PROJECT #18601 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression.

Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease.

There are three dominant alleles (versions) of ApoE that are found in humans.

Each ApoE allele differs only by a single amino acid substitution.

ApoE3 is most common and carries a neutral risk for AD.

Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease.

Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease.

How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression.

Here, we will simulate how one variant of ApoE move in solution.

We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease..

PROJECT INFO

Manager(s): Upasana Mallimadugula

Institution: Washington University in St. Louis

Project URL: https://dbbs.wustl.edu/curstudents/Pages/student_bio.aspx?SID=7595

PROJECT WORK UNIT SUMMARY

Atoms: 308,197

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 03 October 2022 12:16:27

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 10,010,663 621,991 16.09 1 hrs 29 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,541,768 580,253 14.72 2 hrs 38 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 8,152,036 575,862 14.16 2 hrs 42 mins
4 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 7,377,609 561,782 13.13 2 hrs 50 mins
5 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,127,067 553,080 12.89 2 hrs 52 mins
6 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 6,560,316 537,345 12.21 2 hrs 58 mins
7 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,243,678 502,330 10.44 2 hrs 18 mins
8 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 5,024,434 493,253 10.19 2 hrs 21 mins
9 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,749,787 482,627 9.84 2 hrs 26 mins
10 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,492,979 473,810 9.48 3 hrs 32 mins
11 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 4,399,618 468,478 9.39 3 hrs 33 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,163,053 463,827 8.98 3 hrs 40 mins
13 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,080,226 454,049 8.99 3 hrs 40 mins
14 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,563,474 443,219 8.04 3 hrs 59 mins
15 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,445,714 432,337 7.97 3 hrs 1 mins
16 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,181,638 425,332 7.48 3 hrs 13 mins
17 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 3,144,339 423,965 7.42 3 hrs 14 mins
18 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 3,038,259 419,464 7.24 3 hrs 19 mins
19 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,949,826 412,658 7.15 3 hrs 21 mins
20 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,905,705 413,970 7.02 3 hrs 25 mins
21 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,787,178 408,169 6.83 4 hrs 31 mins
22 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,759,612 402,735 6.85 4 hrs 30 mins
23 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,656,477 400,928 6.63 4 hrs 37 mins
24 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,411,173 384,378 6.27 4 hrs 50 mins
25 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,123,468 371,241 5.72 4 hrs 12 mins
26 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,074,728 369,258 5.62 4 hrs 16 mins
27 GeForce RTX 2080 Mobile
TU104M [GeForce RTX 2080 Mobile]
Nvidia TU104M 2,071,268 370,572 5.59 4 hrs 18 mins
28 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,052,485 365,029 5.62 4 hrs 16 mins
29 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,973,289 359,694 5.49 4 hrs 22 mins
30 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,945,225 360,745 5.39 4 hrs 27 mins
31 GeForce RTX 2070 SUPER Mobile / Max-Q
TU104M [GeForce RTX 2070 SUPER Mobile / Max-Q]
Nvidia TU104M 1,789,394 353,242 5.07 5 hrs 44 mins
32 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,728,593 350,817 4.93 5 hrs 52 mins
33 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,671,056 329,743 5.07 5 hrs 44 mins
34 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,486,482 317,825 4.68 5 hrs 8 mins
35 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,405,630 321,679 4.37 5 hrs 30 mins
36 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,399,592 285,442 4.90 5 hrs 54 mins
37 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,396,484 295,206 4.73 5 hrs 4 mins
38 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,304,592 324,832 4.02 6 hrs 59 mins
39 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,257,885 321,388 3.91 6 hrs 8 mins
40 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,169,057 304,443 3.84 6 hrs 15 mins
41 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,152,187 312,824 3.68 7 hrs 31 mins
42 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,144,616 319,023 3.59 7 hrs 41 mins
43 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,089,298 294,564 3.70 6 hrs 29 mins
44 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,042,444 263,496 3.96 6 hrs 4 mins
45 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,016,242 301,312 3.37 7 hrs 7 mins
46 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 950,011 291,022 3.26 7 hrs 21 mins
47 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 915,031 268,379 3.41 7 hrs 2 mins
48 P104-100
GP104 [P104-100]
Nvidia GP104 896,364 280,736 3.19 8 hrs 31 mins
49 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 885,124 275,376 3.21 7 hrs 28 mins
50 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 741,775 266,662 2.78 9 hrs 38 mins
51 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 705,961 265,174 2.66 9 hrs 1 mins
52 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 699,799 257,116 2.72 9 hrs 49 mins
53 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 668,038 251,407 2.66 9 hrs 2 mins
54 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 658,410 251,317 2.62 9 hrs 10 mins
55 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 628,253 248,927 2.52 10 hrs 31 mins
56 Quadro M5000
GM204GL [Quadro M5000]
Nvidia GM204GL 515,434 232,406 2.22 11 hrs 49 mins
57 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 468,922 222,860 2.10 11 hrs 24 mins
58 P106-100
GP106 [P106-100]
Nvidia GP106 430,129 231,262 1.86 13 hrs 54 mins
59 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 410,994 220,283 1.87 13 hrs 52 mins
60 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 380,001 202,449 1.88 13 hrs 47 mins
61 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 366,369 206,629 1.77 14 hrs 32 mins
62 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 345,651 204,601 1.69 14 hrs 12 mins
63 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 311,677 198,733 1.57 15 hrs 18 mins
64 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 309,201 200,958 1.54 16 hrs 36 mins
65 P106-090
GP106 [P106-090]
Nvidia GP106 306,239 193,976 1.58 15 hrs 12 mins
66 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 301,038 192,327 1.57 15 hrs 20 mins
67 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 298,399 179,389 1.66 14 hrs 26 mins
68 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 289,875 190,902 1.52 16 hrs 48 mins
69 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 273,054 194,704 1.40 17 hrs 7 mins
70 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 221,158 172,149 1.28 19 hrs 41 mins
71 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 188,837 149,895 1.26 19 hrs 3 mins
72 T600
TU117GL [T600]
Intel TU117GL 185,214 155,540 1.19 20 hrs 9 mins
73 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 172,261 160,259 1.07 22 hrs 20 mins
74 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 129,146 148,412 0.87 28 hrs 35 mins
75 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 125,935 145,883 0.86 28 hrs 48 mins
76 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 114,705 140,606 0.82 29 hrs 25 mins
77 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 103,419 137,202 0.75 32 hrs 50 mins
78 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 97,327 146,768 0.66 36 hrs 12 mins
79 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 97,289 132,985 0.73 33 hrs 48 mins
80 GeForce GTX 750
GM107 [GeForce GTX 750] 1111
Nvidia GM107 96,968 133,564 0.73 33 hrs 3 mins
81 GeForce GTX 950M
GM107 [GeForce GTX 950M] 1439
Nvidia GM107 91,678 131,093 0.70 34 hrs 19 mins
82 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 88,740 138,726 0.64 38 hrs 31 mins
83 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 74,676 122,237 0.61 39 hrs 17 mins
84 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 73,668 112,940 0.65 37 hrs 48 mins
85 GeForce GTX 660
GK106 [GeForce GTX 660] 1981
Nvidia GK106 67,181 105,824 0.63 38 hrs 48 mins
86 GeForce GTX 860M
GM107 [GeForce GTX 860M] 1389
Nvidia GM107 67,066 114,205 0.59 41 hrs 52 mins
87 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 62,509 81,101 0.77 31 hrs 8 mins
88 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 50,883 93,342 0.55 44 hrs 2 mins
89 GeForce GTX 660
GK106 [GeForce GTX 660]
Nvidia GK106 50,358 97,545 0.52 46 hrs 29 mins
90 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 40,335 82,358 0.49 49 hrs 0 mins
91 Quadro P400
GP107GL [Quadro P400]
Nvidia GP107GL 34,928 81,101 0.43 56 hrs 44 mins
92 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 32,839 81,101 0.40 59 hrs 16 mins
93 GeForce GT 755M
GK107 [GeForce GT 755M]
Nvidia GK107 17,433 81,101 0.21 112 hrs 39 mins
94 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 13,200 81,101 0.16 147 hrs 27 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 03 October 2022 12:16:27

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make