PROJECT #18125 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

We are simulating publicly available protein and small molecule structures of the currently very hot cancer target KRas, see https://www.fiercepharma.com/pharma/amgen-s-lumakras-becomes-first-fda-approved-kras-inhibitor-for-lung-cancer-patients for recent developments.

Folding@home has previously looked at this protein (in project 10490), and the following part of the description is copied from there: This project is "studying a small protein called KRAS, which forms a key link in growth signaling and cancer.

This gene is something like a molecular switch with a timer.

When it is bound to a molecule called GDP, it is off, and does not signal that the cell should grow.

However, other proteins can cause it to swap its GDP for a GTP, turning KRAS on.

In the on state, it signals that the cell should grow and divide.

Normally, after some time, KRAS, with the aid of some partners, will chemically convert its GTP to GDP and return to its inactive state. In many cancers, this protein becomes mutated, and cannot return to its off state.

The result? The cells continue to divide without limit.

What’s worse, cancers with this protein mutated tend to have much poorer prognoses.

As a result, scientists have been trying to target this protein for decades." We are investigating the dynamic behavior of KRas with these publicly disclosed inhibitors so that we can apply this knowledge to our own drug design.

At the same time, we are further testing the adaptive sampling methodology.

All data is being made publicly available at https://console.cloud.google.com/storage/browser/stxfah-bucket, and insights from methodology developments will be shared.

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket.

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 25,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 30 November 2022 06:13:32

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 3,461,928 132,083 26.21 0 hrs 55 mins
2 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 3,342,138 127,317 26.25 0 hrs 55 mins
3 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 3,319,954 129,970 25.54 0 hrs 56 mins
4 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 2,832,847 122,693 23.09 1 hrs 2 mins
5 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 2,815,954 122,910 22.91 1 hrs 3 mins
6 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 2,746,919 122,846 22.36 1 hrs 4 mins
7 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,625,861 121,782 21.56 1 hrs 7 mins
8 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,482,136 116,252 21.35 1 hrs 7 mins
9 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 2,451,086 118,250 20.73 1 hrs 9 mins
10 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 2,416,986 116,997 20.66 1 hrs 10 mins
11 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 2,414,998 115,750 20.86 1 hrs 9 mins
12 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 2,112,606 112,489 18.78 1 hrs 17 mins
13 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,038,648 111,019 18.36 1 hrs 18 mins
14 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 2,010,205 104,412 19.25 1 hrs 15 mins
15 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,946,579 108,968 17.86 1 hrs 21 mins
16 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 1,884,335 107,878 17.47 1 hrs 22 mins
17 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 1,710,385 105,428 16.22 1 hrs 29 mins
18 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 1,681,562 104,564 16.08 1 hrs 30 mins
19 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 1,645,349 102,873 15.99 2 hrs 30 mins
20 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 1,589,009 102,761 15.46 2 hrs 33 mins
21 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 1,487,795 100,299 14.83 2 hrs 37 mins
22 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,444,196 99,337 14.54 2 hrs 39 mins
23 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,278,665 94,451 13.54 2 hrs 46 mins
24 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 1,240,943 87,613 14.16 2 hrs 42 mins
25 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,198,774 92,666 12.94 2 hrs 51 mins
26 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,197,122 93,593 12.79 2 hrs 53 mins
27 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,178,514 91,899 12.82 2 hrs 52 mins
28 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,146,771 90,295 12.70 2 hrs 53 mins
29 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 1,142,667 89,659 12.74 2 hrs 53 mins
30 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,127,011 89,635 12.57 2 hrs 55 mins
31 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,109,667 93,233 11.90 2 hrs 1 mins
32 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,071,870 89,001 12.04 2 hrs 60 mins
33 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 974,766 85,426 11.41 2 hrs 6 mins
34 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 928,973 81,232 11.44 2 hrs 6 mins
35 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 899,274 84,847 10.60 2 hrs 16 mins
36 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 813,747 81,785 9.95 2 hrs 25 mins
37 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 736,606 79,508 9.26 3 hrs 35 mins
38 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 682,942 77,304 8.83 3 hrs 43 mins
39 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 668,766 75,605 8.85 3 hrs 43 mins
40 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 640,712 74,524 8.60 3 hrs 47 mins
41 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 587,277 70,884 8.29 3 hrs 54 mins
42 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 556,428 72,369 7.69 3 hrs 7 mins
43 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 552,331 72,045 7.67 3 hrs 8 mins
44 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 425,567 65,593 6.49 4 hrs 42 mins
45 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 374,574 63,381 5.91 4 hrs 4 mins
46 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 329,536 57,095 5.77 4 hrs 9 mins
47 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 315,278 60,002 5.25 5 hrs 34 mins
48 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 303,775 72,565 4.19 6 hrs 44 mins
49 P106-090
GP106 [P106-090]
Nvidia GP106 299,971 57,792 5.19 5 hrs 37 mins
50 P104-100
GP104 [P104-100]
Nvidia GP104 256,986 57,823 4.44 5 hrs 24 mins
51 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 251,172 55,388 4.53 5 hrs 18 mins
52 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 224,574 53,406 4.21 6 hrs 42 mins
53 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 174,985 49,284 3.55 7 hrs 46 mins
54 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 121,592 43,480 2.80 9 hrs 35 mins
55 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 101,937 41,182 2.48 10 hrs 42 mins
56 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 101,752 39,252 2.59 9 hrs 15 mins
57 GeForce GTX 660
GK106 [GeForce GTX 660] 1981
Nvidia GK106 82,783 39,845 2.08 12 hrs 33 mins
58 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 61,535 35,061 1.76 14 hrs 40 mins
59 Quadro P400
GP107GL [Quadro P400]
Nvidia GP107GL 54,475 33,408 1.63 15 hrs 43 mins
60 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 52,939 21,480 2.46 10 hrs 44 mins
61 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 42,362 34,607 1.22 20 hrs 36 mins
62 GeForce GTX 650 Ti
GK106 [GeForce GTX 650 Ti]
Nvidia GK106 33,183 31,631 1.05 23 hrs 53 mins
63 Quadro K600
GK107 [Quadro K600]
Nvidia GK107 4,077 21,480 0.19 126 hrs 27 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 30 November 2022 06:13:32

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make