Folding project #12912, CANCER research

Research section Research projects and references

Project #12912 overview

Project Summary AI Beta

Proteins need to fold correctly to work. Sometimes mutations change how they fold, leading to diseases like cancer and Alzheimer's. This project studies how different mutations affect protein folding to better understand these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Diego Kleiman
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 25,921
Core: 0x22
Status: Public

Source material

Official Project Description

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Protein

Large biomolecules essential for various biological functions.

Scientific: MedicineBiotechnology / Structural Biology

Proteins are complex molecules that perform many vital roles in living organisms. They are involved in processes like building and repairing tissues, transporting molecules, and catalyzing chemical reactions. Misfolding of proteins can lead to diseases like Alzheimer's and cancer.

Peptide

A short chain of amino acids linked together.

Scientific: MedicineBiotechnology / Molecular Biology

Peptides are chains of amino acids, the building blocks of proteins. They often have specific functions and can act as signaling molecules or hormones. Proteins are made up of one or more peptides.

Mutation

A permanent change in the DNA sequence.

Scientific: MedicineBiotechnology / Genetics

Mutations are changes in the genetic code. They can be caused by various factors and may have no effect, beneficial effects, or harmful effects. Mutations can lead to variations in traits and contribute to diseases like cancer.

Conformation

The three-dimensional shape of a molecule.

Scientific: MedicineBiotechnology / Structural Biology

Conformation refers to the specific arrangement of atoms within a molecule. The shape of a protein is crucial for its function. Changes in conformation can alter a protein's ability to interact with other molecules.

Cancer

A disease characterized by uncontrolled cell growth.

Medical: HealthcareMedicine / Oncology

Cancer is a group of diseases involving abnormal cell growth. Cancer cells divide uncontrollably and can invade surrounding tissues. Treatment options include surgery, chemotherapy, and radiation therapy.

Alzheimer's

A neurodegenerative disease causing memory loss and cognitive decline.

Medical: HealthcareMedicine / Neurology

Alzheimer's disease is a progressive brain disorder that affects memory, thinking, and behavior. It is the most common cause of dementia, characterized by the buildup of amyloid plaques and tau tangles in the brain.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 2060 12GB TU106 [GeForce RTX 2060 12GB]	Nvidia	TU106	2,414,424	230,624	10.47	2 ^hrs 18 ^mins
2	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	2,193,597	218,128	10.06	2 ^hrs 23 ^mins
3	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,097,840	214,044	9.80	2 ^hrs 27 ^mins
4	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,005,046	202,553	9.90	2 ^hrs 25 ^mins
5	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,964,777	202,510	9.70	2 ^hrs 28 ^mins
6	GeForce RTX 2070 Mobile TU106BM [GeForce RTX 2070 Mobile]	Nvidia	TU106BM	1,843,474	200,284	9.20	2 ^hrs 36 ^mins
7	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	1,835,307	205,467	8.93	2 ^hrs 41 ^mins
8	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	1,832,066	205,233	8.93	2 ^hrs 41 ^mins
9	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,744,678	202,357	8.62	2 ^hrs 47 ^mins
10	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,604,985	195,538	8.21	2 ^hrs 55 ^mins
11	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,502,634	180,768	8.31	2 ^hrs 53 ^mins
12	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,496,620	182,180	8.22	2 ^hrs 55 ^mins
13	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,468,368	180,930	8.12	2 ^hrs 57 ^mins
14	P106-090 GP106 [P106-090]	Nvidia	GP106	1,403,833	46,000	30.52	0 ^hrs 47 ^mins
15	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,313,656	181,033	7.26	3 ^hrs 18 ^mins
16	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,232,706	156,493	7.88	3 ^hrs 3 ^mins
17	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,124,166	97,320	11.55	2 ^hrs 5 ^mins
18	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,117,979	163,088	6.86	3 ^hrs 30 ^mins
19	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,091,193	172,896	6.31	3 ^hrs 48 ^mins

20	GeForce RTX 3050 Ti Mobile GA107M [GeForce RTX 3050 Ti Mobile]	Nvidia	GA107M	1,016,570	141,851	7.17	3 ^hrs 21 ^mins
21	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,004,571	158,235	6.35	3 ^hrs 47 ^mins
22	GeForce RTX 3050 6GB Laptop GPU GN20-P0-R-K2 [GeForce RTX 3050 6GB Laptop GPU]	Nvidia	GN20-P0-R-K2	959,226	165,621	5.79	4 ^hrs 9 ^mins
23	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	895,453	155,354	5.76	4 ^hrs 10 ^mins
24	GeForce RTX 3050 6GB GA107 [GeForce RTX 3050 6GB]	Nvidia	GA107	843,218	158,083	5.33	4 ^hrs 30 ^mins
25	GeForce GTX 1060 6GB GP104 [GeForce GTX 1060 6GB]	Nvidia	GP104	821,481	157,659	5.21	4 ^hrs 36 ^mins
26	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	793,251	127,990	6.20	3 ^hrs 52 ^mins
27	Quadro P3200 Mobile GP104GLM [Quadro P3200 Mobile]	Nvidia	GP104GLM	790,947	114,769	6.89	3 ^hrs 29 ^mins
28	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	774,909	152,863	5.07	4 ^hrs 44 ^mins
29	P106-100 GP106 [P106-100]	Nvidia	GP106	768,242	153,683	5.00	4 ^hrs 48 ^mins
30	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	765,155	156,026	4.90	4 ^hrs 54 ^mins
31	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	699,599	149,984	4.66	5 ^hrs 9 ^mins
32	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	690,816	149,710	4.61	5 ^hrs 12 ^mins
33	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	667,982	148,948	4.48	5 ^hrs 21 ^mins
34	Quadro T1200 Mobile TU117GLM [Quadro T1200 Mobile]	Nvidia	TU117GLM	585,902	140,051	4.18	5 ^hrs 44 ^mins
35	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	529,191	59,760	8.86	2 ^hrs 43 ^mins
36	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	513,681	98,472	5.22	4 ^hrs 36 ^mins
37	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	495,393	119,983	4.13	5 ^hrs 49 ^mins
38	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	479,324	130,812	3.66	6 ^hrs 33 ^mins
39	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	468,526	128,668	3.64	6 ^hrs 35 ^mins

40	GeForce GTX 1050 3 GB Max-Q GP107M [GeForce GTX 1050 3 GB Max-Q]	Nvidia	GP107M	315,371	115,111	2.74	8 ^hrs 46 ^mins
41	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	301,707	108,707	2.78	8 ^hrs 39 ^mins
42	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	267,160	108,107	2.47	9 ^hrs 43 ^mins
43	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	244,103	105,008	2.32	10 ^hrs 19 ^mins
44	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	196,550	93,191	2.11	11 ^hrs 23 ^mins
45	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	142,266	52,049	2.73	8 ^hrs 47 ^mins
46	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	133,969	86,474	1.55	15 ^hrs 29 ^mins
47	GeForce GTX 670/GTX 760Ti OEM GK104 [GeForce GTX 670/GTX 760Ti OEM] 2634	Nvidia	GK104	127,068	46,000	2.76	8 ^hrs 41 ^mins
48	GeForce MX150 GP107M [GeForce MX150]	Nvidia	GP107M	126,845	84,449	1.50	15 ^hrs 59 ^mins
49	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	89,887	75,465	1.19	20 ^hrs 9 ^mins
50	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	72,389	75,425	0.96	25 ^hrs 0 ^mins

Research: CANCER Folding Project #12912

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12912

GPU PPD Averages

Research: CANCER Folding Project #12912

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages