PROJECT #18445 RESEARCH FOR BIOFILM
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Biofilms are aggregations of bacteria that occur in response to external stresses.

They are found in natural, industrial, and clinical environments, where they can be an impediment to effective antibiotic treatments.

In Pseudomonas fluorescens, this process is initiated by the Lap system, particularly the LapA adhesin.

LapG, a periplasmic protease, cleaves the N-terminus of LapA, releasing it from its adherent surface and inhibiting the ability to form a biofilm.

LapG’s ability to cleave LapA is prevented by LapD, which keeps the protease away from the cell surface through a unique protein-protein interaction (PPI) interface involving a highly conserved tryptophan of LapD. In an effort to develop molecules that can disrupt biofilm formation, the Bahl lab at the Institute for Protein Innovation has de novo designed high-affinity mini-proteins that mimic LapD and bind LapG.

In this collaborative project, the Voelz lab is using ab initio binding simulations of these mini-proteins to understand the binding mechanism, and investigate how sequence variability influences the binding reaction..

PROJECT INFO

Manager(s): Prof. Vincent Voelz

Institution: Temple University

PROJECT WORK UNIT SUMMARY

Atoms: 60,369

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:26

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 6,343,133 304,897 20.80 1 hrs 9 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,111,213 135,214 45.20 1 hrs 32 mins
3 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 5,947,413 135,177 44.00 1 hrs 33 mins
4 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 5,556,024 130,216 42.67 1 hrs 34 mins
5 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,506,447 130,316 42.25 1 hrs 34 mins
6 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 5,264,676 129,634 40.61 1 hrs 35 mins
7 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 4,882,828 125,986 38.76 1 hrs 37 mins
8 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 3,976,555 117,984 33.70 1 hrs 43 mins
9 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,949,061 116,704 33.84 1 hrs 43 mins
10 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 3,880,972 116,694 33.26 1 hrs 43 mins
11 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 3,777,457 115,906 32.59 1 hrs 44 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,289,068 109,617 30.01 1 hrs 48 mins
13 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 2,873,878 105,822 27.16 1 hrs 53 mins
14 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,741,529 104,096 26.34 1 hrs 55 mins
15 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 2,439,674 100,660 24.24 1 hrs 59 mins
16 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,043,231 85,185 23.99 1 hrs 0 mins
17 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,979,098 93,345 21.20 1 hrs 8 mins
18 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 1,978,958 92,254 21.45 1 hrs 7 mins
19 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,865,319 90,905 20.52 1 hrs 10 mins
20 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,453,027 84,844 17.13 1 hrs 24 mins
21 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,405,091 83,304 16.87 1 hrs 25 mins
22 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,374,763 82,518 16.66 1 hrs 26 mins
23 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,355,969 83,062 16.32 1 hrs 28 mins
24 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,326,645 82,054 16.17 1 hrs 29 mins
25 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,278,350 80,949 15.79 2 hrs 31 mins
26 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,241,423 80,206 15.48 2 hrs 33 mins
27 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 1,202,201 80,192 14.99 2 hrs 36 mins
28 Radeon RX 6700/6700 XT/6750 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT/6750 XT / 6800M]
AMD Navi 22 1,121,922 75,725 14.82 2 hrs 37 mins
29 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,052,807 75,792 13.89 2 hrs 44 mins
30 Radeon PRO W6600
Navi 23 WKS-XL [Radeon PRO W6600]
AMD Navi 23 WKS-XL 954,839 73,246 13.04 2 hrs 50 mins
31 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 951,999 73,046 13.03 2 hrs 50 mins
32 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 936,075 60,370 15.51 2 hrs 33 mins
33 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 883,663 71,465 12.36 2 hrs 56 mins
34 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 867,845 57,948 14.98 2 hrs 36 mins
35 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 821,309 64,246 12.78 2 hrs 53 mins
36 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 814,424 65,002 12.53 2 hrs 55 mins
37 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 805,950 68,863 11.70 2 hrs 3 mins
38 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 680,957 65,620 10.38 2 hrs 19 mins
39 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 646,694 64,730 9.99 2 hrs 24 mins
40 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 626,695 62,766 9.98 2 hrs 24 mins
41 P106-100
GP106 [P106-100]
Nvidia GP106 511,240 59,245 8.63 3 hrs 47 mins
42 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 477,312 58,881 8.11 3 hrs 58 mins
43 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 462,362 49,707 9.30 3 hrs 35 mins
44 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 345,010 52,822 6.53 4 hrs 40 mins
45 P106-090
GP106 [P106-090]
Nvidia GP106 332,347 51,574 6.44 4 hrs 43 mins
46 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 324,443 51,076 6.35 4 hrs 47 mins
47 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 322,068 50,892 6.33 4 hrs 48 mins
48 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 189,964 43,140 4.40 5 hrs 27 mins
49 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 144,289 39,179 3.68 7 hrs 31 mins
50 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 126,062 37,447 3.37 7 hrs 8 mins
51 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 110,573 35,581 3.11 8 hrs 43 mins
52 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 93,844 37,823 2.48 10 hrs 40 mins
53 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 84,065 33,524 2.51 10 hrs 34 mins
54 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 54,811 29,030 1.89 13 hrs 43 mins
55 Quadro P400
GP107GL [Quadro P400]
Nvidia GP107GL 44,881 26,795 1.67 14 hrs 20 mins
56 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 33,786 22,589 1.50 16 hrs 3 mins
57 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 31,053 22,791 1.36 18 hrs 37 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:26

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make