Folding project #14939, PARKINSONS research

Research section Research projects and references

Project #14939 overview

Project Summary AI Beta

This project looks at a type of brain protein called Class C Receptors. These proteins control how brain cells talk to each other and are linked to things like Parkinson's disease, anxiety, depression, and pain relief. By studying how these proteins work, researchers hope to learn more about these diseases and develop new drugs to treat them, especially for opioid addiction.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 296,245
Core: 0x22
Status: Public

No related projects listed.

Source material

Official Project Description

Class C Receptors Class C Receptors consist of human proteins that are involved in the control of neuronal signaling in the brain.

Overactivation/Inactivation of these receptors has been linked to Parkinsons, Anxiety, Depression, Pain Relief.

This receptor also shows significant importance when it comes to treating opioid addiction.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease, and design more effective anti-opioid drugs.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Receptors

Proteins that bind to signaling molecules.

Technical: BiotechnologyNeuroscience / Pharmacology

Receptors are specialized proteins found on the surface of cells. They play a crucial role in cellular communication by binding to specific signaling molecules, such as hormones or neurotransmitters. This binding triggers a series of events within the cell, ultimately leading to a response. Receptors are essential for various physiological processes, including sensory perception, muscle contraction, and hormone regulation.

Parkinsons

A progressive neurodegenerative disorder.

Pathological: HealthcareNeuroscience / Neurodegenerative Diseases

Parkinson's disease is a chronic and progressive neurological disorder characterized by the loss of dopamine-producing neurons in the brain. This leads to a range of motor symptoms, including tremors, rigidity, slow movements (bradykinesia), and postural instability. While there is no cure for Parkinson's disease, medications and therapies can help manage symptoms and improve quality of life.

Anxiety

A feeling of worry, nervousness, or unease.

Psychological: HealthcareMental Health / Neuropsychiatric Disorders

Anxiety is a common human emotion characterized by feelings of worry, fear, apprehension, and restlessness. It can manifest in various ways, including physical symptoms (e.g., rapid heartbeat, sweating), cognitive symptoms (e.g., racing thoughts, difficulty concentrating), and behavioral symptoms (e.g., avoidance behaviors). Anxiety disorders are diagnosed when these feelings are persistent, excessive, and interfere with daily life.

Depression

A mood disorder characterized by persistent sadness and loss of interest.

Psychological: HealthcareMental Health / Neuropsychiatric Disorders

Depression is a serious mental health condition characterized by persistent feelings of sadness, hopelessness, and loss of interest in activities that were once enjoyable. It can affect thoughts, behaviors, and physical well-being. Symptoms may include fatigue, changes in appetite or sleep patterns, difficulty concentrating, and feelings of worthlessness or guilt.

Pain Relief

The reduction or elimination of pain.

Therapeutic: PharmaceuticalsMedicine / Anesthesiology

Pain relief refers to the management and alleviation of pain. This can be achieved through various methods, including medications (e.g., analgesics), physical therapy, nerve blocks, and alternative therapies. The goal is to reduce pain levels, improve function, and enhance quality of life.

Opioid Addiction

A chronic relapsing disorder characterized by compulsive opioid use despite harmful consequences.

Medical Condition: HealthcareMedicine / Addiction Treatment

Opioid addiction is a serious public health concern characterized by a strong dependence on opioids (e.g., heroin, prescription painkillers). It involves craving, compulsive drug-seeking behavior, and continued use despite negative consequences for physical and mental health, relationships, and work.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 5090 GB202 [GeForce RTX 5090]	Nvidia	GB202	34,880,839	38,000	917.92	0 ^hrs 2 ^mins
2	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	23,132,905	232,267	99.60	0 ^hrs 14 ^mins
3	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	17,114,403	299,685	57.11	0 ^hrs 25 ^mins
4	GeForce RTX 5080 GB203 [GeForce RTX 5080]	Nvidia	GB203	17,084,062	38,000	449.58	0 ^hrs 3 ^mins
5	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	16,499,701	109,285	150.98	0 ^hrs 10 ^mins
6	GeForce RTX 5070 Ti GB203 [GeForce RTX 5070 Ti]	Nvidia	GB203	14,327,504	88,057	162.71	0 ^hrs 9 ^mins
7	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	12,837,044	259,006	49.56	0 ^hrs 29 ^mins
8	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	12,312,522	291,918	42.18	0 ^hrs 34 ^mins
9	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	12,309,371	73,099	168.39	0 ^hrs 9 ^mins
10	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	11,992,251	220,557	54.37	0 ^hrs 26 ^mins
11	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	10,602,424	268,071	39.55	0 ^hrs 36 ^mins
12	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	10,280,941	275,090	37.37	0 ^hrs 39 ^mins
13	GeForce RTX 5070 GB205 [GeForce RTX 5070]	Nvidia	GB205	9,844,962	38,000	259.08	0 ^hrs 6 ^mins
14	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,716,743	257,972	37.67	0 ^hrs 38 ^mins
15	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	9,145,292	262,480	34.84	0 ^hrs 41 ^mins
16	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	8,652,817	260,130	33.26	0 ^hrs 43 ^mins
17	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	7,888,386	252,258	31.27	0 ^hrs 46 ^mins
18	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	7,555,408	210,429	35.90	0 ^hrs 40 ^mins
19	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,786,850	122,244	55.52	0 ^hrs 26 ^mins

20	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	6,130,827	231,567	26.48	0 ^hrs 54 ^mins
21	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	6,049,892	174,861	34.60	0 ^hrs 42 ^mins
22	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,721,786	38,000	150.57	0 ^hrs 10 ^mins
23	GeForce RTX 5060 Ti GB206 [GeForce RTX 5060 Ti]	Nvidia	GB206	5,611,528	38,000	147.67	0 ^hrs 10 ^mins
24	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,303,502	192,401	27.56	0 ^hrs 52 ^mins
25	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	5,158,942	157,278	32.80	0 ^hrs 44 ^mins
26	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,835,877	215,707	22.42	1 ^hrs 4 ^mins
27	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,570,604	206,866	22.09	1 ^hrs 5 ^mins
28	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	4,064,854	202,645	20.06	1 ^hrs 12 ^mins
29	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	4,056,399	177,662	22.83	1 ^hrs 3 ^mins
30	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	4,050,660	204,282	19.83	1 ^hrs 13 ^mins
31	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	4,046,375	202,428	19.99	1 ^hrs 12 ^mins
32	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	3,922,556	202,270	19.39	1 ^hrs 14 ^mins
33	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	3,897,375	202,183	19.28	1 ^hrs 15 ^mins
34	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	3,691,138	199,236	18.53	1 ^hrs 18 ^mins
35	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,528,610	194,137	18.18	1 ^hrs 19 ^mins
36	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,491,422	163,755	21.32	1 ^hrs 8 ^mins
37	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,368,264	98,675	34.13	0 ^hrs 42 ^mins
38	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	3,194,245	188,243	16.97	1 ^hrs 25 ^mins
39	GeForce RTX 4050 Max-Q / Mobile AD107M [GeForce RTX 4050 Max-Q / Mobile]	Nvidia	AD107M	3,177,301	189,921	16.73	1 ^hrs 26 ^mins

40	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,157,925	149,745	21.09	1 ^hrs 8 ^mins
41	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	3,153,560	186,389	16.92	1 ^hrs 25 ^mins
42	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	3,062,104	185,679	16.49	1 ^hrs 27 ^mins
43	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	3,013,636	185,348	16.26	1 ^hrs 29 ^mins
44	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,879,223	181,812	15.84	1 ^hrs 31 ^mins
45	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,834,716	168,116	16.86	1 ^hrs 25 ^mins
46	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,718,694	231,695	11.73	2 ^hrs 3 ^mins
47	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,654,021	146,859	18.07	1 ^hrs 20 ^mins
48	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,513,836	38,000	66.15	0 ^hrs 22 ^mins
49	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	2,435,359	80,476	30.26	0 ^hrs 48 ^mins
50	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,393,140	140,869	16.99	1 ^hrs 25 ^mins
51	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,282,134	168,783	13.52	1 ^hrs 47 ^mins
52	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,730,773	153,195	11.30	2 ^hrs 7 ^mins
53	GeForce RTX 3050 Ti Mobile GA107M [GeForce RTX 3050 Ti Mobile]	Nvidia	GA107M	1,701,587	152,242	11.18	2 ^hrs 9 ^mins
54	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,662,053	151,419	10.98	2 ^hrs 11 ^mins
55	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,545,455	148,526	10.41	2 ^hrs 18 ^mins
56	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,528,986	148,630	10.29	2 ^hrs 20 ^mins
57	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,503,740	105,395	14.27	1 ^hrs 41 ^mins
58	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,493,178	147,291	10.14	2 ^hrs 22 ^mins
59	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,450,122	145,915	9.94	2 ^hrs 25 ^mins

60	Radeon Vega FE Vega 10 XTX [Radeon Vega FE]	AMD	Vega 10 XTX	1,341,516	137,914	9.73	2 ^hrs 28 ^mins
61	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,291,335	140,080	9.22	2 ^hrs 36 ^mins
62	Radeon RX 7700S/7600(S) Navi 33 [Radeon RX 7700S/7600(S)]	AMD	Navi 33	1,235,529	133,264	9.27	2 ^hrs 35 ^mins
63	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	1,102,135	132,623	8.31	2 ^hrs 53 ^mins
64	Radeon PRO W6600 Navi 23 XL [Radeon PRO W6600]	AMD	Navi 23 XL	983,993	128,526	7.66	3 ^hrs 8 ^mins
65	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	905,548	125,082	7.24	3 ^hrs 19 ^mins
66	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	863,129	123,111	7.01	3 ^hrs 25 ^mins
67	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	841,597	120,633	6.98	3 ^hrs 26 ^mins
68	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	742,953	117,248	6.34	3 ^hrs 47 ^mins
69	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	720,314	115,383	6.24	3 ^hrs 51 ^mins
70	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	675,564	112,710	5.99	4 ^hrs 0 ^mins
71	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	651,032	111,398	5.84	4 ^hrs 6 ^mins
72	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	616,880	109,653	5.63	4 ^hrs 16 ^mins
73	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	609,260	108,669	5.61	4 ^hrs 17 ^mins
74	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	522,966	101,639	5.15	4 ^hrs 40 ^mins
75	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	407,222	95,465	4.27	5 ^hrs 38 ^mins
76	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	398,759	94,804	4.21	5 ^hrs 42 ^mins
77	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	371,470	91,302	4.07	5 ^hrs 54 ^mins
78	P106-090 GP106 [P106-090]	Nvidia	GP106	352,888	92,590	3.81	6 ^hrs 18 ^mins
79	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	351,806	38,000	9.26	2 ^hrs 36 ^mins

80	R9 380X/R9 M295X Tonga XT/Amethyst XT [R9 380X/R9 M295X]	AMD	Tonga XT/Amethyst XT	259,685	78,947	3.29	7 ^hrs 18 ^mins
81	R9 280X/HD 7900/8970 OEM Tahiti XT [R9 280X/HD 7900/8970 OEM]	AMD	Tahiti XT	254,862	81,596	3.12	7 ^hrs 41 ^mins
82	Radeon R9 285/380 Tonga PRO [Radeon R9 285/380]	AMD	Tonga PRO	243,724	80,489	3.03	7 ^hrs 56 ^mins
83	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	185,942	73,749	2.52	9 ^hrs 31 ^mins
84	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	123,156	64,017	1.92	12 ^hrs 29 ^mins
85	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	57,046	49,773	1.15	20 ^hrs 56 ^mins
86	GeForce MX450 TU117M [GeForce MX450]	Nvidia	TU117M	43,587	45,245	0.96	24 ^hrs 55 ^mins
87	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	37,311	38,000	0.98	24 ^hrs 27 ^mins

Research: PARKINSONS Folding Project #14939

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14939

GPU PPD Averages

Research: PARKINSONS Folding Project #14939

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages