Folding project #14970, STE2-GPCR-DYNAMICS research

Research section Research projects and references

Project #14970 overview

Project Summary AI Beta

This project relates to Ste2, a protein important for how fungi live. Ste2 is part of a group of proteins that can be targeted by medicines. Because we don't know much about how Ste2 works, this study aims to learn more about it so we can better understand and treat fungal infections.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 90,765
Core: 0x22
Status: Public

Source material

Official Project Description

Class D GPCR Ste2 Ste2 is a transmembrane protein of the Class D of G-Protein Coupled Receptors.

These receptors exist as dimers and are important target for understanding the physiological functioning of fungi.

While pivotal for survival, these receptors provide a useful platform for the development of antifungal medications, which can be useful as therapy in human-targeting fungal infections.

The lack of dynamical insights into the function of these proteins is what prompted the emergence of this study.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

GPCR

G Protein-Coupled Receptor

Technical: BiotechnologyPharmacology / Receptor Biology

GPCRs are a large family of cell surface receptors that play a crucial role in transmitting signals from outside the cell to inside. They are involved in a wide range of physiological processes, including vision, smell, taste, and hormone regulation.

Class D GPCR

A subfamily of G Protein-Coupled Receptors characterized by their distinct structure and function.

Scientific: BiotechnologyPharmacology / Receptor Biology

Class D GPCRs are a specific type of cell surface receptor known for their unique structure. They are important for various physiological processes in fungi and have become targets for developing antifungal medications.

Ste2

A transmembrane protein of the Class D GPCR family found in fungi.

Technical: BiotechnologyPharmacology / Receptor Biology

Ste2 is a specific type of cell surface receptor found in certain fungi. It plays a vital role in their survival and has become a target for developing new antifungal medications to treat fungal infections in humans.

Transmembrane Protein

A protein that spans the cell membrane.

Scientific: BiotechnologyBiotechnology / Cellular Biology

Transmembrane proteins are essential components of cell membranes. They have regions that pass through the membrane, allowing them to interact with both the inside and outside of the cell.

Dimer

Two identical molecules joined together.

Scientific: BiotechnologyBiotechnology / Molecular Biology

A dimer is formed when two identical molecules, often proteins, bind together. These complexes play important roles in various biological processes.

Antifungal Medications

Drugs used to treat fungal infections.

Technical: BiotechnologyPharmacology / Drug Development

Antifungal medications are designed to kill or inhibit the growth of fungi. They are essential for treating a wide range of fungal infections in humans.

Therapy

The medical care of a patient.

Clinical: HealthcareMedicine / Treatment

Therapy refers to the treatment provided to patients to manage or cure their illnesses. It can involve various approaches such as medication, surgery, or physical therapy.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	15,956,142	226,417	70.47	0 ^hrs 20 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	11,792,810	234,233	50.35	0 ^hrs 29 ^mins
3	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	10,543,548	84,493	124.79	0 ^hrs 12 ^mins
4	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	9,500,583	215,673	44.05	0 ^hrs 33 ^mins
5	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,120,275	271,431	33.60	0 ^hrs 43 ^mins
6	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,744,036	259,261	33.73	0 ^hrs 43 ^mins
7	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	8,223,124	266,969	30.80	0 ^hrs 47 ^mins
8	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,777,505	122,836	55.18	0 ^hrs 26 ^mins
9	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	6,755,150	252,132	26.79	0 ^hrs 54 ^mins
10	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	6,595,831	79,330	83.14	0 ^hrs 17 ^mins
11	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,508,554	209,329	31.09	0 ^hrs 46 ^mins
12	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,862,137	76,987	76.14	0 ^hrs 19 ^mins
13	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,673,696	230,481	24.62	0 ^hrs 58 ^mins
14	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,585,679	146,766	38.06	0 ^hrs 38 ^mins
15	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,316,914	191,949	27.70	0 ^hrs 52 ^mins
16	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,720,658	224,187	21.06	1 ^hrs 8 ^mins
17	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	4,245,155	216,966	19.57	1 ^hrs 14 ^mins
18	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,080,364	160,169	25.48	0 ^hrs 57 ^mins
19	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,502,206	121,896	28.73	0 ^hrs 50 ^mins

20	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,430,948	144,614	23.72	1 ^hrs 1 ^mins
21	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	3,337,748	196,271	17.01	1 ^hrs 25 ^mins
22	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	3,333,134	83,833	39.76	0 ^hrs 36 ^mins
23	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	3,294,653	40,400	81.55	0 ^hrs 18 ^mins
24	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,107,351	150,257	20.68	1 ^hrs 10 ^mins
25	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,758,166	130,967	21.06	1 ^hrs 8 ^mins
26	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,650,582	104,445	25.38	0 ^hrs 57 ^mins
27	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,647,186	178,806	14.80	1 ^hrs 37 ^mins
28	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,323,303	177,803	13.07	1 ^hrs 50 ^mins
29	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,280,868	176,233	12.94	1 ^hrs 51 ^mins
30	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,268,496	164,006	13.83	1 ^hrs 44 ^mins
31	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,186,389	174,362	12.54	1 ^hrs 55 ^mins
32	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,148,148	86,756	24.76	0 ^hrs 58 ^mins
33	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,133,237	171,372	12.45	1 ^hrs 56 ^mins
34	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,112,825	172,046	12.28	1 ^hrs 57 ^mins
35	RTX 2000 Ada Generation Laptop GPU AD107GLM [RTX 2000 Ada Generation Laptop GPU]	Nvidia	AD107GLM	2,077,414	173,075	12.00	1 ^hrs 60 ^mins
36	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,976,680	168,238	11.75	2 ^hrs 3 ^mins
37	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,883,298	120,547	15.62	1 ^hrs 32 ^mins
38	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,638,968	157,980	10.37	2 ^hrs 19 ^mins
39	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,596,230	107,407	14.86	1 ^hrs 37 ^mins

40	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,520,078	47,831	31.78	0 ^hrs 45 ^mins
41	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,480,650	152,516	9.71	2 ^hrs 28 ^mins
42	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,390,654	150,108	9.26	2 ^hrs 35 ^mins
43	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,390,124	90,876	15.30	1 ^hrs 34 ^mins
44	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,384,713	147,526	9.39	2 ^hrs 33 ^mins
45	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,334,796	117,874	11.32	2 ^hrs 7 ^mins
46	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,241,247	104,123	11.92	2 ^hrs 1 ^mins
47	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,241,118	114,160	10.87	2 ^hrs 12 ^mins
48	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,149,739	139,188	8.26	2 ^hrs 54 ^mins
49	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,053,063	136,335	7.72	3 ^hrs 6 ^mins
50	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,011,111	137,065	7.38	3 ^hrs 15 ^mins
51	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	865,698	45,571	19.00	1 ^hrs 16 ^mins
52	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	828,368	126,083	6.57	3 ^hrs 39 ^mins
53	P106-100 GP106 [P106-100]	Nvidia	GP106	688,420	118,390	5.81	4 ^hrs 8 ^mins
54	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	652,755	40,400	16.16	1 ^hrs 29 ^mins
55	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	632,062	116,720	5.42	4 ^hrs 26 ^mins
56	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	606,213	113,614	5.34	4 ^hrs 30 ^mins
57	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	557,853	106,082	5.26	4 ^hrs 34 ^mins
58	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	536,237	110,303	4.86	4 ^hrs 56 ^mins
59	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	471,698	109,215	4.32	5 ^hrs 33 ^mins

60	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	357,433	95,909	3.73	6 ^hrs 26 ^mins
61	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	304,114	40,400	7.53	3 ^hrs 11 ^mins
62	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	226,458	79,611	2.84	8 ^hrs 26 ^mins
63	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	128,921	68,004	1.90	12 ^hrs 40 ^mins
64	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	84,237	40,400	2.09	11 ^hrs 31 ^mins
65	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	68,491	40,400	1.70	14 ^hrs 9 ^mins
66	GeForce GT 730 GK208B [GeForce GT 730] 692.7	Nvidia	GK208B	23,083	40,400	0.57	42 ^hrs 0 ^mins

Research: STE2-GPCR-DYNAMICS Folding Project #14970

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14970

GPU PPD Averages

Research: STE2-GPCR-DYNAMICS Folding Project #14970

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages