PROJECT #18601 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression.

Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease.

There are three dominant alleles (versions) of ApoE that are found in humans.

Each ApoE allele differs only by a single amino acid substitution.

ApoE3 is most common and carries a neutral risk for AD.

Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease.

Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease.

How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression.

Here, we will simulate how one variant of ApoE move in solution.

We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease..

PROJECT INFO

Manager(s): Upasana Mallimadugula

Institution: Washington University in St. Louis

Project URL: https://dbbs.wustl.edu/curstudents/Pages/student_bio.aspx?SID=7595

PROJECT WORK UNIT SUMMARY

Atoms: 308,197

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Tuesday, 07 February 2023 06:14:50

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 23,345,876 812,533 28.73 0 hrs 50 mins
2 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]
Nvidia AD104 19,454,510 669,074 29.08 0 hrs 50 mins
3 GeForce RTX 4080
AD103 [GeForce RTX 4080]
Nvidia AD103 16,019,486 726,109 22.06 1 hrs 5 mins
4 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,661,550 610,441 15.83 2 hrs 31 mins
5 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,421,545 580,134 14.52 2 hrs 39 mins
6 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 8,294,774 580,036 14.30 2 hrs 41 mins
7 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 7,473,837 557,584 13.40 2 hrs 47 mins
8 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 7,282,789 555,983 13.10 2 hrs 50 mins
9 A40
GA102GL [A40]
Nvidia GA102GL 7,274,941 557,264 13.05 2 hrs 50 mins
10 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,268,268 559,940 12.98 2 hrs 51 mins
11 RTX A6000
GA102GL [RTX A6000]
Nvidia GA102GL 7,011,413 545,674 12.85 2 hrs 52 mins
12 TITAN V
GV100 [TITAN V] M 12288
Nvidia GV100 5,710,080 525,298 10.87 2 hrs 12 mins
13 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,386,213 506,409 10.64 2 hrs 15 mins
14 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,310,016 499,953 10.62 2 hrs 16 mins
15 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,553,491 480,237 9.48 3 hrs 32 mins
16 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,492,293 476,721 9.42 3 hrs 33 mins
17 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 4,208,906 470,188 8.95 3 hrs 41 mins
18 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,122,152 461,044 8.94 3 hrs 41 mins
19 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,953,606 453,703 8.71 3 hrs 45 mins
20 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,387,971 432,357 7.84 3 hrs 4 mins
21 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 2,951,469 414,474 7.12 3 hrs 22 mins
22 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 2,937,722 413,958 7.10 3 hrs 23 mins
23 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,931,669 413,158 7.10 3 hrs 23 mins
24 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,883,307 410,537 7.02 3 hrs 25 mins
25 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,811,443 405,215 6.94 3 hrs 28 mins
26 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,783,219 407,862 6.82 4 hrs 31 mins
27 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,751,765 404,277 6.81 4 hrs 32 mins
28 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 2,725,710 397,157 6.86 3 hrs 30 mins
29 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,693,086 395,981 6.80 4 hrs 32 mins
30 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,548,701 395,172 6.45 4 hrs 43 mins
31 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,540,778 392,383 6.48 4 hrs 42 mins
32 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,501,955 393,139 6.36 4 hrs 46 mins
33 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,395,679 385,860 6.21 4 hrs 52 mins
34 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,357,685 382,364 6.17 4 hrs 54 mins
35 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,341,034 375,735 6.23 4 hrs 51 mins
36 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,306,017 378,432 6.09 4 hrs 56 mins
37 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,139,083 373,274 5.73 4 hrs 11 mins
38 GeForce RTX 2080 Mobile
TU104M [GeForce RTX 2080 Mobile]
Nvidia TU104M 2,071,268 370,572 5.59 4 hrs 18 mins
39 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,951,823 361,139 5.40 4 hrs 26 mins
40 GeForce RTX 2070 SUPER Mobile / Max-Q
TU104M [GeForce RTX 2070 SUPER Mobile / Max-Q]
Nvidia TU104M 1,789,394 353,242 5.07 5 hrs 44 mins
41 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,710,783 326,740 5.24 5 hrs 35 mins
42 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,690,600 343,869 4.92 5 hrs 53 mins
43 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,690,212 350,776 4.82 5 hrs 59 mins
44 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,398,606 307,954 4.54 5 hrs 17 mins
45 RTX A2000
GA106 [RTX A2000]
GA106 1,327,703 321,106 4.13 6 hrs 48 mins
46 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,247,518 311,318 4.01 6 hrs 59 mins
47 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,181,998 305,249 3.87 6 hrs 12 mins
48 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,159,219 294,490 3.94 6 hrs 6 mins
49 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,151,574 303,979 3.79 6 hrs 20 mins
50 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,120,083 301,342 3.72 6 hrs 27 mins
51 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,117,067 319,993 3.49 7 hrs 52 mins
52 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,075,278 271,057 3.97 6 hrs 3 mins
53 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 1,073,579 306,508 3.50 7 hrs 51 mins
54 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,061,627 288,845 3.68 7 hrs 32 mins
55 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 983,187 279,600 3.52 7 hrs 50 mins
56 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 953,757 263,091 3.63 7 hrs 37 mins
57 Quadro P4000
GP104GL [Quadro P4000]
Nvidia GP104GL 915,178 280,969 3.26 7 hrs 22 mins
58 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 900,695 266,559 3.38 7 hrs 6 mins
59 P104-100
GP104 [P104-100]
Nvidia GP104 896,364 280,736 3.19 8 hrs 31 mins
60 GeForce RTX 2060 12GB
TU106 [GeForce RTX 2060 12GB]
Nvidia TU106 876,028 218,413 4.01 6 hrs 59 mins
61 Tesla T4
TU104GL [Tesla T4]
Nvidia TU104GL 786,590 266,297 2.95 8 hrs 8 mins
62 GeForce GTX 1070 Mobile
GP104BM [GeForce GTX 1070 Mobile] 6463
Nvidia GP104BM 782,767 295,610 2.65 9 hrs 4 mins
63 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 781,416 288,702 2.71 9 hrs 52 mins
64 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 769,895 265,174 2.90 8 hrs 16 mins
65 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 762,036 260,339 2.93 8 hrs 12 mins
66 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 703,805 258,367 2.72 9 hrs 49 mins
67 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 641,045 249,297 2.57 9 hrs 20 mins
68 GeForce GTX 780 Ti
GK110 [GeForce GTX 780 Ti] 5046
Nvidia GK110 624,876 252,914 2.47 10 hrs 43 mins
69 Quadro T1200 Mobile
TU117GLM [Quadro T1200 Mobile]
Nvidia TU117GLM 591,808 240,548 2.46 10 hrs 45 mins
70 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 584,698 251,065 2.33 10 hrs 18 mins
71 Quadro M5000
GM204GL [Quadro M5000]
Nvidia GM204GL 515,434 232,406 2.22 11 hrs 49 mins
72 Geforce RTX 3070 Ti Laptop GPU
GA104 [Geforce RTX 3070 Ti Laptop GPU]
Nvidia GA104 479,839 248,166 1.93 12 hrs 25 mins
73 GeForce GTX 1650
TU117 [GeForce GTX 1650] 3091
Nvidia TU117 470,515 224,302 2.10 11 hrs 26 mins
74 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 448,323 245,191 1.83 13 hrs 8 mins
75 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 446,386 223,783 1.99 12 hrs 2 mins
76 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 442,022 220,716 2.00 12 hrs 59 mins
77 P106-100
GP106 [P106-100]
Nvidia GP106 434,603 231,705 1.88 13 hrs 48 mins
78 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 405,025 208,769 1.94 12 hrs 22 mins
79 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 392,923 222,942 1.76 14 hrs 37 mins
80 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 335,892 224,758 1.49 16 hrs 4 mins
81 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 317,800 197,172 1.61 15 hrs 53 mins
82 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 310,302 196,508 1.58 15 hrs 12 mins
83 P106-090
GP106 [P106-090]
Nvidia GP106 296,464 195,937 1.51 16 hrs 52 mins
84 GeForce GTX 970M
GM204 [GeForce GTX 970M] 2365
Nvidia GM204 287,638 189,487 1.52 16 hrs 49 mins
85 Quadro T1000 Mobile
TU117GLM [Quadro T1000 Mobile]
Nvidia TU117GLM 287,514 189,496 1.52 16 hrs 49 mins
86 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 277,160 191,360 1.45 17 hrs 34 mins
87 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 244,859 196,350 1.25 19 hrs 15 mins
88 GeForce GTX Titan Black
GK110 [GeForce GTX Titan Black] 5121
Nvidia GK110 238,982 196,679 1.22 20 hrs 45 mins
89 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 224,361 176,208 1.27 19 hrs 51 mins
90 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 201,472 181,623 1.11 22 hrs 38 mins
91 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 197,054 168,621 1.17 21 hrs 32 mins
92 T600
TU117GL [T600]
Intel TU117GL 185,214 155,540 1.19 20 hrs 9 mins
93 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 168,186 183,131 0.92 26 hrs 8 mins
94 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 125,935 145,883 0.86 28 hrs 48 mins
95 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 122,669 149,059 0.82 29 hrs 10 mins
96 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 114,705 140,606 0.82 29 hrs 25 mins
97 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 106,849 139,364 0.77 31 hrs 18 mins
98 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 103,994 136,041 0.76 31 hrs 24 mins
99 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 100,474 146,737 0.68 35 hrs 3 mins
100 GeForce GTX 750
GM107 [GeForce GTX 750] 1111
Nvidia GM107 96,968 133,564 0.73 33 hrs 3 mins
101 GeForce MX450
TU117M [GeForce MX450]
Nvidia TU117M 94,218 123,501 0.76 31 hrs 28 mins
102 GeForce GTX 950M
GM107 [GeForce GTX 950M] 1439
Nvidia GM107 91,678 131,093 0.70 34 hrs 19 mins
103 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 85,764 138,390 0.62 39 hrs 44 mins
104 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 83,043 138,528 0.60 40 hrs 2 mins
105 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 82,071 133,718 0.61 39 hrs 6 mins
106 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 78,144 124,356 0.63 38 hrs 12 mins
107 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 74,676 122,237 0.61 39 hrs 17 mins
108 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 73,668 112,940 0.65 37 hrs 48 mins
109 GeForce GTX 660
GK106 [GeForce GTX 660] 1981
Nvidia GK106 67,181 105,824 0.63 38 hrs 48 mins
110 GeForce GTX 860M
GM107 [GeForce GTX 860M] 1389
Nvidia GM107 67,066 114,205 0.59 41 hrs 52 mins
111 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 62,509 81,101 0.77 31 hrs 8 mins
112 GeForce GTX 660
GK106 [GeForce GTX 660]
Nvidia GK106 50,358 97,545 0.52 46 hrs 29 mins
113 GeForce GTX 670/GTX 760Ti OEM
GK104 [GeForce GTX 670/GTX 760Ti OEM] 2634
Nvidia GK104 50,154 134,206 0.37 64 hrs 13 mins
114 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 40,335 82,358 0.49 49 hrs 0 mins
115 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 39,150 81,221 0.48 50 hrs 47 mins
116 Quadro P400
GP107GL [Quadro P400]
Nvidia GP107GL 34,928 81,101 0.43 56 hrs 44 mins
117 GeForce GTX 650 Ti
GK106 [GeForce GTX 650 Ti]
Nvidia GK106 29,917 81,101 0.37 65 hrs 4 mins
118 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 26,740 81,408 0.33 73 hrs 4 mins
119 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 18,447 81,101 0.23 106 hrs 31 mins
120 GeForce GT 755M
GK107 [GeForce GT 755M]
Nvidia GK107 15,621 81,101 0.19 125 hrs 36 mins
121 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 8,748 81,101 0.11 222 hrs 30 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Tuesday, 07 February 2023 06:14:50

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make