PROJECT #18454 RESEARCH FOR BIOFILM
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Biofilms are aggregations of bacteria that occur in response to external stresses.

They are found in natural, industrial, and clinical environments, where they can be an impediment to effective antibiotic treatments.

In Pseudomonas fluorescens, this process is initiated by the Lap system, particularly the LapA adhesin.

LapG, a periplasmic protease, cleaves the N-terminus of LapA, releasing it from its adherent surface and inhibiting the ability to form a biofilm.

LapG’s ability to cleave LapA is prevented by LapD, which keeps the protease away from the cell surface through a unique protein-protein interaction (PPI) interface involving a highly conserved tryptophan of LapD. In an effort to develop molecules that can disrupt biofilm formation, the Bahl lab at the Institute for Protein Innovation has de novo designed high-affinity mini-proteins that mimic LapD and bind LapG.

In this collaborative project, the Voelz lab is using ab initio binding simulations of these mini-proteins to understand the binding mechanism, and investigate how sequence variability influences the binding reaction..

PROJECT INFO

Manager(s): Prof. Vincent Voelz

Institution: Temple University

PROJECT WORK UNIT SUMMARY

Atoms: 35,739

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 2,366,432 118,376 19.99 1 hrs 12 mins
2 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 1,973,686 112,141 17.60 1 hrs 22 mins
3 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,843,526 107,182 17.20 1 hrs 24 mins
4 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,838,048 107,840 17.04 1 hrs 24 mins
5 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,803,248 108,962 16.55 1 hrs 27 mins
6 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 1,783,168 108,233 16.48 1 hrs 27 mins
7 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,725,388 106,956 16.13 1 hrs 29 mins
8 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]
AMD Navi 21 1,645,661 92,655 17.76 1 hrs 21 mins
9 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 1,569,091 103,097 15.22 2 hrs 35 mins
10 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 1,530,806 101,710 15.05 2 hrs 36 mins
11 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,365,280 84,824 16.10 1 hrs 29 mins
12 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,315,038 97,301 13.52 2 hrs 47 mins
13 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,251,434 95,643 13.08 2 hrs 50 mins
14 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,240,256 95,626 12.97 2 hrs 51 mins
15 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,182,045 94,167 12.55 2 hrs 55 mins
16 GeForce GTX 1070 Mobile
GP104BM [GeForce GTX 1070 Mobile] 6463
Nvidia GP104BM 1,159,560 95,144 12.19 2 hrs 58 mins
17 Radeon RX 6650 XT
Navi 23 [Radeon RX 6650 XT]
AMD Navi 23 1,147,039 93,641 12.25 2 hrs 58 mins
18 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,140,678 93,235 12.23 2 hrs 58 mins
19 Radeon RX 6650XT
Navi 23 [Radeon RX 6650XT]
AMD Navi 23 1,135,470 93,502 12.14 2 hrs 59 mins
20 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,051,246 89,612 11.73 2 hrs 3 mins
21 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 1,039,085 90,193 11.52 2 hrs 5 mins
22 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,015,393 89,278 11.37 2 hrs 7 mins
23 Radeon RX 6700/6700 XT/6750 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT/6750 XT / 6800M]
AMD Navi 22 954,060 88,502 10.78 2 hrs 14 mins
24 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 888,552 82,338 10.79 2 hrs 13 mins
25 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 855,783 84,250 10.16 2 hrs 22 mins
26 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 850,372 83,163 10.23 2 hrs 21 mins
27 Quadro P4000
GP104GL [Quadro P4000]
Nvidia GP104GL 837,954 83,739 10.01 2 hrs 24 mins
28 Radeon PRO W6600
Navi 23 WKS-XL [Radeon PRO W6600]
AMD Navi 23 WKS-XL 832,207 78,794 10.56 2 hrs 16 mins
29 Radeon RX 6600/6600 XT/6600M
Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 XT-XL 822,547 81,591 10.08 2 hrs 23 mins
30 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 791,036 80,009 9.89 2 hrs 26 mins
31 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 766,128 80,720 9.49 3 hrs 32 mins
32 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 720,044 76,311 9.44 3 hrs 33 mins
33 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 716,275 79,240 9.04 3 hrs 39 mins
34 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 705,332 78,251 9.01 3 hrs 40 mins
35 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 704,691 79,566 8.86 3 hrs 43 mins
36 Tesla T4
TU104GL [Tesla T4]
Nvidia TU104GL 690,769 78,318 8.82 3 hrs 43 mins
37 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 668,484 76,852 8.70 3 hrs 46 mins
38 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 596,713 75,032 7.95 3 hrs 1 mins
39 RX 5600 OEM/5600XT/5700/5700XT
Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]
Navi 10 567,103 73,001 7.77 3 hrs 5 mins
40 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 555,763 73,397 7.57 3 hrs 10 mins
41 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 536,061 72,953 7.35 3 hrs 16 mins
42 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 522,634 57,594 9.07 3 hrs 39 mins
43 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 478,083 70,139 6.82 4 hrs 31 mins
44 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 466,148 68,965 6.76 4 hrs 33 mins
45 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 442,853 67,457 6.56 4 hrs 39 mins
46 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 428,534 67,462 6.35 4 hrs 47 mins
47 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 402,125 64,872 6.20 4 hrs 52 mins
48 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 392,913 66,436 5.91 4 hrs 3 mins
49 Radeon RX 6700/6700XT/6800M
Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]
AMD Navi 22 XT-XL 386,578 38,163 10.13 2 hrs 22 mins
50 RX 5500/5500M/Pro 5500M
Navi 14 [RX 5500/5500M/Pro 5500M]
Navi 14 380,853 65,178 5.84 4 hrs 6 mins
51 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 315,323 58,598 5.38 4 hrs 28 mins
52 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 309,585 60,217 5.14 5 hrs 40 mins
53 P106-090
GP106 [P106-090]
Nvidia GP106 305,487 60,332 5.06 5 hrs 44 mins
54 GeForce GTX 780 Ti
GK110 [GeForce GTX 780 Ti] 5046
Nvidia GK110 289,836 64,307 4.51 5 hrs 19 mins
55 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 269,667 58,149 4.64 5 hrs 11 mins
56 R9 290/390
Hawaii PRO [R9 290/390]
Hawaii PRO 249,872 56,392 4.43 5 hrs 25 mins
57 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 248,296 56,030 4.43 5 hrs 25 mins
58 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 244,419 55,878 4.37 5 hrs 29 mins
59 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 217,531 54,039 4.03 6 hrs 58 mins
60 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 205,798 51,278 4.01 6 hrs 59 mins
61 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 204,175 56,047 3.64 7 hrs 35 mins
62 Quadro T1000 Mobile
TU117GLM [Quadro T1000 Mobile]
Nvidia TU117GLM 203,994 54,773 3.72 6 hrs 27 mins
63 Radeon 680M
Rembrandt [Radeon 680M]
AMD Rembrandt 197,836 50,926 3.88 6 hrs 11 mins
64 Radeon R9 200/HD 7900/8970
Tahiti XT [Radeon R9 200/HD 7900/8970]
AMD Tahiti XT 162,559 49,509 3.28 7 hrs 19 mins
65 R9 380X/R9 M295X
Tonga XT/Amethyst XT [R9 380X/R9 M295X]
AMD Tonga XT/Amethyst XT 140,315 46,606 3.01 8 hrs 58 mins
66 RX Vega M GL
Polaris 22 XL [RX Vega M GL]
Polaris 22 XL 131,142 45,552 2.88 8 hrs 20 mins
67 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 126,770 44,992 2.82 9 hrs 31 mins
68 R9 280X/HD 7900/8970 OEM
Tahiti XT [R9 280X/HD 7900/8970 OEM]
Tahiti XT 114,665 43,402 2.64 9 hrs 5 mins
69 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 112,946 44,520 2.54 9 hrs 28 mins
70 GeForce MX450
TU117M [GeForce MX450]
Nvidia TU117M 106,525 39,834 2.67 9 hrs 58 mins
71 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 102,915 43,374 2.37 10 hrs 7 mins
72 Radeon RX 460/560D
Baffin [Radeon RX 460/560D]
AMD Baffin 92,676 39,810 2.33 10 hrs 19 mins
73 Radeon RX 460
Baffin XT [Radeon RX 460]
AMD Baffin XT 88,797 40,072 2.22 11 hrs 50 mins
74 Vega Mobile 5000 series APU
Cezanne [Vega Mobile 5000 series APU]
AMD Cezanne 67,099 38,198 1.76 14 hrs 40 mins
75 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 64,953 35,395 1.84 13 hrs 5 mins
76 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 63,364 35,627 1.78 13 hrs 30 mins
77 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 44,369 31,360 1.41 17 hrs 58 mins
78 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 41,576 31,944 1.30 18 hrs 26 mins
79 GeForce GTX 650 Ti
GK106 [GeForce GTX 650 Ti]
Nvidia GK106 37,219 30,102 1.24 19 hrs 25 mins
80 Radeon HD 5850
Cypress PRO [Radeon HD 5850]
AMD Cypress PRO 14,315 22,053 0.65 37 hrs 58 mins
81 R7 240/340
Hawaii [R7 240/340]
AMD Hawaii 10,606 22,445 0.47 51 hrs 47 mins
82 Radeon R7/R6/R5 Series
Carrizo [Radeon R7/R6/R5 Series]
AMD Carrizo 7,499 22,053 0.34 71 hrs 35 mins
83 Radeon APU A4-6000 R2
Mullins [Radeon APU A4-6000 R2]
AMD Mullins 2,785 22,053 0.13 190 hrs 3 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make