Folding project #14956, STE2-GPCR-DYNAMICS research

Research section Research projects and references

Project #14956 overview

Project Summary AI Beta

Ste2 is a special protein found in fungi that helps them survive. Researchers want to understand how Ste2 works because it could lead to new medicines to fight fungal infections in humans.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 87,932
Core: 0x22
Status: Public

No related projects listed.

Source material

Official Project Description

Class D GPCR Ste2 Ste2 is a transmembrane protein of the Class D of G-Protein Coupled Receptors.

These receptors exist as dimers and are important target for understanding the physiological functioning of fungi.

While pivotal for survival, these receptors provide a useful platform for the development of antifungal medications, which can be useful as therapy in human-targeting fungal infections.

The lack of dynamical insights into the function of these proteins is what prompted the emergence of this study.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

GPCR

G Protein-Coupled Receptor

Scientific: BiotechnologyPharmacology / Receptor Biology

GPCRs are a large family of cell surface receptors that play a crucial role in transmitting signals from the environment to the inside of cells. They are involved in a wide range of physiological processes, including sensory perception, hormone regulation, and immune response.

Class D GPCR

A subfamily of G protein-coupled receptors characterized by a specific structural arrangement and pharmacological properties.

Scientific: BiotechnologyPharmacology / Receptor Biology

Class D GPCRs are a specialized group within the larger family of GPCRs. They have unique features that distinguish them from other classes and often play important roles in fungal biology.

Ste2

A specific type of Class D GPCR found in the yeast Saccharomyces cerevisiae.

Scientific: BiotechnologyPathology / Fungal Biology

Ste2 is a crucial receptor in yeast that mediates mating responses and plays a role in cell signaling. It's a valuable target for understanding fungal biology and potential antifungal drug development.

Antifungal Medications

Drugs used to treat fungal infections.

Technical: PharmaceuticalsPharmacology / Antimicrobial Drugs

Antifungal medications are designed to inhibit the growth or kill fungi. They are essential for managing a range of fungal diseases in both humans and animals.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	15,793,894	330,950	47.72	0 ^hrs 30 ^mins
2	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	13,499,547	40,000	337.49	0 ^hrs 4 ^mins
3	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	12,891,867	309,413	41.67	0 ^hrs 35 ^mins
4	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	8,905,208	272,475	32.68	0 ^hrs 44 ^mins
5	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	8,728,461	271,611	32.14	0 ^hrs 45 ^mins
6	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,714,712	253,366	34.40	0 ^hrs 42 ^mins
7	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	8,446,665	269,413	31.35	0 ^hrs 46 ^mins
8	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	7,382,070	258,164	28.59	0 ^hrs 50 ^mins
9	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	7,372,891	257,811	28.60	0 ^hrs 50 ^mins
10	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,762,019	249,673	27.08	0 ^hrs 53 ^mins
11	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,211,293	235,627	26.36	0 ^hrs 55 ^mins
12	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,824,647	238,026	24.47	0 ^hrs 59 ^mins
13	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,802,453	40,000	145.06	0 ^hrs 10 ^mins
14	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	5,456,042	205,182	26.59	0 ^hrs 54 ^mins
15	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,558,576	218,083	20.90	1 ^hrs 9 ^mins
16	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,362,978	217,386	20.07	1 ^hrs 12 ^mins
17	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,186,672	213,393	19.62	1 ^hrs 13 ^mins
18	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	4,052,540	106,858	37.92	0 ^hrs 38 ^mins
19	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,816,230	205,244	18.59	1 ^hrs 17 ^mins

20	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	3,578,676	144,113	24.83	0 ^hrs 58 ^mins
21	RTX A4500 GA102GL [RTX A4500]	Nvidia	GA102GL	3,253,324	167,562	19.42	1 ^hrs 14 ^mins
22	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,251,755	196,058	16.59	1 ^hrs 27 ^mins
23	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	3,216,866	195,299	16.47	1 ^hrs 27 ^mins
24	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,160,324	195,548	16.16	1 ^hrs 29 ^mins
25	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	3,131,617	162,793	19.24	1 ^hrs 15 ^mins
26	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,971,593	128,200	23.18	1 ^hrs 2 ^mins
27	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,968,290	160,996	18.44	1 ^hrs 18 ^mins
28	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,760,857	148,244	18.62	1 ^hrs 17 ^mins
29	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,695,937	185,120	14.56	1 ^hrs 39 ^mins
30	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,657,518	184,713	14.39	1 ^hrs 40 ^mins
31	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,494,583	177,338	14.07	1 ^hrs 42 ^mins
32	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,462,016	180,056	13.67	1 ^hrs 45 ^mins
33	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,347,200	40,000	58.68	0 ^hrs 25 ^mins
34	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,345,405	151,535	15.48	1 ^hrs 33 ^mins
35	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,296,171	174,929	13.13	1 ^hrs 50 ^mins
36	GeForce RTX 2070 Mobile TU106BM [GeForce RTX 2070 Mobile]	Nvidia	TU106BM	2,233,490	174,536	12.80	1 ^hrs 53 ^mins
37	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,113,205	170,649	12.38	1 ^hrs 56 ^mins
38	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,080,538	165,367	12.58	1 ^hrs 54 ^mins
39	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,915,641	150,390	12.74	1 ^hrs 53 ^mins

40	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,829,612	162,733	11.24	2 ^hrs 8 ^mins
41	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,679,299	158,418	10.60	2 ^hrs 16 ^mins
42	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,500,036	152,191	9.86	2 ^hrs 26 ^mins
43	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,457,372	151,649	9.61	2 ^hrs 30 ^mins
44	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,374,340	143,925	9.55	2 ^hrs 31 ^mins
45	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,354,817	146,560	9.24	2 ^hrs 36 ^mins
46	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,341,314	79,012	16.98	1 ^hrs 25 ^mins
47	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,253,919	108,831	11.52	2 ^hrs 5 ^mins
48	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,206,929	138,731	8.70	2 ^hrs 46 ^mins
49	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,115,779	115,063	9.70	2 ^hrs 28 ^mins
50	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	1,070,619	96,451	11.10	2 ^hrs 10 ^mins
51	P104-100 GP104 [P104-100]	Nvidia	GP104	1,014,970	134,103	7.57	3 ^hrs 10 ^mins
52	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,007,963	126,997	7.94	3 ^hrs 1 ^mins
53	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	963,037	131,269	7.34	3 ^hrs 16 ^mins
54	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	942,515	131,345	7.18	3 ^hrs 21 ^mins
55	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	908,741	129,845	7.00	3 ^hrs 26 ^mins
56	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	862,342	126,952	6.79	3 ^hrs 32 ^mins
57	Radeon RX 7700S/7600(S) Navi 33 [Radeon RX 7700S/7600(S)]	AMD	Navi 33	760,355	120,610	6.30	3 ^hrs 48 ^mins
58	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	722,346	120,175	6.01	3 ^hrs 60 ^mins
59	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	695,943	116,075	6.00	4 ^hrs 0 ^mins

60	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	624,579	115,242	5.42	4 ^hrs 26 ^mins
61	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	492,723	97,519	5.05	4 ^hrs 45 ^mins
62	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	488,585	105,290	4.64	5 ^hrs 10 ^mins
63	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	410,465	52,290	7.85	3 ^hrs 3 ^mins
64	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	313,510	96,769	3.24	7 ^hrs 24 ^mins
65	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	307,929	90,129	3.42	7 ^hrs 1 ^mins
66	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	299,356	88,874	3.37	7 ^hrs 8 ^mins
67	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	249,492	83,971	2.97	8 ^hrs 5 ^mins
68	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	246,689	83,774	2.94	8 ^hrs 9 ^mins
69	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	220,261	80,816	2.73	8 ^hrs 48 ^mins
70	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	218,808	58,338	3.75	6 ^hrs 24 ^mins
71	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	191,950	78,222	2.45	9 ^hrs 47 ^mins
72	Radeon R9 285/380 Tonga PRO [Radeon R9 285/380]	AMD	Tonga PRO	190,471	76,850	2.48	9 ^hrs 41 ^mins
73	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	184,215	85,079	2.17	11 ^hrs 5 ^mins
74	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	151,546	71,251	2.13	11 ^hrs 17 ^mins
75	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	150,317	71,118	2.11	11 ^hrs 21 ^mins
76	GeForce MX150 GP107M [GeForce MX150]	Nvidia	GP107M	110,855	64,127	1.73	13 ^hrs 53 ^mins
77	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	69,873	45,480	1.54	15 ^hrs 37 ^mins
78	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	55,430	50,959	1.09	22 ^hrs 4 ^mins
79	GeForce GTX 745 GM107 [GeForce GTX 745] 793	Nvidia	GM107	37,199	50,368	0.74	32 ^hrs 30 ^mins

80	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	34,684	51,143	0.68	35 ^hrs 23 ^mins

Research: STE2-GPCR-DYNAMICS Folding Project #14956

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14956

GPU PPD Averages

Research: STE2-GPCR-DYNAMICS Folding Project #14956

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages