PROJECT #18125 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

We are simulating publicly available protein and small molecule structures of the currently very hot cancer target KRas, see https://www.fiercepharma.com/pharma/amgen-s-lumakras-becomes-first-fda-approved-kras-inhibitor-for-lung-cancer-patients for recent developments.

Folding@home has previously looked at this protein (in project 10490), and the following part of the description is copied from there: This project is "studying a small protein called KRAS, which forms a key link in growth signaling and cancer.

This gene is something like a molecular switch with a timer.

When it is bound to a molecule called GDP, it is off, and does not signal that the cell should grow.

However, other proteins can cause it to swap its GDP for a GTP, turning KRAS on.

In the on state, it signals that the cell should grow and divide.

Normally, after some time, KRAS, with the aid of some partners, will chemically convert its GTP to GDP and return to its inactive state. In many cancers, this protein becomes mutated, and cannot return to its off state.

The result? The cells continue to divide without limit.

What’s worse, cancers with this protein mutated tend to have much poorer prognoses.

As a result, scientists have been trying to target this protein for decades." We are investigating the dynamic behavior of KRas with these publicly disclosed inhibitors so that we can apply this knowledge to our own drug design.

At the same time, we are further testing the adaptive sampling methodology.

All data is being made publicly available at https://console.cloud.google.com/storage/browser/stxfah-bucket, and insights from methodology developments will be shared.

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket.

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 25,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Tuesday, 16 August 2022 22:52:19

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 3,439,799 128,902 26.69 1 hrs 54 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 3,417,793 131,194 26.05 1 hrs 55 mins
3 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 3,374,178 130,749 25.81 1 hrs 56 mins
4 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 2,841,994 123,930 22.93 1 hrs 3 mins
5 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 2,719,040 120,919 22.49 1 hrs 4 mins
6 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 2,654,300 121,171 21.91 1 hrs 6 mins
7 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,625,861 121,782 21.56 1 hrs 7 mins
8 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,490,576 116,498 21.38 1 hrs 7 mins
9 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 2,460,840 118,176 20.82 1 hrs 9 mins
10 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 2,414,998 115,750 20.86 1 hrs 9 mins
11 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 2,365,846 115,628 20.46 1 hrs 10 mins
12 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 2,133,220 108,549 19.65 1 hrs 13 mins
13 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 2,112,606 112,489 18.78 1 hrs 17 mins
14 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,038,648 111,019 18.36 1 hrs 18 mins
15 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,013,306 110,103 18.29 1 hrs 19 mins
16 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 1,890,071 107,988 17.50 1 hrs 22 mins
17 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 1,681,562 104,564 16.08 1 hrs 30 mins
18 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 1,645,349 102,873 15.99 2 hrs 30 mins
19 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 1,618,923 103,460 15.65 2 hrs 32 mins
20 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 1,589,009 102,761 15.46 2 hrs 33 mins
21 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 1,487,795 100,299 14.83 2 hrs 37 mins
22 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,451,863 99,459 14.60 2 hrs 39 mins
23 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,273,227 94,347 13.50 2 hrs 47 mins
24 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,181,736 92,198 12.82 2 hrs 52 mins
25 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,177,961 91,871 12.82 2 hrs 52 mins
26 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,155,318 90,855 12.72 2 hrs 53 mins
27 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,148,087 90,150 12.74 2 hrs 53 mins
28 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,113,976 91,271 12.21 2 hrs 58 mins
29 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,109,667 93,233 11.90 2 hrs 1 mins
30 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,060,114 89,876 11.80 2 hrs 2 mins
31 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 973,127 85,399 11.40 2 hrs 6 mins
32 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 899,274 84,847 10.60 2 hrs 16 mins
33 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 886,136 79,569 11.14 2 hrs 9 mins
34 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 827,371 82,068 10.08 2 hrs 23 mins
35 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 813,747 81,785 9.95 2 hrs 25 mins
36 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 737,797 79,518 9.28 3 hrs 35 mins
37 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 674,684 76,998 8.76 3 hrs 44 mins
38 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 663,991 75,347 8.81 3 hrs 43 mins
39 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 645,737 73,906 8.74 3 hrs 45 mins
40 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 587,277 70,884 8.29 3 hrs 54 mins
41 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 574,035 72,929 7.87 3 hrs 3 mins
42 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 442,600 66,507 6.65 4 hrs 36 mins
43 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 368,007 63,355 5.81 4 hrs 8 mins
44 P106-090
GP106 [P106-090]
Nvidia GP106 332,133 60,713 5.47 4 hrs 23 mins
45 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 329,536 57,095 5.77 4 hrs 9 mins
46 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 303,775 72,565 4.19 6 hrs 44 mins
47 P104-100
GP104 [P104-100]
Nvidia GP104 256,986 57,823 4.44 5 hrs 24 mins
48 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 251,172 55,388 4.53 5 hrs 18 mins
49 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 224,094 53,411 4.20 6 hrs 43 mins
50 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 113,181 42,420 2.67 9 hrs 60 mins
51 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 101,937 41,182 2.48 10 hrs 42 mins
52 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 93,961 37,944 2.48 10 hrs 42 mins
53 GeForce GTX 660
GK106 [GeForce GTX 660] 1981
Nvidia GK106 82,783 39,845 2.08 12 hrs 33 mins
54 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 73,827 21,480 3.44 7 hrs 59 mins
55 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 61,535 35,061 1.76 14 hrs 40 mins
56 Quadro P400
GP107GL [Quadro P400]
Nvidia GP107GL 54,624 33,492 1.63 15 hrs 43 mins
57 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 52,939 21,480 2.46 10 hrs 44 mins
58 GeForce GTX 650 Ti
GK106 [GeForce GTX 650 Ti]
Nvidia GK106 31,796 31,828 1.00 24 hrs 1 mins
59 Quadro K600
GK107 [Quadro K600]
Nvidia GK107 4,077 21,480 0.19 126 hrs 27 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Tuesday, 16 August 2022 22:52:19

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make