PROJECT #18601 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression.

Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease.

There are three dominant alleles (versions) of ApoE that are found in humans.

Each ApoE allele differs only by a single amino acid substitution.

ApoE3 is most common and carries a neutral risk for AD.

Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease.

Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease.

How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression.

Here, we will simulate how one variant of ApoE move in solution.

We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease..

PROJECT INFO

Manager(s): Upasana Mallimadugula

Institution: Washington University in St. Louis

Project URL: https://dbbs.wustl.edu/curstudents/Pages/student_bio.aspx?SID=7595

PROJECT WORK UNIT SUMMARY

Atoms: 308,197

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 22 May 2022 15:22:29

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 10,239,492 619,741 16.52 1 hrs 27 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,708,157 590,521 14.75 2 hrs 38 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,981,125 574,705 13.89 2 hrs 44 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,513,455 563,778 13.33 2 hrs 48 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 6,585,800 538,930 12.22 2 hrs 58 mins
6 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,279,130 503,854 10.48 2 hrs 17 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,193,484 493,373 10.53 2 hrs 17 mins
8 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 5,118,373 508,737 10.06 2 hrs 23 mins
9 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,750,481 486,175 9.77 2 hrs 27 mins
10 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,729,301 477,768 9.90 2 hrs 25 mins
11 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 4,399,618 468,478 9.39 3 hrs 33 mins
12 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,254,939 453,350 9.39 3 hrs 33 mins
13 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,129,301 458,959 9.00 3 hrs 40 mins
14 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,448,692 434,112 7.94 3 hrs 1 mins
15 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,391,226 436,339 7.77 3 hrs 5 mins
16 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,991,002 418,324 7.15 3 hrs 21 mins
17 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 2,969,728 414,988 7.16 3 hrs 21 mins
18 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,900,783 414,336 7.00 3 hrs 26 mins
19 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,858,122 405,946 7.04 3 hrs 25 mins
20 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,787,178 408,169 6.83 4 hrs 31 mins
21 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,712,785 400,764 6.77 4 hrs 33 mins
22 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,706,886 403,631 6.71 4 hrs 35 mins
23 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,659,474 401,821 6.62 4 hrs 38 mins
24 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,272,758 382,665 5.94 4 hrs 2 mins
25 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,163,716 378,207 5.72 4 hrs 12 mins
26 GeForce RTX 2080 Mobile
TU104M [GeForce RTX 2080 Mobile]
Nvidia TU104M 2,071,268 370,572 5.59 4 hrs 18 mins
27 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 2,054,342 367,416 5.59 4 hrs 18 mins
28 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,049,318 368,359 5.56 4 hrs 19 mins
29 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,796,559 350,735 5.12 5 hrs 41 mins
30 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,715,720 347,761 4.93 5 hrs 52 mins
31 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,675,299 298,468 5.61 4 hrs 17 mins
32 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,633,895 338,811 4.82 5 hrs 59 mins
33 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,502,537 321,692 4.67 5 hrs 8 mins
34 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,396,923 293,234 4.76 5 hrs 2 mins
35 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,350,240 320,882 4.21 6 hrs 42 mins
36 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,237,465 311,473 3.97 6 hrs 2 mins
37 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,229,550 314,373 3.91 6 hrs 8 mins
38 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,211,446 309,665 3.91 6 hrs 8 mins
39 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,203,709 308,108 3.91 6 hrs 9 mins
40 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,178,250 306,176 3.85 6 hrs 14 mins
41 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,147,016 308,718 3.72 6 hrs 28 mins
42 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,042,964 298,827 3.49 7 hrs 53 mins
43 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,025,764 292,300 3.51 7 hrs 50 mins
44 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,011,022 251,493 4.02 6 hrs 58 mins
45 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,007,965 297,367 3.39 7 hrs 5 mins
46 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 875,462 273,913 3.20 8 hrs 31 mins
47 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 795,353 272,110 2.92 8 hrs 13 mins
48 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 734,680 265,804 2.76 9 hrs 41 mins
49 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 723,063 259,374 2.79 9 hrs 37 mins
50 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 549,955 238,724 2.30 10 hrs 25 mins
51 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 525,230 235,727 2.23 11 hrs 46 mins
52 Quadro M5000
GM204GL [Quadro M5000]
Nvidia GM204GL 515,434 232,406 2.22 11 hrs 49 mins
53 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 501,173 227,275 2.21 11 hrs 53 mins
54 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 399,090 217,795 1.83 13 hrs 6 mins
55 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 329,875 200,341 1.65 15 hrs 35 mins
56 P106-090
GP106 [P106-090]
Nvidia GP106 316,476 197,662 1.60 15 hrs 59 mins
57 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 289,875 190,902 1.52 16 hrs 48 mins
58 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 288,130 191,608 1.50 16 hrs 58 mins
59 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 284,457 190,486 1.49 16 hrs 4 mins
60 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 248,800 182,941 1.36 18 hrs 39 mins
61 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 223,892 184,347 1.21 20 hrs 46 mins
62 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 220,103 173,179 1.27 19 hrs 53 mins
63 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 209,212 149,857 1.40 17 hrs 11 mins
64 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 189,867 167,122 1.14 21 hrs 7 mins
65 T600
TU117GL [T600]
Intel TU117GL 185,214 155,540 1.19 20 hrs 9 mins
66 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 131,744 147,889 0.89 27 hrs 56 mins
67 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 125,935 145,883 0.86 28 hrs 48 mins
68 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 124,763 141,416 0.88 27 hrs 12 mins
69 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 114,705 140,606 0.82 29 hrs 25 mins
70 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 97,289 132,985 0.73 33 hrs 48 mins
71 GeForce GTX 750
GM107 [GeForce GTX 750] 1111
Nvidia GM107 96,968 133,564 0.73 33 hrs 3 mins
72 GeForce GTX 950M
GM107 [GeForce GTX 950M] 1439
Nvidia GM107 91,678 131,093 0.70 34 hrs 19 mins
73 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 90,189 136,299 0.66 36 hrs 16 mins
74 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 74,711 121,655 0.61 39 hrs 5 mins
75 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 74,192 113,214 0.66 37 hrs 37 mins
76 GeForce GTX 860M
GM107 [GeForce GTX 860M] 1389
Nvidia GM107 67,066 114,205 0.59 41 hrs 52 mins
77 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 62,509 81,101 0.77 31 hrs 8 mins
78 GeForce GTX 660
GK106 [GeForce GTX 660]
Nvidia GK106 50,358 97,545 0.52 46 hrs 29 mins
79 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 40,335 82,358 0.49 49 hrs 0 mins
80 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 38,376 81,101 0.47 51 hrs 43 mins
81 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 35,856 81,101 0.44 54 hrs 17 mins
82 GeForce GT 755M
GK107 [GeForce GT 755M]
Nvidia GK107 17,433 81,101 0.21 112 hrs 39 mins
83 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 13,200 81,101 0.16 147 hrs 27 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 22 May 2022 15:22:29

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make