PROJECT #18432 RESEARCH FOR BIOFILM
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Biofilms are aggregations of bacteria that occur in response to external stresses.

They are found in natural, industrial, and clinical environments, where they can be an impediment to effective antibiotic treatments.

In Pseudomonas fluorescens, this process is initiated by the Lap system, particularly the LapA adhesin.

LapG, a periplasmic protease, cleaves the N-terminus of LapA, releasing it from its adherent surface and inhibiting the ability to form a biofilm.

LapG’s ability to cleave LapA is prevented by LapD, which keeps the protease away from the cell surface through a unique protein-protein interaction (PPI) interface involving a highly conserved tryptophan of LapD. In an effort to develop molecules that can disrupt biofilm formation, the Bahl lab at the Institute for Protein Innovation has de novo designed high-affinity mini-proteins that mimic LapD and bind LapG.

In this collaborative project, the Voelz lab is using ab initio binding simulations of these mini-proteins to understand the binding mechanism, and investigate how sequence variability influences the binding reaction..

PROJECT INFO

Manager(s): Prof. Vincent Voelz

Institution: Temple University

PROJECT WORK UNIT SUMMARY

Atoms: 60,340

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 23 May 2022 03:34:39

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 8,859,171 341,714 25.93 1 hrs 56 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,617,438 339,112 25.41 1 hrs 57 mins
3 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,811,118 325,381 24.01 1 hrs 60 mins
4 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,266,739 285,228 18.47 1 hrs 18 mins
5 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 5,036,669 281,815 17.87 1 hrs 21 mins
6 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,738,561 275,768 17.18 1 hrs 24 mins
7 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 4,381,050 268,982 16.29 1 hrs 28 mins
8 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,210,781 265,582 15.85 2 hrs 31 mins
9 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,886,297 258,586 15.03 2 hrs 36 mins
10 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,696,462 254,288 14.54 2 hrs 39 mins
11 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,467,070 248,807 13.93 2 hrs 43 mins
12 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,730,972 229,566 11.90 2 hrs 1 mins
13 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,728,762 229,914 11.87 2 hrs 1 mins
14 GeForce RTX 2070 SUPER Mobile / Max-Q
TU104M [GeForce RTX 2070 SUPER Mobile / Max-Q]
Nvidia TU104M 2,692,757 227,959 11.81 2 hrs 2 mins
15 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,623,707 226,046 11.61 2 hrs 4 mins
16 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,487,410 222,486 11.18 2 hrs 9 mins
17 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 2,425,508 215,970 11.23 2 hrs 8 mins
18 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,326,031 218,065 10.67 2 hrs 15 mins
19 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,304,978 216,883 10.63 2 hrs 15 mins
20 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 2,162,565 210,941 10.25 2 hrs 20 mins
21 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 2,028,672 207,074 9.80 2 hrs 27 mins
22 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,841,174 200,610 9.18 3 hrs 37 mins
23 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,614,603 193,239 8.36 3 hrs 52 mins
24 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile] 4608
Nvidia TU106M 1,504,100 188,819 7.97 3 hrs 1 mins
25 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550
Nvidia TU106M 1,413,737 184,501 7.66 3 hrs 8 mins
26 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,366,886 181,385 7.54 3 hrs 11 mins
27 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,292,589 177,866 7.27 3 hrs 18 mins
28 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,291,888 178,015 7.26 3 hrs 18 mins
29 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,291,660 176,727 7.31 3 hrs 17 mins
30 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,253,115 177,116 7.08 3 hrs 24 mins
31 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,228,132 176,311 6.97 3 hrs 27 mins
32 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,179,052 173,111 6.81 4 hrs 31 mins
33 Quadro P4000
GP104GL [Quadro P4000]
Nvidia GP104GL 993,040 163,972 6.06 4 hrs 58 mins
34 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 899,162 156,888 5.73 4 hrs 11 mins
35 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 821,252 153,969 5.33 4 hrs 30 mins
36 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 751,436 149,623 5.02 5 hrs 47 mins
37 GeForce GTX 1650 Ti Mobile
TU117M [GeForce GTX 1650 Ti Mobile]
Nvidia TU117M 660,535 143,496 4.60 5 hrs 13 mins
38 Quadro T1200 Mobile
TU117GLM [Quadro T1200 Mobile]
Nvidia TU117GLM 650,491 142,466 4.57 5 hrs 15 mins
39 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 643,148 141,051 4.56 5 hrs 16 mins
40 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 631,669 141,117 4.48 5 hrs 22 mins
41 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 623,266 139,539 4.47 5 hrs 22 mins
42 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 595,240 138,498 4.30 6 hrs 35 mins
43 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 593,930 136,669 4.35 6 hrs 31 mins
44 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 532,898 133,457 3.99 6 hrs 1 mins
45 P104-100
GP104 [P104-100]
Nvidia GP104 505,490 130,864 3.86 6 hrs 13 mins
46 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 403,183 118,110 3.41 7 hrs 2 mins
47 GeForce GTX 1650
TU117 [GeForce GTX 1650] 3091
Nvidia TU117 390,820 114,033 3.43 7 hrs 0 mins
48 P106-100
GP106 [P106-100]
Nvidia GP106 369,163 118,063 3.13 8 hrs 41 mins
49 P106-090
GP106 [P106-090]
Nvidia GP106 358,664 116,894 3.07 8 hrs 49 mins
50 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 324,861 111,102 2.92 8 hrs 12 mins
51 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 316,763 111,653 2.84 8 hrs 28 mins
52 T600
TU117GL [T600]
Intel TU117GL 312,926 110,922 2.82 9 hrs 30 mins
53 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 249,894 103,066 2.42 10 hrs 54 mins
54 Tesla K20C
GK110 [Tesla K20C] 3524
Nvidia GK110 242,285 99,314 2.44 10 hrs 50 mins
55 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 211,623 97,760 2.16 11 hrs 5 mins
56 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 143,396 82,664 1.73 14 hrs 50 mins
57 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 141,512 84,296 1.68 14 hrs 18 mins
58 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 122,428 81,534 1.50 16 hrs 59 mins
59 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 121,102 81,272 1.49 16 hrs 6 mins
60 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 101,313 76,607 1.32 18 hrs 9 mins
61 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 99,508 71,528 1.39 17 hrs 15 mins
62 GeForce GTX 860M
GM107 [GeForce GTX 860M] 1389
Nvidia GM107 89,595 73,867 1.21 20 hrs 47 mins
63 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 87,975 73,186 1.20 20 hrs 58 mins
64 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 75,520 69,220 1.09 22 hrs 60 mins
65 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 67,208 67,004 1.00 24 hrs 56 mins
66 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 63,257 64,168 0.99 24 hrs 21 mins
67 GeForce GTX 950M
GM107 [GeForce GTX 950M] 1439
Nvidia GM107 60,615 54,805 1.11 22 hrs 42 mins
68 GeForce GTX 660
GK106 [GeForce GTX 660]
Nvidia GK106 59,429 64,289 0.92 26 hrs 58 mins
69 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 57,050 54,805 1.04 23 hrs 3 mins
70 GeForce MX150
GP108 [GeForce MX150]
Nvidia GP108 54,514 58,655 0.93 26 hrs 49 mins
71 GeForce 940MX
GM108M [GeForce 940MX]
Nvidia GM108M 44,354 58,085 0.76 31 hrs 26 mins
72 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 43,940 55,015 0.80 30 hrs 3 mins
73 GeForce 940M
GM108 [GeForce 940M]
Nvidia GM108 35,734 54,907 0.65 37 hrs 53 mins
74 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 35,510 55,105 0.64 37 hrs 15 mins
75 GeForce 920M
GK208 [GeForce 920M]
Nvidia GK208 32,517 54,805 0.59 40 hrs 27 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 23 May 2022 03:34:39

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make