Official Project Description
Protein misfolding occurs when a peptide cannot fold into its native structure.
Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.
Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.
We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.