Folding project #17640, CANCER research

Research section Research projects and references

Project #17640 overview

Project Summary AI Beta

This project looks at how a drug called Dasatinib sticks to Abl kinase, a protein involved in some leukemias. Researchers want to see if computer simulations can find new ways for drugs to bind to Abl kinase, which could help develop better cancer treatments.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Sukrit Singh
Institution: Memorial Sloan-Kettering Cancer-Center
Website: Open project site

Work unit

Atoms: 94,172
Core: 0x26
Status: Beta

Source material

Official Project Description

This is a project studying the binding of Dasatinib (sold as the drug Sprycel) to Abl kinase, the target of many leukemias.

While the binding of Dasatininb-Abl has been observed in other contexts, it remains unclear if parallel simulations will a) observe it more efficiently and b) observe other binding pathways that may be useful for leveraging in drug discovery projects.

This project therefore serves as both a technical test and scientific project.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Dasatinib

A tyrosine kinase inhibitor used to treat chronic myeloid leukemia.

Drug: BiotechnologyPharmacology / Oncology

Dasatinib is a medication primarily used to treat chronic myeloid leukemia (CML), a type of cancer that affects blood cells. It works by blocking the activity of specific enzymes called tyrosine kinases, which are involved in the uncontrolled growth of cancer cells.

Sprycel

The brand name for the drug Dasatinib.

Brand Name: BiotechnologyPharmacology / Oncology

Sprycel is a brand name for the generic medication Dasatinib. It's used to treat chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

Abl kinase

A type of enzyme involved in cell growth and division.

Protein: BiotechnologyPathology / Oncology

Abl kinase is a protein that plays a crucial role in regulating cell growth and division. When it's overactive, it can contribute to the development of certain cancers, such as leukemia.

Leukemia

A type of cancer that affects blood-forming cells in the bone marrow.

Disease: BiotechnologyPathology / Oncology

Leukemia is a cancer that starts in the bone marrow, where blood cells are made. It disrupts the normal production of healthy blood cells, leading to an overproduction of abnormal white blood cells.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	22,764,840	27,012	842.77	0 ^hrs 2 ^mins
2	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	18,070,560	27,012	668.98	0 ^hrs 2 ^mins
3	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	16,476,801	27,012	609.98	0 ^hrs 2 ^mins
4	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	15,547,683	226,681	68.59	0 ^hrs 21 ^mins
5	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	13,999,878	27,012	518.28	0 ^hrs 3 ^mins
6	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	12,314,351	27,012	455.88	0 ^hrs 3 ^mins
7	RTX 6000 Ada Generation AD102GL [RTX 6000 Ada Generation]	Nvidia	AD102GL	9,979,161	311,587	32.03	0 ^hrs 45 ^mins
8	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	8,722,169	64,161	135.94	0 ^hrs 11 ^mins
9	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,749,940	217,727	35.59	0 ^hrs 40 ^mins
10	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	7,748,364	264,367	29.31	0 ^hrs 49 ^mins
11	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	7,567,326	185,550	40.78	0 ^hrs 35 ^mins
12	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	7,228,704	266,705	27.10	0 ^hrs 53 ^mins
13	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	6,756,278	263,397	25.65	0 ^hrs 56 ^mins
14	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,481,823	156,038	41.54	0 ^hrs 35 ^mins
15	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	6,298,928	75,312	83.64	0 ^hrs 17 ^mins
16	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,548,811	160,348	34.60	0 ^hrs 42 ^mins
17	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,342,413	211,635	25.24	0 ^hrs 57 ^mins
18	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,244,342	217,138	24.15	0 ^hrs 60 ^mins
19	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	5,037,937	234,087	21.52	1 ^hrs 7 ^mins

20	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,923,341	105,573	46.63	0 ^hrs 31 ^mins
21	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	4,750,407	27,012	175.86	0 ^hrs 8 ^mins
22	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	4,664,320	204,763	22.78	1 ^hrs 3 ^mins
23	RTX 4000 SFF Ada Generation AD104GL [RTX 4000 SFF Ada Generation]	Nvidia	AD104GL	4,586,137	27,012	169.78	0 ^hrs 8 ^mins
24	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,518,260	203,870	22.16	1 ^hrs 5 ^mins
25	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,271,992	166,705	25.63	0 ^hrs 56 ^mins
26	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	4,270,924	184,268	23.18	1 ^hrs 2 ^mins
27	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,175,497	141,250	29.56	0 ^hrs 49 ^mins
28	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	3,871,191	61,387	63.06	0 ^hrs 23 ^mins
29	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,617,854	213,972	16.91	1 ^hrs 25 ^mins
30	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,515,693	198,447	17.72	1 ^hrs 21 ^mins
31	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,262,957	27,012	120.80	0 ^hrs 12 ^mins
32	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,162,163	201,794	15.67	1 ^hrs 32 ^mins
33	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,047,431	200,810	15.18	1 ^hrs 35 ^mins
34	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	2,944,938	109,395	26.92	0 ^hrs 53 ^mins
35	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,937,549	199,099	14.75	1 ^hrs 38 ^mins
36	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,854,901	144,703	19.73	1 ^hrs 13 ^mins
37	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,853,441	192,348	14.83	1 ^hrs 37 ^mins
38	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	2,852,245	196,900	14.49	1 ^hrs 39 ^mins
39	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,823,779	167,668	16.84	1 ^hrs 26 ^mins

40	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,796,263	195,913	14.27	1 ^hrs 41 ^mins
41	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,562,067	167,615	15.29	1 ^hrs 34 ^mins
42	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	2,509,259	188,510	13.31	1 ^hrs 48 ^mins
43	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,422,553	195,175	12.41	1 ^hrs 56 ^mins
44	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,376,452	68,663	34.61	0 ^hrs 42 ^mins
45	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,279,937	164,859	13.83	1 ^hrs 44 ^mins
46	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,157,804	180,213	11.97	2 ^hrs 0 ^mins
47	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,150,513	155,381	13.84	1 ^hrs 44 ^mins
48	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,112,114	178,974	11.80	2 ^hrs 2 ^mins
49	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	1,996,663	174,865	11.42	2 ^hrs 6 ^mins
50	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	1,970,871	174,179	11.32	2 ^hrs 7 ^mins
51	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	1,954,974	173,166	11.29	2 ^hrs 8 ^mins
52	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,904,693	111,781	17.04	1 ^hrs 25 ^mins
53	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,890,696	102,851	18.38	1 ^hrs 18 ^mins
54	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,794,799	169,085	10.61	2 ^hrs 16 ^mins
55	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	1,792,091	158,357	11.32	2 ^hrs 7 ^mins
56	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,610,094	163,454	9.85	2 ^hrs 26 ^mins
57	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,562,046	161,370	9.68	2 ^hrs 29 ^mins
58	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,398,747	149,390	9.36	2 ^hrs 34 ^mins
59	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,380,295	133,913	10.31	2 ^hrs 20 ^mins

60	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,370,428	154,336	8.88	2 ^hrs 42 ^mins
61	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	1,354,471	104,836	12.92	1 ^hrs 51 ^mins
62	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,343,127	27,012	49.72	0 ^hrs 29 ^mins
63	Radeon RX 7700S/7600(S) Navi 33 [Radeon RX 7700S/7600(S)]	AMD	Navi 33	1,301,079	141,900	9.17	2 ^hrs 37 ^mins
64	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,292,135	147,763	8.74	2 ^hrs 45 ^mins
65	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,225,986	149,167	8.22	2 ^hrs 55 ^mins
66	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,216,400	69,364	17.54	1 ^hrs 22 ^mins
67	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	1,194,806	27,012	44.23	0 ^hrs 33 ^mins
68	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,190,932	125,722	9.47	2 ^hrs 32 ^mins
69	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,189,060	147,988	8.03	2 ^hrs 59 ^mins
70	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,171,960	148,640	7.88	3 ^hrs 3 ^mins
71	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,165,433	134,702	8.65	2 ^hrs 46 ^mins
72	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	1,128,825	137,673	8.20	2 ^hrs 56 ^mins
73	RTX A1000 GA107GL [RTX A1000]	Nvidia	GA107GL	1,099,715	27,012	40.71	0 ^hrs 35 ^mins
74	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	1,044,607	140,965	7.41	3 ^hrs 14 ^mins
75	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	1,023,859	136,705	7.49	3 ^hrs 12 ^mins
76	GeForce RTX 3050 Ti Mobile GA107M [GeForce RTX 3050 Ti Mobile]	Nvidia	GA107M	1,018,635	138,337	7.36	3 ^hrs 16 ^mins
77	Quadro M6000 GM200GL [Quadro M6000]	Nvidia	GM200GL	884,935	134,742	6.57	3 ^hrs 39 ^mins
78	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	797,135	124,103	6.42	3 ^hrs 44 ^mins
79	P106-100 GP106 [P106-100]	Nvidia	GP106	776,381	128,134	6.06	3 ^hrs 58 ^mins

80	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	770,502	114,131	6.75	3 ^hrs 33 ^mins
81	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	747,811	115,577	6.47	3 ^hrs 43 ^mins
82	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	640,809	122,093	5.25	4 ^hrs 34 ^mins
83	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	624,817	112,836	5.54	4 ^hrs 20 ^mins
84	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	588,307	55,218	10.65	2 ^hrs 15 ^mins
85	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	576,400	115,614	4.99	4 ^hrs 49 ^mins
86	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	541,851	116,199	4.66	5 ^hrs 9 ^mins
87	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	517,163	112,217	4.61	5 ^hrs 12 ^mins
88	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	513,540	112,026	4.58	5 ^hrs 14 ^mins
89	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	453,810	86,023	5.28	4 ^hrs 33 ^mins
90	GeForce GTX Titan Z GK110 [GeForce GTX Titan Z] 8122	Nvidia	GK110	425,608	111,881	3.80	6 ^hrs 19 ^mins
91	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	411,480	107,508	3.83	6 ^hrs 16 ^mins
92	GeForce RTX 2050 GA107M [GeForce RTX 2050]	Nvidia	GA107M	406,561	27,012	15.05	1 ^hrs 36 ^mins
93	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	385,617	102,746	3.75	6 ^hrs 24 ^mins
94	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	371,275	99,064	3.75	6 ^hrs 24 ^mins
95	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	338,124	30,764	10.99	2 ^hrs 11 ^mins
96	R9 290X/390X Hawaii/Grenada XT [R9 290X/390X]	AMD	Hawaii/Grenada XT	326,135	99,970	3.26	7 ^hrs 21 ^mins
97	Radeon RX 580 2048SP Polaris 20 XL [Radeon RX 580 2048SP]	AMD	Polaris 20 XL	294,925	93,896	3.14	7 ^hrs 38 ^mins
98	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	273,553	90,896	3.01	7 ^hrs 58 ^mins
99	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	269,102	91,439	2.94	8 ^hrs 9 ^mins

100	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	243,639	87,195	2.79	8 ^hrs 35 ^mins
101	R9 380X/R9 M295X Tonga XT/Amethyst XT [R9 380X/R9 M295X]	AMD	Tonga XT/Amethyst XT	207,421	82,825	2.50	9 ^hrs 35 ^mins
102	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	171,273	76,718	2.23	10 ^hrs 45 ^mins
103	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	160,586	76,650	2.10	11 ^hrs 27 ^mins
104	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	160,538	75,618	2.12	11 ^hrs 18 ^mins
105	GeForce MX150 GP107M [GeForce MX150]	Nvidia	GP107M	117,004	68,278	1.71	14 ^hrs 0 ^mins
106	Radeon R9 285/380 Tonga PRO [Radeon R9 285/380]	AMD	Tonga PRO	112,774	79,293	1.42	16 ^hrs 52 ^mins
107	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	95,860	27,012	3.55	6 ^hrs 46 ^mins
108	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	94,718	64,078	1.48	16 ^hrs 14 ^mins
109	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	94,083	42,052	2.24	10 ^hrs 44 ^mins
110	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	81,137	27,012	3.00	7 ^hrs 59 ^mins
111	R9 280X/HD 7900/8970 OEM Tahiti XT [R9 280X/HD 7900/8970 OEM]	AMD	Tahiti XT	77,244	63,904	1.21	19 ^hrs 51 ^mins
112	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	46,783	37,889	1.23	19 ^hrs 26 ^mins
113	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	46,361	51,463	0.90	26 ^hrs 38 ^mins
114	Vega Mobile APU Lucienne [Vega Mobile APU]	AMD	Lucienne	6,979	27,012	0.26	92 ^hrs 53 ^mins

Research: CANCER Folding Project #17640

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17640

GPU PPD Averages

Research: CANCER Folding Project #17640

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages