Folding project #12914, CANCER research

Research section Research projects and references

Project #12914 overview

Project Summary AI Beta

Protein misfolding happens when proteins can't fold correctly. This can cause diseases like cancer and Alzheimer's. The project aims to study how mutations affect protein folding to better understand and predict these problems.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Diego Kleiman
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 34,039
Core: 0x22
Status: Public

Source material

Official Project Description

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Protein

A large biomolecule consisting of chains of amino acids.

Scientific: BiopharmaceuticalsBiotechnology / Molecular Biology

Proteins are essential molecules that perform a wide range of functions in living organisms. They are involved in everything from building and repairing tissues to catalyzing biochemical reactions. Proteins are made up of chains of amino acids, which fold into specific three-dimensional structures.

Peptide

A short chain of amino acids linked together.

Scientific: BiopharmaceuticalsBiotechnology / Molecular Biology

Peptides are short chains of amino acids, which are the building blocks of proteins. They can have various biological functions, such as acting as hormones or signaling molecules.

Mutations

Permanent alterations in the DNA sequence.

Scientific: BiopharmaceuticalsBiotechnology / Genetics

Mutations are changes in the DNA sequence that can affect the function of genes. They can be caused by environmental factors or errors during DNA replication.

Cancer

A group of diseases involving abnormal cell growth.

Clinical: HealthcareMedicine / Oncology

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It can affect any part of the body.

Alzheimer's

A neurodegenerative disease that affects memory and cognitive function.

Clinical: HealthcareMedicine / Neurology

Alzheimer's disease is a progressive brain disorder that causes memory loss, thinking problems, and behavioral changes.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,880,119	169,845	16.96	1 ^hrs 25 ^mins
2	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	2,564,854	138,739	18.49	1 ^hrs 18 ^mins
3	GeForce RTX 2060 12GB TU106 [GeForce RTX 2060 12GB]	Nvidia	TU106	2,493,610	137,068	18.19	1 ^hrs 19 ^mins
4	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,013,263	128,098	15.72	1 ^hrs 32 ^mins
5	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,003,640	123,964	16.16	1 ^hrs 29 ^mins
6	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	1,966,189	124,692	15.77	1 ^hrs 31 ^mins
7	GeForce RTX 2070 Mobile TU106BM [GeForce RTX 2070 Mobile]	Nvidia	TU106BM	1,932,485	126,257	15.31	1 ^hrs 34 ^mins
8	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,782,514	122,623	14.54	1 ^hrs 39 ^mins
9	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,753,026	122,169	14.35	1 ^hrs 40 ^mins
10	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,733,740	108,468	15.98	1 ^hrs 30 ^mins
11	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,700,495	119,344	14.25	1 ^hrs 41 ^mins
12	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,597,094	111,339	14.34	1 ^hrs 40 ^mins
13	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,577,179	108,445	14.54	1 ^hrs 39 ^mins
14	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,400,113	102,157	13.71	1 ^hrs 45 ^mins
15	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,367,508	98,068	13.94	1 ^hrs 43 ^mins
16	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,192,368	59,891	19.91	1 ^hrs 12 ^mins
17	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,176,731	101,900	11.55	2 ^hrs 5 ^mins
18	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,173,444	106,576	11.01	2 ^hrs 11 ^mins
19	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,154,430	102,418	11.27	2 ^hrs 8 ^mins

20	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,135,885	87,463	12.99	1 ^hrs 51 ^mins
21	GeForce RTX 3050 6GB Laptop GPU GN20-P0-R-K2 [GeForce RTX 3050 6GB Laptop GPU]	Nvidia	GN20-P0-R-K2	1,075,419	103,118	10.43	2 ^hrs 18 ^mins
22	GeForce RTX 3050 Ti Mobile GA107M [GeForce RTX 3050 Ti Mobile]	Nvidia	GA107M	997,911	96,592	10.33	2 ^hrs 19 ^mins
23	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	979,328	97,435	10.05	2 ^hrs 23 ^mins
24	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	842,168	94,670	8.90	2 ^hrs 42 ^mins
25	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	834,926	77,773	10.74	2 ^hrs 14 ^mins
26	Quadro P3200 Mobile GP104GLM [Quadro P3200 Mobile]	Nvidia	GP104GLM	796,325	43,752	18.20	1 ^hrs 19 ^mins
27	P106-100 GP106 [P106-100]	Nvidia	GP106	783,190	93,175	8.41	2 ^hrs 51 ^mins
28	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	725,155	48,277	15.02	1 ^hrs 36 ^mins
29	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	703,027	86,497	8.13	2 ^hrs 57 ^mins
30	GeForce GTX 1060 6GB GP104 [GeForce GTX 1060 6GB]	Nvidia	GP104	699,415	85,927	8.14	2 ^hrs 57 ^mins
31	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	651,817	59,252	11.00	2 ^hrs 11 ^mins
32	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	576,465	82,539	6.98	3 ^hrs 26 ^mins
33	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	567,848	59,338	9.57	2 ^hrs 30 ^mins
34	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	561,439	21,610	25.98	0 ^hrs 55 ^mins
35	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	448,441	76,125	5.89	4 ^hrs 4 ^mins
36	GeForce GTX Titan Black GK110 [GeForce GTX Titan Black] 5121	Nvidia	GK110	433,442	78,616	5.51	4 ^hrs 21 ^mins
37	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	319,594	63,492	5.03	4 ^hrs 46 ^mins
38	GeForce GTX 1050 3 GB Max-Q GP107M [GeForce GTX 1050 3 GB Max-Q]	Nvidia	GP107M	292,239	68,989	4.24	5 ^hrs 40 ^mins
39	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	284,878	66,637	4.28	5 ^hrs 37 ^mins

40	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	284,278	64,226	4.43	5 ^hrs 25 ^mins
41	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	257,248	63,311	4.06	5 ^hrs 54 ^mins
42	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	248,273	63,689	3.90	6 ^hrs 9 ^mins
43	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	142,118	52,934	2.68	8 ^hrs 56 ^mins
44	Quadro P1000 Mobile GP107GLM [Quadro P1000 Mobile]	Nvidia	GP107GLM	138,231	21,610	6.40	3 ^hrs 45 ^mins
45	GeForce MX150 GP107M [GeForce MX150]	Nvidia	GP107M	123,792	50,645	2.44	9 ^hrs 49 ^mins
46	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	92,870	52,105	1.78	13 ^hrs 28 ^mins
47	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	91,078	45,383	2.01	11 ^hrs 58 ^mins
48	GeForce GTX 660 GK106 [GeForce GTX 660]	Nvidia	GK106	85,538	44,891	1.91	12 ^hrs 36 ^mins
49	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	76,943	40,653	1.89	12 ^hrs 41 ^mins
50	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	26,561	21,610	1.23	19 ^hrs 32 ^mins
51	Quadro NVS 510 GK107 [Quadro NVS 510]	Nvidia	GK107	9,209	21,610	0.43	56 ^hrs 19 ^mins

Research: CANCER Folding Project #12914

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 12914

GPU PPD Averages

Research: CANCER Folding Project #12914

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages