PROJECT #16469 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
Kinases are a major target for a variety of cancer therapies, but their mechanism of action is relatively unknown at a detailed atomic level, preventing us from understanding and optimizing known inhibitors.
One example is the Serine/Threonine Kinase RIPK2.
RIPK2 inhibition is useful for cancer targeting as it prevents RIPK2 from binding a protein partner named XIAP.
In fact, there are already 3 known inhibitors that bind to RIPK2 and prevent RIPK2-XIAP binding! However, it remains difficult to optimize these ligands for clinical purposes because we do not understand how any of these three inhibitors actually act on RIPK2 to prevent XIAP binding behavior.
These four projects are simulating RIPK2 by itself and bound to each of the three inhibitors, with the hope that this will reveal a more detailed mechanism of how each inhibitor works to prevent XIAP binding.
As a bonus, this will help reveal how RIPK2 *binds* XIAP (also unknown)!.
PROJECT INFO
Manager(s): Sukrit Singh
Institution: Memorial Sloan-Kettering Cancer-Center
Project URL: http://sukritsingh.github.io/
PROJECT WORK UNIT SUMMARY
Atoms: 45,166
Core: OPENMM_22
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Tuesday, 07 February 2023 06:14:55
Rank Project |
Model Name Folding@Home Identifier |
Make Brand |
GPU Model |
PPD Average |
Points WU Average |
WUs Day Average |
WU Time Average |
---|---|---|---|---|---|---|---|
1 | GeForce RTX 3090 GA102 [GeForce RTX 3090] |
Nvidia | GA102 | 4,009,529 | 90,302 | 44.40 | 0 hrs 32 mins |
2 | GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti] |
Nvidia | GA102 | 3,749,805 | 86,024 | 43.59 | 0 hrs 33 mins |
3 | GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate] |
Nvidia | GA102 | 3,555,253 | 87,500 | 40.63 | 0 hrs 35 mins |
4 | GeForce RTX 3080 GA102 [GeForce RTX 3080] |
Nvidia | GA102 | 3,314,484 | 85,618 | 38.71 | 0 hrs 37 mins |
5 | GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 |
Nvidia | TU102 | 3,197,390 | 83,882 | 38.12 | 0 hrs 38 mins |
6 | GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti] |
Nvidia | GA104 | 2,931,261 | 81,726 | 35.87 | 0 hrs 40 mins |
7 | GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448 |
Nvidia | TU102 | 2,699,260 | 79,602 | 33.91 | 0 hrs 42 mins |
8 | GeForce RTX 3070 GA104 [GeForce RTX 3070] |
Nvidia | GA104 | 2,205,094 | 74,549 | 29.58 | 0 hrs 49 mins |
9 | TITAN Xp GP102 [TITAN Xp] 12150 |
Nvidia | GP102 | 2,191,908 | 74,787 | 29.31 | 0 hrs 49 mins |
10 | RTX A4000 GA104GL [RTX A4000] |
Nvidia | GA104GL | 2,026,117 | 72,696 | 27.87 | 0 hrs 52 mins |
11 | GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER] |
Nvidia | TU104 | 1,945,956 | 71,682 | 27.15 | 0 hrs 53 mins |
12 | GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465 |
Nvidia | TU106 | 1,854,010 | 70,536 | 26.28 | 0 hrs 55 mins |
13 | GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068 |
Nvidia | TU104 | 1,757,896 | 69,273 | 25.38 | 0 hrs 57 mins |
14 | GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380 |
Nvidia | GP102 | 1,746,972 | 68,803 | 25.39 | 0 hrs 57 mins |
15 | GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate] |
Nvidia | GA104 | 1,728,592 | 68,023 | 25.41 | 0 hrs 57 mins |
16 | GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218 |
Nvidia | TU104 | 1,724,906 | 68,692 | 25.11 | 0 hrs 57 mins |
17 | GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti] |
Nvidia | GA104 | 1,702,292 | 68,505 | 24.85 | 0 hrs 58 mins |
18 | GeForce RTX 3070 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB] |
Nvidia | GA104M | 1,650,470 | 66,741 | 24.73 | 0 hrs 58 mins |
19 | GeForce RTX 2060 TU104 [GeForce RTX 2060] |
Nvidia | TU104 | 1,607,387 | 67,220 | 23.91 | 1 hrs 0 mins |
20 | GeForce RTX 2080 TU104 [GeForce RTX 2080] |
Nvidia | TU104 | 1,587,955 | 67,152 | 23.65 | 1 hrs 1 mins |
21 | Tesla P40 GP102GL [Tesla P40] 11760 |
Nvidia | GP102GL | 1,511,684 | 65,352 | 23.13 | 1 hrs 2 mins |
22 | GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER] |
Nvidia | TU106 | 1,469,309 | 64,169 | 22.90 | 1 hrs 3 mins |
23 | TITAN X GP102 [TITAN X] 6144 |
Nvidia | GP102 | 1,374,118 | 63,649 | 21.59 | 1 hrs 7 mins |
24 | GeForce RTX 3060 GA106 [GeForce RTX 3060] |
Nvidia | GA106 | 1,350,754 | 63,755 | 21.19 | 1 hrs 8 mins |
25 | GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q] |
Nvidia | GA106M | 1,332,054 | 63,344 | 21.03 | 1 hrs 8 mins |
26 | GeForce RTX 2060 TU106 [Geforce RTX 2060] |
Nvidia | TU106 | 1,327,383 | 63,144 | 21.02 | 1 hrs 9 mins |
27 | GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186 |
Nvidia | GP104 | 1,099,511 | 59,666 | 18.43 | 1 hrs 18 mins |
28 | GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463 |
Nvidia | GP104 | 956,833 | 56,616 | 16.90 | 1 hrs 25 mins |
29 | GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti] |
Nvidia | TU116 | 953,000 | 56,253 | 16.94 | 1 hrs 25 mins |
30 | GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile] |
Nvidia | TU106M | 918,790 | 56,012 | 16.40 | 1 hrs 28 mins |
31 | GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER] |
Nvidia | TU116 | 912,881 | 55,127 | 16.56 | 1 hrs 27 mins |
32 | GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497 |
Nvidia | TU106 | 872,105 | 51,849 | 16.82 | 1 hrs 26 mins |
33 | GeForce GTX 1660 TU116 [GeForce GTX 1660] |
Nvidia | TU116 | 837,254 | 54,242 | 15.44 | 2 hrs 33 mins |
34 | Tesla P4 GP104GL [Tesla P4] 5704 |
Nvidia | GP104GL | 642,884 | 48,695 | 13.20 | 2 hrs 49 mins |
35 | GeForce GTX 980 GM204 [GeForce GTX 980] 4612 |
Nvidia | GM204 | 592,394 | 48,057 | 12.33 | 2 hrs 57 mins |
36 | GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER] |
Nvidia | TU116 | 575,682 | 47,590 | 12.10 | 2 hrs 59 mins |
37 | GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372 |
Nvidia | GP106 | 479,075 | 43,058 | 11.13 | 2 hrs 9 mins |
38 | GeForce GTX 1650 TU117 [GeForce GTX 1650] 3091 |
Nvidia | TU117 | 476,546 | 45,438 | 10.49 | 2 hrs 17 mins |
39 | GeForce GTX 970 GM204 [GeForce GTX 970] 3494 |
Nvidia | GM204 | 420,139 | 42,965 | 9.78 | 2 hrs 27 mins |
40 | GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873 |
Nvidia | GP104 | 403,339 | 24,591 | 16.40 | 1 hrs 28 mins |
41 | Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q] |
Nvidia | TU117GLM | 378,190 | 41,893 | 9.03 | 3 hrs 40 mins |
42 | GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q] |
Nvidia | TU117M | 329,307 | 39,743 | 8.29 | 3 hrs 54 mins |
43 | P104-100 GP104 [P104-100] |
Nvidia | GP104 | 300,600 | 38,442 | 7.82 | 3 hrs 4 mins |
44 | GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984 |
Nvidia | TU116 | 296,814 | 39,856 | 7.45 | 3 hrs 13 mins |
45 | GeForce GTX 960 GM206 [GeForce GTX 960] 2308 |
Nvidia | GM206 | 252,641 | 36,102 | 7.00 | 3 hrs 26 mins |
46 | P106-090 GP106 [P106-090] |
Nvidia | GP106 | 229,653 | 35,389 | 6.49 | 4 hrs 42 mins |
47 | GeForce GTX 950 GM206 [GeForce GTX 950] 1572 |
Nvidia | GM206 | 185,750 | 32,035 | 5.80 | 4 hrs 8 mins |
48 | GeForce GTX 690 GK104 [GeForce GTX 690] 3130 |
Nvidia | GK104 | 173,686 | 32,297 | 5.38 | 4 hrs 28 mins |
49 | GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634 |
Nvidia | GK104 | 158,632 | 28,992 | 5.47 | 4 hrs 23 mins |
50 | GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile] |
Nvidia | GP107M | 142,533 | 27,125 | 5.25 | 5 hrs 34 mins |
51 | Quadro P1000 GP107GL [Quadro P1000] |
Nvidia | GP107GL | 110,680 | 27,454 | 4.03 | 6 hrs 57 mins |
52 | GeForce GT 1030 GP108 [GeForce GT 1030] 1127 |
Nvidia | GP108 | 107,687 | 27,323 | 3.94 | 6 hrs 5 mins |
53 | Quadro K2200 GM107GL [Quadro K2200] |
Nvidia | GM107GL | 104,114 | 27,173 | 3.83 | 6 hrs 16 mins |
54 | GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389 |
Nvidia | GM107 | 101,283 | 26,695 | 3.79 | 6 hrs 20 mins |
55 | Quadro K1200 GM107GL [Quadro K1200] |
Nvidia | GM107GL | 71,769 | 23,928 | 3.00 | 8 hrs 0 mins |
56 | GeForce GTX 570 HD GF110 [GeForce GTX 570 HD] 1405 |
Nvidia | GF110 | 44,477 | 20,402 | 2.18 | 11 hrs 1 mins |
57 | GeForce GTX 960M GM107 [GeForce GTX 960M] 1439 |
Nvidia | GM107 | 18,457 | 7,211 | 2.56 | 9 hrs 23 mins |
PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Tuesday, 07 February 2023 06:14:55
Rank Project |
CPU Model |
Logical Processors (LP) |
PPD-PLP AVG PPD per 1 LP |
ALL LP-PPD (Estimated) |
Make |
---|