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Research: CANCER Folding Project #18490

Project #18490 overview

Project Summary AI Beta

This project tries to figure out how well medicines dissolve in water vs. fat using computer simulations. The project relates to a measure called logP, which helps predict if a medicine will work properly in the body.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Prof. Vincent Voelz
Institution
Temple University

Work unit

Atoms
21,100
Core
0xa8
Status
Public
Source material

Official Project Description

A key challenge in computational drug discovery is developing and testing methods to predict experimental partition coefficients for the relative solubility of organic molecules in aqueous vs.

non-polar media.

The logarithm of the partition coeffient, logP, is an important predictor of lipophilicity, which dictates the bioavailability of drugs.

This CPU project is testing expanded-ensemble (EE) simulations as a method for the calculation of logP..

Performance data

Hardware Performance for Project 18490

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:50:52

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN THREADRIPPER PRO 9975WX 32-CORES 64 43,909 2,810,176 AMD
2 RYZEN 9 9950X 16-CORE 32 60,844 1,947,008 AMD
3 RYZEN 7 9700X 8-CORE 16 108,376 1,734,016 AMD
4 RYZEN 9 9900X 12-CORE 24 67,548 1,621,152 AMD
5 RYZEN THREADRIPPER 7980X 64-CORES 64 22,865 1,463,360 AMD
6 CORE I9-10920X CPU @ 3.50GHZ 24 53,418 1,282,032 Intel
7 RYZEN 9 7950X 16-CORE 32 35,203 1,126,496 AMD
8 RYZEN 9 9950X3D 16-CORE 32 33,617 1,075,744 AMD
9 RYZEN 9 7900X 12-CORE 24 29,839 716,136 AMD
10 RYZEN 9 7950X3D 16-CORE 32 20,922 669,504 AMD
11 RYZEN 7 7700 8-CORE 16 40,540 648,640 AMD
12 RYZEN THREADRIPPER 3960X 24-CORE 48 13,445 645,360 AMD
13 RYZEN 9 7900 12-CORE 24 26,663 639,912 AMD
14 RYZEN 9 5950X 16-CORE 32 17,589 562,848 AMD
15 12TH GEN CORE I9-12900K 24 23,322 559,728 Intel
16 RYZEN 7 7700X 8-CORE 16 33,973 543,568 AMD
17 RYZEN 7 7800X3D 8-CORE 16 33,954 543,264 AMD
18 RYZEN 9 5900XT 16-CORE 32 15,650 500,800 AMD
19 CORE I5-14600K 20 24,231 484,620 Intel
20 RYZEN 5 7600 6-CORE 12 40,097 481,164 AMD
21 RYZEN 5 7600X 6-CORE 12 38,771 465,252 AMD
22 APPLE M3 PRO 12 37,629 451,548 Apple
23 12TH GEN CORE I7-12700K 20 22,427 448,540 Intel
24 RYZEN 7 5800X3D 8-CORE 16 25,939 415,024 AMD
25 RYZEN 7 3800X 8-CORE 16 25,765 412,240 AMD
26 RYZEN 9 3900X 12-CORE 24 17,097 410,328 AMD
27 RYZEN 7 5700X 8-CORE 16 24,315 389,040 AMD
28 APPLE M2 ULTRA 24 15,787 378,888 Apple
29 12TH GEN CORE I7-12700F 20 18,678 373,560 Intel
30 RYZEN 5 5500 12 30,710 368,520 AMD
31 EPYC 7713 64-CORE 64 5,721 366,144 AMD
32 RYZEN 7 5800X 8-CORE 16 22,782 364,512 AMD
33 XEON CPU E5-2696 V4 @ 2.20GHZ 44 8,193 360,492 Intel
34 13TH GEN CORE I5-13500 20 16,837 336,740 Intel
35 RYZEN 9 5900X 12-CORE 24 13,735 329,640 AMD
36 RYZEN 5 5600 6-CORE 12 27,183 326,196 AMD
37 RYZEN 5 7500F 6-CORE 12 27,023 324,276 AMD
38 CORE I9-14900K 32 9,966 318,912 Intel
39 13TH GEN CORE I5-13600KF 20 15,878 317,560 Intel
40 13TH GEN CORE I5-13600K 14 21,355 298,970 Intel
41 13TH GEN CORE I9-13900K 32 9,222 295,104 Intel
42 RYZEN 7 8845HS W/ RADEON(TM) 780M GRAPHICS 16 16,902 270,432 AMD
43 RYZEN 9 6900HX 16 16,232 259,712 AMD
44 APPLE M4 PRO 14 18,112 253,568 Apple
45 CORE I7-10700K CPU @ 3.80GHZ 16 15,381 246,096 Intel
46 XEON CPU E5-2680 V2 @ 2.80GHZ 40 6,124 244,960 Intel
47 RYZEN 9 5900 12-CORE 24 10,172 244,128 AMD
48 12TH GEN CORE I5-12600K 16 14,753 236,048 Intel
49 EPYC 7B12 64-CORE 64 3,682 235,648 AMD
50 RYZEN 7 5700G 16 14,253 228,048 AMD
51 11TH GEN CORE I7-11700K @ 3.60GHZ 16 13,842 221,472 Intel
52 13TH GEN CORE I7-13700 24 9,152 219,648 Intel
53 RYZEN 5 5600X 6-CORE 12 18,214 218,568 AMD
54 XEON CPU E3-1270 V6 @ 3.80GHZ 8 25,944 207,552 Intel
55 12TH GEN CORE I5-12400 12 16,889 202,668 Intel
56 RYZEN 7 2700X EIGHT-CORE 16 12,613 201,808 AMD
57 RYZEN 9 3900XT 12-CORE 24 8,361 200,664 AMD
58 RYZEN 5 5600G 12 15,749 188,988 AMD
59 CORE I5-8600K CPU @ 3.60GHZ 6 30,328 181,968 Intel
60 CORE I7-9700 CPU @ 3.00GHZ 8 21,870 174,960 Intel
61 CORE I9-14900KF 24 6,961 167,064 Intel
62 RYZEN 7 5800H 16 10,406 166,496 AMD
63 12TH GEN CORE I3-12100 8 20,275 162,200 Intel
64 CORE I7-8700 CPU @ 3.20GHZ 12 13,203 158,436 Intel
65 CORE I5-9400F CPU @ 2.90GHZ 6 25,358 152,148 Intel
66 CORE I7-9700K CPU @ 3.60GHZ 8 18,996 151,968 Intel
67 11TH GEN CORE I7-11700F @ 2.50GHZ 16 9,279 148,464 Intel
68 CORE I9-10900K CPU @ 3.70GHZ 20 7,218 144,360 Intel
69 RYZEN 5 3600 6-CORE 12 11,286 135,432 AMD
70 CORE I9-8950HK CPU @ 2.90GHZ 12 11,234 134,808 Intel
71 CORE I7-5930K CPU @ 3.50GHZ 12 11,063 132,756 Intel
72 CORE I7-7820X CPU @ 3.60GHZ 16 8,225 131,600 Intel
73 CORE I7-7700K CPU @ 4.20GHZ 8 16,430 131,440 Intel
74 CORE I5-10500T CPU @ 2.30GHZ 12 10,862 130,344 Intel
75 11TH GEN CORE I9-11900 @ 2.50GHZ 16 7,985 127,760 Intel
76 XEON CPU X5690 @ 3.47GHZ 24 5,058 121,392 Intel
77 CORE I5-10600T CPU @ 2.40GHZ 12 10,042 120,504 Intel
78 RYZEN 7 3700X 8-CORE 16 7,365 117,840 AMD
79 XEON SILVER 4114 CPU @ 2.20GHZ 40 2,929 117,160 Intel
80 CORE I5-10600KF CPU @ 4.10GHZ 12 9,576 114,912 Intel
81 CORE I7-8700K CPU @ 3.70GHZ 12 9,485 113,820 Intel
82 CORE I5-8600 CPU @ 3.10GHZ 6 18,693 112,158 Intel
83 CORE I5-9600T CPU @ 2.30GHZ 6 18,655 111,930 Intel
84 CORE I7-5820K CPU @ 3.30GHZ 12 9,265 111,180 Intel
85 APPLE M3 8 13,848 110,784 Apple
86 CORE I5-8600T CPU @ 2.30GHZ 6 18,384 110,304 Intel
87 CORE I7-8700T CPU @ 2.40GHZ 12 8,781 105,372 Intel
88 XEON E-2144G CPU @ 3.60GHZ 8 13,089 104,712 Intel
89 CORE I5-10400 CPU @ 2.90GHZ 12 8,459 101,508 Intel
90 CORE I9-7940X CPU @ 3.10GHZ 28 3,591 100,548 Intel
91 CORE I7-7700 CPU @ 3.60GHZ 8 12,466 99,728 Intel
92 11TH GEN CORE I9-11900F @ 2.50GHZ 16 6,192 99,072 Intel
93 12TH GEN CORE I5-1235U 12 8,244 98,928 Intel
94 11TH GEN CORE I7-11850H @ 2.50GHZ 16 6,139 98,224 Intel
95 CORE I7-8705G CPU @ 3.10GHZ 8 12,008 96,064 Intel
96 XEON CPU E3-1240 V5 @ 3.50GHZ 8 11,923 95,384 Intel
97 CORE I7-10700T CPU @ 2.00GHZ 16 5,861 93,776 Intel
98 CORE I5-14500 20 4,575 91,500 Intel
99 CORE I3-10100F CPU @ 3.60GHZ 8 11,420 91,360 Intel
100 XEON CPU E3-1270 V5 @ 3.60GHZ 8 11,236 89,888 Intel
101 CORE I7-4930K CPU @ 3.40GHZ 12 7,468 89,616 Intel
102 RYZEN 5 2600X SIX-CORE 12 7,294 87,528 AMD
103 CORE I5-5675R CPU @ 3.10GHZ 4 21,456 85,824 Intel
104 CORE I3-10100 CPU @ 3.60GHZ 8 10,651 85,208 Intel
105 CORE I5-10400F CPU @ 2.90GHZ 12 6,973 83,676 Intel
106 12TH GEN CORE I7-12700H 20 4,150 83,000 Intel
107 CORE I7-4790K CPU @ 4.00GHZ 8 10,272 82,176 Intel
108 CORE I7-9750H CPU @ 2.60GHZ 12 6,764 81,168 Intel
109 CORE I5-7400 CPU @ 3.00GHZ 4 20,168 80,672 Intel
110 APPLE M2 8 9,877 79,016 Apple
111 XEON CPU E5-2697 V2 @ 2.70GHZ 24 3,130 75,120 Intel
112 CORE I5-4690 CPU @ 3.50GHZ 4 18,089 72,356 Intel
113 EPYC 7543P 32-CORE 8 9,011 72,088 AMD
114 CORE I5-6600T CPU @ 2.70GHZ 4 17,940 71,760 Intel
115 CORE I7-4770HQ CPU @ 2.20GHZ 8 8,752 70,016 Intel
116 CORE I5-6500 CPU @ 3.20GHZ 4 16,939 67,756 Intel
117 CORE I5-6500T CPU @ 2.50GHZ 4 16,200 64,800 Intel
118 RYZEN 5 3400G 8 7,828 62,624 AMD
119 XEON CPU E5-2680 0 @ 2.70GHZ 16 3,872 61,952 Intel
120 CORE I7-6700K CPU @ 4.00GHZ 8 7,628 61,024 Intel
121 11TH GEN CORE I7-1185G7 @ 3.00GHZ 8 7,608 60,864 Intel
122 XEON CPU E3-1245 V3 @ 3.40GHZ 8 7,566 60,528 Intel
123 CORE I7-3770K CPU @ 3.50GHZ 8 7,501 60,008 Intel
124 CORE I7-4770 CPU @ 3.40GHZ 8 7,350 58,800 Intel
125 XEON CPU E5-1620 V2 @ 3.70GHZ 8 7,082 56,656 Intel
126 RYZEN 5 5600H 12 4,719 56,628 AMD
127 CORE I5-9300H CPU @ 2.40GHZ 8 6,717 53,736 Intel
128 CORE I5-4590 CPU @ 3.30GHZ 4 13,423 53,692 Intel
129 CORE I7-7700HQ CPU @ 2.80GHZ 8 6,350 50,800 Intel
130 APPLE M1 8 6,262 50,096 Apple
131 CORE I7-3770 CPU @ 3.40GHZ 8 5,855 46,840 Intel
132 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 5,791 46,328 Intel
133 APPLE M1 PRO 10 4,631 46,310 Apple
134 CORE I5-3470S CPU @ 2.90GHZ 4 11,367 45,468 Intel
135 CORE I5-8350U CPU @ 1.70GHZ 8 5,575 44,600 Intel
136 XEON CPU E5-1620 0 @ 3.60GHZ 8 5,542 44,336 Intel
137 CORE I7-4770K CPU @ 3.50GHZ 8 5,488 43,904 Intel
138 XEON CPU E5-1630 V3 @ 3.70GHZ 8 5,380 43,040 Intel
139 CORE I5-4570S CPU @ 2.90GHZ 4 10,548 42,192 Intel
140 CORE I7-4850HQ CPU @ 2.30GHZ 8 5,125 41,000 Intel
141 RYZEN 7 4800U 16 2,453 39,248 AMD
142 CORE I7-8665U CPU @ 1.90GHZ 8 4,842 38,736 Intel
143 11TH GEN CORE I7-11700 @ 2.50GHZ 16 2,352 37,632 Intel
144 XEON CPU E31245 @ 3.30GHZ 8 4,523 36,184 Intel
145 12TH GEN CORE I5-12450H 12 2,821 33,852 Intel
146 RYZEN 5 5500U 12 2,789 33,468 AMD
147 12TH GEN CORE I7-12700 20 1,412 28,240 Intel
148 CORE I7-7600U CPU @ 2.80GHZ 4 7,002 28,008 Intel
149 XEON CPU X5650 @ 2.67GHZ 12 2,238 26,856 Intel
150 CORE I7-6700 CPU @ 3.40GHZ 8 3,270 26,160 Intel
151 12TH GEN CORE I5-12600KF 16 1,537 24,592 Intel
152 CORE I5-8365U CPU @ 1.60GHZ 8 2,887 23,096 Intel
153 CORE I7-2600 CPU @ 3.40GHZ 8 2,767 22,136 Intel
154 CORE I3-4160T CPU @ 3.10GHZ 4 5,280 21,120 Intel
155 XEON CPU X5667 @ 3.07GHZ 8 2,454 19,632 Intel
156 CORE I3-2120 CPU @ 3.30GHZ 4 4,624 18,496 Intel
157 CORE I7-14650HX 24 699 16,776 Intel
158 13TH GEN CORE I5-13400F 16 829 13,264 Intel
159 CORE I3-3110M CPU @ 2.40GHZ 4 3,121 12,484 Intel
160 CORE I7 CPU 975 @ 3.33GHZ 8 1,544 12,352 Intel
161 CORE I3-6006U CPU @ 2.00GHZ 4 3,068 12,272 Intel
162 CORE I3-6100 CPU @ 3.70GHZ 4 1,999 7,996 Intel
163 CORE I5-2520M CPU @ 2.50GHZ 4 1,644 6,576 Intel
164 CORE I7-6500U CPU @ 2.50GHZ 4 1,254 5,016 Intel