Folding project #17636, CANCER research

Research section Research projects and references

Project #17636 overview

Project Summary AI Beta

This project looks at how the drug Dasatinib (Sprycel) attaches to Abl protein, which is important for some blood cancers. Scientists want to see if computer simulations can find new ways Dasatinib works, which could help develop better cancer drugs.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Sukrit Singh
Institution: Memorial Sloan-Kettering Cancer-Center
Website: Open project site

Work unit

Atoms: 94,172
Core: 0x22
Status: Public

No related projects listed.

Source material

Official Project Description

This is a project studying the binding of Dasatinib (sold as the drug Sprycel) to Abl kinase, the target of many leukemias.

While the binding of Dasatininb-Abl has been observed in other contexts, it remains unclear if parallel simulations will a) observe it more efficiently and b) observe other binding pathways that may be useful for leveraging in drug discovery projects.

This project therefore serves as both a technical test and scientific project.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Dasatinib

A tyrosine kinase inhibitor used to treat chronic myeloid leukemia.

Drug: BiotechnologyPharmacology / Oncology

Dasatinib is a medication used to treat certain types of blood cancers, particularly chronic myeloid leukemia (CML). It works by blocking the activity of specific proteins involved in cancer cell growth and proliferation.

Sprycel

The brand name for the drug Dasatinib.

Brand Name: BiotechnologyPharmacology / Oncology

Sprycel is the brand name given to the medication Dasatinib. It's a commonly prescribed drug for treating chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

Abl kinase

A type of enzyme involved in cell signaling and growth.

Protein: BiotechnologyPathology / Oncology

Abl kinase is a protein that plays a crucial role in regulating cell growth and division. When it becomes overactive due to genetic mutations, it can contribute to the development of certain cancers, particularly leukemia.

Leukemia

A type of cancer that affects the blood and bone marrow.

Disease: BiotechnologyPathology / Oncology

Leukemia is a group of cancers that start in the bone marrow, the spongy tissue inside bones where blood cells are made. It causes an overproduction of abnormal white blood cells, which can crowd out healthy cells and disrupt normal blood function.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	20,248,837	27,012	749.62	0 ^hrs 2 ^mins
2	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	17,605,853	27,012	651.78	0 ^hrs 2 ^mins
3	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	14,921,372	29,320	508.91	0 ^hrs 3 ^mins
4	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	14,593,520	234,702	62.18	0 ^hrs 23 ^mins
5	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	13,466,720	35,894	375.18	0 ^hrs 4 ^mins
6	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	10,571,294	44,533	237.38	0 ^hrs 6 ^mins
7	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	10,507,653	27,012	389.00	0 ^hrs 4 ^mins
8	GeForce RTX 4090 Laptop GPU AD103M / GN21-X11 [GeForce RTX 4090 Laptop GPU]	Nvidia	AD103M / GN21-X11	10,255,256	303,535	33.79	0 ^hrs 43 ^mins
9	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	8,774,935	284,183	30.88	0 ^hrs 47 ^mins
10	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	8,547,755	120,778	70.77	0 ^hrs 20 ^mins
11	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	8,080,883	142,687	56.63	0 ^hrs 25 ^mins
12	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,828,814	271,961	28.79	0 ^hrs 50 ^mins
13	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	6,679,760	260,872	25.61	0 ^hrs 56 ^mins
14	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	6,441,752	248,754	25.90	0 ^hrs 56 ^mins
15	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,315,143	255,510	24.72	0 ^hrs 58 ^mins
16	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	5,988,487	224,239	26.71	0 ^hrs 54 ^mins
17	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,535,535	138,563	39.95	0 ^hrs 36 ^mins
18	RTX A5000 GA102GL [RTX A5000]	Nvidia	GA102GL	5,360,262	245,154	21.86	1 ^hrs 6 ^mins
19	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,353,627	102,613	52.17	0 ^hrs 28 ^mins

20	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,230,732	228,016	22.94	1 ^hrs 3 ^mins
21	GeForce RTX 4060 Ti 16GB AD106 [GeForce RTX 4060 Ti 16GB]	Nvidia	AD106	4,909,426	237,620	20.66	1 ^hrs 10 ^mins
22	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,811,466	192,859	24.95	0 ^hrs 58 ^mins
23	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,688,604	188,550	24.87	0 ^hrs 58 ^mins
24	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	4,441,870	228,175	19.47	1 ^hrs 14 ^mins
25	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	4,328,680	131,759	32.85	0 ^hrs 44 ^mins
26	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,062,994	218,884	18.56	1 ^hrs 18 ^mins
27	RTX 4000 SFF Ada Generation AD104GL [RTX 4000 SFF Ada Generation]	Nvidia	AD104GL	3,979,969	27,012	147.34	0 ^hrs 10 ^mins
28	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	3,768,957	210,175	17.93	1 ^hrs 20 ^mins
29	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,545,928	207,678	17.07	1 ^hrs 24 ^mins
30	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,543,046	212,222	16.69	1 ^hrs 26 ^mins
31	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	3,478,433	206,617	16.84	1 ^hrs 26 ^mins
32	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,318,285	207,318	16.01	1 ^hrs 30 ^mins
33	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,249,521	206,167	15.76	1 ^hrs 31 ^mins
34	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,130,794	202,618	15.45	1 ^hrs 33 ^mins
35	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,996,840	186,109	16.10	1 ^hrs 29 ^mins
36	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,930,292	165,801	17.67	1 ^hrs 21 ^mins
37	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,890,634	197,140	14.66	1 ^hrs 38 ^mins
38	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	2,883,696	159,856	18.04	1 ^hrs 20 ^mins
39	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,876,568	56,918	50.54	0 ^hrs 28 ^mins

40	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,808,994	165,628	16.96	1 ^hrs 25 ^mins
41	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	2,712,189	152,618	17.77	1 ^hrs 21 ^mins
42	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	2,619,050	27,012	96.96	0 ^hrs 15 ^mins
43	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,617,158	153,767	17.02	1 ^hrs 25 ^mins
44	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	2,573,054	191,088	13.47	1 ^hrs 47 ^mins
45	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,485,906	187,437	13.26	1 ^hrs 49 ^mins
46	Radeon RX 6800(XT)/6900XT Navi 21 [Radeon RX 6800(XT)/6900XT]	AMD	Navi 21	2,475,149	152,224	16.26	1 ^hrs 29 ^mins
47	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,453,354	104,127	23.56	1 ^hrs 1 ^mins
48	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,418,235	184,929	13.08	1 ^hrs 50 ^mins
49	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,397,536	186,311	12.87	1 ^hrs 52 ^mins
50	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,373,819	210,877	11.26	2 ^hrs 8 ^mins
51	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	1,992,980	163,678	12.18	1 ^hrs 58 ^mins
52	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,917,253	170,015	11.28	2 ^hrs 8 ^mins
53	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,825,770	168,733	10.82	2 ^hrs 13 ^mins
54	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	1,821,920	169,374	10.76	2 ^hrs 14 ^mins
55	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,648,460	152,286	10.82	2 ^hrs 13 ^mins
56	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	1,547,295	135,950	11.38	2 ^hrs 7 ^mins
57	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,307,490	152,329	8.58	2 ^hrs 48 ^mins
58	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,245,775	150,258	8.29	2 ^hrs 54 ^mins
59	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,238,185	128,589	9.63	2 ^hrs 30 ^mins

60	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,200,352	27,012	44.44	0 ^hrs 32 ^mins
61	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,171,280	121,155	9.67	2 ^hrs 29 ^mins
62	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,154,604	143,132	8.07	2 ^hrs 59 ^mins
63	P104-100 GP104 [P104-100]	Nvidia	GP104	1,146,848	145,987	7.86	3 ^hrs 3 ^mins
64	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,099,015	127,764	8.60	2 ^hrs 47 ^mins
65	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	1,084,902	143,452	7.56	3 ^hrs 10 ^mins
66	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,059,385	133,904	7.91	3 ^hrs 2 ^mins
67	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	1,035,164	27,012	38.32	0 ^hrs 38 ^mins
68	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	1,013,366	120,778	8.39	2 ^hrs 52 ^mins
69	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,003,359	123,511	8.12	2 ^hrs 57 ^mins
70	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	970,593	127,015	7.64	3 ^hrs 8 ^mins
71	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	970,227	137,331	7.06	3 ^hrs 24 ^mins
72	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	948,855	27,012	35.13	0 ^hrs 41 ^mins
73	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	913,804	108,342	8.43	2 ^hrs 51 ^mins
74	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	843,230	134,297	6.28	3 ^hrs 49 ^mins
75	P106-100 GP106 [P106-100]	Nvidia	GP106	806,548	129,832	6.21	3 ^hrs 52 ^mins
76	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	802,158	75,167	10.67	2 ^hrs 15 ^mins
77	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	775,645	127,925	6.06	3 ^hrs 57 ^mins
78	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	745,862	127,817	5.84	4 ^hrs 7 ^mins
79	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	726,161	97,441	7.45	3 ^hrs 13 ^mins

80	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	700,877	91,924	7.62	3 ^hrs 9 ^mins
81	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	626,900	85,115	7.37	3 ^hrs 16 ^mins
82	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	611,105	118,464	5.16	4 ^hrs 39 ^mins
83	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	602,730	56,623	10.64	2 ^hrs 15 ^mins
84	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	534,296	114,777	4.66	5 ^hrs 9 ^mins
85	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	506,600	111,987	4.52	5 ^hrs 18 ^mins
86	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	488,301	96,292	5.07	4 ^hrs 44 ^mins
87	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	480,822	27,012	17.80	1 ^hrs 21 ^mins
88	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	468,113	68,587	6.83	3 ^hrs 31 ^mins
89	Quadro K6000 GK110GL [Quadro K6000]	Nvidia	GK110GL	457,767	106,902	4.28	5 ^hrs 36 ^mins
90	Tesla K40c GK110 [Tesla K40c] 5046	Nvidia	GK110	428,191	107,257	3.99	6 ^hrs 1 ^mins
91	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	401,550	105,024	3.82	6 ^hrs 17 ^mins
92	P106-090 GP106 [P106-090]	Nvidia	GP106	389,847	101,554	3.84	6 ^hrs 15 ^mins
93	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	359,895	72,160	4.99	4 ^hrs 49 ^mins
94	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	342,273	94,544	3.62	6 ^hrs 38 ^mins
95	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	291,634	92,224	3.16	7 ^hrs 35 ^mins
96	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	284,352	79,650	3.57	6 ^hrs 43 ^mins
97	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	269,466	96,808	2.78	8 ^hrs 37 ^mins
98	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	243,220	87,128	2.79	8 ^hrs 36 ^mins
99	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	203,359	81,892	2.48	9 ^hrs 40 ^mins

100	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	203,197	58,643	3.46	6 ^hrs 56 ^mins
101	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	160,177	69,604	2.30	10 ^hrs 26 ^mins
102	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	134,307	27,012	4.97	4 ^hrs 50 ^mins
103	R9 380X/R9 M295X Tonga XT/Amethyst XT [R9 380X/R9 M295X]	AMD	Tonga XT/Amethyst XT	125,982	75,377	1.67	14 ^hrs 22 ^mins
104	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	105,713	27,012	3.91	6 ^hrs 8 ^mins
105	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	99,033	37,379	2.65	9 ^hrs 4 ^mins
106	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	98,356	27,012	3.64	6 ^hrs 35 ^mins
107	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	93,858	63,375	1.48	16 ^hrs 12 ^mins
108	Radeon 660M-680M Rembrandt [Radeon 660M-680M]	AMD	Rembrandt	89,785	27,012	3.32	7 ^hrs 13 ^mins
109	HD 7850/R7 265/R9 270 1024SP Pitcairn PRO [HD 7850/R7 265/R9 270 1024SP]	AMD	Pitcairn PRO	88,943	27,012	3.29	7 ^hrs 17 ^mins
110	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	57,994	28,923	2.01	11 ^hrs 58 ^mins
111	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	56,875	53,419	1.06	22 ^hrs 32 ^mins
112	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	39,983	54,489	0.73	32 ^hrs 42 ^mins
113	RX Vega 10 Mobile Picasso APU [RX Vega 10 Mobile]	AMD	Picasso APU	33,322	27,012	1.23	19 ^hrs 27 ^mins
114	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	32,819	45,079	0.73	32 ^hrs 58 ^mins
115	Vega Mobile APU Lucienne [Vega Mobile APU]	AMD	Lucienne	17,874	36,145	0.49	48 ^hrs 32 ^mins

Research: CANCER Folding Project #17636

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17636

GPU PPD Averages

Research: CANCER Folding Project #17636

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages