PROJECT #18432 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Biofilms are aggregations of bacteria that occur in response to external stresses.  They are found in natural, industrial, and clinical environments, where they can be an impediment to effective antibiotic treatments.  In Pseudomonas fluorescens, this process is initiated by the Lap system, particularly the LapA adhesin. LapG, a periplasmic protease, cleaves the N-terminus of LapA, releasing it from its adherent surface and inhibiting the ability to form a biofilm. LapG’s ability to cleave LapA is prevented by LapD, which keeps the protease away from the cell surface through a unique protein-protein interaction (PPI) interface involving a highly conserved tryptophan of LapD.

In an effort to develop molecules that can disrupt biofilm formation, the Bahl lab at the Institute for Protein Innovation has de novo designed high-affinity mini-proteins that mimic LapD and bind LapG.  In this collaborative project, the Voelz lab is using ab initio binding simulations of these mini-proteins to understand the binding mechanism, and investigate how sequence variability influences the binding reaction.

PROJECT INFO

Manager(s): Prof. Vincent Voelz

Institution: Temple University

PROJECT WORK UNIT SUMMARY

Atoms: 60,340

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:07

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,617,438 339,112 25.41 1 hrs 57 mins
2 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 8,072,200 326,066 24.76 1 hrs 58 mins
3 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,353,399 285,369 18.76 1 hrs 17 mins
4 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 5,070,649 282,695 17.94 1 hrs 20 mins
5 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 4,022,838 261,435 15.39 2 hrs 34 mins
6 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,881,658 258,513 15.02 2 hrs 36 mins
7 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,693,011 254,265 14.52 2 hrs 39 mins
8 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,474,912 249,001 13.96 2 hrs 43 mins
9 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,751,538 229,549 11.99 2 hrs 0 mins
10 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,728,762 229,914 11.87 2 hrs 1 mins
11 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,724,239 229,941 11.85 2 hrs 2 mins
12 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,326,031 218,065 10.67 2 hrs 15 mins
13 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 2,151,151 210,196 10.23 2 hrs 21 mins
14 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,054,975 208,130 9.87 2 hrs 26 mins
15 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 2,013,374 207,657 9.70 2 hrs 29 mins
16 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,877,386 202,389 9.28 3 hrs 35 mins
17 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile] 4608
Nvidia TU106M 1,504,658 189,015 7.96 3 hrs 1 mins
18 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550
Nvidia TU106M 1,407,754 184,250 7.64 3 hrs 8 mins
19 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,374,016 181,103 7.59 3 hrs 10 mins
20 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,320,617 180,379 7.32 3 hrs 17 mins
21 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,213,339 170,743 7.11 3 hrs 23 mins
22 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,184,984 174,208 6.80 4 hrs 32 mins
23 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,175,896 173,850 6.76 4 hrs 33 mins
24 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,120,975 168,177 6.67 4 hrs 36 mins
25 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 905,456 157,934 5.73 4 hrs 11 mins
26 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 873,887 157,774 5.54 4 hrs 20 mins
27 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 752,475 149,537 5.03 5 hrs 46 mins
28 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 681,063 142,877 4.77 5 hrs 2 mins
29 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 677,733 144,343 4.70 5 hrs 7 mins
30 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 631,592 141,144 4.47 5 hrs 22 mins
31 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 595,240 138,498 4.30 6 hrs 35 mins
32 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 493,287 127,889 3.86 6 hrs 13 mins
33 P104-100
GP104 [P104-100]
Nvidia GP104 485,257 129,310 3.75 6 hrs 24 mins
34 GeForce GTX 1650
TU117 [GeForce GTX 1650] 3091
Nvidia TU117 390,820 114,033 3.43 7 hrs 0 mins
35 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 377,121 115,845 3.26 7 hrs 22 mins
36 P106-100
GP106 [P106-100]
Nvidia GP106 371,973 118,409 3.14 8 hrs 38 mins
37 P106-090
GP106 [P106-090]
Nvidia GP106 358,664 116,894 3.07 8 hrs 49 mins
38 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 296,892 109,398 2.71 9 hrs 51 mins
39 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 250,571 103,386 2.42 10 hrs 54 mins
40 Tesla K20C
GK110 [Tesla K20C] 3524
Nvidia GK110 167,749 88,728 1.89 13 hrs 42 mins
41 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 142,594 82,382 1.73 14 hrs 52 mins
42 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 116,408 80,554 1.45 17 hrs 36 mins
43 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 66,747 66,887 1.00 24 hrs 3 mins
44 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 58,812 70,043 0.84 29 hrs 35 mins
45 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 55,294 61,861 0.89 27 hrs 51 mins
46 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 50,102 60,662 0.83 29 hrs 4 mins
47 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 43,940 55,015 0.80 30 hrs 3 mins
48 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 36,087 55,113 0.65 37 hrs 39 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:07

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make