Folding project #14967, STE2-GPCR-DYNAMICS research

Research section Research projects and references

Project #14967 overview

Project Summary AI Beta

This project looks at Ste2, a protein important for fungi to survive. It exists in pairs and could be used to develop new antifungal medicines. Since we don't know how Ste2 works, scientists are studying it to understand its function better.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 89,960
Core: 0x22
Status: Public

Source material

Official Project Description

Class D GPCR Ste2 Ste2 is a transmembrane protein of the Class D of G-Protein Coupled Receptors.

These receptors exist as dimers and are important target for understanding the physiological functioning of fungi.

While pivotal for survival, these receptors provide a useful platform for the development of antifungal medications, which can be useful as therapy in human-targeting fungal infections.

The lack of dynamical insights into the function of these proteins is what prompted the emergence of this study.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

GPCR

G Protein-Coupled Receptor

Scientific: BiotechnologyReceptor Pharmacology / G-Protein Coupled Receptors

GPCRs are a large family of cell surface receptors that activate intracellular signaling pathways upon binding to ligands. They play crucial roles in diverse physiological processes and are major targets for therapeutic interventions.

Class D GPCR

A classification of G Protein-Coupled Receptors based on their structural and functional characteristics.

Scientific: BiotechnologyReceptor Pharmacology / G-Protein Coupled Receptors

Class D GPCRs are a specific type of GPCR known for their unique structure and roles in various biological processes. They are important targets for drug development, particularly in the context of fungal infections.

Ste2

A specific G-Protein Coupled Receptor found in fungi.

Scientific: BiotechnologyCellular Biology / Fungal Signaling

Ste2 is a transmembrane protein that acts as a receptor for pheromone signaling in fungi. It plays a vital role in mating and other cellular processes. Research on Ste2 provides insights into fungal biology and potential antifungal drug targets.

Transmembrane Protein

A protein that spans the cell membrane.

Scientific: BiotechnologyCellular Biology / Protein Structure

Transmembrane proteins are crucial for various cellular functions. They act as channels, transporters, or receptors, facilitating communication and transport across the cell membrane.

Dimer

A complex formed by two identical molecules.

Scientific: BiotechnologyMolecular Biology / Protein Interactions

Dimers are common protein structures where two identical protein subunits associate to form a functional unit. This interaction can influence protein stability, activity, and cellular localization.

Antifungal Medications

Drugs used to treat fungal infections.

Medical: Biotechnology/PharmaceuticalsPharmacology / Infectious Diseases

Antifungal medications are essential for combating fungal infections in humans and animals. These drugs target specific cellular processes in fungi, inhibiting their growth and spread.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	16,617,992	264,401	62.85	0 ^hrs 23 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	12,935,721	238,924	54.14	0 ^hrs 27 ^mins
3	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	10,843,649	81,362	133.28	0 ^hrs 11 ^mins
4	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	10,109,311	55,315	182.76	0 ^hrs 8 ^mins
5	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	10,013,414	278,383	35.97	0 ^hrs 40 ^mins
6	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	8,785,764	280,150	31.36	0 ^hrs 46 ^mins
7	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	8,699,094	281,354	30.92	0 ^hrs 47 ^mins
8	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,471,732	267,058	31.72	0 ^hrs 45 ^mins
9	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	7,483,868	115,630	64.72	0 ^hrs 22 ^mins
10	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	7,349,760	267,022	27.52	0 ^hrs 52 ^mins
11	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,814,557	203,536	33.48	0 ^hrs 43 ^mins
12	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,606,318	220,634	29.94	0 ^hrs 48 ^mins
13	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,444,541	229,756	28.05	0 ^hrs 51 ^mins
14	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	6,338,263	72,419	87.52	0 ^hrs 16 ^mins
15	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,750,360	187,188	30.72	0 ^hrs 47 ^mins
16	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,101,537	235,724	21.64	1 ^hrs 7 ^mins
17	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	4,278,662	194,079	22.05	1 ^hrs 5 ^mins
18	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,045,111	217,282	18.62	1 ^hrs 17 ^mins
19	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,650,252	173,080	21.09	1 ^hrs 8 ^mins

20	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,637,441	42,000	86.61	0 ^hrs 17 ^mins
21	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,572,604	42,000	85.06	0 ^hrs 17 ^mins
22	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	3,491,108	202,282	17.26	1 ^hrs 23 ^mins
23	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,285,227	204,599	16.06	1 ^hrs 30 ^mins
24	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	3,182,150	202,060	15.75	1 ^hrs 31 ^mins
25	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,966,048	196,634	15.08	1 ^hrs 35 ^mins
26	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,824,008	193,794	14.57	1 ^hrs 39 ^mins
27	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,818,434	193,129	14.59	1 ^hrs 39 ^mins
28	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,688,330	191,025	14.07	1 ^hrs 42 ^mins
29	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,530,693	187,801	13.48	1 ^hrs 47 ^mins
30	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,447,219	185,620	13.18	1 ^hrs 49 ^mins
31	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,307,781	182,044	12.68	1 ^hrs 54 ^mins
32	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,277,532	180,210	12.64	1 ^hrs 54 ^mins
33	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,106,805	159,154	13.24	1 ^hrs 49 ^mins
34	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,102,811	79,078	26.59	0 ^hrs 54 ^mins
35	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,087,966	175,104	11.92	2 ^hrs 1 ^mins
36	GeForce RTX 2070 Mobile TU106BM [GeForce RTX 2070 Mobile]	Nvidia	TU106BM	2,006,498	172,906	11.60	2 ^hrs 4 ^mins
37	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,984,880	154,389	12.86	1 ^hrs 52 ^mins
38	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,851,959	145,659	12.71	1 ^hrs 53 ^mins
39	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,724,407	164,806	10.46	2 ^hrs 18 ^mins

40	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,714,426	165,598	10.35	2 ^hrs 19 ^mins
41	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,690,619	165,278	10.23	2 ^hrs 21 ^mins
42	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,592,138	95,412	16.69	1 ^hrs 26 ^mins
43	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,417,215	110,157	12.87	1 ^hrs 52 ^mins
44	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,410,197	42,000	33.58	0 ^hrs 43 ^mins
45	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,368,219	153,169	8.93	2 ^hrs 41 ^mins
46	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,332,037	75,826	17.57	1 ^hrs 22 ^mins
47	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,326,760	114,400	11.60	2 ^hrs 4 ^mins
48	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,186,427	144,864	8.19	2 ^hrs 56 ^mins
49	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	956,543	136,286	7.02	3 ^hrs 25 ^mins
50	Radeon Vega FE Vega 10 XTX [Radeon Vega FE]	AMD	Vega 10 XTX	946,772	133,375	7.10	3 ^hrs 23 ^mins
51	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	845,046	128,448	6.58	3 ^hrs 39 ^mins
52	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	831,437	51,781	16.06	1 ^hrs 30 ^mins
53	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	824,341	76,244	10.81	2 ^hrs 13 ^mins
54	P106-100 GP106 [P106-100]	Nvidia	GP106	752,651	125,329	6.01	3 ^hrs 60 ^mins
55	Radeon RX 7700S/7600(S) Navi 33 [Radeon RX 7700S/7600(S)]	AMD	Navi 33	747,564	127,301	5.87	4 ^hrs 5 ^mins
56	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	743,856	125,012	5.95	4 ^hrs 2 ^mins
57	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	734,917	124,252	5.91	4 ^hrs 3 ^mins
58	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	708,118	69,667	10.16	2 ^hrs 22 ^mins
59	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	614,380	120,957	5.08	4 ^hrs 44 ^mins

60	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	610,729	117,879	5.18	4 ^hrs 38 ^mins
61	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	558,277	42,000	13.29	1 ^hrs 48 ^mins
62	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	545,350	111,337	4.90	4 ^hrs 54 ^mins
63	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	513,647	49,159	10.45	2 ^hrs 18 ^mins
64	GeForce GTX 1050 3 GB Max-Q GP107M [GeForce GTX 1050 3 GB Max-Q]	Nvidia	GP107M	314,147	93,810	3.35	7 ^hrs 10 ^mins
65	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	306,379	68,849	4.45	5 ^hrs 24 ^mins
66	Radeon RX 580 2048SP Polaris 20 XL [Radeon RX 580 2048SP]	AMD	Polaris 20 XL	259,200	42,000	6.17	3 ^hrs 53 ^mins
67	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	247,694	86,673	2.86	8 ^hrs 24 ^mins
68	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	239,630	42,000	5.71	4 ^hrs 12 ^mins
69	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	232,516	84,932	2.74	8 ^hrs 46 ^mins
70	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	224,254	67,428	3.33	7 ^hrs 13 ^mins
71	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	138,838	71,475	1.94	12 ^hrs 21 ^mins
72	GeForce MX150 GP107M [GeForce MX150]	Nvidia	GP107M	115,521	66,914	1.73	13 ^hrs 54 ^mins
73	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	89,973	61,748	1.46	16 ^hrs 28 ^mins
74	Quadro P400 GP107GL [Quadro P400]	Nvidia	GP107GL	34,670	42,000	0.83	29 ^hrs 4 ^mins
75	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	23,041	42,000	0.55	43 ^hrs 45 ^mins

Research: STE2-GPCR-DYNAMICS Folding Project #14967

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14967

GPU PPD Averages

Research: STE2-GPCR-DYNAMICS Folding Project #14967

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages