PROJECT #16474 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
In cancer treatment it is common to target multiple different putative proteins, because multiple proteins can malfunction in tumors to drive cancer.
One such protein, particularly known to be important in endocrine gland tumors (the places where hormones are secreted), is Menin-1 (Menin).
Menin is a protein found in the nucleus protein and plays a key role in regulating cell-signaling and gene expression (which genes turn on and off).
While the explicit details of Menin's behavior are not known, targeting it's inhibition with small-molecules (ligands) has demonstrated promising potential in blocking tumor growth.
However, like with many disease, mutations within Menin can *also* counteract this ligand-binding behavior.
Therefore, it is not just important to study how Menin works, or how to target it with small molecules, but also how mutations impact Menin-Ligand interactions.
This set of projects seeks to answer the latter two questions - how do small molecules inhibit Menin and how do mutations within Menin alter small-molecule affinity.
In projects 16472 & 16473, we simulate Menin by itself and Menin bound to a known small molecule inhibitor that is shown to treat tumors in patients! Thanks to the powerhouse efforts at cataloguing cancer mutations at Memorial Sloan-Kettering, we also know of 3 mutations that impact the ability of Menin to bind this inhibitor.
Projects 16474–16483 simulate either a) each of these Menin mutants or b) Menin mutants bound to this inhibitor. Bonus: Some of these structures are being simulated with the help of the AlphaFold database!.
PROJECT INFO
Manager(s): Sukrit Singh
Institution: Memorial Sloan-Kettering Cancer-Center
Project URL: http://sukritsingh.github.io/
PROJECT WORK UNIT SUMMARY
Atoms: 187,472
Core: OPENMM_22
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Sunday, 26 June 2022 09:57:09
Rank Project |
Model Name Folding@Home Identifier |
Make Brand |
GPU Model |
PPD Average |
Points WU Average |
WUs Day Average |
WU Time Average |
---|---|---|---|---|---|---|---|
1 | GeForce RTX 3090 GA102 [GeForce RTX 3090] |
Nvidia | GA102 | 6,992,038 | 496,759 | 14.08 | 2 hrs 42 mins |
2 | GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti] |
Nvidia | GA102 | 6,279,167 | 477,491 | 13.15 | 2 hrs 50 mins |
3 | GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate] |
Nvidia | GA102 | 5,719,835 | 466,812 | 12.25 | 2 hrs 58 mins |
4 | GeForce RTX 3080 GA102 [GeForce RTX 3080] |
Nvidia | GA102 | 5,704,800 | 466,667 | 12.22 | 2 hrs 58 mins |
5 | GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448 |
Nvidia | TU102 | 4,869,999 | 443,425 | 10.98 | 2 hrs 11 mins |
6 | GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 |
Nvidia | TU102 | 4,525,476 | 432,180 | 10.47 | 2 hrs 18 mins |
7 | GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti] |
Nvidia | GA104 | 4,423,646 | 428,987 | 10.31 | 2 hrs 20 mins |
8 | GeForce RTX 3070 GA104 [GeForce RTX 3070] |
Nvidia | GA104 | 3,425,943 | 393,598 | 8.70 | 3 hrs 45 mins |
9 | GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068 |
Nvidia | TU104 | 3,197,609 | 385,818 | 8.29 | 3 hrs 54 mins |
10 | TITAN Xp GP102 [TITAN Xp] 12150 |
Nvidia | GP102 | 2,666,027 | 362,378 | 7.36 | 3 hrs 16 mins |
11 | GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218 |
Nvidia | TU104 | 2,622,315 | 356,346 | 7.36 | 3 hrs 16 mins |
12 | GeForce RTX 2080 TU104 [GeForce RTX 2080] |
Nvidia | TU104 | 2,589,384 | 359,454 | 7.20 | 3 hrs 20 mins |
13 | GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER] |
Nvidia | TU104 | 2,586,661 | 357,889 | 7.23 | 3 hrs 19 mins |
14 | Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT] |
AMD | Navi 21 | 2,505,141 | 353,794 | 7.08 | 3 hrs 23 mins |
15 | GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465 |
Nvidia | TU106 | 2,379,606 | 349,672 | 6.81 | 4 hrs 32 mins |
16 | GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380 |
Nvidia | GP102 | 2,296,310 | 343,835 | 6.68 | 4 hrs 36 mins |
17 | GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate] |
Nvidia | GA106 | 2,168,668 | 339,203 | 6.39 | 4 hrs 45 mins |
18 | GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate] |
Nvidia | GA104 | 2,160,953 | 338,473 | 6.38 | 4 hrs 46 mins |
19 | GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497 |
Nvidia | TU106 | 2,083,040 | 334,502 | 6.23 | 4 hrs 51 mins |
20 | GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER] |
Nvidia | TU106 | 2,062,537 | 326,949 | 6.31 | 4 hrs 48 mins |
21 | TITAN X GP102 [TITAN X] 6144 |
Nvidia | GP102 | 2,034,790 | 328,720 | 6.19 | 4 hrs 53 mins |
22 | GeForce RTX 3070 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB] |
Nvidia | GA104M | 1,974,812 | 328,643 | 6.01 | 4 hrs 60 mins |
23 | Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT] |
AMD | Navi 21 | 1,901,777 | 311,288 | 6.11 | 4 hrs 56 mins |
24 | Radeon VII Vega 20 [Radeon VII] 13,284 |
AMD | Vega 20 | 1,796,654 | 318,368 | 5.64 | 4 hrs 15 mins |
25 | GeForce RTX 2060 TU106 [Geforce RTX 2060] |
Nvidia | TU106 | 1,734,272 | 314,544 | 5.51 | 4 hrs 21 mins |
26 | Tesla P40 GP102GL [Tesla P40] 11760 |
Nvidia | GP102GL | 1,702,072 | 311,921 | 5.46 | 4 hrs 24 mins |
27 | GeForce RTX 2060 TU104 [GeForce RTX 2060] |
Nvidia | TU104 | 1,663,880 | 310,507 | 5.36 | 4 hrs 29 mins |
28 | GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q] |
Nvidia | GA106M | 1,601,392 | 307,254 | 5.21 | 5 hrs 36 mins |
29 | GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463 |
Nvidia | GP104 | 1,299,648 | 286,227 | 4.54 | 5 hrs 17 mins |
30 | GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile] |
Nvidia | TU106M | 1,259,148 | 283,113 | 4.45 | 5 hrs 24 mins |
31 | Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT] |
AMD | Navi 10 | 1,235,907 | 280,867 | 4.40 | 5 hrs 27 mins |
32 | GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti] |
Nvidia | TU116 | 1,152,031 | 274,532 | 4.20 | 6 hrs 43 mins |
33 | Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64] |
AMD | Vega 10 XL/XT | 1,150,276 | 269,813 | 4.26 | 6 hrs 38 mins |
34 | GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER] |
Nvidia | TU116 | 1,076,478 | 264,338 | 4.07 | 6 hrs 54 mins |
35 | GeForce GTX 1660 TU116 [GeForce GTX 1660] |
Nvidia | TU116 | 918,069 | 255,526 | 3.59 | 7 hrs 41 mins |
36 | GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550 |
Nvidia | TU106M | 822,531 | 192,710 | 4.27 | 6 hrs 37 mins |
37 | GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372 |
Nvidia | GP106 | 779,715 | 241,060 | 3.23 | 7 hrs 25 mins |
38 | P104-100 GP104 [P104-100] |
Nvidia | GP104 | 739,176 | 236,750 | 3.12 | 8 hrs 41 mins |
39 | Tesla P4 GP104GL [Tesla P4] 5704 |
Nvidia | GP104GL | 698,072 | 232,508 | 3.00 | 8 hrs 60 mins |
40 | GeForce GTX 970 GM204 [GeForce GTX 970] 3494 |
Nvidia | GM204 | 532,571 | 213,203 | 2.50 | 10 hrs 36 mins |
41 | P106-100 GP106 [P106-100] |
Nvidia | GP106 | 502,659 | 208,422 | 2.41 | 10 hrs 57 mins |
42 | Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q] |
Nvidia | TU117GLM | 418,733 | 193,824 | 2.16 | 11 hrs 7 mins |
43 | Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590] |
AMD | Ellesmere XT | 399,581 | 192,301 | 2.08 | 12 hrs 33 mins |
44 | GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER] |
Nvidia | TU116 | 372,349 | 137,907 | 2.70 | 9 hrs 53 mins |
45 | GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q] |
Nvidia | TU117M | 322,932 | 179,003 | 1.80 | 13 hrs 18 mins |
46 | P106-090 GP106 [P106-090] |
Nvidia | GP106 | 286,422 | 172,727 | 1.66 | 14 hrs 28 mins |
47 | GeForce GTX 770 GK104 [GeForce GTX 770] 3213 |
Nvidia | GK104 | 281,799 | 171,801 | 1.64 | 15 hrs 38 mins |
48 | GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile] |
Nvidia | GP107M | 277,565 | 170,896 | 1.62 | 15 hrs 47 mins |
49 | GeForce GTX 950 GM206 [GeForce GTX 950] 1572 |
Nvidia | GM206 | 249,532 | 164,755 | 1.51 | 16 hrs 51 mins |
50 | GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634 |
Nvidia | GK104 | 202,161 | 147,642 | 1.37 | 18 hrs 32 mins |
51 | GeForce GTX 690 GK104 [GeForce GTX 690] 3130 |
Nvidia | GK104 | 181,465 | 132,623 | 1.37 | 18 hrs 32 mins |
52 | Quadro K2200 GM107GL [Quadro K2200] |
Nvidia | GM107GL | 136,451 | 134,928 | 1.01 | 24 hrs 44 mins |
53 | Quadro P620 GP107GL [Quadro P620] |
Nvidia | GP107GL | 133,767 | 134,021 | 1.00 | 24 hrs 3 mins |
54 | Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950] |
AMD | Tahiti PRO | 92,416 | 69,600 | 1.33 | 18 hrs 4 mins |
55 | GeForce GT 1030 GP108 [GeForce GT 1030] 1127 |
Nvidia | GP108 | 79,921 | 98,871 | 0.81 | 30 hrs 41 mins |
56 | GRID M40 GM107GL [GRID M40] |
Nvidia | GM107GL | 77,518 | 112,072 | 0.69 | 35 hrs 42 mins |
57 | Radeon RX Vega gfx902 raven [Radeon RX Vega gfx902] |
AMD | raven | 20,072 | 69,600 | 0.29 | 83 hrs 13 mins |
58 | Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2] |
AMD | Mullins | 5,304 | 69,600 | 0.08 | 315 hrs 56 mins |
PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Sunday, 26 June 2022 09:57:09
Rank Project |
CPU Model |
Logical Processors (LP) |
PPD-PLP AVG PPD per 1 LP |
ALL LP-PPD (Estimated) |
Make |
---|
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