PROJECT #18431 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Biofilms are aggregations of bacteria that occur in response to external stresses.  They are found in natural, industrial, and clinical environments, where they can be an impediment to effective antibiotic treatments.  In Pseudomonas fluorescens, this process is initiated by the Lap system, particularly the LapA adhesin. LapG, a periplasmic protease, cleaves the N-terminus of LapA, releasing it from its adherent surface and inhibiting the ability to form a biofilm. LapG’s ability to cleave LapA is prevented by LapD, which keeps the protease away from the cell surface through a unique protein-protein interaction (PPI) interface involving a highly conserved tryptophan of LapD.

In an effort to develop molecules that can disrupt biofilm formation, the Bahl lab at the Institute for Protein Innovation has de novo designed high-affinity mini-proteins that mimic LapD and bind LapG.  In this collaborative project, the Voelz lab is using ab initio binding simulations of these mini-proteins to understand the binding mechanism, and investigate how sequence variability influences the binding reaction.

PROJECT INFO

Manager(s): Prof. Vincent Voelz

Institution: Temple University

PROJECT WORK UNIT SUMMARY

Atoms: 60,328

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:07

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 5,689,502 285,971 19.90 1 hrs 12 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 5,587,898 286,068 19.53 1 hrs 14 mins
3 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,285,914 278,061 19.01 1 hrs 16 mins
4 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,029,653 255,299 15.78 2 hrs 31 mins
5 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,960,003 255,505 15.50 2 hrs 33 mins
6 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 3,924,262 253,835 15.46 2 hrs 33 mins
7 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 3,857,615 249,138 15.48 2 hrs 33 mins
8 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,579,502 247,804 14.44 2 hrs 40 mins
9 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,455,967 244,971 14.11 2 hrs 42 mins
10 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,313,526 237,585 13.95 2 hrs 43 mins
11 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,216,874 238,126 13.51 2 hrs 47 mins
12 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 3,090,304 236,047 13.09 2 hrs 50 mins
13 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,037,558 233,877 12.99 2 hrs 51 mins
14 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,982,096 233,405 12.78 2 hrs 53 mins
15 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,924,959 231,693 12.62 2 hrs 54 mins
16 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 2,749,926 239,576 11.48 2 hrs 5 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,674,105 224,508 11.91 2 hrs 1 mins
18 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,593,986 220,833 11.75 2 hrs 3 mins
19 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,485,589 220,716 11.26 2 hrs 8 mins
20 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,276,049 213,012 10.69 2 hrs 15 mins
21 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 2,182,672 209,678 10.41 2 hrs 18 mins
22 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 2,122,441 205,220 10.34 2 hrs 19 mins
23 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,054,938 205,857 9.98 2 hrs 24 mins
24 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,032,174 205,461 9.89 2 hrs 26 mins
25 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,977,693 203,563 9.72 2 hrs 28 mins
26 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 1,949,931 202,554 9.63 2 hrs 30 mins
27 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,877,708 200,216 9.38 3 hrs 34 mins
28 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,869,698 199,440 9.37 3 hrs 34 mins
29 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,831,739 197,044 9.30 3 hrs 35 mins
30 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,786,979 195,457 9.14 3 hrs 38 mins
31 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,663,900 192,208 8.66 3 hrs 46 mins
32 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 1,608,213 188,887 8.51 3 hrs 49 mins
33 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile] 4608
Nvidia TU106M 1,465,651 184,424 7.95 3 hrs 1 mins
34 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,435,615 182,623 7.86 3 hrs 3 mins
35 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,414,249 180,851 7.82 3 hrs 4 mins
36 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,355,883 177,291 7.65 3 hrs 8 mins
37 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,319,978 171,237 7.71 3 hrs 7 mins
38 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550
Nvidia TU106M 1,227,194 167,047 7.35 3 hrs 16 mins
39 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,224,786 173,324 7.07 3 hrs 24 mins
40 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,205,845 171,472 7.03 3 hrs 25 mins
41 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,177,863 171,811 6.86 4 hrs 30 mins
42 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,146,091 168,487 6.80 4 hrs 32 mins
43 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 1,142,913 169,272 6.75 4 hrs 33 mins
44 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 1,007,112 161,355 6.24 4 hrs 51 mins
45 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 990,819 159,180 6.22 4 hrs 51 mins
46 RTX A2000 Mobile
GA107GLM [RTX A2000 Mobile]
GA107GLM 904,027 157,331 5.75 4 hrs 11 mins
47 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 892,265 155,843 5.73 4 hrs 12 mins
48 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 826,406 152,177 5.43 4 hrs 25 mins
49 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 820,942 151,652 5.41 4 hrs 26 mins
50 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 811,693 150,230 5.40 4 hrs 27 mins
51 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 726,106 145,712 4.98 5 hrs 49 mins
52 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 643,287 139,615 4.61 5 hrs 13 mins
53 GeForce GTX 1650 Ti Mobile
TU117M [GeForce GTX 1650 Ti Mobile]
Nvidia TU117M 640,513 139,626 4.59 5 hrs 14 mins
54 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 628,212 137,942 4.55 5 hrs 16 mins
55 GeForce GTX 1070 Mobile
GP104BM [GeForce GTX 1070 Mobile] 6463
Nvidia GP104BM 625,582 136,327 4.59 5 hrs 14 mins
56 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 619,174 132,197 4.68 5 hrs 7 mins
57 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 614,251 137,710 4.46 5 hrs 23 mins
58 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 573,060 133,981 4.28 6 hrs 37 mins
59 P104-100
GP104 [P104-100]
Nvidia GP104 479,194 126,971 3.77 6 hrs 22 mins
60 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 440,111 122,194 3.60 7 hrs 40 mins
61 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 436,115 122,297 3.57 7 hrs 44 mins
62 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 406,289 118,255 3.44 7 hrs 59 mins
63 Quadro T1000 Mobile
TU117GLM [Quadro T1000 Mobile]
Nvidia TU117GLM 394,770 119,080 3.32 7 hrs 14 mins
64 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 369,286 114,820 3.22 7 hrs 28 mins
65 P106-100
GP106 [P106-100]
Nvidia GP106 363,188 115,742 3.14 8 hrs 39 mins
66 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 362,232 114,175 3.17 8 hrs 34 mins
67 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 340,649 110,680 3.08 8 hrs 48 mins
68 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 338,541 113,132 2.99 8 hrs 1 mins
69 Tesla K20Xm
GK110 [Tesla K20Xm] 3935
Nvidia GK110 323,513 100,130 3.23 7 hrs 26 mins
70 GeForce GTX 1650
TU117 [GeForce GTX 1650] 3091
Nvidia TU117 299,809 89,997 3.33 7 hrs 12 mins
71 P106-090
GP106 [P106-090]
Nvidia GP106 293,536 107,768 2.72 9 hrs 49 mins
72 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 239,687 100,089 2.39 10 hrs 1 mins
73 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 206,442 95,492 2.16 11 hrs 6 mins
74 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 187,879 92,687 2.03 12 hrs 50 mins
75 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 170,300 89,416 1.90 13 hrs 36 mins
76 Tesla K20C
GK110 [Tesla K20C] 3524
Nvidia GK110 167,363 88,330 1.89 13 hrs 40 mins
77 Radeon R9 200/HD 7900/8970
Tahiti XT [Radeon R9 200/HD 7900/8970]
AMD Tahiti XT 164,078 69,272 2.37 10 hrs 8 mins
78 Radeon HD 7800
Pitcairn [Radeon HD 7800]
AMD Pitcairn 146,891 84,602 1.74 14 hrs 49 mins
79 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 143,005 77,005 1.86 13 hrs 55 mins
80 Quadro K5000
GK104 [Quadro K5000]
Nvidia GK104 138,981 84,043 1.65 15 hrs 31 mins
81 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 133,016 82,972 1.60 15 hrs 58 mins
82 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 129,429 80,764 1.60 15 hrs 59 mins
83 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 127,606 81,707 1.56 15 hrs 22 mins
84 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 122,527 76,612 1.60 15 hrs 0 mins
85 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 108,397 77,532 1.40 17 hrs 10 mins
86 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 97,693 72,996 1.34 18 hrs 56 mins
87 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 92,883 61,208 1.52 16 hrs 49 mins
88 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 90,983 73,034 1.25 19 hrs 16 mins
89 Radeon HD 7800 Series
Pitcairn PRO [Radeon HD 7800 Series]
AMD Pitcairn PRO 86,116 70,920 1.21 20 hrs 46 mins
90 Radeon RX Vega gfx902
raven [Radeon RX Vega gfx902]
AMD raven 76,662 68,212 1.12 21 hrs 21 mins
91 Ryzen 4900HS mobile
Renoir [Ryzen 4900HS mobile]
AMD Renoir 58,245 63,099 0.92 26 hrs 0 mins
92 GeForce 940MX
GM107 [GeForce 940MX]
Nvidia GM107 57,918 62,887 0.92 26 hrs 4 mins
93 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 50,581 57,054 0.89 27 hrs 4 mins
94 GeForce 940M
GM108 [GeForce 940M]
Nvidia GM108 35,900 54,497 0.66 36 hrs 26 mins
95 GeForce GTX 560 Ti
GF114 [GeForce GTX 560 Ti]
Nvidia GF114 35,080 53,635 0.65 37 hrs 42 mins
96 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 33,719 53,635 0.63 38 hrs 11 mins
97 GeForce GT 640
GK107 [GeForce GT 640] 693
Nvidia GK107 30,261 53,635 0.56 43 hrs 32 mins
98 Radeon R7 200 Series
Hawaii [Radeon R7 200 Series]
AMD Hawaii 20,589 53,635 0.38 63 hrs 31 mins
99 Quadro NVS 510
GK107 [Quadro NVS 510]
Nvidia GK107 18,437 54,316 0.34 71 hrs 42 mins
100 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 11,406 53,635 0.21 113 hrs 51 mins
101 Radeon APU A4-6000 R2
Mullins [Radeon APU A4-6000 R2]
AMD Mullins 5,254 53,635 0.10 245 hrs 0 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:07

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make