PROJECT #16484 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
In cancer treatment it is common to target multiple different putative proteins, because multiple proteins can malfunction in tumors to drive cancer.
One such protein, particularly known to be important in endocrine gland tumors (the places where hormones are secreted), is Menin-1 (Menin).
Menin is a protein found in the nucleus protein and plays a key role in regulating cell-signaling and gene expression (which genes turn on and off).
While the explicit details of Menin's behavior are not known, targeting it's inhibition with small-molecules (ligands) has demonstrated promising potential in blocking tumor growth.
However, like with many disease, mutations within Menin can *also* counteract this ligand-binding behavior.
Therefore, it is not just important to study how Menin works, or how to target it with small molecules, but also how mutations impact Menin-Ligand interactions.
This set of projects seeks to answer the latter two questions - how do small molecules inhibit Menin and how do mutations within Menin alter small-molecule affinity.
In projects 16472 & 16473, we simulate Menin by itself and Menin bound to a known small molecule inhibitor that is shown to treat tumors in patients! Thanks to the powerhouse efforts at cataloguing cancer mutations at Memorial Sloan-Kettering, we also know of 3 mutations that impact the ability of Menin to bind this inhibitor.
Projects 16474–16487 simulate either a) each of these Menin mutants or b) Menin mutants bound to this inhibitor. Bonus: Some of these structures are being simulated with the help of the AlphaFold database!.
PROJECT INFO
Manager(s): Sukrit Singh
Institution: Memorial Sloan-Kettering Cancer-Center
Project URL: http://sukritsingh.github.io/
PROJECT WORK UNIT SUMMARY
Atoms: 187,500
Core: OPENMM_22
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Friday, 03 February 2023 06:15:15
Rank Project |
Model Name Folding@Home Identifier |
Make Brand |
GPU Model |
PPD Average |
Points WU Average |
WUs Day Average |
WU Time Average |
---|---|---|---|---|---|---|---|
1 | GeForce RTX 3090 GA102 [GeForce RTX 3090] |
Nvidia | GA102 | 6,919,533 | 492,819 | 14.04 | 2 hrs 43 mins |
2 | GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti] |
Nvidia | GA102 | 6,780,727 | 488,903 | 13.87 | 2 hrs 44 mins |
3 | GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate] |
Nvidia | GA102 | 6,493,850 | 485,632 | 13.37 | 2 hrs 48 mins |
4 | GeForce RTX 3080 GA102 [GeForce RTX 3080] |
Nvidia | GA102 | 5,469,846 | 456,197 | 11.99 | 2 hrs 0 mins |
5 | GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 |
Nvidia | TU102 | 4,556,270 | 431,103 | 10.57 | 2 hrs 16 mins |
6 | GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti] |
Nvidia | GA104 | 4,454,641 | 429,896 | 10.36 | 2 hrs 19 mins |
7 | GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448 |
Nvidia | TU102 | 4,205,219 | 420,674 | 10.00 | 2 hrs 24 mins |
8 | GeForce RTX 3070 GA104 [GeForce RTX 3070] |
Nvidia | GA104 | 3,711,960 | 404,451 | 9.18 | 3 hrs 37 mins |
9 | GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068 |
Nvidia | TU104 | 3,327,598 | 389,466 | 8.54 | 3 hrs 49 mins |
10 | GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti] |
Nvidia | GA104 | 3,105,979 | 381,442 | 8.14 | 3 hrs 57 mins |
11 | GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER] |
Nvidia | TU104 | 3,005,627 | 377,139 | 7.97 | 3 hrs 1 mins |
12 | Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT] |
AMD | Navi 21 | 2,942,496 | 367,700 | 8.00 | 3 hrs 60 mins |
13 | TITAN Xp GP102 [TITAN Xp] 12150 |
Nvidia | GP102 | 2,891,710 | 372,512 | 7.76 | 3 hrs 6 mins |
14 | GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate] |
Nvidia | GA104 | 2,800,022 | 367,934 | 7.61 | 3 hrs 9 mins |
15 | GeForce RTX 2080 TU104 [GeForce RTX 2080] |
Nvidia | TU104 | 2,694,469 | 363,762 | 7.41 | 3 hrs 14 mins |
16 | GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465 |
Nvidia | TU106 | 2,382,146 | 348,865 | 6.83 | 4 hrs 31 mins |
17 | GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218 |
Nvidia | TU104 | 2,356,741 | 343,608 | 6.86 | 3 hrs 30 mins |
18 | GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380 |
Nvidia | GP102 | 2,298,877 | 340,609 | 6.75 | 4 hrs 33 mins |
19 | GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497 |
Nvidia | TU106 | 2,177,568 | 338,896 | 6.43 | 4 hrs 44 mins |
20 | GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER] |
Nvidia | TU106 | 2,129,106 | 336,254 | 6.33 | 4 hrs 47 mins |
21 | GeForce RTX 3060 GA106 [GeForce RTX 3060] |
Nvidia | GA106 | 2,127,087 | 336,213 | 6.33 | 4 hrs 48 mins |
22 | Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT] |
AMD | Navi 21 | 2,058,265 | 328,486 | 6.27 | 4 hrs 50 mins |
23 | GeForce RTX 3060 GA104 [GeForce RTX 3060] |
Nvidia | GA104 | 2,029,989 | 331,267 | 6.13 | 4 hrs 55 mins |
24 | GeForce RTX 2060 TU106 [Geforce RTX 2060] |
Nvidia | TU106 | 1,990,609 | 328,591 | 6.06 | 4 hrs 58 mins |
25 | GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate] |
Nvidia | GA106 | 1,907,296 | 320,291 | 5.95 | 4 hrs 2 mins |
26 | GeForce RTX 3070 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB] |
Nvidia | GA104M | 1,668,009 | 310,089 | 5.38 | 4 hrs 28 mins |
27 | GeForce RTX 2060 TU104 [GeForce RTX 2060] |
Nvidia | TU104 | 1,657,609 | 308,780 | 5.37 | 4 hrs 28 mins |
28 | GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate] |
Nvidia | GA104 | 1,454,240 | 295,966 | 4.91 | 5 hrs 53 mins |
29 | Radeon VII Vega 20 [Radeon VII] 13,284 |
AMD | Vega 20 | 1,428,274 | 294,351 | 4.85 | 5 hrs 57 mins |
30 | GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186 |
Nvidia | GP104 | 1,370,040 | 290,488 | 4.72 | 5 hrs 5 mins |
31 | GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile] |
Nvidia | TU106M | 1,307,966 | 286,506 | 4.57 | 5 hrs 15 mins |
32 | GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873 |
Nvidia | GP104 | 1,259,160 | 279,910 | 4.50 | 5 hrs 20 mins |
33 | GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER] |
Nvidia | TU116 | 1,222,165 | 279,902 | 4.37 | 5 hrs 30 mins |
34 | GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti] |
Nvidia | TU116 | 1,159,582 | 274,545 | 4.22 | 6 hrs 41 mins |
35 | GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463 |
Nvidia | GP104 | 1,131,094 | 266,608 | 4.24 | 6 hrs 39 mins |
36 | Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64] |
AMD | Vega 10 XL/XT | 1,042,788 | 255,880 | 4.08 | 6 hrs 53 mins |
37 | RTX A2000 Mobile GA107GLM [RTX A2000 Mobile] |
Nvidia | GA107GLM | 1,006,653 | 262,739 | 3.83 | 6 hrs 16 mins |
38 | Radeon RX 6700/6700 XT / 6800M Navi 22 [Radeon RX 6700/6700 XT / 6800M] |
AMD | Navi 22 | 992,311 | 254,517 | 3.90 | 6 hrs 9 mins |
39 | Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT] |
AMD | Navi 10 | 985,869 | 253,025 | 3.90 | 6 hrs 10 mins |
40 | GeForce GTX 1660 TU116 [GeForce GTX 1660] |
Nvidia | TU116 | 869,474 | 249,395 | 3.49 | 7 hrs 53 mins |
41 | GeForce GTX 980 GM204 [GeForce GTX 980] 4612 |
Nvidia | GM204 | 811,687 | 243,839 | 3.33 | 7 hrs 13 mins |
42 | GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372 |
Nvidia | GP106 | 799,239 | 242,845 | 3.29 | 7 hrs 18 mins |
43 | P104-100 GP104 [P104-100] |
Nvidia | GP104 | 720,146 | 233,432 | 3.09 | 8 hrs 47 mins |
44 | GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550 |
Nvidia | TU106M | 648,075 | 151,717 | 4.27 | 6 hrs 37 mins |
45 | GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935 |
Nvidia | GP106 | 639,017 | 224,298 | 2.85 | 8 hrs 25 mins |
46 | Radeon R9 Fury X Fiji XT [Radeon R9 Fury X] |
AMD | Fiji XT | 621,860 | 223,205 | 2.79 | 9 hrs 37 mins |
47 | GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER] |
Nvidia | TU116 | 603,479 | 220,969 | 2.73 | 9 hrs 47 mins |
48 | P106-100 GP106 [P106-100] |
Nvidia | GP106 | 488,207 | 205,858 | 2.37 | 10 hrs 7 mins |
49 | GeForce GTX 970 GM204 [GeForce GTX 970] 3494 |
Nvidia | GM204 | 460,146 | 192,973 | 2.38 | 10 hrs 4 mins |
50 | Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M] |
AMD | Navi 14 | 452,141 | 200,729 | 2.25 | 11 hrs 39 mins |
51 | GeForce GTX 1650 TU117 [GeForce GTX 1650] |
Nvidia | TU117 | 434,256 | 192,060 | 2.26 | 11 hrs 37 mins |
52 | Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590] |
AMD | Ellesmere XT | 410,905 | 193,835 | 2.12 | 11 hrs 19 mins |
53 | Radeon R9 200/HD 7900/8970 Tahiti XT [Radeon R9 200/HD 7900/8970] |
AMD | Tahiti XT | 354,785 | 184,784 | 1.92 | 13 hrs 30 mins |
54 | Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile] |
Nvidia | TU117GLM | 345,613 | 184,101 | 1.88 | 13 hrs 47 mins |
55 | GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q] |
Nvidia | TU117M | 344,944 | 184,241 | 1.87 | 13 hrs 49 mins |
56 | P106-090 GP106 [P106-090] |
Nvidia | GP106 | 309,122 | 176,848 | 1.75 | 14 hrs 44 mins |
57 | GeForce GTX 960 GM206 [GeForce GTX 960] 2308 |
Nvidia | GM206 | 280,225 | 171,119 | 1.64 | 15 hrs 39 mins |
58 | GeForce GTX 770 GK104 [GeForce GTX 770] 3213 |
Nvidia | GK104 | 274,982 | 170,467 | 1.61 | 15 hrs 53 mins |
59 | GeForce GTX 950 GM206 [GeForce GTX 950] 1572 |
Nvidia | GM206 | 246,469 | 163,236 | 1.51 | 16 hrs 54 mins |
60 | GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile] |
Nvidia | GP107M | 246,160 | 164,047 | 1.50 | 16 hrs 60 mins |
61 | GeForce GTX 680 GK104 [GeForce GTX 680] 3250 |
Nvidia | GK104 | 235,433 | 161,604 | 1.46 | 16 hrs 28 mins |
62 | GeForce GTX 690 GK104 [GeForce GTX 690] 3130 |
Nvidia | GK104 | 229,998 | 159,985 | 1.44 | 17 hrs 42 mins |
63 | Radeon R9 200 Series Hawaii [Radeon R9 200 Series] |
AMD | Hawaii | 187,497 | 149,753 | 1.25 | 19 hrs 10 mins |
64 | GeForce GT 1030 GP108 [GeForce GT 1030] 1127 |
Nvidia | GP108 | 175,405 | 97,315 | 1.80 | 13 hrs 19 mins |
65 | Quadro P620 GP107GL [Quadro P620] |
Nvidia | GP107GL | 132,618 | 133,510 | 0.99 | 24 hrs 10 mins |
66 | Radeon HD 7800 Pitcairn [Radeon HD 7800] |
AMD | Pitcairn | 132,172 | 131,262 | 1.01 | 24 hrs 50 mins |
67 | Quadro K5000 GK104 [Quadro K5000] |
Nvidia | GK104 | 111,366 | 69,346 | 1.61 | 15 hrs 57 mins |
68 | Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902] |
AMD | raven | 60,155 | 102,305 | 0.59 | 41 hrs 49 mins |
69 | GeForce GT 730 GK208B [GeForce GT 730] 692.7 |
Nvidia | GK208B | 31,505 | 82,641 | 0.38 | 63 hrs 57 mins |
PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Friday, 03 February 2023 06:15:15
Rank Project |
CPU Model |
Logical Processors (LP) |
PPD-PLP AVG PPD per 1 LP |
ALL LP-PPD (Estimated) |
Make |
---|