PROJECT #18431 RESEARCH FOR BIOFILM
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Biofilms are aggregations of bacteria that occur in response to external stresses.

They are found in natural, industrial, and clinical environments, where they can be an impediment to effective antibiotic treatments.

In Pseudomonas fluorescens, this process is initiated by the Lap system, particularly the LapA adhesin.

LapG, a periplasmic protease, cleaves the N-terminus of LapA, releasing it from its adherent surface and inhibiting the ability to form a biofilm.

LapG’s ability to cleave LapA is prevented by LapD, which keeps the protease away from the cell surface through a unique protein-protein interaction (PPI) interface involving a highly conserved tryptophan of LapD. In an effort to develop molecules that can disrupt biofilm formation, the Bahl lab at the Institute for Protein Innovation has de novo designed high-affinity mini-proteins that mimic LapD and bind LapG.

In this collaborative project, the Voelz lab is using ab initio binding simulations of these mini-proteins to understand the binding mechanism, and investigate how sequence variability influences the binding reaction..

PROJECT INFO

Manager(s): Prof. Vincent Voelz

Institution: Temple University

PROJECT WORK UNIT SUMMARY

Atoms: 60,328

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 03 October 2022 12:16:28

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,462,958 298,017 21.69 1 hrs 6 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 5,689,502 285,971 19.90 1 hrs 12 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 5,609,848 286,408 19.59 1 hrs 14 mins
4 TITAN V
GV100 [TITAN V] M 12288
Nvidia GV100 5,386,581 283,629 18.99 1 hrs 16 mins
5 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,546,441 267,798 16.98 1 hrs 25 mins
6 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,535,399 262,576 17.27 1 hrs 23 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 3,936,709 254,070 15.49 2 hrs 33 mins
8 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 3,857,615 249,138 15.48 2 hrs 33 mins
9 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,619,397 248,559 14.56 2 hrs 39 mins
10 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,587,204 247,994 14.46 2 hrs 40 mins
11 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,397,179 239,619 14.18 2 hrs 42 mins
12 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,373,838 242,288 13.92 2 hrs 43 mins
13 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,333,308 241,921 13.78 2 hrs 45 mins
14 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 3,090,304 236,047 13.09 2 hrs 50 mins
15 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,990,321 233,609 12.80 2 hrs 52 mins
16 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,924,959 231,693 12.62 2 hrs 54 mins
17 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 2,832,374 229,475 12.34 2 hrs 57 mins
18 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 2,749,926 239,576 11.48 2 hrs 5 mins
19 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,674,105 224,508 11.91 2 hrs 1 mins
20 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,639,210 222,500 11.86 2 hrs 1 mins
21 GeForce RTX 2070 SUPER Mobile / Max-Q
TU104M [GeForce RTX 2070 SUPER Mobile / Max-Q]
Nvidia TU104M 2,632,943 222,770 11.82 2 hrs 2 mins
22 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,527,538 220,522 11.46 2 hrs 6 mins
23 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,485,589 220,716 11.26 2 hrs 8 mins
24 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,246,597 212,335 10.58 2 hrs 16 mins
25 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 2,182,672 209,678 10.41 2 hrs 18 mins
26 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 2,181,943 208,115 10.48 2 hrs 17 mins
27 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,032,174 205,461 9.89 2 hrs 26 mins
28 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,977,693 203,563 9.72 2 hrs 28 mins
29 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 1,949,931 202,554 9.63 2 hrs 30 mins
30 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,914,807 201,332 9.51 3 hrs 31 mins
31 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,870,873 198,061 9.45 3 hrs 32 mins
32 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,812,689 196,593 9.22 3 hrs 36 mins
33 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,796,137 195,212 9.20 3 hrs 37 mins
34 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,663,900 192,208 8.66 3 hrs 46 mins
35 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile] 4608
Nvidia TU106M 1,446,768 183,535 7.88 3 hrs 3 mins
36 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,412,814 177,346 7.97 3 hrs 1 mins
37 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,373,606 178,390 7.70 3 hrs 7 mins
38 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 1,351,372 178,365 7.58 3 hrs 10 mins
39 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,275,063 175,215 7.28 3 hrs 18 mins
40 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,267,832 174,932 7.25 3 hrs 19 mins
41 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 1,244,135 173,665 7.16 3 hrs 21 mins
42 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550
Nvidia TU106M 1,243,230 167,623 7.42 3 hrs 14 mins
43 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,238,932 172,836 7.17 3 hrs 21 mins
44 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,237,025 173,768 7.12 3 hrs 22 mins
45 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,177,863 171,811 6.86 4 hrs 30 mins
46 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,062,146 163,028 6.52 4 hrs 41 mins
47 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 1,051,172 164,567 6.39 4 hrs 45 mins
48 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 1,006,858 161,351 6.24 4 hrs 51 mins
49 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 986,858 156,149 6.32 4 hrs 48 mins
50 RTX A2000 Mobile
GA107GLM [RTX A2000 Mobile]
Nvidia GA107GLM 904,027 157,331 5.75 4 hrs 11 mins
51 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 898,755 156,229 5.75 4 hrs 10 mins
52 Quadro P4000
GP104GL [Quadro P4000]
Nvidia GP104GL 868,989 150,751 5.76 4 hrs 10 mins
53 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 832,488 151,836 5.48 4 hrs 23 mins
54 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 812,623 150,351 5.40 4 hrs 26 mins
55 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 764,000 143,594 5.32 5 hrs 31 mins
56 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 721,616 145,244 4.97 5 hrs 50 mins
57 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 711,068 144,082 4.94 5 hrs 52 mins
58 GeForce GTX 1650 Ti Mobile
TU117M [GeForce GTX 1650 Ti Mobile]
Nvidia TU117M 640,513 139,626 4.59 5 hrs 14 mins
59 GeForce GTX 1070 Mobile
GP104BM [GeForce GTX 1070 Mobile] 6463
Nvidia GP104BM 625,582 136,327 4.59 5 hrs 14 mins
60 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 620,549 137,625 4.51 5 hrs 19 mins
61 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 615,291 137,825 4.46 5 hrs 23 mins
62 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 573,060 133,981 4.28 6 hrs 37 mins
63 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 553,139 131,907 4.19 6 hrs 43 mins
64 P104-100
GP104 [P104-100]
Nvidia GP104 484,225 127,366 3.80 6 hrs 19 mins
65 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 450,835 123,712 3.64 7 hrs 35 mins
66 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 440,111 122,194 3.60 7 hrs 40 mins
67 GeForce GTX 1650
TU117 [GeForce GTX 1650] 3091
Nvidia TU117 426,510 108,018 3.95 6 hrs 5 mins
68 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 422,989 119,805 3.53 7 hrs 48 mins
69 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 413,841 121,194 3.41 7 hrs 2 mins
70 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 403,019 117,915 3.42 7 hrs 1 mins
71 Quadro T1000 Mobile
TU117GLM [Quadro T1000 Mobile]
Nvidia TU117GLM 394,770 119,080 3.32 7 hrs 14 mins
72 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 376,323 116,120 3.24 7 hrs 24 mins
73 Tesla K20C
GK110 [Tesla K20C] 3524
Nvidia GK110 372,787 116,224 3.21 7 hrs 29 mins
74 P106-100
GP106 [P106-100]
Nvidia GP106 362,743 115,716 3.13 8 hrs 39 mins
75 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 340,649 110,680 3.08 8 hrs 48 mins
76 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 336,938 113,006 2.98 8 hrs 3 mins
77 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 334,250 112,392 2.97 8 hrs 4 mins
78 T600
TU117GL [T600]
Intel TU117GL 323,613 111,080 2.91 8 hrs 14 mins
79 Tesla K20Xm
GK110 [Tesla K20Xm] 3935
Nvidia GK110 323,513 100,130 3.23 7 hrs 26 mins
80 P106-090
GP106 [P106-090]
Nvidia GP106 292,688 107,594 2.72 9 hrs 49 mins
81 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 242,915 100,602 2.41 10 hrs 56 mins
82 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 222,598 95,280 2.34 10 hrs 16 mins
83 Radeon R9 200/HD 7900/8970
Tahiti XT [Radeon R9 200/HD 7900/8970]
AMD Tahiti XT 171,464 72,031 2.38 10 hrs 5 mins
84 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 157,560 87,110 1.81 13 hrs 16 mins
85 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 152,756 86,575 1.76 14 hrs 36 mins
86 Radeon HD 7800
Pitcairn [Radeon HD 7800]
AMD Pitcairn 146,891 84,602 1.74 14 hrs 49 mins
87 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 144,503 84,366 1.71 14 hrs 1 mins
88 Quadro K5000
GK104 [Quadro K5000]
Nvidia GK104 138,981 84,043 1.65 15 hrs 31 mins
89 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 129,062 72,938 1.77 14 hrs 34 mins
90 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 120,845 80,077 1.51 16 hrs 54 mins
91 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 115,530 71,416 1.62 15 hrs 50 mins
92 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 114,789 78,589 1.46 16 hrs 26 mins
93 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 106,761 76,618 1.39 17 hrs 13 mins
94 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 103,528 73,785 1.40 17 hrs 6 mins
95 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 99,900 75,133 1.33 18 hrs 3 mins
96 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 89,561 72,588 1.23 19 hrs 27 mins
97 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 88,629 71,645 1.24 19 hrs 24 mins
98 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 87,767 64,768 1.36 18 hrs 43 mins
99 GeForce GTX 860M
GM107 [GeForce GTX 860M] 1389
Nvidia GM107 87,572 72,275 1.21 20 hrs 48 mins
100 Radeon HD 7800 Series
Pitcairn PRO [Radeon HD 7800 Series]
AMD Pitcairn PRO 86,116 70,920 1.21 20 hrs 46 mins
101 Radeon RX Vega gfx902
raven [Radeon RX Vega gfx902]
AMD raven 78,306 68,915 1.14 21 hrs 7 mins
102 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 77,689 69,072 1.12 21 hrs 20 mins
103 Polaris11
Baffin [Polaris11]
AMD Baffin 67,410 61,897 1.09 22 hrs 2 mins
104 GeForce 940MX
GM107 [GeForce 940MX]
Nvidia GM107 57,918 62,887 0.92 26 hrs 4 mins
105 GeForce GTX 660
GK106 [GeForce GTX 660]
Nvidia GK106 57,312 62,532 0.92 26 hrs 11 mins
106 Radeon R7 250X/HD 7700/8760
R575A [Radeon R7 250X/HD 7700/8760]
AMD R575A 56,436 61,858 0.91 26 hrs 18 mins
107 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 50,581 57,054 0.89 27 hrs 4 mins
108 GeForce MX130
GM108M [GeForce MX130]
Nvidia GM108M 42,301 55,287 0.77 31 hrs 22 mins
109 Ryzen 4900HS mobile
Renoir [Ryzen 4900HS mobile]
AMD Renoir 42,257 58,367 0.72 33 hrs 9 mins
110 GeForce 940MX
GM108M [GeForce 940MX]
Nvidia GM108M 42,066 56,953 0.74 32 hrs 30 mins
111 GeForce 940M
GM108 [GeForce 940M]
Nvidia GM108 35,900 54,497 0.66 36 hrs 26 mins
112 GeForce GTX 560 Ti
GF114 [GeForce GTX 560 Ti]
Nvidia GF114 35,080 53,635 0.65 37 hrs 42 mins
113 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 33,786 53,639 0.63 38 hrs 6 mins
114 GeForce GT 640
GK107 [GeForce GT 640] 693
Nvidia GK107 30,261 53,635 0.56 43 hrs 32 mins
115 Ryzen vega 8 mobile
Raven [Ryzen vega 8 mobile]
AMD Raven 29,686 53,635 0.55 43 hrs 22 mins
116 FirePro W4100
Cape Verde GL [FirePro W4100]
AMD Cape Verde GL 27,077 53,635 0.50 48 hrs 32 mins
117 Radeon Vega Series / Radeon Vega Mobile Series
Picasso/Raven 2 [Radeon Vega Series / Radeon Vega Mobile Series]
AMD Picasso/Raven 2 25,197 53,635 0.47 51 hrs 5 mins
118 Radeon R7 200 Series
Hawaii [Radeon R7 200 Series]
AMD Hawaii 20,589 53,635 0.38 63 hrs 31 mins
119 Quadro NVS 510
GK107 [Quadro NVS 510]
Nvidia GK107 18,437 54,316 0.34 71 hrs 42 mins
120 FirePro W2100
Oland GL [FirePro W2100]
AMD Oland GL 17,989 53,635 0.34 72 hrs 33 mins
121 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 11,406 53,635 0.21 113 hrs 51 mins
122 Radeon APU A4-6000 R2
Mullins [Radeon APU A4-6000 R2]
AMD Mullins 4,415 53,635 0.08 292 hrs 34 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 03 October 2022 12:16:28

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make