PROJECT #18117 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

We are simulating publicly available protein and small molecule structures of the currently very hot cancer target KRas, see https://www.fiercepharma.com/pharma/amgen-s-lumakras-becomes-first-fda-approved-kras-inhibitor-for-lung-cancer-patients for recent developments. Folding@home has previously looked at this protein (in project 10490), and the following part of the description is copied from there:

This project is "studying a small protein called KRAS, which forms a key link in growth signaling and cancer. This gene is something like a molecular switch with a timer. When it is bound to a molecule called GDP, it is off, and does not signal that the cell should grow. However, other proteins can cause it to swap its GDP for a GTP, turning KRAS on. In the on state, it signals that the cell should grow and divide. Normally, after some time, KRAS, with the aid of some partners, will chemically convert its GTP to GDP and return to its inactive state.

In many cancers, this protein becomes mutated, and cannot return to its off state. The result? The cells continue to divide without limit. What’s worse, cancers with this protein mutated tend to have much poorer prognoses. As a result, scientists have been trying to target this protein for decades."

We are investigating the dynamic behavior of KRas with these publicly disclosed inhibitors so that we can apply this knowledge to our own drug design. At the same time, we are further testing the adaptive sampling methodology. All data is being made publicly available at https://console.cloud.google.com/storage/browser/stxfah-bucket, and insights from methodology developments will be shared. 

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/

All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 25,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 03 December 2021 04:36:08

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 2,739,226 121,870 22.48 1 hrs 4 mins
2 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 2,597,189 117,531 22.10 1 hrs 5 mins
3 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 2,593,766 118,406 21.91 1 hrs 6 mins
4 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 2,536,774 119,443 21.24 1 hrs 8 mins
5 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 2,457,504 118,065 20.81 1 hrs 9 mins
6 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,447,693 118,298 20.69 1 hrs 10 mins
7 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,275,405 115,747 19.66 1 hrs 13 mins
8 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 2,244,187 115,021 19.51 1 hrs 14 mins
9 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 2,124,631 112,935 18.81 1 hrs 17 mins
10 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,083,670 111,103 18.75 1 hrs 17 mins
11 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,033,659 111,358 18.26 1 hrs 19 mins
12 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 1,940,493 109,577 17.71 1 hrs 21 mins
13 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,910,695 108,261 17.65 1 hrs 22 mins
14 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 1,863,011 108,152 17.23 1 hrs 24 mins
15 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 1,836,528 103,969 17.66 1 hrs 22 mins
16 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 1,795,852 104,295 17.22 1 hrs 24 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 1,718,299 104,944 16.37 1 hrs 28 mins
18 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 1,620,757 101,648 15.94 2 hrs 30 mins
19 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 1,491,875 100,333 14.87 2 hrs 37 mins
20 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,408,457 98,318 14.33 2 hrs 41 mins
21 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,369,457 97,496 14.05 2 hrs 43 mins
22 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,349,345 96,993 13.91 2 hrs 44 mins
23 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,244,885 94,390 13.19 2 hrs 49 mins
24 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 1,241,854 90,097 13.78 2 hrs 44 mins
25 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,221,906 93,055 13.13 2 hrs 50 mins
26 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,207,406 91,021 13.27 2 hrs 49 mins
27 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,098,750 90,708 12.11 2 hrs 59 mins
28 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,073,118 88,761 12.09 2 hrs 59 mins
29 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,042,819 88,953 11.72 2 hrs 3 mins
30 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550
Nvidia TU106M 980,712 87,329 11.23 2 hrs 8 mins
31 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 933,503 83,851 11.13 2 hrs 9 mins
32 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 929,497 83,224 11.17 2 hrs 9 mins
33 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 903,202 83,770 10.78 2 hrs 14 mins
34 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 840,588 82,996 10.13 2 hrs 22 mins
35 RTX A2000 Mobile
GA107GLM [RTX A2000 Mobile]
GA107GLM 795,058 81,864 9.71 2 hrs 28 mins
36 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 709,736 78,012 9.10 3 hrs 38 mins
37 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 665,020 76,690 8.67 3 hrs 46 mins
38 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 659,431 76,488 8.62 3 hrs 47 mins
39 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 649,400 75,232 8.63 3 hrs 47 mins
40 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 642,718 75,835 8.48 3 hrs 50 mins
41 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 638,149 75,685 8.43 3 hrs 51 mins
42 GeForce GTX 1070 Mobile
GP104BM [GeForce GTX 1070 Mobile] 6463
Nvidia GP104BM 632,489 74,151 8.53 3 hrs 49 mins
43 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 566,116 72,820 7.77 3 hrs 5 mins
44 GeForce GTX 1650 Ti Mobile
TU117M [GeForce GTX 1650 Ti Mobile]
Nvidia TU117M 544,214 71,909 7.57 3 hrs 10 mins
45 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 509,479 69,489 7.33 3 hrs 16 mins
46 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 429,044 65,091 6.59 4 hrs 38 mins
47 Quadro T1000 Mobile
TU117GLM [Quadro T1000 Mobile]
Nvidia TU117GLM 336,984 61,526 5.48 4 hrs 23 mins
48 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 309,419 59,658 5.19 5 hrs 38 mins
49 GeForce GTX 670/GTX 760Ti OEM
GK104 [GeForce GTX 670/GTX 760Ti OEM] 2634
Nvidia GK104 240,645 55,008 4.37 5 hrs 29 mins
50 P106-090
GP106 [P106-090]
Nvidia GP106 237,531 54,520 4.36 6 hrs 31 mins
51 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 223,795 53,414 4.19 6 hrs 44 mins
52 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 222,873 52,842 4.22 6 hrs 41 mins
53 P104-100
GP104 [P104-100]
Nvidia GP104 220,993 53,289 4.15 6 hrs 47 mins
54 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 196,608 51,428 3.82 6 hrs 17 mins
55 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 186,066 50,320 3.70 6 hrs 29 mins
56 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 175,059 49,173 3.56 7 hrs 44 mins
57 P106-100
GP106 [P106-100]
Nvidia GP106 166,331 48,353 3.44 7 hrs 59 mins
58 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 136,985 45,200 3.03 8 hrs 55 mins
59 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 102,239 40,534 2.52 10 hrs 31 mins
60 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 80,225 37,874 2.12 11 hrs 20 mins
61 GeForce 940M
GM108 [GeForce 940M]
Nvidia GM108 42,188 29,950 1.41 17 hrs 2 mins
62 GeForce GTX 460 v2
GF114 [GeForce GTX 460 v2] 1045.6
Nvidia GF114 31,608 27,895 1.13 21 hrs 11 mins
63 GeForce GT 640
GK107 [GeForce GT 640] 693
Nvidia GK107 22,540 21,678 1.04 23 hrs 5 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 03 December 2021 04:36:08

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make