PROJECT #18446 RESEARCH FOR BIOFILM
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Biofilms are aggregations of bacteria that occur in response to external stresses.

They are found in natural, industrial, and clinical environments, where they can be an impediment to effective antibiotic treatments.

In Pseudomonas fluorescens, this process is initiated by the Lap system, particularly the LapA adhesin.

LapG, a periplasmic protease, cleaves the N-terminus of LapA, releasing it from its adherent surface and inhibiting the ability to form a biofilm.

LapG’s ability to cleave LapA is prevented by LapD, which keeps the protease away from the cell surface through a unique protein-protein interaction (PPI) interface involving a highly conserved tryptophan of LapD. In an effort to develop molecules that can disrupt biofilm formation, the Bahl lab at the Institute for Protein Innovation has de novo designed high-affinity mini-proteins that mimic LapD and bind LapG.

In this collaborative project, the Voelz lab is using ab initio binding simulations of these mini-proteins to understand the binding mechanism, and investigate how sequence variability influences the binding reaction..

PROJECT INFO

Manager(s): Prof. Vincent Voelz

Institution: Temple University

PROJECT WORK UNIT SUMMARY

Atoms: 60,389

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:26

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,062,619 134,314 45.14 1 hrs 32 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 5,922,879 134,544 44.02 1 hrs 33 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 5,633,231 130,355 43.21 1 hrs 33 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,599,269 130,815 42.80 1 hrs 34 mins
5 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 5,354,029 130,055 41.17 1 hrs 35 mins
6 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 5,151,239 259,765 19.83 1 hrs 13 mins
7 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,066,147 127,841 39.63 1 hrs 36 mins
8 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 3,990,782 117,439 33.98 1 hrs 42 mins
9 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 3,959,861 117,209 33.78 1 hrs 43 mins
10 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 3,860,502 115,275 33.49 1 hrs 43 mins
11 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 3,737,012 115,073 32.48 1 hrs 44 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,165,643 107,286 29.51 1 hrs 49 mins
13 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 2,740,996 104,724 26.17 1 hrs 55 mins
14 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,693,147 102,922 26.17 1 hrs 55 mins
15 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,649,727 101,885 26.01 1 hrs 55 mins
16 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,433,839 98,661 24.67 1 hrs 58 mins
17 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 2,368,552 98,812 23.97 1 hrs 0 mins
18 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,897,986 91,489 20.75 1 hrs 9 mins
19 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,885,154 91,885 20.52 1 hrs 10 mins
20 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 1,666,902 88,511 18.83 1 hrs 16 mins
21 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,468,111 81,794 17.95 1 hrs 20 mins
22 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,437,840 83,947 17.13 1 hrs 24 mins
23 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,400,459 83,016 16.87 1 hrs 25 mins
24 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,379,912 82,229 16.78 1 hrs 26 mins
25 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,308,538 78,619 16.64 1 hrs 27 mins
26 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,231,807 79,668 15.46 2 hrs 33 mins
27 Radeon RX 6700/6700 XT/6750 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT/6750 XT / 6800M]
AMD Navi 22 1,230,385 78,925 15.59 2 hrs 32 mins
28 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,156,820 78,233 14.79 2 hrs 37 mins
29 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 1,147,181 78,487 14.62 2 hrs 39 mins
30 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,083,017 75,892 14.27 2 hrs 41 mins
31 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,078,086 75,175 14.34 2 hrs 40 mins
32 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]
AMD Navi 21 973,704 75,245 12.94 2 hrs 51 mins
33 Radeon PRO W6600
Navi 23 WKS-XL [Radeon PRO W6600]
AMD Navi 23 WKS-XL 957,195 73,130 13.09 2 hrs 50 mins
34 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 914,056 71,736 12.74 2 hrs 53 mins
35 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 879,053 71,128 12.36 2 hrs 57 mins
36 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 813,185 62,809 12.95 2 hrs 51 mins
37 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 735,707 66,754 11.02 2 hrs 11 mins
38 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 717,224 64,519 11.12 2 hrs 10 mins
39 P106-100
GP106 [P106-100]
Nvidia GP106 708,880 66,280 10.70 2 hrs 15 mins
40 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 699,414 61,622 11.35 2 hrs 7 mins
41 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 696,598 66,672 10.45 2 hrs 18 mins
42 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 611,707 61,935 9.88 2 hrs 26 mins
43 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 608,147 62,407 9.74 2 hrs 28 mins
44 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 519,266 59,783 8.69 3 hrs 46 mins
45 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 400,849 42,453 9.44 3 hrs 33 mins
46 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 342,598 52,087 6.58 4 hrs 39 mins
47 P106-090
GP106 [P106-090]
Nvidia GP106 328,849 50,991 6.45 4 hrs 43 mins
48 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 320,040 50,871 6.29 4 hrs 49 mins
49 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 306,432 50,019 6.13 4 hrs 55 mins
50 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 168,348 41,036 4.10 6 hrs 51 mins
51 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 143,192 39,024 3.67 7 hrs 32 mins
52 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 120,518 37,361 3.23 7 hrs 26 mins
53 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 110,601 35,730 3.10 8 hrs 45 mins
54 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 101,428 37,488 2.71 9 hrs 52 mins
55 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 82,330 33,108 2.49 10 hrs 39 mins
56 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 64,984 27,579 2.36 10 hrs 11 mins
57 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 58,754 28,984 2.03 12 hrs 50 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:26

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make