Folding project #14972, PARKINSONS research

Research section Research projects and references

Project #14972 overview

Project Summary AI Beta

This project relates to studying special proteins in the brain called Class C Receptors. They're important for things like controlling mood and pain, and even helping people recover from opioid addiction. Scientists use computer simulations to figure out how these proteins work, which could lead to better treatments for diseases like Parkinson's and depression.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 303,587
Core: 0x22
Status: Public

Source material

Official Project Description

Class C Receptors Class C Receptors consist of human proteins that are involved in the control of neuronal signaling in the brain.

Overactivation/Inactivation of these receptors has been linked to Parkinsons, Anxiety, Depression, Pain Relief.

This receptor also shows significant importance when it comes to treating opioid addiction.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease, and design more effective anti-opioid drugs.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class C Receptors

Group of human proteins controlling neuronal signaling in the brain.

Scientific: BiotechnologyNeuroscience / Pharmacology

Class C receptors are a family of proteins found in the human brain that play a crucial role in transmitting signals between nerve cells. These receptors are involved in various neurological functions, including mood regulation, pain perception, and movement control. Imbalances in Class C receptor activity have been implicated in disorders such as Parkinson's disease, anxiety, depression, and opioid addiction. Researchers are studying these receptors to develop new treatments for these conditions.

Parkinsons

A progressive neurodegenerative disorder affecting movement.

Pathological: BiotechnologyNeuroscience / Neurology

Parkinson's disease is a chronic and progressive neurological disorder that affects movement. It is caused by the death of dopamine-producing neurons in the brain, leading to symptoms such as tremor, stiffness, slow movements, and balance problems. There is no cure for Parkinson's disease, but medications and therapies can help manage symptoms and improve quality of life.

Anxiety

A feeling of worry, nervousness, or unease.

Psychological: HealthcareMental Health / Psychiatry

Anxiety is a common human emotion characterized by feelings of worry, nervousness, fear, and apprehension. It can manifest as physical symptoms such as increased heart rate, sweating, trembling, and shortness of breath. Anxiety disorders are diagnosed when these feelings are excessive, persistent, and interfere with daily life.

Depression

A mood disorder characterized by persistent sadness and loss of interest.

Psychological: HealthcareMental Health / Psychiatry

Depression is a mental health disorder that causes persistent feelings of sadness, hopelessness, and loss of interest in activities. It can affect various aspects of life, including work, relationships, and overall well-being. Symptoms may include fatigue, changes in sleep and appetite, difficulty concentrating, and thoughts of death or suicide.

Pain Relief

The reduction or elimination of pain.

Therapeutic: PharmaceuticalsMedicine / Anesthesiology

Pain relief refers to the management and reduction of pain. It can be achieved through various methods, including medications (analgesics), physical therapies, psychological interventions, and alternative medicine practices. The goal of pain relief is to improve patient comfort, function, and quality of life.

Opioid Addiction

A chronic condition characterized by the compulsive use of opioid drugs despite harmful consequences.

Medical: HealthcareMedicine / Addiction Medicine

Opioid addiction is a serious and complex medical condition characterized by an uncontrollable craving for opioid medications. It involves changes in brain chemistry that make it difficult to resist using opioids, even when they cause harm to physical health, relationships, or finances. Treatment for opioid addiction often involves a combination of medication, therapy, and support groups.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	36,138,726	105,000	344.18	0 ^hrs 4 ^mins
2	RTX PRO 6000 Blackwell Workstation Edition GB202GL [RTX PRO 6000 Blackwell Workstation Edition]	Nvidia	GB202GL	32,052,910	105,000	305.27	0 ^hrs 5 ^mins
3	B200 GB100 [B200]	Nvidia	GB100	29,150,665	105,000	277.63	0 ^hrs 5 ^mins
4	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	23,856,657	352,341	67.71	0 ^hrs 21 ^mins
5	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	16,863,318	287,857	58.58	0 ^hrs 25 ^mins
6	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	16,402,847	468,035	35.05	0 ^hrs 41 ^mins
7	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	16,340,349	261,980	62.37	0 ^hrs 23 ^mins
8	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	15,996,938	143,170	111.73	0 ^hrs 13 ^mins
9	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	11,872,582	540,222	21.98	1 ^hrs 6 ^mins
10	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	11,762,113	105,000	112.02	0 ^hrs 13 ^mins
11	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	11,100,391	202,192	54.90	0 ^hrs 26 ^mins
12	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	10,641,268	537,202	19.81	1 ^hrs 13 ^mins
13	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	10,439,674	119,449	87.40	0 ^hrs 16 ^mins
14	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	10,392,722	549,710	18.91	1 ^hrs 16 ^mins
15	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	7,099,986	254,577	27.89	0 ^hrs 52 ^mins
16	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	6,818,407	105,000	64.94	0 ^hrs 22 ^mins
17	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,740,705	322,333	20.91	1 ^hrs 9 ^mins
18	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,229,670	105,000	59.33	0 ^hrs 24 ^mins
19	GeForce RTX 4080 Max-Q / Mobile AD104M [GeForce RTX 4080 Max-Q / Mobile]	Nvidia	AD104M	6,149,879	458,495	13.41	1 ^hrs 47 ^mins

20	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	6,035,361	461,955	13.06	1 ^hrs 50 ^mins
21	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,908,116	331,963	17.80	1 ^hrs 21 ^mins
22	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,768,864	209,976	27.47	0 ^hrs 52 ^mins
23	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,558,934	317,235	17.52	1 ^hrs 22 ^mins
24	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,544,919	105,000	52.81	0 ^hrs 27 ^mins
25	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	5,240,270	225,441	23.24	1 ^hrs 2 ^mins
26	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	5,067,491	105,000	48.26	0 ^hrs 30 ^mins
27	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,768,871	416,942	11.44	2 ^hrs 6 ^mins
28	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,491,254	406,905	11.04	2 ^hrs 10 ^mins
29	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,823,963	396,827	9.64	2 ^hrs 29 ^mins
30	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,375,501	164,323	20.54	1 ^hrs 10 ^mins
31	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,216,992	264,637	12.16	1 ^hrs 58 ^mins
32	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,193,930	323,175	9.88	2 ^hrs 26 ^mins
33	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	3,031,480	105,000	28.87	0 ^hrs 50 ^mins
34	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,992,972	365,695	8.18	2 ^hrs 56 ^mins
35	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,938,654	362,270	8.11	2 ^hrs 58 ^mins
36	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,569,191	237,354	10.82	2 ^hrs 13 ^mins
37	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,529,476	105,000	24.09	0 ^hrs 60 ^mins
38	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,527,448	333,190	7.59	3 ^hrs 10 ^mins
39	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,442,383	341,606	7.15	3 ^hrs 21 ^mins

40	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,430,835	105,000	23.15	1 ^hrs 2 ^mins
41	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,253,232	216,643	10.40	2 ^hrs 18 ^mins
42	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,855,805	307,172	6.04	3 ^hrs 58 ^mins
43	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,707,164	304,964	5.60	4 ^hrs 17 ^mins
44	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,574,984	105,000	15.00	1 ^hrs 36 ^mins
45	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,464,849	188,592	7.77	3 ^hrs 5 ^mins
46	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,453,427	105,000	13.84	1 ^hrs 44 ^mins
47	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,435,865	277,253	5.18	4 ^hrs 38 ^mins
48	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	1,275,052	105,000	12.14	1 ^hrs 59 ^mins
49	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,213,989	284,434	4.27	5 ^hrs 37 ^mins
50	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,167,377	105,000	11.12	2 ^hrs 10 ^mins
51	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	819,529	105,000	7.81	3 ^hrs 4 ^mins
52	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	809,000	105,000	7.70	3 ^hrs 7 ^mins
53	Radeon PRO W6600 Navi 23 XL [Radeon PRO W6600]	AMD	Navi 23 XL	689,173	184,052	3.74	6 ^hrs 25 ^mins
54	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	593,989	179,326	3.31	7 ^hrs 15 ^mins
55	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	567,607	105,000	5.41	4 ^hrs 26 ^mins
56	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	548,415	225,441	2.43	9 ^hrs 52 ^mins
57	Radeon RX 580 2048SP Polaris 20 XL [Radeon RX 580 2048SP]	AMD	Polaris 20 XL	401,191	186,889	2.15	11 ^hrs 11 ^mins
58	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	332,017	105,000	3.16	7 ^hrs 35 ^mins
59	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	95,967	105,000	0.91	26 ^hrs 16 ^mins

60	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	91,738	105,000	0.87	27 ^hrs 28 ^mins

Research: PARKINSONS Folding Project #14972

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14972

GPU PPD Averages

Research: PARKINSONS Folding Project #14972

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages