PROJECT #18123 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

We are simulating publicly available protein and small molecule structures of the currently very hot cancer target KRas, see https://www.fiercepharma.com/pharma/amgen-s-lumakras-becomes-first-fda-approved-kras-inhibitor-for-lung-cancer-patients for recent developments.

Folding@home has previously looked at this protein (in project 10490), and the following part of the description is copied from there: This project is "studying a small protein called KRAS, which forms a key link in growth signaling and cancer.

This gene is something like a molecular switch with a timer.

When it is bound to a molecule called GDP, it is off, and does not signal that the cell should grow.

However, other proteins can cause it to swap its GDP for a GTP, turning KRAS on.

In the on state, it signals that the cell should grow and divide.

Normally, after some time, KRAS, with the aid of some partners, will chemically convert its GTP to GDP and return to its inactive state. In many cancers, this protein becomes mutated, and cannot return to its off state.

The result? The cells continue to divide without limit.

What’s worse, cancers with this protein mutated tend to have much poorer prognoses.

As a result, scientists have been trying to target this protein for decades." We are investigating the dynamic behavior of KRas with these publicly disclosed inhibitors so that we can apply this knowledge to our own drug design.

At the same time, we are further testing the adaptive sampling methodology.

All data is being made publicly available at https://console.cloud.google.com/storage/browser/stxfah-bucket, and insights from methodology developments will be shared.

This is a project run by Roivant Sciences (formerly Silicon Therapeutics) as was officially announced in this press release: https://foldingathome.org/2021/04/20/maximizing-the-impact-of-foldinghome-by-engaging-industry-collaborators/ All data is being made publicly available as soon as it is received at https://console.cloud.google.com/storage/browser/stxfah-bucket.

PROJECT INFO

Manager(s): Rafal Wiewiora

Institution: Roivant Sciences (Silicon Therapeutics)

Project URL: roivant.com

PROJECT WORK UNIT SUMMARY

Atoms: 25,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 30 June 2022 00:49:55

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 TITAN V
GV100 [TITAN V] M 12288
Nvidia GV100 4,277,985 153,493 27.87 1 hrs 52 mins
2 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,316,566 124,721 18.57 1 hrs 18 mins
3 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,173,080 122,541 17.73 1 hrs 21 mins
4 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,131,114 121,852 17.49 1 hrs 22 mins
5 GeForce RTX 2070 SUPER Mobile / Max-Q
TU104M [GeForce RTX 2070 SUPER Mobile / Max-Q]
Nvidia TU104M 1,926,807 117,192 16.44 1 hrs 28 mins
6 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,867,586 116,057 16.09 1 hrs 29 mins
7 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,863,762 106,769 17.46 1 hrs 22 mins
8 GeForce RTX 2080 Mobile
TU104M [GeForce RTX 2080 Mobile]
Nvidia TU104M 1,641,006 109,029 15.05 2 hrs 36 mins
9 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,540,589 109,213 14.11 2 hrs 42 mins
10 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 1,423,565 106,211 13.40 2 hrs 47 mins
11 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,390,773 105,424 13.19 2 hrs 49 mins
12 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,350,174 103,438 13.05 2 hrs 50 mins
13 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,321,019 103,728 12.74 2 hrs 53 mins
14 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,262,781 102,756 12.29 2 hrs 57 mins
15 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,212,461 100,668 12.04 2 hrs 60 mins
16 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,153,793 98,348 11.73 2 hrs 3 mins
17 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,131,592 98,056 11.54 2 hrs 5 mins
18 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 999,801 93,513 10.69 2 hrs 15 mins
19 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 987,131 92,249 10.70 2 hrs 15 mins
20 Quadro P4000
GP104GL [Quadro P4000]
Nvidia GP104GL 968,827 93,890 10.32 2 hrs 20 mins
21 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 839,002 89,307 9.39 3 hrs 33 mins
22 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 763,361 86,311 8.84 3 hrs 43 mins
23 Quadro T1200 Mobile
TU117GLM [Quadro T1200 Mobile]
Nvidia TU117GLM 745,045 86,232 8.64 3 hrs 47 mins
24 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 677,322 81,320 8.33 3 hrs 53 mins
25 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 642,458 81,228 7.91 3 hrs 2 mins
26 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 550,371 76,732 7.17 3 hrs 21 mins
27 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 546,441 60,025 9.10 3 hrs 38 mins
28 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 526,708 76,120 6.92 3 hrs 28 mins
29 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 517,879 75,359 6.87 3 hrs 30 mins
30 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 488,470 74,307 6.57 4 hrs 39 mins
31 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 485,972 74,558 6.52 4 hrs 41 mins
32 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 395,191 69,182 5.71 4 hrs 12 mins
33 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 354,209 67,161 5.27 5 hrs 33 mins
34 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 343,940 65,083 5.28 5 hrs 32 mins
35 P106-090
GP106 [P106-090]
Nvidia GP106 322,124 64,762 4.97 5 hrs 50 mins
36 P104-100
GP104 [P104-100]
Nvidia GP104 281,277 62,270 4.52 5 hrs 19 mins
37 T600
TU117GL [T600]
Intel TU117GL 260,885 60,390 4.32 6 hrs 33 mins
38 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 255,839 59,666 4.29 6 hrs 36 mins
39 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 241,976 58,118 4.16 6 hrs 46 mins
40 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 216,188 56,743 3.81 6 hrs 18 mins
41 GeForce GTX 780
GK110 [GeForce GTX 780] 3977
Nvidia GK110 198,605 55,097 3.60 7 hrs 39 mins
42 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 143,697 49,453 2.91 8 hrs 16 mins
43 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 141,660 49,320 2.87 8 hrs 21 mins
44 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 137,748 48,741 2.83 8 hrs 30 mins
45 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 132,652 48,036 2.76 9 hrs 41 mins
46 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 124,037 47,255 2.62 9 hrs 9 mins
47 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 116,794 43,298 2.70 9 hrs 54 mins
48 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 116,632 46,097 2.53 9 hrs 29 mins
49 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 107,853 44,953 2.40 10 hrs 0 mins
50 GeForce GTX 750
GM107 [GeForce GTX 750] 1111
Nvidia GM107 106,937 44,925 2.38 10 hrs 5 mins
51 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 105,094 44,575 2.36 10 hrs 11 mins
52 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 88,523 42,119 2.10 11 hrs 25 mins
53 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 80,167 40,815 1.96 12 hrs 13 mins
54 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 68,325 38,893 1.76 14 hrs 40 mins
55 GeForce GTX 660
GK106 [GeForce GTX 660]
Nvidia GK106 66,238 38,107 1.74 14 hrs 48 mins
56 GeForce 930M
GM108 [GeForce 930M]
Nvidia GM108 37,040 31,704 1.17 21 hrs 33 mins
57 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 28,840 28,144 1.02 23 hrs 25 mins
58 GeForce GT 720
GK208 [GeForce GT 720]
Nvidia GK208 18,313 24,000 0.76 31 hrs 27 mins
59 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 17,480 24,000 0.73 33 hrs 57 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 30 June 2022 00:49:55

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make