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Research: CANCER Folding Project #18493

Project #18493 overview

Project Summary AI Beta

This project is trying out a new computer simulation method called 'expanded-ensemble' to predict how well drugs dissolve in water versus oily substances. This helps figure out if a drug will be effective because its solubility affects how much of the drug reaches the body.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Prof. Vincent Voelz
Institution
Temple University

Work unit

Atoms
17,700
Core
0xa8
Status
Public
Source material

Official Project Description

A key challenge in computational drug discovery is developing and testing methods to predict experimental partition coefficients for the relative solubility of organic molecules in aqueous vs.

non-polar media.

The logarithm of the partition coeffient, logP, is an important predictor of lipophilicity, which dictates the bioavailability of drugs.

This CPU project is testing expanded-ensemble (EE) simulations as a method for the calculation of logP..

Performance data

Hardware Performance for Project 18493

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:50:49

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN THREADRIPPER 7980X 64-CORES 64 18,070 1,156,480 AMD
2 RYZEN 9 7950X 16-CORE 32 36,047 1,153,504 AMD
3 12TH GEN CORE I9-12900K 24 41,783 1,002,792 Intel
4 RYZEN 9 9950X 16-CORE 32 28,967 926,944 AMD
5 RYZEN THREADRIPPER 3960X 24-CORE 48 15,163 727,824 AMD
6 RYZEN 9 7900X 12-CORE 24 29,779 714,696 AMD
7 RYZEN 9 7900 12-CORE 24 26,577 637,848 AMD
8 RYZEN 9 5950X 16-CORE 32 18,821 602,272 AMD
9 13TH GEN CORE I9-13900K 32 18,263 584,416 Intel
10 RYZEN 7 7700X 8-CORE 16 34,679 554,864 AMD
11 RYZEN 7 7800X3D 8-CORE 16 34,055 544,880 AMD
12 CORE I5-14600K 20 26,209 524,180 Intel
13 12TH GEN CORE I7-12700K 20 24,542 490,840 Intel
14 RYZEN 9 7950X3D 16-CORE 32 14,931 477,792 AMD
15 RYZEN 5 7600 6-CORE 12 36,888 442,656 AMD
16 APPLE M2 ULTRA 24 18,202 436,848 Apple
17 RYZEN 7 5800X 8-CORE 16 24,373 389,968 AMD
18 RYZEN 7 5800X3D 8-CORE 16 24,285 388,560 AMD
19 12TH GEN CORE I7-12700F 20 19,118 382,360 Intel
20 XEON CPU E5-2696 V4 @ 2.20GHZ 44 8,680 381,920 Intel
21 RYZEN 7 3800X 8-CORE 16 22,634 362,144 AMD
22 RYZEN 7 5700X 8-CORE 16 22,312 356,992 AMD
23 RYZEN 5 7600X 6-CORE 12 29,243 350,916 AMD
24 13TH GEN CORE I5-13600K 14 24,686 345,604 Intel
25 RYZEN 9 5900 12-CORE 24 13,904 333,696 AMD
26 RYZEN 9 3900X 12-CORE 24 12,706 304,944 AMD
27 11TH GEN CORE I7-11700K @ 3.60GHZ 16 18,284 292,544 Intel
28 RYZEN 9 5900X 12-CORE 24 11,985 287,640 AMD
29 CORE I9-14900KF 24 11,555 277,320 Intel
30 XEON CPU E5-2680 V2 @ 2.80GHZ 40 6,834 273,360 Intel
31 RYZEN 7 7700 8-CORE 16 16,830 269,280 AMD
32 CORE I7-10700K CPU @ 3.80GHZ 16 15,889 254,224 Intel
33 EPYC 7B12 64-CORE 64 3,940 252,160 AMD
34 CORE I7-7820X CPU @ 3.60GHZ 16 15,538 248,608 Intel
35 CORE I9-10900K CPU @ 3.70GHZ 20 12,142 242,840 Intel
36 CORE I9-14900K 32 7,574 242,368 Intel
37 RYZEN 7 5700X3D 8-CORE 16 15,138 242,208 AMD
38 RYZEN THREADRIPPER 2990WX 32-CORE 64 3,756 240,384 AMD
39 RYZEN 7 5700G 16 14,557 232,912 AMD
40 13TH GEN CORE I7-13700 24 9,699 232,776 Intel
41 RYZEN 5 5600 6-CORE 12 19,026 228,312 AMD
42 XEON CPU E7-8894 V4 @ 2.40GHZ 48 4,666 223,968 Intel
43 RYZEN 5 5600X 6-CORE 12 18,456 221,472 AMD
44 RYZEN 9 3900XT 12-CORE 24 9,129 219,096 AMD
45 11TH GEN CORE I7-11700KF @ 3.60GHZ 16 12,413 198,608 Intel
46 RYZEN 5 5600G 12 16,453 197,436 AMD
47 RYZEN Z1 EXTREME 16 12,243 195,888 AMD
48 CORE I7-10700 CPU @ 2.90GHZ 16 11,980 191,680 Intel
49 RYZEN 7 5800H 16 11,579 185,264 AMD
50 RYZEN 9 3900 12-CORE 24 7,552 181,248 AMD
51 CORE I5-8600K CPU @ 3.60GHZ 6 29,278 175,668 Intel
52 11TH GEN CORE I7-11700F @ 2.50GHZ 16 10,892 174,272 Intel
53 CORE I5-10400 CPU @ 2.90GHZ 12 13,859 166,308 Intel
54 CORE I5-10600KF CPU @ 4.10GHZ 12 13,371 160,452 Intel
55 RYZEN 7 2700X EIGHT-CORE 16 9,714 155,424 AMD
56 11TH GEN CORE I7-11800H @ 2.30GHZ 16 9,696 155,136 Intel
57 RYZEN 5 3600 6-CORE 12 12,593 151,116 AMD
58 RYZEN 7 3700X 8-CORE 16 9,007 144,112 AMD
59 11TH GEN CORE I7-11850H @ 2.50GHZ 16 8,362 133,792 Intel
60 CORE I7-5930K CPU @ 3.50GHZ 12 10,995 131,940 Intel
61 RYZEN 5 5600H 12 10,300 123,600 AMD
62 CORE I7-7700K CPU @ 4.20GHZ 8 15,291 122,328 Intel
63 CORE I9-8950HK CPU @ 2.90GHZ 12 10,181 122,172 Intel
64 11TH GEN CORE I9-11900F @ 2.50GHZ 16 7,491 119,856 Intel
65 CORE I7-5820K CPU @ 3.30GHZ 12 9,842 118,104 Intel
66 13TH GEN CORE I5-13500 20 5,863 117,260 Intel
67 CORE I7-8700K CPU @ 3.70GHZ 12 9,433 113,196 Intel
68 XEON SILVER 4114 CPU @ 2.20GHZ 40 2,703 108,120 Intel
69 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 12,223 97,784 Intel
70 CORE I7-10700T CPU @ 2.00GHZ 16 6,075 97,200 Intel
71 RYZEN 5 2600X SIX-CORE 12 7,990 95,880 AMD
72 CORE I7-8700 CPU @ 3.20GHZ 12 7,743 92,916 Intel
73 CORE I5-5675R CPU @ 3.10GHZ 4 22,750 91,000 Intel
74 APPLE M2 PRO 10 8,936 89,360 Apple
75 CORE I7-8705G CPU @ 3.10GHZ 8 11,016 88,128 Intel
76 EPYC 7543P 32-CORE 8 10,929 87,432 AMD
77 CORE I7-4790K CPU @ 4.00GHZ 8 10,437 83,496 Intel
78 12TH GEN CORE I7-12700H 20 4,121 82,420 Intel
79 CORE I7-4770HQ CPU @ 2.20GHZ 8 10,261 82,088 Intel
80 XEON CPU E3-1270 V5 @ 3.60GHZ 8 10,098 80,784 Intel
81 CORE I5-4690 CPU @ 3.50GHZ 4 19,246 76,984 Intel
82 CORE I7-9750H CPU @ 2.60GHZ 12 5,973 71,676 Intel
83 XEON CPU X5680 @ 3.33GHZ 12 5,676 68,112 Intel
84 CORE I5-10300H CPU @ 2.50GHZ 8 8,376 67,008 Intel
85 CORE I5-9600K CPU @ 3.70GHZ 6 10,964 65,784 Intel
86 CORE I7-3770K CPU @ 3.50GHZ 8 7,897 63,176 Intel
87 11TH GEN CORE I5-11400 @ 2.60GHZ 12 5,145 61,740 Intel
88 CORE I5-6500 CPU @ 3.20GHZ 4 15,181 60,724 Intel
89 CORE I7-4770 CPU @ 3.40GHZ 8 7,496 59,968 Intel
90 XEON CPU E5-2697 V2 @ 2.70GHZ 24 2,431 58,344 Intel
91 11TH GEN CORE I7-11700 @ 2.50GHZ 16 3,585 57,360 Intel
92 CORE I7-3770 CPU @ 3.40GHZ 8 7,123 56,984 Intel
93 APPLE M1 PRO 10 5,690 56,900 Apple
94 APPLE M1 8 6,990 55,920 Apple
95 CORE I7-7700HQ CPU @ 2.80GHZ 8 6,974 55,792 Intel
96 CORE I5-4590 CPU @ 3.30GHZ 4 13,844 55,376 Intel
97 XEON CPU E5-1620 V2 @ 3.70GHZ 8 6,828 54,624 Intel
98 CORE I5-9300H CPU @ 2.40GHZ 8 6,678 53,424 Intel
99 XEON CPU E5-2680 0 @ 2.70GHZ 16 3,248 51,968 Intel
100 XEON CPU E5-1620 0 @ 3.60GHZ 8 6,215 49,720 Intel
101 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 6,047 48,376 Intel
102 CORE I5-10400F CPU @ 2.90GHZ 12 3,945 47,340 Intel
103 CORE I5-3470S CPU @ 2.90GHZ 4 11,553 46,212 Intel
104 CORE I7-6700K CPU @ 4.00GHZ 8 5,767 46,136 Intel
105 RYZEN 5 5500U 12 3,737 44,844 AMD
106 12TH GEN CORE I5-1235U 12 3,472 41,664 Intel
107 XEON CPU E5-1630 V3 @ 3.70GHZ 8 5,184 41,472 Intel
108 CORE I5-8400 CPU @ 2.80GHZ 6 6,873 41,238 Intel
109 12TH GEN CORE I7-12700KF 20 2,058 41,160 Intel
110 XEON CPU X5650 @ 2.67GHZ 12 3,341 40,092 Intel
111 CORE I7-4770K CPU @ 3.50GHZ 8 4,942 39,536 Intel
112 11TH GEN CORE I7-1185G7 @ 3.00GHZ 8 4,888 39,104 Intel
113 11TH GEN CORE I5-1145G7 @ 2.60GHZ 8 4,852 38,816 Intel
114 CORE I7-6700 CPU @ 3.40GHZ 8 4,730 37,840 Intel
115 RYZEN 5 1400 QUAD-CORE 8 4,434 35,472 AMD
116 12TH GEN CORE I7-12700 20 1,644 32,880 Intel
117 CORE I7-8665U CPU @ 1.90GHZ 8 3,727 29,816 Intel
118 CORE I7-14700K 28 1,042 29,176 Intel
119 CORE I7-7600U CPU @ 2.80GHZ 4 6,529 26,116 Intel
120 12TH GEN CORE I5-12600KF 16 1,566 25,056 Intel
121 CORE I7-2760QM CPU @ 2.40GHZ 8 2,948 23,584 Intel
122 XEON CPU E5540 @ 2.53GHZ 16 1,335 21,360 Intel
123 CORE I7-8550U CPU @ 1.80GHZ 8 2,627 21,016 Intel
124 CORE I5-4200M CPU @ 2.50GHZ 4 5,146 20,584 Intel
125 CORE I3-4160T CPU @ 3.10GHZ 4 4,904 19,616 Intel
126 CORE I5-4570S CPU @ 2.90GHZ 4 4,452 17,808 Intel
127 CORE I3-2120 CPU @ 3.30GHZ 4 3,881 15,524 Intel
128 CORE I5-2400 CPU @ 3.10GHZ 4 3,722 14,888 Intel
129 CORE I5-3210M CPU @ 2.50GHZ 4 3,378 13,512 Intel
130 13TH GEN CORE I5-13400F 16 827 13,232 Intel
131 CORE I3-3110M CPU @ 2.40GHZ 4 3,080 12,320 Intel
132 CORE I3-6006U CPU @ 2.00GHZ 4 2,567 10,268 Intel
133 CORE I7-6500U CPU @ 2.50GHZ 4 1,619 6,476 Intel