A kingdom of eukaryotic organisms that includes yeasts, molds, and mushrooms.

Biological: BiotechnologyMycology / Microbiology

Fungi are diverse microorganisms with various roles in ecosystems. Some species can cause infections in humans, while others are beneficial in food production and medicine.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	16,332,207	278,066	58.74	0 ^hrs 25 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	12,746,965	297,197	42.89	0 ^hrs 34 ^mins
3	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	9,461,581	79,585	118.89	0 ^hrs 12 ^mins
4	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,383,417	282,544	33.21	0 ^hrs 43 ^mins
5	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	9,246,403	253,343	36.50	0 ^hrs 39 ^mins
6	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,754,864	269,984	32.43	0 ^hrs 44 ^mins
7	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	7,781,187	262,387	29.66	0 ^hrs 49 ^mins
8	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	7,243,437	260,550	27.80	0 ^hrs 52 ^mins
9	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	6,814,503	253,731	26.86	0 ^hrs 54 ^mins
10	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,587,875	250,406	26.31	0 ^hrs 55 ^mins
11	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	6,563,852	59,325	110.64	0 ^hrs 13 ^mins
12	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,253,509	245,648	25.46	0 ^hrs 57 ^mins
13	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,599,802	48,845	114.64	0 ^hrs 13 ^mins
14	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,516,897	99,796	55.28	0 ^hrs 26 ^mins
15	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,431,047	233,840	23.23	1 ^hrs 2 ^mins
16	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,274,350	233,500	22.59	1 ^hrs 4 ^mins
17	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,575,547	220,263	20.77	1 ^hrs 9 ^mins
18	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	4,336,371	197,620	21.94	1 ^hrs 6 ^mins
19	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,744,601	164,680	22.74	1 ^hrs 3 ^mins

20	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	3,358,980	40,400	83.14	0 ^hrs 17 ^mins
21	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,270,549	199,300	16.41	1 ^hrs 28 ^mins
22	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	2,932,644	185,549	15.81	1 ^hrs 31 ^mins
23	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,877,026	121,745	23.63	1 ^hrs 1 ^mins
24	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,873,145	133,339	21.55	1 ^hrs 7 ^mins
25	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,746,684	125,390	21.91	1 ^hrs 6 ^mins
26	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,599,638	183,704	14.15	1 ^hrs 42 ^mins
27	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,553,334	168,753	15.13	1 ^hrs 35 ^mins
28	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,352,345	178,541	13.18	1 ^hrs 49 ^mins
29	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,345,919	178,363	13.15	1 ^hrs 49 ^mins
30	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,343,869	175,749	13.34	1 ^hrs 48 ^mins
31	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,096,140	171,571	12.22	1 ^hrs 58 ^mins
32	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,049,635	168,134	12.19	1 ^hrs 58 ^mins
33	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,013,065	166,935	12.06	1 ^hrs 59 ^mins
34	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,833,283	127,908	14.33	1 ^hrs 40 ^mins
35	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	1,831,577	163,818	11.18	2 ^hrs 9 ^mins
36	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,691,131	149,321	11.33	2 ^hrs 7 ^mins
37	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,626,675	155,132	10.49	2 ^hrs 17 ^mins
38	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,574,496	156,475	10.06	2 ^hrs 23 ^mins
39	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,509,319	76,592	19.71	1 ^hrs 13 ^mins

40	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,496,572	153,099	9.78	2 ^hrs 27 ^mins
41	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,458,311	122,898	11.87	2 ^hrs 1 ^mins
42	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,378,867	52,887	26.07	0 ^hrs 55 ^mins
43	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,376,221	149,587	9.20	2 ^hrs 37 ^mins
44	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,279,521	138,162	9.26	2 ^hrs 35 ^mins
45	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,177,002	64,132	18.35	1 ^hrs 18 ^mins
46	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,134,089	139,134	8.15	2 ^hrs 57 ^mins
47	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,118,094	140,256	7.97	3 ^hrs 1 ^mins
48	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,042,013	135,784	7.67	3 ^hrs 8 ^mins
49	GeForce RTX 3050 6GB GA107 [GeForce RTX 3050 6GB]	Nvidia	GA107	991,057	40,400	24.53	0 ^hrs 59 ^mins
50	Radeon RX 7700S/7600(S) Navi 33 [Radeon RX 7700S/7600(S)]	AMD	Navi 33	897,445	127,862	7.02	3 ^hrs 25 ^mins
51	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	831,547	126,572	6.57	3 ^hrs 39 ^mins
52	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	757,315	40,400	18.75	1 ^hrs 17 ^mins
53	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	704,141	73,344	9.60	2 ^hrs 30 ^mins
54	P106-100 GP106 [P106-100]	Nvidia	GP106	691,565	118,880	5.82	4 ^hrs 8 ^mins
55	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	597,536	113,187	5.28	4 ^hrs 33 ^mins
56	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	591,323	40,400	14.64	1 ^hrs 38 ^mins
57	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	553,889	40,400	13.71	1 ^hrs 45 ^mins
58	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	532,480	107,224	4.97	4 ^hrs 50 ^mins
59	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	507,910	40,400	12.57	1 ^hrs 55 ^mins

60	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	293,214	72,117	4.07	5 ^hrs 54 ^mins
61	Radeon RX 580 2048SP Polaris 20 XL [Radeon RX 580 2048SP]	AMD	Polaris 20 XL	287,746	88,631	3.25	7 ^hrs 24 ^mins
62	GeForce GTX 1050 3 GB Max-Q GP107M [GeForce GTX 1050 3 GB Max-Q]	Nvidia	GP107M	250,698	40,400	6.21	3 ^hrs 52 ^mins
63	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	221,951	81,976	2.71	8 ^hrs 52 ^mins
64	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	66,793	63,228	1.06	22 ^hrs 43 ^mins

Research: STE2-GPCR-DYNAMICS Folding Project #14971

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14971

GPU PPD Averages

Research: STE2-GPCR-DYNAMICS Folding Project #14971

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages