PROJECT #16467 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Kinases are a major target for a variety of cancer therapies, but their mechanism of action is relatively unknown at a detailed atomic level, preventing us from understanding and optimizing known inhibitors. 

One example is the Serine/Threonine Kinase RIPK2. RIPK2 inhibition is useful for cancer targeting as it prevents RIPK2 from binding a protein partner named XIAP. In fact, there are already 3 known inhibitors that bind to RIPK2 and prevent RIPK2-XIAP binding! However, it remains difficult to optimize these ligands for clinical purposes because we do not understand how any of these three inhibitors actually act on RIPK2 to prevent XIAP binding behavior. 

These four projects are simulating RIPK2 by itself and bound to each of the three inhibitors, with the hope that this will reveal a more detailed mechanism of how each inhibitor works to prevent XIAP binding. As a bonus, this will help reveal how RIPK2 *binds* XIAP (also unknown)! 

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Memorial Sloan-Kettering Cancer-Center

Project URL: http://sukritsingh.github.io/

PROJECT WORK UNIT SUMMARY

Atoms: 45,135

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 17 October 2021 08:34:53

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 4,497,618 95,273 47.21 1 hrs 31 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 4,093,867 91,687 44.65 1 hrs 32 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 3,448,081 82,348 41.87 1 hrs 34 mins
4 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 3,370,459 87,154 38.67 1 hrs 37 mins
5 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 3,153,099 84,356 37.38 1 hrs 39 mins
6 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 2,949,162 82,222 35.87 1 hrs 40 mins
7 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 2,804,177 81,418 34.44 1 hrs 42 mins
8 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 2,210,423 75,282 29.36 1 hrs 49 mins
9 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,155,324 74,936 28.76 1 hrs 50 mins
10 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 1,950,615 72,251 27.00 1 hrs 53 mins
11 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 1,901,934 70,999 26.79 1 hrs 54 mins
12 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 1,877,290 71,323 26.32 1 hrs 55 mins
13 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 1,873,056 71,540 26.18 1 hrs 55 mins
14 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 1,801,574 70,365 25.60 1 hrs 56 mins
15 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 1,790,742 70,307 25.47 1 hrs 57 mins
16 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 1,782,633 70,201 25.39 1 hrs 57 mins
17 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 1,719,214 69,419 24.77 1 hrs 58 mins
18 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,714,685 69,302 24.74 1 hrs 58 mins
19 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,642,035 67,928 24.17 1 hrs 60 mins
20 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,635,928 68,489 23.89 1 hrs 0 mins
21 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 1,555,569 66,656 23.34 1 hrs 2 mins
22 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 1,516,473 66,049 22.96 1 hrs 3 mins
23 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,444,874 65,489 22.06 1 hrs 5 mins
24 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 1,353,836 64,259 21.07 1 hrs 8 mins
25 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,344,568 63,911 21.04 1 hrs 8 mins
26 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,167,149 60,874 19.17 1 hrs 15 mins
27 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,007,139 58,077 17.34 1 hrs 23 mins
28 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 963,534 57,565 16.74 1 hrs 26 mins
29 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 932,884 56,219 16.59 1 hrs 27 mins
30 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 905,058 52,117 17.37 1 hrs 23 mins
31 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 873,587 55,610 15.71 2 hrs 32 mins
32 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 661,829 50,356 13.14 2 hrs 50 mins
33 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 570,730 47,044 12.13 2 hrs 59 mins
34 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 556,269 47,691 11.66 2 hrs 3 mins
35 GeForce GTX 1650
TU117 [GeForce GTX 1650] 3091
Nvidia TU117 551,219 47,903 11.51 2 hrs 5 mins
36 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 535,219 46,982 11.39 2 hrs 6 mins
37 GeForce GTX 1650
TU116 [GeForce GTX 1650] 2984
Nvidia TU116 449,959 44,682 10.07 2 hrs 23 mins
38 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 448,488 44,518 10.07 2 hrs 23 mins
39 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 381,493 42,453 8.99 3 hrs 40 mins
40 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 373,921 41,968 8.91 3 hrs 42 mins
41 P104-100
GP104 [P104-100]
Nvidia GP104 302,701 39,098 7.74 3 hrs 6 mins
42 P106-090
GP106 [P106-090]
Nvidia GP106 280,046 38,245 7.32 3 hrs 17 mins
43 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 274,124 37,920 7.23 3 hrs 19 mins
44 P106-100
GP106 [P106-100]
Nvidia GP106 244,568 36,277 6.74 4 hrs 34 mins
45 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 227,186 35,497 6.40 4 hrs 45 mins
46 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 186,791 32,151 5.81 4 hrs 8 mins
47 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 176,512 32,485 5.43 4 hrs 25 mins
48 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 173,266 31,589 5.49 4 hrs 23 mins
49 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 110,643 27,960 3.96 6 hrs 4 mins
50 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 101,874 27,339 3.73 6 hrs 26 mins
51 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 92,898 26,256 3.54 7 hrs 47 mins
52 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 85,929 24,966 3.44 7 hrs 58 mins
53 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 76,127 14,009 5.43 4 hrs 25 mins
54 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 73,261 24,347 3.01 8 hrs 59 mins
55 GeForce GTX 750
GM107 [GeForce GTX 750] 1111
Nvidia GM107 71,903 24,342 2.95 8 hrs 7 mins
56 GeForce GT 840M
GM108 [GeForce GT 840M]
Nvidia GM108 34,919 16,191 2.16 11 hrs 8 mins
57 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 27,289 17,617 1.55 15 hrs 30 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 17 October 2021 08:34:53

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make